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Search Results: 1 - 10 of 26948 matches for " Ji Young Ko "
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Lack of Association between Stroke and Left Atrial Out-Pouching Structures: Results of a Case-Control Study
Ji Young Ko, Young Dae Kim, Yoo Jin Hong, Hye-Jeong Lee, Jin Hur, Byoung Wook Choi, Ji Hoe Heo, Young Jin Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076617
Abstract: Background and Purpose Clinical significance of out-pouching structures of the left atrium (LA) as potential embolic sources remains unclear. We sought to evaluate the association between stroke and LA out-pouching structures. Methods A case-control study was conducted to assess the prevalence of LA out-pouching structures in subjects with and without stroke. Case subjects were 270 stroke patients who had undergone cardiac CT. Control subjects were 270 age- and sex-matched patients without a history of stroke and who had undergone cardiac CT. Presence of LA out-pouching structures was determined by ECG-gated cardiac CT. The location of out-pouching structures was categorized as near Bachmann bundle, anterior, inferoseptal, inferior, and lateral. The prevalence, number and location of out-pouching structures and clinical characteristics were compared between the two groups. Results One hundred sixty eight out-pouching structures were identified in 139 stroke patients (51%), while a total of 169 out-pouching structures were found in 155 control patients (57%) (p=0.1949). The prevalence of LA out-pouching structures with different locations was not significantly different between the stroke group and control group. In the stroke group, the prevalence of out-pouching structures was not significantly different by subtypes of ischemic stroke and the prevalence of LA out-pouching structures was not different between patients with atrial fibrillation (AF) and without AF. Conclusion The left atrial out-pouching structures are commonly seen in a population with and without stroke with similar prevalence. Our study suggests that LA out-pouching structures are not significant risk factors of stroke.
Resonant Transmission Through a Pair of Ridge-Loaded Circular Sub-Wavelength Apertures
Jong-Ig Lee;Young-Ki Cho;Ji-Hwan Ko;Junho Yeo
PIER M , 2012, DOI: 10.2528/PIERM12021907
Abstract: This paper deals with resonant transmission through a pair of ridge-loaded circular sub-wavelength apertures in an infinite perfect electric conductor (PEC) plane. The effect of the distance between the two resonant circular sub-wavelength apertures allocated along the ridge direction (``parallel'' case) and perpendicular to the ridge direction (``collinear'' case) on the transmission cross section (TCS) is analyzed numerically by using a method of moments (MoM). It is found that the TCS for the parallel case varies more sensitively to the distance than that for the collinearly located case, and the maximum TCS for the parallel case is tripled compared to the TCS value of a single resonant aperture. For the case of maximum TCS in the parallel configuration, the directivity in the broadside direction is about 8.76 times (=9.43 dB) compared to that for the single resonant aperture. For the purpose of validation, the single resonant aperture and a pair of resonant apertures in the parallel configuration with a distance for maximum TCS are fabricated on a stainless steel plate with 0.3 mm thickness, and their transmission characteristics are measured. Experimental results show that the transmittance, which is a transmitted power density measured at 50 cm away from the aperture plane, for the parallel resonant apertures is about 7 times (=8.43 dB) higher than that for the single aperture, which agrees well with the simulation.
Ji Hea Woo,Jooyeon Ko,Young Eun Choi,Her Jin Gang
Biology of Sport , 2013,
Abstract: The axe kick, in Olympic style taekwondo, has been identified as the most popular scoring technique aimed to the head during full contact competition. The first purpose of this study was to identify and investigate design issues with the current World Taekwondo Federation approved chest protector. A secondary purpose was to develop a novel chest protector addressing the identified design issues and to conduct a biomechanical analysis. Fifteen male elite Taekwondo players were selected to perform three different styles of the axe kick, i.e., front, in-out, and out-in axe kick five times each for a total of 45 kicks. Two-way repeated measures ANOVA showed significant differences between the novel and existing chest protector conditions for vertical height of the toe, downward kicking foot speed, hip flexion angle and ipsilateral shoulder flexion extension range of motion (ROM) (p<0.05). There were no significant differences between the control condition (no chest protector) and the novel chest protector condition for these variables (p>0.05). These results indicate that the novel chest protector interferes less with both the lower and upper limbs during the performance of the axe kick and provides a more natural, free-moving alternative to the current equipment used.
