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Search Results: 1 - 10 of 26958 matches for " Ji Young Shin "
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Gingival peripheral odontoma in a child: Case report of an uncommon lesion  [PDF]
Ji Hyun Kwon, Young Ah Cho, Hong Keun Hyun, Teo Jeon Shin, Young Jae Kim
Open Journal of Stomatology (OJST) , 2013, DOI: 10.4236/ojst.2013.31020
Odontomas are defined as hamartomas of odontogenic origin. They are composed of all dental tissues are represented, occurring in a more or less disorderly pattern. Intraosseous (central) odontomas are the odontogenic tumors of greatest incidence. Otherwise, odontomas arising in the extraosseous soft tissue, also known as peripheral odontoma, are extremely uncommon. This article presents a case of peripheral odontoma in a child referred to SNUDH for treatment. A 2-year-old girl was referred to The SNUDH regarding an asymptomatic nodule on the left maxillary buccal gingiva. Clinical examination revealed a 7 mm × 6 mm × 3 mm, sessile mucosal lesion on the buccal gingival between #62 and #63. The lesion was firm on palpation and covered with an intact non-ulcerated mucosa. There was no other mucosal pathology. Under N2O-O2 inhalation sedation, an excisional biopsy of the lesion was performed. The diagnosis was peripheral odontoma. Summary: Odontoma in an extraosseous location represents a challenge for diagnosis. This article reports a case of peripheral odontoma and its clinical presentation, histological evaluation and treatment. A 2-year-old girl reported a firm asymptomatic nodule on left maxillary buccal gingival. The procedures for diagnosis included intraoral examination, excisional biopsy and histological analysis. The diagnosis was peripheral odontoma. Peripheral odontoma is rare and the differential diagnosis with other gingival masses is rather difficult and must include inflammatory and reactive processes. The definitive diagnosis is based on microscopic features.
The Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Idiopathic Interstitisal Pneumonia  [PDF]
Ji Young Shin, Yu Jin Kim, Sun Young Kyung, Seung Yeon Ha, Sung Hwan Jeong
Open Journal of Respiratory Diseases (OJRD) , 2014, DOI: 10.4236/ojrd.2014.43014
Background: Idiopathic interstitial pneumonia is characterized by fibroblast proliferation and extracellular matrix (ECM) accumulation. Matrix metalloproteases (MMPs) and tissue inhibitors of metalloproteases (TIMPs) have been shown to regulate remodeling of the ECM, which indicates that they are important factors in the process of lung fibrosis. Therefore, we evaluated the expression of MMPs and TIMPs in tissues obtained from patients with idiopathic interstitial pneumonia and control tissues. Methods: Thirty-seven patients who were diagnosed with IIP (22: IPF, 13: NSIP, 2: COP) and 5 controls were enrolled in this study. The MMP-2 and -9 activity in lung tissue obtained from these patients was analyzed using gelatin zymography and the levels of TIMP-1 and -2 were measured by western blotting. We also evaluated the expression of MMP-2 and -9, as well as that of TIMP-1 and -2 in lung tissue using immunohistochemistry. Results: The levels of MMP-2 and MMP-9 were significantly increased in patients with IPF compared to those with NSIP and COP. The activities of TIMP-1 and -2 were also higher in patients with IPF than NSIP/COP patients and control subjects. There were no significant differences observed in the activities of MMPs and TIMPs obtained from patients with NSIP/COP and control subjects. The immunohistochemical analysis showed that TIMP-2 and MMP-2 were strongly stained at the fibroblasts of the fibroblastic foci in patients with IPF. Conclusions: These results suggest that over-expression of gelatinases and TIMPs in patients with IPF are important factors in the irreversible fibrosis that is associated with lung parenchyma.
