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Search Results: 1 - 10 of 3607 matches for " Jens Hillebrand "
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P-Body Components, microRNA Regulation, and Synaptic Plasticity
Jens Hillebrand,Scott A. Barbee,Mani Ramaswami
The Scientific World Journal , 2007, DOI: 10.1100/tsw.2007.206
Abstract:
The Me31B DEAD-Box Helicase Localizes to Postsynaptic Foci and Regulates Expression of a CaMKII Reporter mRNA in Dendrites of Drosophila Olfactory Projection Neurons
Jens Hillebrand,Kangyu Pan,Anil Kokaram,Scott Barbee,Roy Parker,Mani Ramaswami
Frontiers in Neural Circuits , 2010, DOI: 10.3389/fncir.2010.00121
Abstract: mRNP granules at adult central synapses are postulated to regulate local mRNA translation and synapse plasticity. However, they are very poorly characterized in vivo. Here, in Drosophila olfactory synapses, we present early observations and characterization of candidate synaptic mRNP particles, one of which contains a widely conserved, DEAD-box helicase, Me31B. In Drosophilas, Me31B is required for translational repression of maternal and miRNA-target mRNAs. A role in neuronal translational control is primarily suggested by Me31B’s localization, in cultured primary neurons, to neuritic mRNP granules that contain: (i) various translational regulators; (ii) CaMKII mRNA; and (iii) several P-body markers including the mRNA hydrolases, Dcp1, and Pcm/Xrn-1. In adult neurons, Me31B localizes to P-body like cytoplasmic foci/particles in neuronal soma. In addition it is present to synaptic foci that may lack RNA degradative enzymes and localize predominantly to dendritic elements of olfactory sensory and projection neurons (PNs). MARCM clones of PNs mutant for Me31B show loss of both Me31B and Dcp1-positive dendritic puncta, suggesting potential interactions between these granule types. In PNs, expression of validated hairpin-RNAi constructs against Me31B causes visible knockdown of endogenous protein, as assessed by the brightness and number of Me31B puncta. Knockdown of Me31B also causes a substantial elevation in observed levels of a translational reporter of CaMKII, a postsynaptic protein whose mRNA has been shown to be localized to PN dendrites and to be translationally regulated, at least in part through the miRNA pathway. Thus, neuronal Me31B is present in dendritic particles in vivo and is required for repression of a translationally regulated synaptic mRNA.
Superdense Coding with GHZ and Quantum Key Distribution with W in the ZX-calculus
Anne Hillebrand
Electronic Proceedings in Theoretical Computer Science , 2012, DOI: 10.4204/eptcs.95.10
Abstract: Quantum entanglement is a key resource in many quantum protocols, such as quantum teleportation and quantum cryptography. Yet entanglement makes protocols presented in Dirac notation difficult to verify. This is why Coecke and Duncan have introduced a diagrammatic language for quantum protocols, called the ZX-calculus. This diagrammatic notation is both intuitive and formally rigorous. It is a simple, graphical, high level language that emphasises the composition of systems and naturally captures the essentials of quantum mechanics. In the author's MSc thesis it has been shown for over 25 quantum protocols that the ZX-calculus provides a relatively easy and more intuitive presentation. Moreover, the author embarked on the task to apply categorical quantum mechanics on quantum security; earlier works did not touch anything but Bennett and Brassard's quantum key distribution protocol, BB84. Superdense coding with the Greenberger-Horne-Zeilinger state and quantum key distribution with the W-state are presented in the ZX-calculus in this paper.
Effects of Total Resources, Resource Ratios, and Species Richness on Algal Productivity and Evenness at Both Metacommunity and Local Scales
Lars Gamfeldt,Helmut Hillebrand
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0021972
Abstract: The study of the interrelationship between productivity and biodiversity is a major research field in ecology. Theory predicts that if essential resources are heterogeneously distributed across a metacommunity, single species may dominate productivity in individual metacommunity patches, but a mixture of species will maximize productivity across the whole metacommunity. It also predicts that a balanced supply of resources within local patches should favor species coexistence, whereas resource imbalance would favor the dominance of one species. We performed an experiment with five freshwater algal species to study the effects of total supply of resources, their ratios, and species richness on biovolume production and evenness at the scale of both local patches and metacommunities. Generally, algal biovolume increased, whereas algal resource use efficiency (RUE) and evenness decreased with increasing total supply of resources in mixed communities containing all five species. In contrast to predictions for biovolume production, the species mixtures did not outperform all monocultures at the scale of metacommunities. In other words, we observed no general transgressive overyielding. However, RUE was always higher in mixtures than predicted from monocultures, and analyses indicate that resource partitioning or facilitation in mixtures resulted in higher-than-expected productivity at high resource supply. Contrasting our predictions for the local scale, balanced supply of resources did not generally favor higher local evenness, however lowest evenness was confined to patches with the most imbalanced supply. Thus, our study provides mixed support for recent theoretical advancements to understand biodiversity-productivity relationships.