Multi-Indication Carbamazepine and the Risk of Severe Cutaneous Adverse Drug Reactions in Korean Elderly Patients: A Korean Health Insurance Data-Based Study
Ji Young Kim, Joongyub Lee, Young-Jin Ko, Ju-Young Shin, Sun-Young Jung, Nam-Kyong Choi, Byung-Joo Park
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083849
Abstract: Objective To evaluate the risk of severe cutaneous adverse drug reactions (SCAR) after exposure to multi-indication antiepileptic drugs for in Korean elderly patients. Methods We used a nationwide database from the Korean Health Insurance Review and Assessment Service claims constructed for the monitoring of drug utilization among the entire Korean elderly population from January 2005 to June 2006. We identified cases of SCARs among inpatients aged ≥65 years and those newly diagnosed with erythema multiforme according to the International Classification of Diseases, 10th revision code (L51). Each case was matched to four controls for gender, age, and the first hospitalization date as the index date. The use of carbamazepine, gabapentin, lamotrigine, topiramate, phenobarbital, phenytoin, and valproate during a 60-day period before the index date was compared. A conditional logistic regression analysis was performed to calculate the odds ratios (OR) and 95% confidence intervals (CI) of SCARs for antiepileptic drug. Results We identified 286 cases of SCAR and 1,144 matched controls. Among the 25 patients who were prescribed antiepileptic drugs within 60 days of the index date. There were 11 cases (3.8%) of severe ocular manifestations, and most elderly patients were first-time or short-term users of antiepileptic drugs. Among the 10 cases of carbamazepine use, only 2 cases were prescribed carbamazepine for seizure. All antiepileptic drugs were associated with an increased SCAR risk (adjusted OR = 3.42, 95% CI: 1.75–6.63). The SCAR risk was highest in patients treated with carbamazepine (adjusted OR = 10.39, 95% CI: 2.64–40.86, for multi-indication; adjusted OR = 6.84, 95% CI: 1.55–30.10, for neuropathic pain). Conclusion Carbamazepine use was associated with a nearly 10-fold increase in severe cutaneous drug reactions in Korean elderly patients. This association was consistently high with SCAR patients who received carbamazepine for neuropathic pain.
Targeted Inhibition of FAK, PYK2 and BCL-XL Synergistically Enhances Apoptosis in Ovarian Clear Cell Carcinoma Cell Lines
Heejei Yoon, Yoon-La Choi, Ji-Young Song, Ingu Do, So Young Kang, Young-Hyeh Ko, Sangyong Song, Byoung-Gie Kim
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088587
Abstract: Ovarian clear cell carcinoma (OCCC) displays a higher resistance to first line chemotherapy, requiring the development of new therapeutics. We previously identified a frequent chromosomal gain at 8q24 that harbors the focal-adhesion kinase (FAK) gene; the potential of this gene as a therapeutic target remains to be evaluated in OCCCs. We first examined the dependence of OCCCs on FAK and the PI3K/AKT signaling pathway. FAK was overexpressed in 20% of 67 OCCC samples, and this overexpression was correlated with its copy number gain. FAK copy number gains and mutations in PIK3CA accounted for about 40% of OCCC samples, suggesting that the FAK/PI3K/AKT axis is an attractive candidate for targeted therapeutics. We, therefore, treated ovarian cancer cell lines, including OCCC subtypes, with the FAK inhibitors PF-562,271 (PF271), and PF-573,228 (PF228). Ovarian cancer cells were more sensitive to PF271 than PF228. We then searched for single agents that exhibited a synergistic effect on cell death in combination with PF271. We found that co-treatment of PF271 with ABT-737, a BCL-2/BCL-XL antagonist, was profoundly effective at inducing apoptosis. RMGI and OVISE cells were more sensitive to ABT-737 than OVMANA and SKOV3 cells, which have PIK3CA mutations. Mechanistically, PF271 treatment resulted in the transient down-regulation of the anti-apoptotic protein MCL1 via the PI3K/AKT pathway. Therefore, PF271/ABT-737 treatment led to the inhibition of the anti-apoptotic proteins MCL1 and BCL-XL/BCL-2. We suggest that pharmacological inhibition of BCL-XL and FAK/PYK2 can be a potential therapeutic strategy for the treatment of OCCC.