Knitting Practice in Korea: A Geography of Everyday Experiences
Hye Young Shin,Ji Soo Ha
Asian Culture and History , 2011, DOI: 10.5539/ach.v3n1p105
Abstract: The recent resurgence of knitting is an ambiguous social phenomenon because it has pre-industrial connotations in late modern society. Knitting is inherently an ambiguous practice which blurs the boundary between production and consumption, the material and the mental and subject and object. This paper explores Korean knitting practice from the angle of social practice. An examination of knitting practice in Korea revealed that the inherent heterogeneity is intricately intertwined with the complex landscape of knitting practice, which is dispersed in a range of different forms of subgroups. Also, the multifaceted aspect of these subgroups which combines consumption, production, education and socialization, refers to the complicated and contrasting aspects of contemporary consumption and consumers. This paper particularly pays attention to the role of practical understanding as a form of skill, know-how and knowledge in the formulation and transformation of knitting practice. It also examines the emotional landscape of knitting practice, which is constructed and mediated in close interconnection with the material dimensions of the practice.
Pemetrexed in Previously Treated Non-small Cell Lung Cancer Patients with Poor Performance Status
Sun Young JUNG,Su Jin YOO,Ji Young SHIN,Ji Won PARK
Chinese Journal of Lung Cancer , 2011,
Abstract: Background and objective Pemetrexed have been approved for the treatment of patients affected by advanced non-small cell lung cancner (NSCLC) in progression after first-line chemotherapy. We evaluated the activity and feasibility of pemetrexed in previously treated NSCLC. Methods Patients with histologically or cytologically confirmed NSCLC were evaluated from April 2007 to March 2009. The patients had relapsed or progressed after prior chemotherapy treatment. Pemetrexed (500 mg/m2) was administered intravenously once every 3 weeks after progression to prior chemotherapy. The tumor response was evaluated according to RECIST criteria by chest CT at every 2 cycles of chemotherapy. Results A total 61 patients were eligible for analysis. Performance status of them (100%) was over 2. The response rate and disease control rate were 14.7% and 37.7% respectively. Non-squamous cell carcinoma histology was significantly associated with a superior response rate (P=0.045) and disease control rate (P=0.008). The median survival time and the median progression free survival (PFS) time were 6.11 months and 2.17 months, respectively. Comparing the efficacy of pemetrexed in these two settings [second-line versus (12/61) more than third (49/61)], there was no significant difference in regard to median survival (11.18 months vs 11.46 months, P=0.922,5), but PFS was more longer in third- or further-line groups than second-line group (1.39 months vs 2.25 months, P=0.015,
Selection of Health Care Workers for Screening for Latent Tuberculosis Infection  [PDF]
Jin Young Lee, Ji Young Park, Myung Shin Kim, Je Hun Kim, Jin-Young Lee
Journal of Tuberculosis Research (JTR) , 2019, DOI: 10.4236/jtr.2019.72007
Abstract: Introduction: The rate of latent tuberculosis infections (LTBIs) in health care workers (HCWs) is higher than that in non-HCWs. We studied to investigate the prevalence and risk factors of LTBIs and the acceptance rate for treatment of LTBI among HCWs in South Korea, a country with an intermediate tuberculosis (TB) burden. Methodology: LTBI screening was conducted for HCWs at a tertiary and a secondary hospital from April 2017 to August 2017. This was a retrospective study included all HCWs who underwent LTBI examination. HCWs were classified by the degree of risk into four groups, based on two factors: possibility of exposure to TB, and impact on patients at the time of TB onset in the HCWs. The interferon-gamma release assay was used for the diagnosis of LTBI. Results: A total of 1326 HCWs were included; they comprised 801 HCWs from a tertiary hospital and 525 from a secondary hospital. A total of 235 (17.7%) HCWs were diagnosed with LTBIs. According to risk classification, there was no significant difference (P = 0.24). In multivariate analysis, age was the only independent risk factor (P < 0.001). The acceptance rate for LTBI treatment was 60.43%, and there were no associated factors in multivariate analysis. Conclusions: HCWs did not show any significant difference in the rate of LTBI by the degree of risk, and age was the independent risk factor. LTBI screening should be conducted for all HCWs regardless of risk classification.
