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Search Results: 1 - 10 of 4995 matches for " Jiae Choi "
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Ginseng for Health Care: A Systematic Review of Randomized Controlled Trials in Korean Literature
Jiae Choi, Tae-Hun Kim, Tae-Young Choi, Myeong Soo Lee
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0059978
Abstract: Objective This systematic review was performed to summarise randomised clinical trials (RCTs) assessing the efficacy and safety of ginseng in the Korean literature. Method The study involved systematic searches conducted in eight Korean Medical databases. The methodological quality of all of the included studies was assessed using the Cochrane Risk of Bias tool. We included all RCTs on any type of ginseng compared to placebo, active treatment or no treatment in healthy individuals or patients regardless of conditions. Results In total, 1415 potentially relevant studies were identified, and 30 randomised clinical trials were included. Nine RCTs assessed the effects of ginseng on exercise capacity, cognitive performance, somatic symptoms, quality of life, and sleeping in healthy persons. Six RCTs tested ginseng compared with placebo for erectile dysfunction, while another four studies evaluated the effects of ginseng against no treatment for gastric and colon cancer. Two RCTs compared the effect of red ginseng on diabetes mellitus with no treatment or placebo, and the other nine RCTs assessed the effects of ginseng compared with placebo or no treatment on various conditions. The methodological caveats of the included trials make their contribution to the current clinical evidence of ginseng somewhat limited. However, the 20 newly added trials (66.7% of the 30 trials) may provide useful information for future trials. Ginseng appears to be generally safe, and no serious adverse effects have been reported. Conclusions The clinical effects of ginseng have been tested in a wide range of conditions in Korea. Although the quality of RCTs published in the Korean literature was generally poor, this review is useful for researchers to access studies that were originally published in languages that they would otherwise be unable to read and due to the paucity of evidence on this subject.
Screening for novel enzymes from metagenome and SIGEX, as a way to improve it
Jiae Yun, Sangryeol Ryu
Microbial Cell Factories , 2005, DOI: 10.1186/1475-2859-4-8
Abstract: More than 99% of bacteria in the environment cannot be cultured using conventional methods [1,2]. To study and use the genomes of such uncultured microbes, metagenomics has been in the spotlight since the 1990s [3]. Many studies have constructed metagenomic libraries to search for novel biocatalysts or molecules for biotechnological and pharmaceutical applications. To date, metagenomics has uncovered a variety of novel genes ranged from small genes conferring enzymes to complex gene clusters encoding proteins involved in antibiotic production, using different kinds of vectors such as plasmids, cosmids, fosmids and bacterial artificial chromosomes [4]. However, the efficiency of searching for novel catalysts from metagenome can still be improved. Screening for desired traits needs improvement because this step is still labor-intensive and time-consuming. This mini-review discusses the strategies that have been used in metagenome screening, particularly the recently introduced screening strategy, SIGEX. The characteristics of the discussed strategies are summarized in Table 1.Two strategies are generally used to screen and identify novel biocatalysts or genes involved in the production of antibiotic from metagenomic libraries: function-based and sequence-based screening. In function-based screening, clones expressing desired traits are selected from libraries, and aspects of molecular biology and biochemistry of active clones are analyzed. Many enzymes of industrial importance have been discovered using this strategy (Table 1). This approach enables the rapid acquisition of clones that have potential of direct application in industry. Moreover, this screening method can detect genes with completely novel DNA sequences, which may have functions distinct from known biocatalysts. However, function-based screening has several limitations. This method requires expression of the function of interest in the host cell (e.g. Escherichia coli) as well as clustering of all of th
Natural Science Foundation Committee Making All-out Efforts to Advance China''s Sci-tech Journals to International Arena


中国科技期刊研究 , 2008,
Abstract: 基于我国经济快速发展、科技投入大幅增长和科技自主创新能力尚不高的现实,认为当前我国学术期刊的发展机遇与挑战并存。笔者指出我国科技期刊做大做强需要期刊的编辑、审稿人、论文的作者和相关的政府部门共同努力。
Reliability and validity of the Korean standard pattern identification for stroke (K-SPI-Stroke) questionnaire
Byoung-Kab Kang, Tae Yong Park, Tae Woong Moon, Ju Ah Lee, Mi Mi Ko, Jiae Choi, Myeong Soo Lee
BMC Complementary and Alternative Medicine , 2012, DOI: 10.1186/1472-6882-12-55
Abstract: Between September 2006 and December 2010, 2,905 patients from 11 Korean medical hospitals were asked to complete the K-SPI-Stroke questionnaire as a part of project ' Fundamental study for the standardization and objectification of pattern identification in traditional Korean medicine for stroke (SOPI-Stroke). Each patient was independently diagnosed by two TKM physicians from the same site according to one of four patterns, as suggested by the Korea Institute of Oriental Medicine: 1) a Qi deficiency pattern, 2) a Dampness-phlegm pattern, 3) a Yin deficiency pattern, or 4) a Fire-heat pattern. We estimated the internal consistency using Cronbach’s α coefficient, the discriminant validity using the means score of patterns, and the predictive validity using the classification accuracy of the K-SPI-Stroke questionnaire.The K-SPI-Stroke questionnaire had satisfactory internal consistency (α?=?0.700) and validity, with significant differences in the mean of scores among the four patterns. The overall classification accuracy of this questionnaire was 65.2 %.These results suggest that the K-SPI-Stroke questionnaire is a reliable and valid instrument for estimating the severity of the four patterns.
