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Search Results: 1 - 10 of 36372 matches for " Ji-Hyun Kim "
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Behavioral inhibition in female college students with schizotypal traits: An event-related potential study  [PDF]
Ji-Hyun Lee, Myung-Sun Kim
Open Journal of Psychiatry (OJPsych) , 2012, DOI: 10.4236/ojpsych.2012.224051
Abstract: This study investigated behavioral inhibition in female college students with psychometrically defined schizotypal traits using a Go/NoGo task and event-related potentials (ERPs). The schizotypal-trait (n = 15) and normal control (n = 15) groups were selected based on scores of the Schizotypal Personality Questionnaire (SPQ). The Go/NoGo task consisted of Go (requires response) and NoGo (requires no response) conditions. In terms of response time and accuracy rate for the Go/NoGo task, the two groups did not differ significantly. In terms of ERPs, the control group showed greater N2 amplitudes in response to NoGo (NoGo-N2) than to Go stimuli (Go-N2), whereas the schizotypal-trait group showed no significant difference in NoGo-N2 and Go-N2 amplitudes. In addition, the schizotypal-trait group showed reduced NoGo-N2 amplitudes at the frontal site compared to controls, and an association between SPQ scores and NoGo-N2 amplitudes measured at the frontal site. The two groups did not differ in P3 amplitudes. Since the N2 reflects the detection of response conflict and behavioral inhibition, the present results indicate that nonclinical individuals with schizotypal traits have difficulties in detecting response conflict and behavioral inhibition.
Optimal Efficiency of Self-Assembling Light-Harvesting Arrays
Ji-Hyun Kim,Jianshu Cao
Physics , 2010,
Abstract: Using a classical master equation that describes energy transfer over a given lattice, we explore how energy transfer efficiency along with the photon capturing ability depends on network connectivity, on transfer rates, and on volume fractions - the numbers and relative ratio of fluorescence chromophore components, e.g., donor (D), acceptor (A), and bridge (B) chromophores. For a one-dimensional AD array, the exact analytical expression for efficiency shows a steep increase with a D-to-A transfer rate when a spontaneous decay is sufficiently slow. This result implies that the introduction of B chromophores can be a useful method for improving efficiency for a two-component AD system with inefficient D-to-A transfer and slow spontaneous decay. Analysis of this one-dimensional system can be extended to higher-dimensional systems with chromophores arranged in structures such as a helical or stacked-disk rod, which models the self-assembling monomers of the tobacco mosaic virus coat protein. For the stacked-disk rod, we observe the following: (1) With spacings between sites fixed, a staggered conformation is more efficient than an eclipsed conformation. (2) For a given ratio of A and D chromophores, the uniform distribution of acceptors that minimizes the mean first passage time to acceptors is a key point to designing the optimal network for a donor-acceptor system with a relatively small D-to-A transfer rate. (3) For a three-component ABD system with a large B-to-A transfer rate, a key design strategy is to increase the number of the pathways in accordance with the directional energy flow from D to B to A chromophores.