Do Quantity and Quality of Irradiance Influence Migration Behavior Motile Cells of the Green Alga, Ulva fasciata?  [PDF]
Hyun-Woung Shin, Han Seong Lee, Sang Mok Jung, Min Kyu Choo, Ji Young Cho, Kwang Soo Lee, Celia M. Smith
Open Journal of Marine Science (OJMS) , 2014, DOI: 10.4236/ojms.2014.44028
Abstract: Motile cells of the green alga, Ulva fasciata respond to the quantity and quality of irradiance simultaneously. The specific responses of motile cell types (gametes and spores) by irradiance influence migration behavior in coastal water environment. Gametes maximally aggregated at the highest white light intensity (250 μmol·m-2·s-1), while spores maximally aggregated in the dark (0 μmol m-2·s-1) of this study. Gametes maximally aggregated in green irradiance over blue, red and dark while spore maximally aggregated in the dark. The results of quantity are spectral responses are likely to be underline the ecological success and physiological strategies in varied irradiance environments includes: 1) gametes respond to specific quantities and spectral irradiance; 2) spores respond negatively to quantity and quality of irradiance to enhance the probability of finding substratum; and 3) populations of adults that come from these motile cells behaviors. The specific quantities and spectral qualities of irradiance responses show specific ecological migration that can be attributed to photosynthesis under limiting irradiance in coastal waters for the motile cells of U. fasciata.
Mapping Contaminants Associated with Autism: A Public Health Pilot in New Jersey  [PDF]
Erin Speiser Ihde, Themba Nyirenda, Aridaman K. Jain, Ji Meng Loh, Francisco Artigas, Christine Hobble, Dom Elefante, Saleh Kojak, Jin Young Shin, Lawrence Rosen
Journal of Geographic Information System (JGIS) , 2014, DOI: 10.4236/jgis.2014.66058
Abstract: The rise in reported prevalence rates of autism spectrum disorders (ASDs) is a national concern that continues to grow at a record pace. New Jersey has the highest prevalence rate of autism spectrum disorders (ASDs) among states surveyed, with approximately 1 in 45 children diagnosed. The pilot study focused on toxins potentially linked to autism: arsenic, lead, manganese, mercury, organophosphate pesticides, polychlorinated biphenyls, trichloroethylene, and vinyl chloride. In northern NJ there were approximately 4600 Known Contaminated Sites (KCSNJ) where these toxins were detected. A total of 269,790 sample detections were identified. Our objective was to identify and map these sites, and identify methods by which more robust contaminant data could be collected and analyzed. This study resulted in eight original maps showing sample detections. These maps will aid researchers and public health advocates in future analyses exploring links between autism and these toxins. Concentrations of multiple toxins associated with ASDs were most dense near urban industrial or mixed residential/industrial areas, though no conclusions can be made regarding association or causality between the sample detections and autism. Based in part on this study, NJDEP has made and will continue to make improvements to contaminant data collection systems.
1H NMR-Based Metabolite Profiling of Planktonic and Biofilm Cells in Acinetobacter baumannii 1656-2
Jinki Yeom, Ji-Hyun Shin, Ji-Young Yang, Jungmin Kim, Geum-Sook Hwang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057730
Abstract: Acinetobacter baumannii is an aerobic and gram-negative pathogenic bacterium that is resistant to most antibiotics. Recently, A. baumannii 1656-2 exhibited the ability to form biofilms under clinical conditions. In this study, global metabolite profiling of both planktonic and biofilm forms of A. baumannii 1656-2 was performed using high-resolution nuclear magnetic resonance (NMR) spectroscopy and multivariate statistical analysis to investigate the metabolic patterns leading to biofilm formation. Principal components analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) score plots showed a distinct separation between planktonic and biofilm cells. Metabolites including acetates, pyruvate, succinate, UDP-glucose, AMP, glutamate, and lysine were increasingly involved in the energy metabolism of biofilm formation. In particular, the ratio of N-acetyl-D-glucosamine (GlcNAc) to D-glucosamine (GlcNH2) was significantly higher during biofilm formation than under the planktonic condition. This study demonstrates that NMR-based global metabolite profiling of bacterial cells can provide valuable insight into the metabolic changes in multidrug resistant and biofilm-forming bacteria such as A. baumannii 1656-2.
