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Search Results: 1 - 10 of 202804 matches for " Jeremy N Adams "
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Exploring the usefulness of comprehensive care plans for children with medical complexity (CMC): a qualitative study
Sherri Adams, Eyal Cohen, Sanjay Mahant, Jeremy N Friedman, Radha MacCulloch, David B Nicholas
BMC Pediatrics , 2013, DOI: 10.1186/1471-2431-13-10
Abstract: This qualitative study utilized in-depth semi-structured interviews and focus groups. HCPs (n = 15) and parents (n = 15) of CMC who had all used a comprehensive care plan were recruited from a tertiary pediatric academic health sciences center. Themes were identified through grounded theory analysis of interview and focus group data.A multi-dimensional model of perceived care plan usefulness emerged. The model highlights three integral aspects of the care plan: care plan characteristics, activating factors and perceived outcomes of using a care plan. Care plans were perceived as a useful tool that centralized and focused the care of the child. Care plans were reported to flatten the hierarchical relationship between HCPs and parents, resulting in enhanced reciprocal information exchange and strengthened relationships. Participants expressed that a standardized template that is family-centered and includes content relevant to both the medical and social needs of the child is beneficial when integrated into overall care planning and delivery for CMC.Care plans are perceived to be a useful tool to both health care providers and parents of CMC. These findings inform the utility and development of a comprehensive care plan template as well as a model of how and when to best utilize care plans within family-centered models of care.Children with medical complexity (CMC) are vulnerable to care that is inadequate and poorly coordinated [1-6], leading to family stress, unsafe care [3,7-9], poor health outcomes, and increased rates of hospitalization [10,11]. Recent literature strongly advocates that these children be cared for in a medical home [12] and receive a written medical care plan to facilitate their transition through the health care system [12,13]. Work done by Berry and colleagues looking at the experiences of parents and health care providers caring for children with tracheotomy demonstrated the need for provider led care plans and the utilization of web-based tec
Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study
Jeremy N Adams, Amanda J Cox, Barry I Freedman, Carl D Langefeld, J Jeffrey Carr, Donald W Bowden
Cardiovascular Diabetology , 2013, DOI: 10.1186/1475-2840-12-31
Abstract: This study examined the association of HP genotypes with subclinical CVD, T2DM risk, and associated risk factors in a T2DM-enriched sample. Haptoglobin genotypes were determined in 1208 European Americans (EA) from 473 Diabetes Heart Study (DHS) families via PCR. Three promoter SNPs (rs5467, rs5470, and rs5471) were also genotyped.Analyses revealed association between HP2-2 duplication and increased carotid intima-media thickness (IMT; p?=?0.001). No association between HP and measures of calcified arterial plaque were observed, but the HP polymorphism was associated with triglyceride concentrations (p?=?0.005) and CVD mortality (p?=?0.04). We found that the HP2-2 genotype was associated with increased T2DM risk with an odds ratio (OR) of 1.49 (95% CI 1.18-1.86, p?=?6.59x10-4). Promoter SNPs were not associated with any traits.This study suggests association between the HP duplication and IMT, triglycerides, CVD mortality, and T2DM in an EA population enriched for T2DM. Lack of association with atherosclerotic calcified plaque likely reflect differences in the pathogenesis of these CVD phenotypes. HP variation may contribute to the heritable risk for CVD complications in T2DM.Cardiovascular disease (CVD) is one of the major complications associated with type 2 diabetes mellitus (T2DM). As of 2011, 25.8 million Americans had diagnosed T2DM [1]. More than 50% of individuals with T2DM had coronary heart disease, stroke, or cardiac disease [2]. T2DM is an independent risk factor for development of CVD with the relative risk of CVD mortality of 2.1 in men and 4.9 in women, relative to non-T2DM affected individuals [3,4]. There is increasing evidence that genetic and environmental factors contribute to this risk.Haptoglobin (HP) is a 54 kDa protein, found abundantly in the serum [5,6]. The HP gene has two major alleles: HP1, (containing five exons) and HP2, (containing seven exons) which likely arose from a duplication event involving exons 3 and 4, producing a 61 kDa pro
A Switch in Hepatic Cortisol Metabolism across the Spectrum of Non Alcoholic Fatty Liver Disease
Adeeba Ahmed, Elizabeth Rabbitt, Theresa Brady, Claire Brown, Peter Guest, Iwona J. Bujalska, Craig Doig, Philip N. Newsome, Stefan Hubscher, Elwyn Elias, David H. Adams, Jeremy W. Tomlinson, Paul M. Stewart
