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Search Results: 1 - 10 of 325993 matches for " Jesús Mosquera "
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Papel del receptor para compuestos de glicosilación avanzada (RAGE) en la inflamación
Mosquera,Jesús A;
Investigación Clínica , 2010,
Abstract: the receptor for advanced glycation end products (rage) is a transmembrane protein on the cellular surface that recognizes tridimensional molecules, instead of aminoacid sequences, making this molecule capable of interacting with diverse ligands. rage represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. rage signaling has been implicated in multiple human illnesses, including diabetes, atherosclerosis, arthritis, alzheimer's disease, atherosclerosis and aging associated diseases. in addition to advanced glycation end products (age), rage has other important ligands such as: high mobility group box 1 protein (hmgb1, also termed amphoterin), the group of calcium binding cellular factors s100 (also termed calgranulin), amiloid beta peptides and mac-1, a beta-2 integrin (cd11b/cd18). ligation of rage on the cellular surface triggers a series of cellular signaling events, including the activation and translocation to the nucleus of transcription factor nf-κb, leading to the production of pro-inflammatory cytokines, chemokines, adhesion molecules and oxidative stress and causing inflammation. more recent work has revealed the role of rage in inflammatory cell recruitment and extravasation of leukocytes across the endothelial barrier with further inflammatory events. recent therapeutic strategies show that rage is an important target to treat rage activation-associated diseases.
Américo Negrette In memorian
Jesús Mosquera
Investigación Clínica , 2003,
Abstract:
Papel del receptor para compuestos de glicosilación avanzada (RAGE) en la inflamación Role of the receptor for advanced glycation end products (RAGE) in inflammation
Jesús A Mosquera
Investigación Clínica , 2010,
Abstract: Los receptores para los compuestos de glicosilación avanzada (RAGE) son moléculas ubicadas en la superficie celular (transmembrana), que interactúan con patrones moleculares tridimensionales, más que con secuencia de aminoácidos, lo que los hace adecuados para unirse a varios ligandos. Estos receptores representan un elemento importante en la inmunidad innata contra patógenos, pero también interactúan con ligandos endógenos originando inflamación crónica. Esta característica los hace potenciales inductores de enfermedades asociadas a la inflamación crónica como la diabetes, la enfermedad de Alzheimer, artritis, ateroesclerosis y trastornos degenerativos relacionados con la vejez. Los principales ligandos de RAGE aparte de los compuestos de glicosilación, son las proteínas de alta movilidad del grupo de caja 1 (HMGB1; llamada también Anfoterina), las proteínas del grupo S100 que fijan calcio, también llamadas calgranulinas, los péptidos amiloides β y el Mac-1, una beta-2 integrina (CD11b/CD18). La unión de RAGE con su ligando en la superficie celular induce la activación de varias vías de se alización intracelular que llevan como punto central, a la translocación del factor de transcripcion NF-κB del citoplasma al núcleo, éste al actuar sobre el ADN, induce la producción de moléculas de adhesión, citocinas, quimiocinas y estrés oxidativo, entre otros efectos. Además de inducir las se alizaciones, la molécula per se es capaz de actuar como un receptor de otras moléculas en el endotelio y permitir la extravasación y la infiltración de leucocitos a los tejidos, aumentando el fenómeno inflamatorio. Estudios recientes demuestran que RAGE es un blanco terapéutico importante para el tratamiento de las enfermedades asociadas a su activación. The receptor for advanced glycation end products (RAGE) is a transmembrane protein on the cellular surface that recognizes tridimensional molecules, instead of aminoacid sequences, making this molecule capable of interacting with diverse ligands. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. RAGE signaling has been implicated in multiple human illnesses, including diabetes, atherosclerosis, arthritis, Alzheimer's disease, atherosclerosis and aging associated diseases. In addition to advanced glycation end products (AGE), RAGE has other important ligands such as: high mobility group box 1 protein (HMGB1, also termed amphoterin), the group of calcium binding cellular factors S100 (also termed calgranulin), amiloid beta
Síndrome Respiratorio Agudo Severo (SRAS): Lecciones y Retos
Valero,Nereida; Larreal,Yraima; Mosquera,Jesús; Rincón,Enrique;
Investigación Clínica , 2005,
Abstract: after four months of silence before a new incursion of severe acute respiratory syndrome virus (sars), world wide investigators specially from asia had have to face a coronavirus capable of great spreading and inducing high morbidity. the source and the capacity of this virus to associate with other opportunist microorganisms to induce progression of the disease, remain unclear. the comparison of the genomic sequence of different strains has generated discrepancies as for if the sars epidemic arose as an unique outbreak or it was produced for more than one genotype. however, this fact is secondary to the imminent threat that was controlled in august of 2003, after affecting 8.422 individuals, but before which we should be remain alert, since it is clear that the end of the sars is not yet here; and that the appearance of a single case can mean the beginning of a new wave, joining the outbreak of other diseases such as the avian flu. in this regard, it is very important to know the epidemic bases of morbid-mortality of sars and to keep a world wide surveillance in order to detect possible further cases.