Intravenous Suitability Studies of Commonly Used Oxacillin Sodium Solutions in the ACCUFUSER® Infusion Device  [PDF]
Min-Jeong Kim, Ga-Young Lee, Yoo-Shin Park, Shin-Hee Kim, Sang-Yeon Kim, Mina Kang, Min-Ji Kim, Ju-Seop Kang
Pharmacology & Pharmacy (PP) , 2011, DOI: 10.4236/pp.2011.23027
Abstract: Our study compares two commonly used solutions of oxacillin sodium, 5.0 mg/mL in either 0.9% sodium chloride (NS) or 5% dextrose water (D5W), for their continued suitability for IV usage, and stability of active compound over time, when stored at two different controlled temperatures for six weeks. Both solutions were stored in an intravenous infusion device commercially available as Accufuser® and kept at a continuously maintained temperature of either 4 ± 2?C (CT) or 25 ± 2?C (RT). Suitability for IV administration was assessed by measuring changes in macrographical transparency and pH over time, and drug stability was assessed by measuring changes in oxacillin concentration over time using high-performance liquid chromatography (HPLC). After 6 weeks, concentrations of oxacillin were unchanged in the CT solutions, while both RT solutions showed significant decreases in the concentration of oxacillin after only two weeks. Final concentration compared to starting concentrations after 6 weeks at RT, were 36.57% in NS, while virtually no oxacillin was detectable in D5W. Also pH measurements showed a slight decrement at 2 weeks with RT, and at 6 weeks, there was a significant change in pH in both NS and D5W at RT. There was no significant change in color, transparency or appearance after 6 weeks in any of the oxacillin solutions stored in the Accufuser® infusion device. In summary, two commonly used IV solutions for oxacillin administration(5 mg/mL in NS or D5W) stored ready to use in the Accufuser® showed significant changes over time when maintained at RT, that would make the solutions inappropriate for therapeutic use. Both solutions when maintained in CT were not significantly altered and continued to be appropriate in pH and drug concentration for IV therapy. This suggests that ready-to-use solutions of oxacillin sodium in the Accufuser® infusion device can be kept at CT for up to 6 weeks safely but should not be stored at RT due to loss of potency and changes in pH.
Discordance between Perceived and Actual Cancer Stage among Cancer Patients in Korea: A Nationwide Survey
Hye-Young Shim, Jong-Hyock Park, So-Young Kim, Dong Wook Shin, Ji-Yeon Shin, Bo Young Park, Jung-Sik Huh, Hee-Young Shin, Young Joo Won, Hong Gwan Seo
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090483
Abstract: Purpose We assessed the accuracy of communication between doctors and patients by evaluating the consistency between patient perception of cancer stage and the medical records, and analyzed the most influential factors of incongruence among cancer patients at 10 cancer centers across Korea. Methods Information was gathered from cancer patients at the National Cancer Center and nine regional cancer centers located in every province of Korea between 1 July 2008 and 31 August 2008. Data were analyzed using Pearson's χ2 test and multivariate logistic regression analysis. Results The stages of cancer reported by the 1,854 patients showed a low degree of congruence with the stages given in medical records (k = 0.35, P<0.001). Only 57.1% of the patients had accurate knowledge of their cancer stage. In total, 18.5% underestimated their stage of disease, and the more advanced the cancer stage, the more likely they were to underestimate it, in order of local (14.2%), regional (23.7%), and distant (51.6%). Logistic regression analysis showed that congruence was lower in patients with cervical cancer (odds ratio [OR] = 0.51, 95% confidence interval [CI] = 0.30–0.87), recurrence (OR = 0.64, 95% CI = 0.50–0.83), and treatment at the National Cancer Center (OR = 0.53, 95% CI = 0.39–0.72). Conclusion There are knowledge gaps between patients' perceived and actual stage of cancer. Patients with cervical cancer, recurrence, and who received treatment at a regional cancer center showed less understanding of their cancer stage.
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