oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2020 ( 52 )

2019 ( 460 )

2018 ( 521 )

2017 ( 536 )

Custom range...

Search Results: 1 - 10 of 326623 matches for " Jerónimo Graf S "
All listed articles are free for downloading (OA Articles)
Page 1 /326623
Display every page Item
Síndrome hemolítico-urémico y Streptococo pneumoniae: Report of one case
Reynolds H,Enrique; Espinoza R,Mauricio; M?nckeberg F,Gustavo; Graf S,Jerónimo;
Revista médica de Chile , 2002, DOI: 10.4067/S0034-98872002000600012
Abstract: hemolytic-uremic syndrome (hus) is an uncommon complication of pneumococcal infection. highly suggesting findings in a patient with streptococcus pneumoniae infection are: microangyopatic hemolytic anemia, thrombocytopenia and acute renal failure. we report a 41 years old woman, admitted to the hospital due to a severe pneumonia, that required the surgical drainage of an empyema. on admission, a drop in packed red cell volume from 41 to 25%, the presence of schistocytes in the blood smear, an elevation of ldh to 1,700 iu/l, a fall in haptoglobin to 5.8 mg/dl and a thrombocytopenia of 72,000 per mm3 were detected. these alterations coincided with an oliguric acute renal failure. she was treated with hemodialysis and the hemolytic syndrome was managed with plasmapheresis. she was discharged 35 days after admission and in the follow up, after 2.5 months, her serum creatinine is 1.2 mg/dl and her packed red cell volume is 41% (rev méd chile 2002; 130: 677-680)
Síndrome hemolítico-urémico y Streptococo pneumoniae: Report of one case Hemolytic-uremic syndrome after an infection caused by Streptococcus pneumoniae
Enrique Reynolds H,Mauricio Espinoza R,Gustavo M?nckeberg F,Jerónimo Graf S
Revista médica de Chile , 2002,
Abstract: Hemolytic-uremic syndrome (HUS) is an uncommon complication of pneumococcal infection. Highly suggesting findings in a patient with Streptococcus pneumoniae infection are: microangyopatic hemolytic anemia, thrombocytopenia and acute renal failure. We report a 41 years old woman, admitted to the hospital due to a severe pneumonia, that required the surgical drainage of an empyema. On admission, a drop in packed red cell volume from 41 to 25%, the presence of schistocytes in the blood smear, an elevation of LDH to 1,700 IU/L, a fall in haptoglobin to 5.8 mg/dL and a thrombocytopenia of 72,000 per mm3 were detected. These alterations coincided with an oliguric acute renal failure. She was treated with hemodialysis and the hemolytic syndrome was managed with plasmapheresis. She was discharged 35 days after admission and in the follow up, after 2.5 months, her serum creatinine is 1.2 mg/dL and her packed red cell volume is 41% (Rev Méd Chile 2002; 130: 677-680)
Ajuste a la ventilación mecánica guiado por curvas presión-volumen de flujo lento en pacientes con síndrome de distress respiratorio agudo e injuria pulmonar aguda Mechanical ventilatory parameters guided by the low flow pressure-volume curve in patients with acute lung injury/acute respiratory distress syndrome
Vinko Tomicic F,Jorge Molina B,Jerónimo Graf S,Mauricio Espinoza R
Revista médica de Chile , 2007,
Abstract: Background: Mechanical ventilation may contribute to lung injury and then enhance systemic inflammation. Optimal ventilatory parameters such as tidal volume (V T) and positive end expiratory pressure (PEEP) can be determined using different methods. Low flow pressure volume (P/V-LF) curve is a useful tool to assess the respiratory system mechanics and set ventilatory parameters. Aim: To set V T and PEEP according P/V-LF curve analysis and evaluate its effects on gas exchange and hemodynamic parameters. Materials and methods: Twenty seven patients underwent P/V-LF within the first 72 hours of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). P/V-LF curves were obtained from the ventilator and both lower and upper inflexion points determined. Gas exchange and hemodynamic parameters were measured before and after modifying ventilator settings guided by P/V-LF curves. Results: Ventilatory parameters set according P/V-LF curve, led to a rise of PEEP and