Developing indicators of pattern identification in patients with stroke using traditional Korean medicine
Ju Lee, Tae-Yong Park, Jungsup Lee, Tae-Woong Moon, Jiae Choi, Byoung-Kab Kang, Mi Ko, Myeong Lee
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-136
Abstract: We sorted out stroke patterns with an expert committee organized by the Korean Institute of Oriental Medicine. The expert committee composed a document for a standardized pattern of identification for stroke based on the traditional Korean medical literature, and we evaluated the clinical significance of the document through a field test.We established five stroke patterns from the traditional Korean medical literature and extracted 117 indicators required for diagnosis. The indicators were evaluated by a field test and verified by the expert committee.This study sought to develop indicators of PI based on the traditional Korean medical literature. This process contributed to the standardization of traditional Korean medical diagnoses.Pattern identification is a system of diagnosis in traditional Korean medicine (TKM) that is characterized by its own theoretical basis and practical experience [1]. This unique system entails a comprehensive symptom analysis and an investigation of the illness, its cause and nature, the patient's physical condition and the patient's treatment through four examinations (inspection, listening and smelling, inquiry and palpation) [2]. TKM has advantages, such as one-to-one personalized care accompanying the patient's diagnosis. However, these characteristics are criticized because of the ambiguous process of diagnosis. Different ways of pattern identifications are often used for diagnosis by different Oriental medical clinicians in identical patients [3]. Oriental medical clinicians have claimed that differences exist between Western medicine and TKM in terms of therapy and the objective for treating and diagnosing patients. However, standardized and objective methods for diagnosis in TKM are needed. The Korea Institute of Oriental Medicine (KIOM) has conducted a fundamental study for the standardization and objectification of pattern identification in TKM for stroke (SOPI-Stroke) since 2005 [4-6]. We organized a committee comprised of p
Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library
Eunyoung Choi, Jiae Lee, Jungsu Oh, Inju Park, Cecil Han, Chongil Yi, Do Kim, Byung-Nam Cho, Edward M Eddy, Chunghee Cho
BMC Genomics , 2007, DOI: 10.1186/1471-2164-8-256
Abstract: We analyzed the mouse spermatocyte UniGene library containing 2155 gene-oriented transcript clusters. We predict that 11% of these genes are testis-specific and systematically identified 24 authentic genes specifically and abundantly expressed in the testis via in silico and in vitro approaches. Northern blot analysis disclosed various transcript characteristics, such as expression level, size and the presence of isoform. Expression analysis revealed developmentally regulated and stage-specific expression patterns in all of the genes. We further analyzed the genes at the protein and cellular levels. Transfection assays performed using GC-2 cells provided information on the cellular characteristics of the gene products. In addition, antibodies were generated against proteins encoded by some of the genes to facilitate their identification and characterization in spermatogenic cells and sperm. Our data suggest that a number of the gene products are implicated in transcriptional regulation, nuclear integrity, sperm structure and motility, and fertilization. In particular, we found for the first time that Mm.333010, predicted to contain a trypsin-like serine protease domain, is a sperm acrosomal protein.We identify 24 authentic genes with spermatogenic cell-specific expression, and provide comprehensive information about the genes. Our findings establish a new basis for future investigation into molecular mechanisms underlying male reproduction.During male reproduction, germ cells are processed from the primordial stage through spermatogenesis occurring in the seminiferous tubules of testis. The tightly regulated process that occurs in mitotic, meiotic, and post-meiotic phases drives successful male germ cell development or spermatogenesis [1-3]. Spermatogonial stem cells located around the outer region next to the basal lamina surrounding seminiferous tubules undergo mitosis, and some differentiate into later-stage spermatogonia that gradually become primary spermatocyt
Systematic identification and integrative analysis of novel genes expressed specifically or predominantly in mouse epididymis
Jungsu Oh, Jiae Lee, Jong-Min Woo, Eunyoung Choi, Inju Park, Cecil Han, Namhoe Baek, Hoyong Lee, Do Kim, Chunghee Cho
BMC Genomics , 2006, DOI: 10.1186/1471-2164-7-314
Abstract: We systematically identified 32 novel genes with epididymis-specific or -predominant expression in the mouse epididymis UniGene library, containing 1505 gene-oriented transcript clusters, by in silico and in vitro analyses. The Northern blot analysis revealed various characteristics of the genes at the transcript level, such as expression level, size and the presence of isoform. We found that expression of the half of the genes is regulated by androgens. Further expression analyses demonstrated that the novel genes are region-specific and developmentally regulated. Computational analysis showed that 15 of the genes lack human orthologues, suggesting their implication in male reproduction unique to the mouse. A number of the novel genes are putative epididymal protease inhibitors or β-defensins. We also found that six of the genes have secretory activity, indicating that they may interact with sperm and have functional roles in sperm maturation.We identified and characterized 32 novel epididymis-specific or -predominant genes by an integrative approach. Our study is unique in the aspect of systematic identification of novel epididymal genes and should be a firm basis for future investigation into molecular mechanisms underlying sperm maturation in the epididymis.The mammalian epididymis is a segmented organ comprised of a single highly convoluted tubule divided into four regions: the initial segment, caput, corpus, and cauda regions. As sperm produced in the testis pass through the epididymis, they undergo sequential, marked changes to develop motility and the ability to fertilize an egg [1,2]. Sperm are transcriptionally and translationally inactive. Therefore, post-testicular maturation of sperm is not under the control of the germinal genome but rather it is mediated by factors within the lumen of the epididymis. The contents of the epididymal lumen are constantly changing due to ion transport across the epithelium and protein secretion into the epididymal lumen.