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0029531
Abstract: Context Non alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. NAFLD represents a spectrum of liver disease ranging from reversible hepatic steatosis, to non alcoholic steato-hepatitis (NASH) and cirrhosis. The potential role of glucocorticoids (GC) in the pathogenesis of NAFLD is highlighted in patients with GC excess, Cushing's syndrome, who develop central adiposity, insulin resistance and in 20% of cases, NAFLD. Although in most cases of NAFLD, circulating cortisol levels are normal, hepatic cortisol availability is controlled by enzymes that regenerate cortisol (F) from inactive cortisone (E) (11β-hydroxysteroid dehydrogenase type 1, 11β-HSD1), or inactivate cortisol through A-ring metabolism (5α- and 5β-reductase, 5αR and 5βR). Objective and Methods In vitro studies defined 11β-HSD1 expression in normal and NASH liver samples. We then characterised hepatic cortisol metabolism in 16 patients with histologically proven NAFLD compared to 32 obese controls using gas chromatographic analysis of 24 hour urine collection and plasma cortisol generation profile following oral cortisone. Results In patients with steatosis 5αR activity was increased, with a decrease in hepatic 11β-HSD1 activity. Total cortisol metabolites were increased in this group consistent with increased GC production rate. In contrast, in patients with NASH, 11β-HSD1 activity was increased both in comparison to patients with steatosis, and controls. Endorsing these findings, 11β-HSD1 mRNA and immunostaining was markedly increased in NASH patients in peri septal hepatocytes and within CD68 positive macrophages within inflamed cirrhotic septa. Conclusion Patients with hepatic steatosis have increased clearance and decreased hepatic regeneration of cortisol and we propose that this may represent a protective mechanism to decrease local GC availability to preserve hepatic metabolic phenotype. With progression to NASH, increased 11β-HSD1 activity and consequent cortisol regeneration may serve to limit hepatic inflammation.
Notas sobre el uso de la antropología en el campo de la salud pública Notes on the use of anthropology in the field of public health
Richard N Adams
Revista Cubana de Salud Pública , 2012,
Energy, Complexity and Strategies of Evolution
Richard N. Adams
Avá : Revista de Antropología , 2009,
Cavum Vergae with Transient Loss of Conciousness in a Child: A Case Report and Brief Literature Review
FU Uduma, N Adams
Asian Journal of Medical Sciences , 2014, DOI: 10.3126/ajms.v5i1.8107
Abstract: Cavum vergae is a triangular fluid filled cavity posterior to foramen of Monro. They are seen in premature and term infants up to 2 months of age. It is of little clinical significance. Our patient is a 14year old girl with cavum vergae diagnosed with brain computed tomography and magnetic resonance imaging. These investigations were sequel to episodes of headache and one hour loss of consciousness with no antecedent complaints. Since no complicating evidence of hydrocephalus was seen, she was managed symptomatically. DOI: http://dx.doi.org/10.3126/ajms.v5i1.8107 ? Asian Journal of Medical Science Vol.5(1) 2014 pp.73-76
An Investigation of the Loss of Planet-Forming Potential in Intermediate Sized Young Embedded Star Clusters
Lisa Holden,Edward Landis,Jeremy Spitzig,Fred C. Adams
Physics , 2010, DOI: 10.1086/658081
Abstract: A large fraction of stars forming in our galaxy are born within clusters embedded in giant molecular clouds. In these environments, the background UV radiation fields impinging upon circumstellar disks can often dominate over the radiation fields produced by each disk's central star. As a result, this background radiation can drive the evaporation of circumstellar disks and lead to the loss of planet forming potential within a cluster. This paper presents a detailed analysis of this process for clusters whose stellar membership falls within the range $100 \le N \le 1000$. For these intermediate-sized clusters, the background UV field is often dominated by the most massive stellar member. Due to the steep slope of the initial mass function, the amount of background UV light that bathes clusters of similar size displays significant variance. As a result, we perform a statistical analysis of this problem by calculating distributions of FUV flux values impinging upon star/disk systems for several cluster scenarios. We find that in the absence of dust attenuation, giant planet formation would likely be inhibited in approximately half of systems forming within intermediate-sized clusters regardless of stellar membership. In contrast, the presence of dust can significantly lower this value, with the effect considerably more pronounced in more populated clusters.