Bovine and Human Serum Albumin Interactions with 3-Carboxyphenoxathiin Studied by Fluorescence and Circular Dichroism Spectroscopy
Aurica Varlan,Mihaela Hillebrand
Molecules , 2010, DOI: 10.3390/molecules15063905
Abstract: The interactions of 3-carboxyphenoxathiin with Bovine Serum Albumin (BSA) and Human Serum Albumin (HSA) have been studied by fluorescence and circular dichroism spectroscopy. The binding of 3-carboxyphenoxathiin quenches the BSA and HSA fluorescence, revealing a 1:1 interaction with a binding constant of about 105 M-1. In addition, according to the synchronous fluorescence spectra of BSA and HSA in presence of 3-carboxyphenoxathiin, the tryptophan residues of the proteins are most perturbed by the binding process. Finally, the distance between the acceptor, 3-carboxyphenoxathiin, and the donor, BSA or HSA, was estimated on the basis of the F?rster resonance energy transfer (FRET). The fluorescence results are correlated with those obtained from the circular dichroism spectra, which reveal the change of the albumin conformation during the interaction process.
THEORETICAL STUDY OF THE EXCITED STATE PROPERTIES OF 4-ACETYLDIPHENYLSULFIDE
Sorana Ionescu,Mihaela Hillebrand
Analele Universitatii Bucuresti : Chimie , 2003,
Abstract: The experimental data on 4-acetyldiphenylsulfide (I) were previously explained byconsidering the possibility of twisted intramolecular charge transfer (TICT) excited stateformation. In the present paper solvent dependent semiempirical calculations were performed insolvents of different polarities. The ground and excited states potential energy surfaces werebuilt in terms of the torsion angle about the single bond joining the two aromatic fragments ofthe molecule, acting as D and A. The ground state has quasiplanar geometry, but in the excitedstates also the orthogonal conformation corresponds to a minimum, stabilised in methanol due tothe large charge separation between the D and A fragments. The possibility of forming TICTexcited states for I and the solvent polarity effect on the relative stability of the TICT state isdiscussed.
Double Quantum Entanglement to Understand Superconductivity  [PDF]
Jens Cordelair
World Journal of Condensed Matter Physics (WJCMP) , 2013, DOI: 10.4236/wjcmp.2013.34032
Abstract:

The feature of quantum entanglement in doublet and multiplet systems is briefly described and used to create a new model for the superconducting phase.

Superconductivity  [PDF]
Jens Cordelair
World Journal of Condensed Matter Physics (WJCMP) , 2014, DOI: 10.4236/wjcmp.2014.44026
Abstract: The feature of quantum entanglement is used to create a new model for the superconducting state.
Entanglement: A Modern Aspect of Nature  [PDF]
Jens Cordelair
World Journal of Condensed Matter Physics (WJCMP) , 2015, DOI: 10.4236/wjcmp.2015.53025
Abstract: The intention of this paper is to provide an easy to understand introduction to the peculiarities of entangled systems. A novel description for strong (mass entanglement) and weak (spin-or-bital and thermal entanglement) quantum entangled particles is discussed and applied to the phenomena of superconductivity, superfluidity and ultracold gases. A brief statement about how to represent the physical reality of quantum-entanglement as Quantum-Field-Theory (QFT) is noted.
Efeito do EGB761 (Extrato de Ginkgo biloba) sobre a qualidade de vida em pacientes asmáticos moderados submetidos a tratamento de manuten??o
Hillebrand, M. D.;Oliveira, W. F.;
Revista Brasileira de Farmacognosia , 2004, DOI: 10.1590/S0102-695X2004000300010
Abstract: the search for efficient and alternative therapies for the asthma control is an important factor to the improvement of life quality in asthmatic patients. the effects of ginkgo biloba extract (ginkgo biloba l.) in the response of asthmatics to the maintenance treatment for persistent moderate asthma were studied in a blind, randomized, placebo-controlled clinical trial.
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