Síndrome Respiratorio Agudo Severo (SRAS): Lecciones y Retos Severe Acute Respiratory Syndrome (SARS): Lesson and challenges
Nereida Valero,Yraima Larreal,Jesús Mosquera,Enrique Rincón
Investigación Clínica , 2005,
Abstract: Después de varios meses de silencio, ante una nueva incursión del virus causante del Síndrome Respiratorio Agudo Severo (SRAS), investigadores en todo el mundo y especialmente asiáticos se enfrentan a un coronavirus que ha demostrado gran transmisibilidad y morbilidad y que constituye una gran incógnita en cuanto a origen y asociación con otros patógenos que actuando como oportunistas puedan agravar la progresión de la enfermedad. La comparación de la secuencia genómica de distintas cepas ha generado discrepancias en cuanto a si la epidemia de SRAS surgió como un brote único o fue producida por más de un genotipo; sin embargo este hecho es secundario ante la inminente amenaza que fue controlada en agosto de 2003 después de afectar a 8.422 individuos pero ante la cual se debe permanecer alerta, dado que está claro que no se ha marcado el fin del SRAS y que la aparición de un solo caso puede significar el comienzo de una nueva oleada, aunado a la aparición de otras enfermedades como la influenza aviaria. De allí la importancia de conocer las bases epidemiológicas sobre las cuales se ha establecido la morbi-mortalidad de esta afección y asegurar la persistencia de la vigilancia mundial en el futuro, hecho crucial para detectar a tiempo posibles casos y por ende controlar su diseminación. After four months of silence before a new incursion of severe acute respiratory syndrome virus (SARS), world wide investigators specially from Asia had have to face a coronavirus capable of great spreading and inducing high morbidity. The source and the capacity of this virus to associate with other opportunist microorganisms to induce progression of the disease, remain unclear. The comparison of the genomic sequence of different strains has generated discrepancies as for if the SARS epidemic arose as an unique outbreak or it was produced for more than one genotype. However, this fact is secondary to the imminent threat that was controlled in August of 2003, after affecting 8.422 individuals, but before which we should be remain alert, since it is clear that the end of the SARS is not yet here; and that the appearance of a single case can mean the beginning of a new wave, joining the outbreak of other diseases such as the avian flu. In this regard, it is very important to know the epidemic bases of morbid-mortality of SARS and to keep a world wide surveillance in order to detect possible further cases.
Increased number of IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of the cervix
Mindiola,Raimy; Callejas,Diana; Nú?ez-Troconis,José; Araujo,Mary; Delgado,Mariela; Mosquera,Jesús;
Investigación Clínica , 2008,
Abstract: previous studies have shown the involvement of the immune response in the progression of human uterine cervix cancer. the aim of this study was to determine the expression of interleukin-2 (il-2), il-2 receptor (il-2r) and interleukin 10 (il-10) in different grades of cervical intraepithelial neoplasias of the exocervix (cin 1, 2 and 3), and its relationship with the serum cytokine profiles and human papilomavirus (hpv) infection status. indirect immunofluorescence was used to study the expression of il-2, il-2r and il-10 in human cervical samples from 50 patients and 9 normal controls. serum il-2, il-2r and il-10 were measured by elisa and hpv dna and hpv types were identified by pcr. increased number of il-2, il-2r and il-10 positive cells were observed in the cervix from patients with cin, associated with the grades of dysplasia. a significant correlation was observed between il-2 and il-2r (p>0.0001), il-2 and il-10 (p > 0,0001), as well as il-10 and il-2r (p> 0.0001). twenty percent of patients were hpv positive and 84 % of those patients were tissue cytokine positive. these results suggest that il-2, il-2r and il-10 tissue expression may play a role in the development of cervical intraepithelial dysplasias.
FENOLOGíA DEL PALO CRUZ (Brownea rosa-de-monte Bergius) EN UN BOSQUE SECO DE BOLIVAR, CAUCA
Gómez-Mosquera,Daniel Alejandro; Macías-Pinto,Diego Jesús;
Colombia Forestal , 2012,
Abstract: the reproductive phenology of brownea-rosa-de-monte, known as "palo cruz" was determined applying a transect method for phenological monitoring. six trees in a relict forest located along salinas creek, in the village of la carbonera, municipality of bolivar, cauca were monitored. the species has two annual cycles including four phenological stages (foliation, button inflorescence, flowering and fruiting). analysis of the intensities of different phenological stages and climatic variables suggests an inverse relationship between the timing of flowering and fruiting and temperature and relative humidity. an inverse relationship also exists between the numbers of inflorescences and rainfall. reproduction in this species is therefore asynchronous and strongly influenced by climatic variables.