Isolation and functional characterization of CE1 binding proteins
Sun-ji Lee, Ji Park, Mi Lee, Ji-hyun Yu, Soo Kim
BMC Plant Biology , 2010, DOI: 10.1186/1471-2229-10-277
Abstract: To isolate CE1 binding proteins, we carried out yeast one-hybrid screens. Reporter genes containing a trimer of the CE1 element were prepared and introduced into a yeast strain. The yeast was transformed with library DNA that represents RNA isolated from ABA-treated Arabidopsis seedlings. From the screen of 3.6 million yeast transformants, we isolated 78 positive clones. Analysis of the clones revealed that a group of AP2/ERF domain proteins binds the CE1 element. We investigated their expression patterns and analyzed their overexpression lines to investigate the in vivo functions of the CE element binding factors (CEBFs). Here, we show that one of the CEBFs, AtERF13, confers ABA hypersensitivity in Arabidopsis, whereas two other CEBFs enhance sugar sensitivity.Our results indicate that a group of AP2/ERF superfamily proteins interacts with CE1. Several CEBFs are known to mediate defense or abiotic stress response, but the physiological functions of other CEBFs remain to be determined. Our in vivo functional analysis of several CEBFs suggests that they are likely to be involved in ABA and/or sugar response. Together with previous results reported by others, our current data raise an interesting possibility that the coupling element CE1 may function not only as an ABRE but also as an element mediating biotic and abiotic stress responses.Abscisic acid (ABA) is a phytohormone that controls seed germination, seedling growth and seed development [1]. In particular, ABA plays an essential role in the protective responses of plants to adverse environmental conditions, such as drought, high salinity and extreme temperatures [2].At the molecular level, ABA-dependent processes entail changes in gene expression patterns. Numerous genes are either up- or down-regulated by ABA in seedlings [3,4]. The ABA regulation of these genes is generally at the transcriptional level, and a number of cis-regulatory elements responsible for the regulation by ABA have been determined [5]. One
1H NMR-Based Metabolite Profiling of Planktonic and Biofilm Cells in Acinetobacter baumannii 1656-2
Jinki Yeom, Ji-Hyun Shin, Ji-Young Yang, Jungmin Kim, Geum-Sook Hwang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057730
Abstract: Acinetobacter baumannii is an aerobic and gram-negative pathogenic bacterium that is resistant to most antibiotics. Recently, A. baumannii 1656-2 exhibited the ability to form biofilms under clinical conditions. In this study, global metabolite profiling of both planktonic and biofilm forms of A. baumannii 1656-2 was performed using high-resolution nuclear magnetic resonance (NMR) spectroscopy and multivariate statistical analysis to investigate the metabolic patterns leading to biofilm formation. Principal components analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) score plots showed a distinct separation between planktonic and biofilm cells. Metabolites including acetates, pyruvate, succinate, UDP-glucose, AMP, glutamate, and lysine were increasingly involved in the energy metabolism of biofilm formation. In particular, the ratio of N-acetyl-D-glucosamine (GlcNAc) to D-glucosamine (GlcNH2) was significantly higher during biofilm formation than under the planktonic condition. This study demonstrates that NMR-based global metabolite profiling of bacterial cells can provide valuable insight into the metabolic changes in multidrug resistant and biofilm-forming bacteria such as A. baumannii 1656-2.
The Fission Yeast GATA Factor, Gaf1, Modulates Sexual Development via Direct Down-Regulation of ste11+ Expression in Response to Nitrogen Starvation
Lila Kim, Kwang-Lae Hoe, Yeong Man Yu, Ji-Hyun Yeon, Pil Jae Maeng
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042409
Abstract: Gaf1 is the first GATA family zinc-finger transcription factor identified in Schizosaccharomyces pombe. Here, we report that Gaf1 functions as a negatively acting transcription factor of ste11+, delaying the entrance of cells exposed to transient nitrogen starvation into the meiotic cycle. gaf1Δ strains exhibited accelerated G1-arrest upon nitrogen starvation. Moreover, gaf1Δ mutation caused increased mating and sporulation frequency under both nitrogen-starved and unstarved conditions, while overexpression of gaf1+ led to a significant impairment of sporulation. By microarray analysis, we found that approximately 63% (116 genes) of the 183 genes up-regulated in unstarved gaf1Δ cells were nitrogen starvation-responsive genes, and furthermore that 25 genes among the genes up-regulated by gaf1Δ mutation are Ste11 targets (e.g., gpa1+, ste4+, spk1+, ste11+, and mei2+). The phenotype caused by gaf1Δ mutation was masked by ste11Δ mutation, indicating that ste11+ is epistatic to gaf1+ with respect to sporulation efficiency, and accordingly that gaf1+ functions upstream of ste11+ in the signaling pathway governing sexual development. gaf1Δ strains showed accelerated ste11+ expression under nitrogen starvation and increased ste11+ expression even under normal conditions. Electrophoretic mobility shift assay analysis demonstrated that Gaf1 specifically binds to the canonical GATA motif (5′-HGATAR-3′) spanning from ?371 to ?366 in ste11+ promoter. Consequently, Gaf1 provides the prime example for negative regulation of ste11+ transcription through direct binding to a cis-acting motif of its promoter.
