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Powerful Efficacy of GCSB-5 Treatment for Improving Fatigue and Motor Function in Multiple Sclerosis (MS): A Randomized Double Blind, Place-bo-Controlled Study  [PDF]
Ji Yun Shin
Open Access Library PrePrints (OALib PrePrints) , 2016, DOI: 10.4236/oalib.preprints.1200150
Abstract:
Multiple Sclerosis (MS) is the most common disability in young adults that requires early symptomatic treatment to prevent long-term disability. Among young adults, MS is the most common central nerv-ous system (CNS) chronic inflammatory illness that is characterized by demyelination in the CNS. However, current disease-modifying treatments are not sufficiently effective for preventing the variety of symptoms during the course of disease.
Application of Electrocoagulation and Electrolysis on the Precipitation of Heavy Metals and Particulate Solids in Washwater from the Soil Washing  [PDF]
Ho Y. Shim, Kyo S. Lee, Dong S. Lee, Dae S. Jeon, Mi S. Park, Ji S. Shin, Yun K. Lee, Ji W. Goo, Soo B. Kim, Doug Y. Chung
Journal of Agricultural Chemistry and Environment (JACEN) , 2014, DOI: 10.4236/jacen.2014.34015
Abstract: Soil washing, ex situ mechanical technique, is one of the few permanent treatment alternatives to remove metal contaminants from soils by employing physical separation based on mineral processing technologies to remove discrete particles or metal-bearing particles and/or chemical extraction based on leaching or dissolving process to extract the metals from the soils into an aqueous solution. However, washwater remained from soil washing process contains discrete particulate particles along with heavy metals as solution phase to be treated separately, as well as this process can produce large amount of sludge that requires further treatment, slow metal precipitation, poor settling, the aggregation of metal precipitates. Electrical treatments including electrocoagulation and electrolysis can be effective in removing these substances from washwater. This paper reviews the theoretical models in applying electrocoagulation and electrolysis to remove heavy metals and discrete particulate particles in washwater by examining and comparing the status of washwater treatment technologies which have been undertaken, mostly in the US and EU for the period 1990-2012.
Maternal Outcomes According to Placental Position in Placental Previa
Dong Gyu Jang, Ji Sun We, Jae Un Shin, Yun Jin Choi, Hyun Sun Ko, In Yang Park, Jong Chul Shin
International Journal of Medical Sciences , 2011,
Abstract: Purpose: The purpose of this retrospective cohort study was to elucidate whether the location of placenta below uterine incision in cesarean section is important in the development of maternal complications in placenta previa patients. Methods: The study was conducted on 409 patients 414 parturition at 3 hospitals in affiliation with the Catholic Medical Center, Seoul, Korea from May 1999 to December 2009. The subjects were divided to two groups: the group whose placenta was located in the anterior portion of the uterus (anterior group) and the group whose placenta was located in the posterior portion of the uterus (posterior group). And then they are compared to each other. Logistic regression was used to control for confounding factors. Results: In the anterior group, regardless of confounding factors, the incidence of excessive blood loss (OR 2.97; 95% CI: 1.64-5.37), massive transfusion (OR 3.31; 95% CI: 1.33-8.26), placental accreta (OR 2.60, 95% CI: 1.40-4.83), and hysterectomy (OR 3.47, 95% CI: 1.39-8.68) was higher. Conclusion: Sonographic determination of the placental position where its location beneath the uterine incision is very important to predict maternal outcomes in placenta previa patients, and such cases, close attention should be paid for massive hemorrhage.