Gene expression profile analysis of genes in rat hippocampus from antidepressant treated rats using DNA microarray
Jun-Ho Lee, Eunjung Ko, Young-Eun Kim, Ji-Young Min, Jian Liu, Yangseok Kim, Minkyu Shin, Moochang Hong, Hyunsu Bae
BMC Neuroscience , 2010, DOI: 10.1186/1471-2202-11-152
Abstract: We used a genome-wide microarray system containing 30,000 clones to evaluate total RNA that had been isolated from the brains of treated rats to identify the genes involved in the therapeutic mechanisms of various antidepressants, a tricyclic antidepressant (imipramine). a selective serotonin reuptake inhibitor (fluoxetine), a monoamine oxidase inhibitor (phenelzine) and psychoactive herbal extracts of Nelumbinis Semen (NS). To confirm the differential expression of the identified genes, we analyzed the amount of mRNA that was isolated from the hippocampus of rats that had been treated with antidepressants by real-time RT-PCR using primers specific for selected genes of interest. These data demonstrate that antidepressants interfere with the expression of a large array of genes involved in signaling, survival and protein metabolism, suggesting that the therapeutic effect of these antidepressants is very complex. Surprisingly, unlike other antidepressants, we found that the standardized herbal medicine, Nelumbinis Semen, is free of factors that can induce neurodegenerative diseases such as caspase 8, α-synuclein, and amyloid precursor protein. In addition, the production of the inflammatory cytokine, IFNγ, was significantly decreased in rat hippocampus in response to treatment with antidepressants, while the inhibitory cytokine, TGFβ, was significantly enhanced.These results suggest that antidepressants function by regulating neurotransmission as well as suppressing immunoreactivity in the central nervous system.Most antidepressants enhance serotonergic or noradrenergic neurotransmission by inhibiting monoamine oxidase or by binding to neurotransmitter transporters, thereby inhibiting neurotransmitter re-uptake. Although antidepressants are widely used to treat depression, they often produce various adverse side effects such as sexual dysfunction, anxiety, blurred vision, headache, sleep disruption, constipation, nausea, sedation, and weight gain [1,2]. There are man
A Study on Comparison of Building Energy Simulation and Measurement Results for a City Hall  [PDF]
Young-Sun Ko, Sang Tae No
Journal of Building Construction and Planning Research (JBCPR) , 2015, DOI: 10.4236/jbcpr.2015.31001
Abstract: In recent years, the number of public office buildings which were built by the glass curtain wall increased rapidly, but through the results of the investigation of the government, these buildings have been found that the heating and cooling load is high, and showed low energy efficiency. So in this study, through energy simulation, the energy consumption of public office building was verified and measured; environment data and calculated data were compared to make more precise simulation. The heating and cooling load was calculated via EnergyPlus; building was modeled by Google SketchUp connected to EnergyPlus. The results of this study were as follows: in simulation, incident solar radiation from large curtain wall should be underestimated. And using site-measured outdoor environment data can increase accuracy of simulation result.
Immunomodulatory Effects of Liriope Platyphylla Water Extract on Lipopolysaccharide-Activated Mouse Macrophage
Hye Kyung Kim,Ji Young Lee,Hyo-Sang Han,Young-Jin Kim,Hyun Joo Kim,Yoon-Sang Kim,Hyung Min Kim,Seong-Gyu Ko,Hyo-Jin An,Young-Jong Lee,Wansu Park
Nutrients , 2012, DOI: 10.3390/nu4121887
Abstract: The tuber of Liriope platyphylla Wang et Tang (Liliaceae), also known as Liriopis tuber, is famous in Oriental medicine owing to its tonic, antitussive, expectorant and anti-asthmatic properties. In the present study, the effects of Liriopis tuber water extract (LP) on proinflammatory mediators secreted from lipopolysaccharide (LPS)-induced cultured RAW 264.7 mouse macrophages were investigated. Nitric oxide (NO), prostaglandin E2 (PGE2) and intracellular calcium release were measured after 24 h incubation. Various cytokines and nuclear transcription factors (NF-κB and CREB) of LPS-induced RAW 264.7 were measured by a multiplex bead array assay based on xMAP technology. LP (up to 200 μg/mL) significantly decreased levels of nitric oxide (NO), interleukin (IL)-6, IL-10, IL-12p40, interferon-inducible protein-10, keratinocyte-derived chemokine, monocyte chemotactic protein-1, vascular endothelial growth factor, granulocyte macrophage-colony stimulating factor, platelet derived growth factor, PGE2, intracellular calcium, NF-κB and CREB in LPS-induced RAW 264.7 cells ( p < 0.05). The results suggest that LP has immunomodulatory activity to reduce excessive immune reactions during the activation of macrophages by LPS. Further studies are needed to verify the precise mechanism regulating immunomodulatory activities of LP.