reduction of V T: 11.6±2.8 to 14.1±2.1 cm H2O, and 9.7±2.4 to 8.8±2.2 mL/kg (p <0.01). Arterial to inspired oxygen fraction ratio increased from 158.0±66 to 188.5±68.5 (p <0.01), and oxygenation index was reduced, 13.7±8.2 to 12.3±7.2 (p <0.05). Cardiac output and oxygen delivery index (IDO2) were not modified. Demographic data, gas exchange improvement and respiratory system mechanics showed no significant difference between patients with extra-pulmonary and pulmonary ALI/ARDS. There was no evidence of significant adverse events related with this technique. Conclusion: P/V-LF curves information allowed us to adjust ventilatory parameters and optimize gas exchange without detrimental effects on oxygen delivery in mechanically ventilated ALI/ARDS patients
Volumen sanguíneo intratorácico versus presión arterial de oclusión pulmonar como estimadores de precarga cardíaca en pacientes críticos Intrathoracic blood volume versus pulmonary artery occlusion pressure as estimators of cardiac preload in critically ill patients
Vinko Tomicic F,Jerónimo Graf S,Ghislaine Echevarría O,Mauricio Espinoza R
Revista médica de Chile , 2005,
Abstract: Background:Monitoring of cardiac preload by determination of pulmonary artery occlusion pressure (PAOP) has been traditionally used to guide fluid therapy to optimize cardiac output (CO). Since factors such as intrathoracic pressure and ventricular compliance may modify PAOP, volumetric estimators of preload have been developed. The PiCCO system is able to measure CO and intrathoracic blood volume (ITBV) by transpulmonary thermodilution. Aim: To compare a volumetric (ITBV) versus a pressure (PAOP) determination to accurately estimate cardiac preload in severely ill patients. Patients and Methods: From June 2001 to October 2003, 22 mechanically ventilated patients with hemodynamic instability underwent hemodynamic monitoring with pulmonary artery catheter (PAC) and PiCCO system. ITBV index (ITBVI), PAOP and CI were measured simultaneously by both methods. One hundred thirty eight deltas (D) were obtained from the difference of ITBVI, PAOP, CI-PAC and CI-PiCCO between 6-12 am and 6-12 pm. Linear regression analysis of DITBVI versus D CI-PiCCO and D PAOP versus DCI-PAC were made. Results: Mean age of patients was 60.8 ± 19.4 years. APACHE II was 23.9 ± 7. Fifteen patients met criteria for acute respiratory distress syndrome (ARDS). Delta ITBVI significantly correlated with DCI-PiCCO (r=0.54; 95% confidence interval = 0.41-0.65; p <0.01). There was no correlation between DPAOP and DCI-PAC. Conclusion: ITBVI correlated better with CI than PAOP, and therefore it seems to be a more accurate estimator of preload in unstable, mechanically ventilated patients
Volumen sanguíneo intratorácico versus presión arterial de oclusión pulmonar como estimadores de precarga cardíaca en pacientes críticos
Tomicic F,Vinko; Graf S,Jerónimo; Echevarría O,Ghislaine; Espinoza R,Mauricio; Abarca Z,Juan; Montes S,José Miguel; Torres M,Javier; Nú?ez U,Gastón; Guerrero P,Julia; Luppi N,Mario; Canals L,Claudio;
Revista médica de Chile , 2005, DOI: 10.4067/S0034-98872005000600001
Abstract: background:monitoring of cardiac preload by determination of pulmonary artery occlusion pressure (paop) has been traditionally used to guide fluid therapy to optimize cardiac output (co). since factors such as intrathoracic pressure and ventricular compliance may modify paop, volumetric estimators of preload have been developed. the picco system is able to measure co and intrathoracic blood volume (itbv) by transpulmonary thermodilution. aim: to compare a volumetric (itbv) versus a pressure (paop) determination to accurately estimate cardiac preload in severely ill patients. patients and methods: from june 2001 to october 2003, 22 mechanically ventilated patients with hemodynamic instability underwent hemodynamic monitoring with pulmonary artery catheter (pac) and picco system. itbv index (itbvi), paop and ci were measured simultaneously by both methods. one hundred thirty eight deltas (d) were obtained from the difference of itbvi, paop, ci-pac and ci-picco between 6-12 am and 6-12 pm. linear regression analysis of ditbvi versus e ci-picco and e paop versus dci-pac were made. results: mean age of patients was 60.8 ± 19.4 years. apache ii was 23.9 ± 7. fifteen patients met criteria for acute respiratory distress syndrome (ards). delta itbvi significantly correlated with dci-picco (r=0.54; 95% confidence interval = 0.41-0.65; p <0.01). there was no correlation between dpaop and dci-pac. conclusion: itbvi correlated better with ci than paop, and therefore it seems to be a more accurate estimator of preload in unstable, mechanically ventilated patients