Modulation of Glucose Metabolism by Balanced Deep-Sea Water Ameliorates Hyperglycemia and Pancreatic Function in Streptozotocin-Induced Diabetic Mice
Byung Geun Ha, Jung-Eun Park, Eun Ji Shin, Yun Hee Shon
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0102095
Abstract: The aim of this study was to determine the effects of balanced deep-sea water (BDSW) on hyperglycemia and glucose intolerance in streptozotocin (STZ)-induced diabetic mice. BDSW was prepared by mixing DSW mineral extracts and desalinated water to yield a final hardness of 1000–4000 ppm. Male ICR mice were assigned to 6 groups; mice in each group were given tap water (normal and STZ diabetic groups) or STZ with BDSW of varying hardness (0, 1000, 2000, and 4000 ppm) for 4 weeks. The STZ with BDSW group exhibited lowered fasting plasma glucose levels than the STZ-induced diabetic group. Oral glucose tolerance tests showed that BDSW improves impaired glucose tolerance in STZ-induced diabetic mice. Histopathological evaluation of the pancreas showed that BDSW restores the morphology of the pancreatic islets of Langerhans and increases the secretion of insulin in STZ-induced diabetic mice. Quantitative real-time PCR assay revealed that the expression of hepatic genes involved in gluconeogenesis, glucose oxidation, and glycogenolysis was suppressed, while the expression of the genes involved in glucose uptake, β-oxidation, and glucose oxidation in muscle were increased in the STZ with BDSW group. BDSW stimulated PI3-K, AMPK, and mTOR pathway-mediated glucose uptake in C2C12 myotubes. BDSW increased AMPK phosphorylation in C2C12 myotubes and improved impaired AMPK phosphorylation in the muscles of STZ-induced diabetic mice. Taken together, these results suggest that BDSW is a potential anti-diabetic agent, owing to its ability to suppress hyperglycemia and improve glucose intolerance by modulating glucose metabolism, recovering pancreatic islets of Langerhans and increasing glucose uptake.
Anti-Diabetic Effect of Balanced Deep-Sea Water and Its Mode of Action in High-Fat Diet Induced Diabetic Mice
Byung Geun Ha,Eun Ji Shin,Jung-Eun Park,Yun Hee Shon
Marine Drugs , 2013, DOI: 10.3390/md11114193
Abstract: In this study, we investigated the effects of balanced deep-sea water (BDSW) on hyperglycemia and glucose intolerance in high-fat diet (HFD)-induced diabetic C57BL/6J mice. BDSW was prepared by mixing deep-sea water (DSW) mineral extracts and desalinated water to give a final hardness of 500–2000. Mice given an HFD with BDSW showed lowered fasting plasma glucose levels compared to HFD-fed mice. Oral and intraperitoneal glucose tolerance tests showed that BDSW improves impaired glucose tolerance in HFD-fed mice. Histopathological evaluation of the pancreas showed that BDSW recovers the size of the pancreatic islets of Langerhans, and increases the secretion of insulin and glucagon in HFD-fed mice. Quantitative reverse transcription polymerase chain reaction results revealed that the expression of hepatic genes involved in glucogenesis, glycogenolysis and glucose oxidation were suppressed, while those in glucose uptake, β-oxidation, and glucose oxidation in muscle were increased in mice fed HFD with BDSW. BDSW increased AMP-dependent kinase (AMPK) phosphorylation in 3T3-L1 pre- and mature adipocytes and improved impaired AMPK phosphorylation in the muscles and livers of HFD-induced diabetic mice. BDSW stimulated phosphoinositol-3-kinase and AMPK pathway-mediated glucose uptake in 3T3-L1 adipocytes. Taken together, these results suggest that BDSW has potential as an anti-diabetic agent, given its ability to suppress hyperglycemia and improve glucose intolerance by increasing glucose uptake.
WordRank: Learning Word Embeddings via Robust Ranking
Shihao Ji,Hyokun Yun,Pinar Yanardag,Shin Matsushima,S. V. N. Vishwanathan
Computer Science , 2015,
Abstract: Embedding words in a vector space has gained a lot of research attention in recent years. While state-of-the-art methods provide efficient computation of word similarities via a low-dimensional matrix embedding, their motivation is often left unclear. In this paper, we argue that word embedding can be naturally viewed as a ranking problem. Then, based on this insight, we propose a novel framework WordRank that efficiently estimates word representations via robust ranking. The performance of WordRank is measured in word similarity and word analogy benchmarks, and the results are compared to the state-of-the-art word embedding techniques. Our algorithm produces a vector space with meaningful substructure, as evidenced by its performance of 77.4% accuracy on a popular word similarity benchmark and 76% on the Google word analogy benchmark. WordRank performs especially well on small corpora.
