oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 529 )

2018 ( 718 )

2017 ( 707 )

2016 ( 993 )

Custom range...

Search Results: 1 - 10 of 405648 matches for " Jennifer M. Kofonow "
All listed articles are free for downloading (OA Articles)
Page 1 /405648
Display every page Item
Tobacco Smoke Mediated Induction of Sinonasal Microbial Biofilms
Natalia Goldstein-Daruech,Emily K. Cope,Ke-Qing Zhao,Katarina Vukovic,Jennifer M. Kofonow,Laurel Doghramji,Bernardo González,Alexander G. Chiu,David W. Kennedy,James N. Palmer,Jeffery G. Leid,James L. Kreindler,Noam A. Cohen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0015700
Abstract: Cigarette smokers and those exposed to second hand smoke are more susceptible to life threatening infection than non-smokers. While much is known about the devastating effect tobacco exposure has on the human body, less is known about the effect of tobacco smoke on the commensal and commonly found pathogenic bacteria of the human respiratory tract, or human respiratory tract microbiome. Chronic rhinosinusitis (CRS) is a common medical complaint, affecting 16% of the US population with an estimated aggregated cost of $6 billion annually. Epidemiologic studies demonstrate a correlation between tobacco smoke exposure and rhinosinusitis. Although a common cause of CRS has not been defined, bacterial presence within the nasal and paranasal sinuses is assumed to be contributory. Here we demonstrate that repetitive tobacco smoke exposure induces biofilm formation in a diverse set of bacteria isolated from the sinonasal cavities of patients with CRS. Additionally, bacteria isolated from patients with tobacco smoke exposure demonstrate robust in vitro biofilm formation when challenged with tobacco smoke compared to those isolated from smoke na?ve patients. Lastly, bacteria from smoke exposed patients can revert to a non-biofilm phenotype when grown in the absence of tobacco smoke. These observations support the hypothesis that tobacco exposure induces sinonasal biofilm formation, thereby contributing to the conversion of a transient and medically treatable infection to a persistent and therapeutically recalcitrant condition.
Regulation of Virulence Gene Expression Resulting from Streptococcus pneumoniae and Nontypeable Haemophilus influenzae Interactions in Chronic Disease
Emily K. Cope, Natalia Goldstein-Daruech, Jennifer M. Kofonow, Lanette Christensen, Bridget McDermott, Fernando Monroy, James N. Palmer, Alexander G. Chiu, Mark E. Shirtliff, Noam A. Cohen, Jeff G. Leid
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0028523
Abstract: Chronic rhinosinusitis (CRS) is a common inflammatory disease of the sinonasal cavity mediated, in part, by polymicrobial communities of bacteria. Recent molecular studies have confirmed the importance of Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi) in CRS. Here, we hypothesize that interaction between S. pneumoniae and NTHi mixed-species communities cause a change in bacterial virulence gene expression. We examined CRS as a model human disease to validate these polymicrobial interactions. Clinical strains of S. pneumoniae and NTHi were grown in mono- and co-culture in a standard biofilm assay. Reverse transcriptase real-time PCR (RTqPCR) was used to measure gene expression of key virulence factors. To validate these results, we investigated the presence of the bacterial RNA transcripts in excised human tissue from patients with CRS. Consequences of physical or chemical interactions between microbes were also investigated. Transcription of NTHi type IV pili was only expressed in co-culture in vitro, and expression could be detected ex vivo in diseased tissue. S. pneumoniae pyruvate oxidase was up-regulated in co-culture, while pneumolysin and pneumococcal adherence factor A were down-regulated. These results were confirmed in excised human CRS tissue. Gene expression was differentially regulated by physical contact and secreted factors. Overall, these data suggest that interactions between H. influenzae and S. pneumoniae involve physical and chemical mechanisms that influence virulence gene expression of mixed-species biofilm communities present in chronically diseased human tissue. These results extend previous studies of population-level virulence and provide novel insight into the importance of S. pneumoniae and NTHi in CRS.
Mild Stimulation versus Conventional IVF: A Cost-Effectiveness Evaluation  [PDF]
Natalie M. Crawford, Kashika M. Sahay, Jennifer E. Mersereau
Open Journal of Obstetrics and Gynecology (OJOG) , 2016, DOI: 10.4236/ojog.2016.63023
Abstract: Purpose: To compare the strategy for mild stimulation IVF versus conventional stimulation IVF. Methods: A decision tree analytic model was created to compare IVF with mild stimulation versus convention stimulation in infertile women <38 years of age to evaluate which strategy is the least costly per live birth. Results: Using base-case estimates of costs and probabilities in women <38 years old with unexplained infertility, the cumulative live birth rate in the mild versus conventional stimulation group was 15.8% versus 28.6%, respectively. The average cost for mild and convention IVF was $8789 and $14,364 per arm, respectively. In base case analysis, the ICER was $43,516 representing the additional cost per live birth with conventional IVF. One-way sensitivity analysis evaluated the robustness of the data and revealed a tradeoff in which mild IVF stimulation had lower total costs and also lower live births versus conventional stimulation. Conclusions: Mild stimulation IVF has a lower cost per cycle but is also associated with lower live birth rates. Patient care decisions should be individualized irrespective of cost.
Desmitificación del inmigrante alemán en Don Helmuth, el colono de Carlos Fuenzalida Valdivia
Valko,Jennifer M;
Acta literaria , 2010, DOI: 10.4067/S0717-68482010000100004
Abstract: the novel don helmuth, the colonist (1960) follows the criollista model to treat the subject of german colonization in southern chile. although it was published on near the centennial of german arrival, and is one of the few works in spanish that portrays the establishment of the community, it has been largely ignored by critics. this essay analyzes the theme of "mythical" foundational narratives to examine the development of the protagonist, helmuth hensau. on the one hand, it demonstrates that the text demythifies the immigrant figure by including the criminal activities of the main character and those of his compatriots, and that the novel supplements historiography by discussing these negative aspects of settlement which are generally omitted. on the other, it proposes that it is precisely these illicit activities that permit the narrator to symbolically incorporate germans into their adopted homeland as a new chilean national "type".