Ajuste a la ventilación mecánica guiado por curvas presión-volumen de flujo lento en pacientes con síndrome de distress respiratorio agudo e injuria pulmonar aguda
Tomicic F,Vinko; Molina B,Jorge; Graf S,Jerónimo; Espinoza R,Mauricio; Antúnez R,Miguel; Errázuriz C,Isabel; Aguilera F,Pablo; Izquierdo M,Francisco; López,Tania; Canals L,Claudio;
Revista médica de Chile , 2007, DOI: 10.4067/S0034-98872007000300005
Abstract: background: mechanical ventilation may contribute to lung injury and then enhance systemic inflammation. optimal ventilatory parameters such as tidal volume (vt) and positive end expiratory pressure (peep) can be determined using different methods. low flow pressure volume (p/v-lf) curve is a useful tool to assess the respiratory system mechanics and set ventilatory parameters. aim: to set vt and peep according p/v-lf curve analysis and evaluate its effects on gas exchange and hemodynamic parameters. materials and methods: twenty seven patients underwent p/v-lf within the first 72 hours of acute lung injury/acute respiratory distress syndrome (ali/ards). p/v-lf curves were obtained from the ventilator and both lower and upper inflexion points determined. gas exchange and hemodynamic parameters were measured before and after modifying ventilator settings guided by p/v-lf curves. results: ventilatory parameters set according p/v-lf curve, led to a rise of peep and reduction of vt: 11.6±2.8 to 14.1±2.1 cm h2o, and 9.7±2.4 to 8.8±2.2 ml/kg (p <0.01). arterial to inspired oxygen fraction ratio increased from 158.0±66 to 188.5±68.5 (p <0.01), and oxygenation index was reduced, 13.7±8.2 to 12.3±7.2 (p <0.05). cardiac output and oxygen delivery index (ido2) were not modified. demographic data, gas exchange improvement and respiratory system mechanics showed no significant difference between patients with extra-pulmonary and pulmonary ali/ards. there was no evidence of significant adverse events related with this technique. conclusion: p/v-lf curves information allowed us to adjust ventilatory parameters and optimize gas exchange without detrimental effects on oxygen delivery in mechanically ventilated ali/ards patients
Bone marrow malignancies as paradigms of dysfunctional cell adhesion mechanisms
Sérgio Jerónimo Rodrigues Dias
Journal of Hematological Malignancies , 2012, DOI: 10.5430/jhm.v2n1p19
Abstract: In adult bone marrow (BM), hematopoietic stem/progenitor cells (HSPCs) reside in micro-environments which provide instructions for self-renewal, survival, proliferation, differentiation and migration. Adequate response to such complex signals implies communication between HSCs, BM stroma and extracellular matrix molecules (ECM). This is achieved mainly through adhesion molecules. Malignant hematopoietic cells also interact with the BM microenvironment, which provides them with proliferative and survival advantages. Most of the studies on haematological diseases describe cell-ECM interactions as key mechanisms in tumor progression, while genetic alterations of HSC are considered major initiators of the malignant process. However, accumulating evidence suggests that an altered BM microenvironment provides anomalous cell adhesion signals, facilitating tumor initiation. Myeloproliferative and myelodysplastic syndromes are good examples of hematological disorders where alterations in BM microenvironment may play an important role in disease initiation. This review discusses the role for adhesion signals in regulating the BM microenvironment in normalcy and disease.