Effects of Flow-Induced Shear Stress on Limbal Epithelial Stem Cell Growth and Enrichment
Yun Gyeong Kang, Ji Won Shin, So Hee Park, Min-Jae Oh, Hyo Soon Park, Jung-Woog Shin, Su-Hyang Kim
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093023
Abstract: The roles of limbal epithelial stem cells (LESCs) are widely recognized, but for these cells to be utilized in basic research and potential clinical applications, researchers must be able to efficiently isolate them and subsequently maintain their stemness in vitro. We aimed to develop a biomimetic environment for LESCs involving cells from their in vivo niche and the principle of flow-induced shear stress, and to subsequently demonstrate the potential of this novel paradigm. LESCs, together with neighboring cells, were isolated from the minced limbal tissues of rabbits. At days 8 and 9 of culture, the cells were exposed to a steady flow or intermittent flow for 2 h per day in a custom-designed bioreactor. The responses of LESCs and epithelial cells were assessed at days 12 and 14. LESCs and epithelial cells responded to both types of flow. Proliferation of LESCs, as assessed using a BrdU assay, was increased to a greater extent under steady flow conditions. Holoclones were found under intermittent flow, indicating that differentiation into transient amplifying cells had occurred. Immunofluorescent staining of Bmi-1 suggested that steady flow has a positive effect on the maintenance of stemness. This finding was confirmed by real-time PCR. Notch-1 and p63 were more sensitive to intermittent flow, but this effect was transient. K3 and K12 expression, indicative of differentiation of LESCs into epithelial cells, was induced by flow and lasted longer under intermittent flow conditions. In summary, culture of LESCs in a bioreactor under a steady flow paradigm, rather than one of intermittent flow, is beneficial for both increasing proliferation and maintaining stemness. Conversely, intermittent flow appears to induce differentiation of LESCs. This novel experimental method introduces micro-mechanical stimuli to traditional culture techniques, and has potential for regulating the proliferation and differentiation of LESCs in vitro, thereby facilitating research in this field.
The promoter -1031(T/C) polymorphism in tumor necrosis factor-alpha associated with polycystic ovary syndrome
Ji-Hyun Yun, Jin-Woo Choi, Kyung-Ju Lee, Joong-Sik Shin, Kwang-Hyun Baek
Reproductive Biology and Endocrinology , 2011, DOI: 10.1186/1477-7827-9-131
Abstract: The -1031(T/C) polymorphism of TNF-alpha gene was analyzed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) in a total of 217 PCOS patients and 144 matched female controls of healthy women. And statistical analysis was performed using HapAnalyzer. X2 test and logistic regression were utilized analyze the association between two groups. A p-value under 0.05 was considered statistically significant.The genotype and allelic frequencies were in Hardy-Weinberg equilibrium (HWE). There was strong association between the -1031(T/C) polymorphism in the promoter region of TNF-alpha gene and PCOS (p-value = 0.0003, odd ratio (OR) = 2.53). In addition, the frequency of C allele was significantly higher in PCOS patients compared with controls. Sequence analyses also showed the -1031(T/C) polymorphism of TNF-alpha gene.This is the first study on the -1031(T/C) polymorphism of TNF-alpha gene in PCOS. We concluded that the -1031(T/C) polymorphism of TNF-alpha gene is associated with PCOS in a Korean population. Therefore, it is possible that it may be considered as a clinical biomarker to diagnose for PCOS, and is helpful in understanding the etiology for the pathogenesis of PCOS.Polycystic ovary syndrome (PCOS) is one the most common gynecological disorder and affects up to 5% women in reproductive ages [1-4]. Generally, PCOS patients show the symptoms of obesity, increased risk of type 2 diabetes mellitus, menstrual irregularity, and anovulation [5-9]. A number of groups focused on the studies for single nucleotide polymorphisms and expected that could be associated with PCOS. However, its etiology is still not fully identified [10,11].Up to now, several association studies were reported that the some of polymorphisms of tumor necrosis factor-α (TNF-α) are related with gynecological diseases including pre-eclampsia, endometriosis [12]. It is a multifunctional proinflammation cytokine and has a significant source of genetic variability [13,14]. Man