Roles of RpoN in the resistance of Campylobacter jejuni under various stress conditions
Sunyoung Hwang, Byeonghwa Jeon, Jiae Yun, Sangryeol Ryu
BMC Microbiology , 2011, DOI: 10.1186/1471-2180-11-207
Abstract: Survivability of an rpoN mutant was compared with the wild-type C. jejuni under various stress conditions. While the growth of the rpoN mutant was as comparably as that of the wild type in shaking cultures, the rpoN mutant exhibited significant survival defects when cultured statically. The rpoN mutant was more sensitive to osmotic stress (0.8% NaCl) with abnormally-elongated cell morphology. Compared to the wile type, the rpoN mutant was more susceptible to acid stress (pH 5) and more resistant to hydrogen peroxide. However, the rpoN mutation had little effect on the resistance of C. jejuni to alkaline pH, heat, cold and antimicrobials.The results demonstrate that RpoN plays an important role in C. jejuni's defense against various stresses which this bacterial pathogen may encounter during transmission to and infection of humans.Campylobacter is a leading cause of human gastroenteritis and is annually responsible for estimated 400-500 million cases of human infection worldwide [1]. Among Campylobacter species, C. jejuni is the major human-pathogenic species, accounting for more than 90% of human campylobacteriosis [2,3]. Human C. jejuni infections are primarily caused by the consumption of contaminated poultry, because the spillage of intestinal content containing a large number of C. jejuni during slaughter can contaminate cooling water, knives and poultry meat in the processing plant [4]. During transmission of C. jejuni from animals, primarily poultry, to humans, this important zoonotic foodborne pathogen encounters various stresses, such as non-growth temperatures, starvation, hypo- and hyper-osmotic stress, and desiccation [5,6]. Despite the well-known fact that Campylobacter is a fastidious bacterium, human campylobacteriosis cases have significantly increased presumably due to the ability of this pathogen to survive under harsh environmental conditions [7-10] in addition to its low infectious dose (400~800 bacteria) [11]. For example, high genetic diversity
The development of a culturally relevant preventive intervention  [PDF]
Heeseung Choi
Open Journal of Nursing (OJN) , 2012, DOI: 10.4236/ojn.2012.22019
Abstract: Researchers often publish the numerical findings of their intervention studies while overlooking the experiential findings that could help promote more appropriate and effective interventions in the future. The present paper describes the process by which we developed a culturally relevant preventive intervention for Korean American adolescents aged 11 to 14 years and their parents. We discuss the main findings of a series of pilot studies and demonstrated how lessons learned from each study guided the development process and informed the research that followed. Program development is an iterative process that incorporates feedback from study participants. Cultural relevance is ensured when participants’ voices are reflected in the program development, implementation, and evaluation process. The final outcome of the development process was the preventive intervention improving parent-child relationships, increasing parental knowledge, enhancing parental self-efficacy, and decreasing parental stress among Korean American parents, and ultimately promoting Korean American adolescents’ mental health. The specific aims of this two-group, repeated-measures, controlled randomized study were to test the feasibility of the PRIDE (Promoting Intergenerational Dialogue about Emotional Problems) intervention and to compare its efficacy with an attention control (AC) group regarding parental knowledge, parental and filial self-efficacy, parent-child (P-C) communication, P-C conflicts, and P-C satisfaction.
How a Proactive Interventionist Can Make Strikes More Effective: Evidence from the Korean Banking Sector  [PDF]
ChungIL Choi
American Journal of Industrial and Business Management (AJIBM) , 2013, DOI: 10.4236/ajibm.2013.34051

This paper argues, through a case study of two industry-wide strikes in the Korean banking sector, that a proactive interventionist strike is more effective than a reactive pragmatist one in a union’s response to restructuring. Evidence from the two strikes shows that unions were able to achieve more successful outcomes from the strike in which they engaged proactively by an interventionist mode. In this case the unions identified opportunities, took the initiative and devised effective strategies that pre-empted the other parties before they had fully prepared their restructuring planning. Such a strategic capacity was gained from active organizational learning in unions derived from their previous strike failure.

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