Desmitificación del inmigrante alemán en Don Helmuth, el colono de Carlos Fuenzalida Valdivia Demythification of the german immigrant in Don Helmuth, el colono by Carlos Fuenzalida Valdivia
Jennifer M Valko
Acta Literaria , 2010,
Abstract: La novela Don Helmuth, el colono (1960) sigue las pautas criollistas para tratar el tema de la colonización alemana en el sur de Chile hacia mediados del siglo XIX. Aunque se publicó hacia el centenario de la llegada de los germanos y es una de las pocas obras en espa ol que describe el proceso de asentamiento de la comunidad, ha sido desatendida por las críticas. Este ensayo analiza el tema de narrativas "míticas" fundacionales para examinar el desarrollo del protagonista, Helmuth Hensau, y demuestra, por una parte, que el texto desmitifica la figura del inmigrante al incluir las actividades delictivas del personaje principal y sus compatriotas, convirtiendo a la novela en suplemento a la historiografía, la cual usualmente omite dichos aspectos negativos. Por otra parte, plantea que estas mismas actividades ilícitas permiten al narrador integrar simbólicamente a los alemanes a su patria adoptiva como un nuevo "tipo" nacional chileno. The novel Don Helmuth, the colonist (1960) follows the criollista model to treat the subject of German colonization in southern Chile. Although it was published on near the centennial of German arrival, and is one of the few works in Spanish that portrays the establishment of the community, it has been largely ignored by critics. This essay analyzes the theme of "mythical" foundational narratives to examine the development of the protagonist, Helmuth Hensau. On the one hand, it demonstrates that the text demythifies the immigrant figure by including the criminal activities of the main character and those of his compatriots, and that the novel supplements historiography by discussing these negative aspects of settlement which are generally omitted. On the other, it proposes that it is precisely these illicit activities that permit the narrator to symbolically incorporate Germans into their adopted homeland as a new Chilean national "type".
Diagnóstico y tratamiento del vértigo
M. Jennifer Derebery
Revista Cubana de Medicina , 2000,
Abstract:
Tensions within Identity: Notes on How Criminalized Women Negotiate Identity through Addiction
Jennifer M. Kilty
Aporia : The Nursing Journal , 2011,
Abstract: Drawing on conceptualizations of a loss of personal power versus empowerment, criminalized womenin Canada engage two seemingly opposed discourses to explain their substance use. When feeling a lossof control/power participants constructed substance use as a disease, and when feeling in control of theirsubstance use they described becoming substance free as based on an empowered choice to use/quit using.This article explores the connection between choice/disease discourses and correctional treatment discoursesthrough an examination of women’s narratives about identity management and negotiation related tosubstance use. Based on 22 life history interviews with formerly incarcerated women and four social workerswho assist criminalized women as they transition from prison to the community, this research suggests thatcriminalized women construct a distinct drug using or ‘addict’ identity that they separate from their ‘true’ orcore conceptualization of self.
Holistic education and visions of rehumanized futures
Jennifer M. Gidley
RoSE : Research on Steiner Education , 2010,
Abstract: This paper reports the findings of qualitative research which investigated the views and visions of their futures of Steiner-educated senior secondary students in Australia. The students’ visions of their “positive preferred futures” were strongly focused on social futures in contrast to the wider youth futures research, which demonstrated a stronger focus on techno-fix solutions. In exploring the human qualities the students thought they should develop to contribute to their ideal world in 2020, they identified such factors as more activism, more awareness, attitude and values changes, more spirituality and future care. The findings also showed that the students valued social equality, diversity, tolerance and community as important contributions to a peaceful, communicative world. Many of the students’ preferred futures also paid attention to the needs of the environment, reflecting not just sustainable development but views that were closer to the eco-philosophers who argue for a re-enchantment of the world. In conclusion, there is an exploration of theoretical and practical links between the findings and recent speculations of educational futurists in regard to educating young people for the 21st century.
Excerpt from Dead Stars: American and Philippine Literary Perspectives on the American Colonization of the Philippines
Jennifer M. McMahon
Journal of Transnational American Studies , 2011,
Abstract: Dead Stars: American and Philippine Literary Perspectives on the American Colonization of the Philippines examines the American colonization of the Philippines from three distinct but related literary perspectives. The first is the reaction of anti-imperialist American writers Mark Twain, W. E. B. Du Bois, and William James to America’s first foray into the role of colonizer and how their varied essays, letters, and speeches provide an incisive delineation of fundamental conflicts in American identity at the turn of the twentieth century. The book then analyzes how these same conflicts surface in the colonial regime’s use of American literature as a tool to inculcate American values in the colonial educational system. Finally, Dead Stars considers the way three early and important Filipino writers—Paz Marquez Benitez, Maximo Kalaw, and Juan C. Laya—interpret and represent these same tensions in their fiction.
Teaching the Central Dogma of Molecular Biology using Jewelry
Jennifer M. DeBruyn
Journal of Microbiology & Biology Education , 2012, DOI: 10.1128/jmbe.v13i1.356
Abstract: -
Page 1 /405648
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.