Similarity networks for classification: a case study in the Horse Colic problem
Lluís Belanche,Jerónimo Hernández
Computer Science , 2014,
Abstract: This paper develops a two-layer neural network in which the neuron model computes a user-defined similarity function between inputs and weights. The neuron transfer function is formed by composition of an adapted logistic function with the mean of the partial input-weight similarities. The resulting neuron model is capable of dealing directly with variables of potentially different nature (continuous, fuzzy, ordinal, categorical). There is also provision for missing values. The network is trained using a two-stage procedure very similar to that used to train a radial basis function (RBF) neural network. The network is compared to two types of RBF networks in a non-trivial dataset: the Horse Colic problem, taken as a case study and analyzed in detail.
The Epigenetics of Renal Cell Tumors: from Biology to Biomarkers
Rui Henrique,Ana Sílvia Luís,Carmen Jerónimo
Frontiers in Genetics , 2012, DOI: 10.3389/fgene.2012.00094
Abstract: Renal cell tumors (RCT) collectively constitute the third most common type of genitourinary neoplasms, only surpassed by prostate and bladder cancer. They comprise a heterogeneous group of neoplasms with distinctive clinical, morphological, and genetic features. Epigenetic alterations are a hallmark of cancer cells and their role in renal tumorigenesis is starting to emerge. Aberrant DNA methylation, altered chromatin remodeling/histone onco-modifications and deregulated microRNA expression not only contribute to the emergence and progression of RCTs, but owing to their ubiquity, they also constitute a promising class of biomarkers tailored for disease detection, diagnosis, assessment of prognosis, and prediction of response to therapy. Moreover, due to their dynamic and reversible properties, those alterations represent a target for epigenetic-directed therapies. In this review, the current knowledge about epigenetic mechanisms and their altered status in RCT is summarized and their envisaged use in a clinical setting is also provided.
Estabelecimento de parametros para avalia??o de tolerancia à seca, em genótipos de feijoeiro
Pimentel, Carlos;Cruz Perez, Andrés Jernimo de La;
Pesquisa Agropecuária Brasileira , 2000, DOI: 10.1590/S0100-204X2000000100005
Abstract: aiming to establish parameters for drought tolerance evaluation, fifteen genotypes of bean (phaseolus vulgaris l.) were evaluated during a water stress period, applied at the pre-flowering stage through leaf water potential (yf) and some other variables. among the genotypes studied, a 222, a 285, bat 477, bat 561 and ipa 7 showed highest yf during the water stress, indicating a better stomatal control by these genotypes, while the cultivars carioca and ouro negro showed a more rapid recuperation, after being rehydrated. all the anthracnose tolerant genotypes evaluated presented an efficient stomatal control. the potential for nitrogen biological fixation, evaluated by the number and weight of nodules, was significantly affected only on few genotypes. leaf area and shoot dry weight were the morphological variables more sensitive to water stress. the number of pods per plant was only affected on xodó and cnf 0145 genotypes, while the carioca, a 285, cnf 0145, bat 477, cv. 121 genotypes, and the lm 30036 line, showed a decrease on the seed weight per plant, under water stress. besides having the highest yf, the a 222 and ipa 7 genotypes were the only ones that did not show a significant reduction on the leaf area and seed weight per plant, although the first one had a low plant production under stress.
Page 1 /326623
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.