Constitutive phosphorylation of the FOXO1 transcription factor in gastric cancer cells correlates with microvessel area and the expressions of angiogenesis-related molecules
Sue Kim, Jiyeon Yoon, Young Ko, Mee Chang, Jong-Wan Park, Hee Lee, Min A Kim, Ji Kim, Woo Kim, Byung Lee
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-264
Abstract: Immunohistochemistry was performed on tissue array slides containing 272 gastric carcinoma specimens, and the correlations between the cytoplasmic pFOXO1 expression in gastric cancer cells and CD34-immunopositive microvessel area (MVA) or the expressions of angiogenesis-related molecules were analyzed. In vitro analyses with Western blotting and semiquantitative reverse transcription-polymerase chain reaction were performed using the stable SNU-638 gastric cancer cell line transfected with lentivirus-delivered FOXO1 short hairpin RNA.The cytoplasmic expression of pFOXO1 in tumor cells was observed in 85% of gastric carcinoma cases, and was found to be positively associated with higher MVA (P = 0.048). Moreover, pFOXO1 expression was positively correlated with the expressions of several angiogenesis-related proteins, including hypoxia inducible factor-1α (HIF-1α, P = 0.003), vessel endothelial growth factor (P = 0.004), phosphorylated protein kinase B (P < 0.001), and nuclear factor-κB (P = 0.040). In contrast, the expression of pFOXO1 was not correlated with that of phosphorylated signal transducer and activator of transcription 3 or β-catenin. In addition, cell culture experiments showed that FOXO1 suppression increased the mRNA and protein expressions of HIF-1α.Our results suggest that pFOXO1 expression in cancer cells plays a role in gastric cancer angiogenesis via mechanisms involving various angiogenesis-related molecules. Animal experiments are needed to confirm the anti-angiogenic role of FOXO1 in human gastric cancer.The FOXO (Forkhead box, class O) is a subfamily of forkhead transcription factor and consists of FOXO1A (FKHR: Forkhead in rhabdomyosarcoma, also known as FOXO1), FOXO3A (FKHR-like 1), MLLT7 (AFX: acute-lymphocytic-leukaemia-1 fused gene from chromosome X, also known as FOXO4) and FOXO6 [1]. Phosphorylated FOXOs could not exhibit transcriptional activity because the phosphorylated forms are exported from the nucleus [2]. FOXOs are now emerging a
Constitutive activation of glycogen synthase kinase-3β correlates with better prognosis and cyclin-dependent kinase inhibitors in human gastric cancer
Yu Cho, Ji Kim, Jiyeon Yoon, Sung Cho, Young Ko, Jong-Wan Park, Hye Lee, Hee Lee, Woo Kim, Byung Lee
BMC Gastroenterology , 2010, DOI: 10.1186/1471-230x-10-91
Abstract: Immunohistochemistry was performed on tissue array slides containing 281 human gastric carcinoma specimens. In addition, gastric cancer cells were cultured and treated with a GSK-3β inhibitor lithium chloride (LiCl) for immunoblot analysis.We found that pGSK-3β was expressed in 129 (46%) of 281 cases examined, and was higher in the early-stages of pathologic tumor-node-metastasis (P < 0.001). The expression of pGSK-3β inversely correlated with lymphatic invasion (P < 0.001) and lymph node metastasis (P < 0.001) and correlated with a longer patient survival (P < 0.001). In addition, pGSK-3β expression positively correlated with that of p16, p21, p27, p53, APC, PTEN, MGMT, SMAD4, or KAI1 (P < 0.05), but not with that of cyclin D1. This was confirmed by immunoblot analysis using SNU-668 gastric cancer cells treated with LiCl.GSK-3β activation was frequently observed in early-stage gastric carcinoma and was significantly correlated with better prognosis. Thus, these findings suggest that GSK-3β activation is a useful prognostic marker for the early-stage gastric cancer.It is thought that human cancers, including gastric carcinoma, develop due to the accumulation of genetic alterations, such as oncogene activation and tumor suppressor gene loss [1-3]. Thus, it is important to identify genetic alterations that affect the behaviors of malignant tumors.Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine protein kinase whose activity is regulated by site-specific phosphorylation. Complete activation of GSK-3β generally requires phosphorylation at Tyr216 and, conversely, phosphorylation at Ser9 inhibits GSK-3β activity [4]. Although GSK-3β was first described as a component of the metabolic pathway for glycogen synthase regulation, it is now known that GSK-3β is a multi-functional kinase [5]. GSK-3β has more than 40 protein substrates and involved in a wide range of cellular processes, including differentiation, growth, motility and apoptosis [6].The function of GSK-3β
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