Children affected with HIV/AIDS: Information of HIV/AIDS in five Colombian cities
Trejos,Ana María; Tuesca,Rafael de Jesús; Mosquera,Mario;
Colombia Médica , 2011,
Abstract: objectives: to describe information about hiv/aids in a youth population under 18 years of age affected with hiv/aids and caregivers in five colombian cities: cali, buenaventura, barranquilla, santa marta, and cartagena. methods: 286 personal surveys were conducted: 11 of children who were aware of their status of involvement with hiv/aids and 275 of caregivers of children who did not know their status of involvement with hiv/aids. the surveys were conducted in health institutions in the state and private sectors and private, using instruments in line with training programs from participating institutions to inquire about hiv/aids. descriptive analysis was performed of the data and tabulation was done with the spss program. results: most children who knew their status of involvement with hiv/aids report that by acquiring the hiv virus, they may develop other diseases; however, half of these fail to recognize that aids weakens the body's ability to fight infection. the children surveyed partly recognized the hiv/aids transmission and treatment mechanisms, while caregivers possess adequate information on the disease. we found reasons to delay the delivery of diagnosis by caregivers 96.2% (n=275) related to avoiding psychological harm to the children, and that if they were to know said status, they might inadvertently disclose this to others, probably exposing them to stigma and/or discrimination. likewise, professionals providing health services to hiv seropositive children express lack of training regarding the proper procedure and age to reveal such information. conclusions: it is a priority to enhance the capacity, information, and education of patients about effects, characteristics, manifestations, and treatment of the disease within the comprehensive health management processes conducive to supporting affected families.
Ni?ez afectada con VIH/SIDA: Uso y acceso a Servicios de Salud en cinco ciudades colombianas
Trejos Herrera,Ana María; Tuesca Molina,Rafael de Jesús; Mosquera Vásquez,Mario;
Revista Salud Uninorte , 2011,
Abstract: objective: to describe patterns of use and barriers to access to health services for children affected with hiv/aids living in cali, buenaventura, barranquilla, santa marta and cartagena. materials and methods: 286 personal surveys conducted with 11 children who knew their hiv diagnosis and, 275 caregivers of children who did not know their hiv status of involvement. using an instrument designed by the authors, a descriptive analysis and tabulation was performed of data and tabulation in spss, version 15, in spanish. results: [96.2% (n=275)] of the caregivers reported the delivery delay of diagnosis for fear of stigma if the child discloses the diagnosis inadvertently to other people and, to protect it from possible psychological damage that generates the news. a pattern was found of frequent use of health service whose waiting time exceeds 30 minutes [53.8% (n=154)]. most children do not receive home care [85.7% (n=245)]. caregivers reported receiving health care respectfully and friendly [70.6% (n=259)], however, in the testimonies of focus groups in buenaventura shows the lack of guarantee of a respectful and, to provide the necessary confidentiality regarding the diagnosis of hiv/aids. discussion: health services must overcome some obstacles to ensuring not only access to care, but also to increase the availability, fairness, integrity and quality from the perspective of rights and in order to benefit people living with hiv/aids for hiv / aids.
DETECCIóN DE Brucella abortus POR PCR EN MUESTRAS DE SANGRE Y LECHE DE VACUNOS
Mosquera C,Xiomara; Bernal V,Carmen; Muskus L,Carlos; Berdugo G,Jesús;
Revista MVZ Córdoba , 2008,
Abstract: objective. to evaluate the use of polymerase chain reaction in the detection of brucella abortus in cattle blood and milk samples. materials and methods. between 2004 and 2005 a descriptive study was carried out. one hundred and thirty six females from three different herds located in durania, norte de santander, colombia were used. the antibodies to brucella were detected using ring test (rt). primers b4 and b5 of internal region of gen bcsp31 (genbank, number access m20404) were used. from those rt positive animals, blood and milk samples were obtained and along with 33 negative milk samples were evaluated by pcr. blood samples were not analyzed for antibody detection. different dna extraction protocols were evaluated and a brucella abortus gene was amplified using specific primers. results. the 13.2% of milk samples were positive to rt (18/136), 30.3% (10/33) of negative samples for rt and 94.1% (16/17) of positive samples were both positive by pcr. it was demonstrated that pcr is an useful tool to detect brucella abortus dna, either in milk and blood samples. conclusions. it was determined by pcr a dna fragment of brucella abortus in blood and milk of cattle. the preliminary results showed that it is possible to perform pcr as diagnostic test of brucellosis in colombia
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