Single-Port Access Laparoscopy-Assisted Vaginal Hysterectomy: Our Initial Experiences with 100 Cases
Young-Sam Choi,Kwang-Sik Shin,Jin Choi,Ji-No Park,Yun-Sang Oh,Tae-Eel Rhee
Minimally Invasive Surgery , 2012, DOI: 10.1155/2012/543627
Abstract: Objectives. To present our initial experiences with laparoscopically assisted vaginal hysterectomy performed using homemade transumbilical single-port system. Materials and Methods. We reviewed the medical records of one hundred patients who underwent single-port access laparoscopically assisted vaginal hysterectomy (SPA-LAVH). SPA-LAVH was performed with homemade single port system and conventional rigid laparoscopic instruments. Results. All procedures were successfully completed through the single-port system and vagina without need for extraumbilical puncture or conversion to laparotomy. The median patient age was 48.2 ± 6.5 years. Thirty-three patients had history of past abdominopelvic surgery. The median total operative time, largest dimension of the uterus, and weight of the uterus were 73.1 ± 24.6?min, 10.5 ± 2.1?cm, and 300.8 ± 192.5?gram, respectively. The median decline in the hemoglobin from before surgery to postoperative day 1 was 1.8 ± 0.9?g/dL. Bladder injury in occurred one patient who was repaired through intraoperative laparoscopic suture. The postoperative course was uneventful in most patients except for three who had a transient paralytic ileus, five who had pelvic hematoma, but they were recovered following conservative managements. No port-related complications were noted, and the cosmetic results were excellent. Conclusions. SPA-LAVH is technically safe procedure, and the homemade single-port system offers reliable access for single-port surgery. 1. Introduction To optimize the benefits of minimally invasive procedures, surgeons have attempted to reduce the overall abdominal wall trauma by decreasing either the size of the ports or the number of trocars. In these efforts, transumbilical single-port surgery uses an umbilical single incision technique to access the peritoneal cavity and target organs. Owing to the nature of umbilicus, single-port laparoscopy through the umbilicus offers an exciting opportunity to perform laparoscopic surgery with no visible scar. However, transumbilical single-port laparoscopy is not a new concept in gynecologic surgery [1–5]. In 1969, Wheeless and Thompson first published the technique and the results of a large series of laparoscopic tubal ligations using single-trocar laparoscopy. Later, Wheeless reported a large series of one-incision tubal ligation. Additionally, in 1991, the first laparoscopic total abdominal hysterectomy with bilateral salpingooophorectomy (BSO) using only a single incision was reported by Pelosi and Pelosi III. One year later, four supracervical hysterectomies with BSO
GPS Receiver with Enhanced User Positioning Time
Seung-Hyun Yoon,Ji-Woon Jung,Su-Bong Kim,Hyun-Chang Shin,Jae-Hyang Lee,Kyu-Yun Lee,Hyo-Sun Shim
Computer Science , 2015,
Abstract: This paper introduces a Global Positioning System (GPS) Receiver that locates user's position instantly. Recently, many mobile devices require location information to add user position into their contents, and some applications require quick positioning when the device is initially switched on. In order to reduce the time to fix user's position, we propose the Instant-On GPS receiver system which is implemented on an ARM based FPGA board, and operates under a very low power mode. We've developed a repeated sleep mode by periods to control the GPS receiver's main power in order to achieve reduced power consumption. By using a high resolution Real Time Clock (RTC), we can estimate frame sync timing without receiving the current frame sync preamble data from a satellite when GPS turns back on. However, the navigation solution needs to be calculated once in advance. The performance results of the proposed GPS receiver in both real world and simulation environment are presented.
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