Observation and Numerical Simulations with Radar and Surface Data Assimilation for Heavy Rainfall over Central Korea

Ji-Hyun HA,Hyung-Woo KIM,Dong-Kyou LEE,

大气科学进展 , 2011,
Abstract: This study investigated the impact of multiple-Doppler radar data and surface data assimilation on forecasts of heavy rainfall over the central Korean Peninsula; the Weather Research and Forecasting (WRF) model and its three-dimensional variational data assimilation system (3DVAR) were used for this purpose. During data assimilation, the WRF 3DVAR cycling mode with incremental analysis updates (IAU) was used. A maximum rainfall of 335.0 mm occurred during a 12-h period from 2100 UTC 11 July 2006 to 0900 UTC 12 July 2006. Doppler radar data showed that the heavy rainfall was due to the back-building formation of mesoscale convective systems (MCSs). New convective cells were continuously formed in the upstream region, which was characterized by a strong southwesterly low-level jet (LLJ). The LLJ also facilitated strong convergence due to horizontal wind shear, which resulted in maintenance of the storms. The assimilation of both multiple-Doppler radar and surface data improved the accuracy of precipitation forecasts and had a more positive impact on quantitative forecasting (QPF) than the assimilation of either radar data or surface data only. The back-building characteristic was successfully forecasted when the multiple-Doppler radar data and surface data were assimilated. In data assimilation experiments, the radar data helped forecast the development of convective storms responsible for heavy rainfall, and the surface data contributed to the occurrence of intensified low-level winds. The surface data played a significant role in enhancing the thermal gradient and modulating the planetary boundary layer of the model, which resulted in favorable conditions for convection.
Work-Related Risk Factors by Severity for Acute Pesticide Poisoning Among Male Farmers in South Korea
Ji-Hyun Kim,Jaeyoung Kim,Eun Shil Cha,Yousun Ko,Doo Hwan Kim,Won Jin Lee
International Journal of Environmental Research and Public Health , 2013, DOI: 10.3390/ijerph10031100
Abstract: The objective of this study was to explore work-related risk factors of acute occupational pesticide poisoning among male farmers according to the severity of the poisoning. A nationwide sampling survey of male farmers was conducted in South Korea in 2011. A total of 1,958 male farmers were interviewed. Severity of occupational pesticide poisoning in 2010 was evaluated according to symptoms, types of treatment, and number of pesticide poisoning incidents per individual. A multinomial logistic regression model was used to estimate the odds ratio with 95% confidence intervals for risk factors of acute occupational pesticide poisoning. We found that the risk of acute occupational pesticide poisoning increased with lifetime days of pesticide application (OR = 1.74; 95% CI = 1.32–2.29), working a farm of three or more acres in size (OR = 1.49), not wearing personal protective equipment such as gloves (OR = 1.29) or masks (OR = 1.39). Those who engaged in inappropriate work behaviors such as not following pesticide label instructions (OR = 1.61), applying the pesticide in full sun (OR = 1.48), and applying the pesticide upwind (OR = 1.54) had a significantly increased risk of pesticide poisoning. There was no significant risk difference by type of farming. In addition, the magnitude of these risk factors did not differ significantly by severity of acute pesticide poisoning. In fact, our findings suggest that work-related risk factors contributed to the development of acute occupational pesticide poisoning without relation to its severity. Therefore, prevention strategies for reducing occupational pesticide poisoning, regardless of severity, should be recommended to all types of farming and the level of poisoning severity.