Galaxy Kinematics with VIRUS-P: The Dark Matter Halo of M87
Jeremy D. Murphy,Karl Gebhardt,Joshua J. Adams
Physics , 2011, DOI: 10.1088/0004-637X/729/2/129
Abstract: We present 2-D stellar kinematics of M87 out to R = 238" taken with the integral field spectrograph VIRUS-P. We run a large set of axisymmetric, orbit-based dynamical models and find clear evidence for a massive dark matter halo. While a logarithmic parameterization for the dark matter halo is preferred, we do not constrain the dark matter scale radius for an NFW profile and therefore cannot rule it out. Our best-fit logarithmic models return an enclosed dark matter fraction of 17.2 +/- 5.0 % within one effective radius (R_e ~ 100"), rising to 49.4 (+7.2,-8.8) % within 2 R_e. Existing SAURON data (R < 13"), and globular cluster kinematic data covering 145" < R < 540" complete the kinematic coverage to R = 47 kpc. At this radial distance the logarithmic dark halo comprises 85.3 (+2.5,-2.4) % of the total enclosed mass of 5.7^(+1.3)_(-0.9) X 10^(12) M_sun making M87 one of the most massive galaxies in the local universe. Our best-fit logarithmic dynamical models return a stellar mass-to-light ratio of 9.1^(+0.2)_(-0.2) (V-band), a dark halo circular velocity of 800^(+75)_(-25) kms, and a dark halo scale radius of 36^(+7)_(-3) kpc. The stellar M/L, assuming an NFW dark halo, is well constrained to 8.20^(+0.05)_(-0.10) (V-band). The stars in M87 are found to be radially anisotropic out to R ~ 0.5 R_e then isotropic or slightly tangentially anisotropic to our last stellar data point at R = 2.4 R_e where the anisotropy of the stars and globular clusters are in excellent agreement. The globular clusters then become radially anisotropic in the last two modeling bins at R = 3.4 R_e and R = 4.8 R_e. As one of the most massive galaxies in the local universe, constraints on both the mass distribution of M87 and anisotropy of its kinematic components strongly informs our theories of early-type galaxy formation and evolution in dense environments.
Inhibition of Herpes Simplex Virus-1 by the Modified Green Tea Polyphenol EGCG-Stearate  [PDF]
Shivani N. Patel, Sandra D. Adams, Lee H. Lee
Advances in Bioscience and Biotechnology (ABB) , 2018, DOI: 10.4236/abb.2018.912046

Epigallocatechin gallate (EGCG), a green tea polyphenol possesses antioxidant, antibacterial, anticancer and antiviral properties. EGCG-Stearate (EGCG-S) is of interest for this study because of its stability and lipophilic properties. The chemical modification of EGCG-S increased its lipid solubility. Herpes simplex virus-1 (HSV-1), a member of the family Herpesviridae, and Alphaherpesvirinae subfamily is a leading cause of human viral diseases in the United States. In this study, 25 μM, 50 μM, 75 μM, and 100 μM of EGCG and EGCG-S were used to carry out cytotoxicity, cell viability and cell proliferation assays to determine the maximum non-cytotoxic concentrations on cultured A549 cells. The results suggested that 75 μM of EGCG and EGCG-S is the appropriate concentration to further study the effect on the infection of HSV-1 in A549 cells. Infectivity, antiviral, and inverted microscopy assays were performed to study the effects of EGCG and EGCG-S on HSV-1 infection. An antiviral assay was performed using luminescence and it indicated that EGCG-S treated HSV-1 showed up to 90% inhibition. Confocal microscopy images further supported the inhibitory effects of 75 μM EGCG-S on HSV-1 infection in A549 cells. The long-term goal of this research is to use EGCG-S as a possible novel topical therapeutic treatment to limit the spread of HSV-1 infections.

High Temperature Phase Transitions in Two-Scalar Theories with Large $N$ Techniques
J. A. Adams,N. Tetradis
Physics , 1994, DOI: 10.1016/0370-2693(95)00044-L
Abstract: We consider a theory of a scalar one-component field $\phi$ coupled to a scalar $N$-component field $\chi$. Using large $N$ techiques we calculate the effective potential in the leading order in $1/N$. We show that this is equivalent to a resummation of an infinite subclass of graphs in perturbation theory, which involve fluctuations of the $\chi$ field only. We study the temperature dependence of the expectation value of the $\phi$ field and the resulting first and second order phase transitions.
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