Verification of Damage Detection Algorithm by Prototype Building Structure Test  [PDF]
Ji-Hyun Hwang, Ki-Tae Park
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510100

Safety related accidents of buildings and civil engineering structures have been reported all over the world. With the increasing importance of securing the safety of social infrastructure and optimum performance levels to prevent these accidents, a lot of attention has been concentrated on monitoring performance degradation due to structural defects and deterioration. In this study, the algorithm was developed to evaluate the safety of structures by analyzing signals of time domain and frequency domain, and the developed algorithm was verified through a forced vibration test. From the results of time-domain and frequency-domain data analysis, the damage detection results by each sensor location with a high degree of accuracy were derived in both methods.

Transcription Factor σB Plays an Important Role in the Production of Extracellular Membrane-Derived Vesicles in Listeria monocytogenes
Jung Hwa Lee, Chi-Won Choi, Taewon Lee, Seung Il Kim, Je-Chul Lee, Ji-Hyun Shin
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073196
Abstract: Gram-negative bacteria produce extracellular outer membrane vesicles (OMVs) that interact with host cells. Unlike Gram-negative bacteria, less is known about the production and role of extracellular membrane vesicles (MVs) in Gram-positive bacteria. The food-borne pathogen Listeria monocytogenes can survive under extreme environmental and energy stress conditions and the transcription factor σB is involved in this survival ability. Here, we first determined the production of MVs from L. monocytogenes and evaluated whether general stress transcription factor σB affected production of MVs in L. monocytogenes. L. monocytogenes secreted MVs during in vitro broth culture. The wild-type strain actively produced MVs approximately nine times more and also produced more intact shapes of MVs than those of the isogenic ΔsigB mutant. A proteomic analysis showed that 130 and 89 MV proteins were identified in the wild-type and ΔsigB mutant strains, respectively. Wild-type strain-derived MVs contained proteins regulated by σB such as transporters (OpuCA and OpuCC), stress response (Kat), metabolism (LacD), translation (InfC), and cell division protein (FtsZ). Gene Ontology (GO) enrichment analysis showed that wild-type-derived MV proteins corresponded to several GO terms, including response to stress (heat, acid, and bile resistance) and extracellular polysaccharide biosynthetic process, but not the ΔsigB mutant. Internalin B (InlB) was almost three times more contained in MVs derived from the wild-type strain than in MVs derived from the ΔsigB mutant. Taken together, these results suggest that σB plays a pivotal role in the production of MVs and protein profiles contained in MVs. L. monocytogenes MVs may contribute to host infection and survival ability under various stressful conditions.
The Protective Effect of Apamin on LPS/Fat-Induced Atherosclerotic Mice
Soo-Jung Kim,Ji-Hyun Park,Kyung-Hyun Kim,Woo-Ram Lee,Sok Cheon Pak,Sang-Mi Han,Kwan-Kyu Park
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/305454
Abstract: Apamin, a peptide component of bee venom (BV), has anti-inflammatory properties. However, the molecular mechanisms by which apamin prevents atherosclerosis are not fully understood. We examined the effect of apamin on atherosclerotic mice. Atherosclerotic mice received intraperitoneal (ip) injections of lipopolysaccharide (LPS, 2 mg/kg) to induce atherosclerotic change and were fed an atherogenic diet for 12 weeks. Apamin (0.05 mg/kg) was administered by ip injection. LPS-induced THP-1-derived macrophage inflammation treated with apamin reduced expression of tumor necrosis factor (TNF)-α, vascular cell adhesion molecule (VCAM)-1, and intracellular cell adhesion molecule (ICAM)-1, as well as the nuclear factor kappa B (NF-κB) signaling pathway. Apamin decreased the formation of atherosclerotic lesions as assessed by hematoxylin and elastic staining. Treatment with apamin reduced lipids, Ca2
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