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Search Results: 1 - 10 of 212916 matches for " Jennifer L. Hatton "
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Clinical Use of PPAR Ligands in Cancer
Jennifer L. Hatton,Lisa D. Yee
PPAR Research , 2008, DOI: 10.1155/2008/159415
Abstract: The role of PPAR in adipocyte differentiation has fueled intense interest in the function of this steroid nuclear receptor for regulation of malignant cell growth and differentiation. Given the antiproliferative and differentiating effects of PPAR ligands on liposarcoma cells, investigation of PPAR expression and ligand activation in other solid tumors such as breast, colon, and prostate cancers ensued. The anticancer effects of PPAR ligands in cell culture and rodent models of a multitude of tumor types suggest broad applicability of these agents to cancer therapy. This review focuses on the clinical use of PPAR ligands, specifically the thiazolidinediones, for the treatment and prevention of cancer.
Auditory Brainstem Responses to Bone-Conducted Brief Tones in Young Children with Conductive or Sensorineural Hearing Loss
Jennifer L. Hatton,Renée M. Janssen,David R. Stapells
International Journal of Otolaryngology , 2012, DOI: 10.1155/2012/284864
Abstract: The bone-conduction (BC) tone ABR has been used clinically for over 20 years. The current study formally evaluated the test performance of the BC tone-evoked ABR in infants with hearing loss. Method. By comparing BC-ABR results to follow-up behavioural results, this study addressed two questions: (i) whether the BC tone ABR was successful in differentiating children with conductive versus sensorineural hearing loss (Study A; conductive: 68 ears; SNHL: 129 ears) and (ii) the relationship between BC ABR and behavioural hearing loss severity (Study B: 2000 Hz: 104 ears; 500 Hz: 47 ears). Results. Results demonstrate that the “normal” BC-ABR levels accurately differentiated normal versus elevated cochlear sensitivity (accuracy: 98% for 2000 Hz; 98% for 500 Hz). A subset of infants in Study A with elevated BC-ABR (i.e., no response at normal level) had additional testing at higher intensities, which allowed for categorization of the degree of cochlear impairment. Study B results indicate that the BC ABR accurately categorizes the degree of cochlear hearing loss for 2000 Hz (accuracy = 95.2%). A preliminary dBnHL-to-dBHL correction factor of “0 dB” was determined for 2000 Hz BC ABR. Conclusions. These findings further support the use of BC tone ABR for diagnostic ABR testing.
Use of Oral Agents and/or Insulin in the Treatment of Diabetes during Pregnancy: An Examination of Outcomes in Pregestational versus Gestational Diabetics  [PDF]
Edwin Henslee, Amanda Hatton, Selman I. Welt, Jennifer Holmes, Lindsay Penrose, Samuel Prien, Naghma Farooqi
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.416144
Abstract: The management of diabetes in pregnancy varies depending on whether the condition was first diagnosed during pregnancy (gestational diabetes) or was diagnosed before pregnancy (pregestational diabetes). Little has been published comparing the relative efficacy of various oral agents for the treatment of gestational diabetes and the reported experience with the insulin pump in pregnancy for pregestational diabetes remains meager. We conducted a retrospective chart review of women managed in a specialized diabetic clinic to compare the results of treatment of gestational diabetes with oral agents, glyburide and acarbose, to those treated with split-mixed insulin and treatment of pregestational diabetes with either the insulin pump or conventional splitmixed insulin. Gestational diabetics treated with split-mixed insulin were hospitalized significantly more often (p < 0.001) than those treated with oral agents only. The incidence of several important pregnancy complications (growth restriction, preterm labor, preeclampsia, oligohydramnios) did not differ between groups. Pregestational diabetics managed with an insulin pump had comparable glycemic control, as measured by hemoglobin A1c, to those managed with split-mixed insulin. Infant birth weights and Apgar scores were similar in each group. There were no perinatal deaths in either group. Acarbose and glyburide showed comparable efficacy in treating gestational diabetics. In addition, our experience adds to the small number of pregnant women with pregestational diabetes who were managed with an insulin pump that have been reported in the literature.
The Impact of Cervical Cancer Treatment on Sexual Function and Intimate Relationships: Is Anyone Listening?  [PDF]
Jennifer L. Hunter
Open Journal of Obstetrics and Gynecology (OJOG) , 2014, DOI: 10.4236/ojog.2014.48069

The purpose of this research was to describe women’s narrative accounts of the impact of cervical cancer treatment on their sexual function and intimate relationships, and to evaluate what changes in care and education are needed to enhance quality of life and intimacy after treatment. The research approach was a narrative design, using semi-structured, in-depth interviews. Narratives were examined within and across interviews, and thematic content analysis completed. The study was done in a gynecologic oncology clinic at a public hospital in the Midwest United States. The sample consisted of twelve women, ranging in age from 27 to 59, who had completed the cervical cancer treatment with chemo-radiation or radiation and surgery, and were now followed by their gynecologic oncologists. Across narratives, five major themes were identified, including unexpected physical complications, not “getting back to normal,” emotional pain and isolation, lack of available information, and inadequate health care provider response to treatment complications and sexual relationship problems. Women’s stories reveal that sex and intimacy issues for cervical cancer survivors remain within a culture of silence. In many situations, health professionals did not provide information that realistically prepared women and partners for probable consequences of treatment, did not assess sexual issues before or after treatment, did not recognize various symptoms as being complications of cancer treatment, did not make referrals, and/or recognized complications, but accepted them as “normal” and without solution. Ethical implications for health professionals and the need for education, communication, and the development of new lines of research are discussed.

Geometric visualization of self-propulsion in a complex medium
Ross L. Hatton,Yang Ding,Howie Choset,Daniel I. Goldman
Physics , 2013, DOI: 10.1103/PhysRevLett.110.078101
Abstract: Combining geometric mechanics theory, laboratory robotic experiment and numerical simulation, we study the locomotion in granular media (GM) of the simplest non-inertial swimmer, the Purcell three-link swimmer. Using granular resistive force laws as inputs, the theory relates translation and rotation of the body to shape changes (movements of the links). This allows analysis, visualization, and prediction of effective movements that are verified by experiment. The geometric approach also facilitates comparison between swimming in GM and in viscous fluids.
Simulating galaxy surveys with FIRST (PACS & SPIRE)
A. -L. Melchior,F. Combes,B. Guiderdoni,S. Hatton
Physics , 2001,
Abstract: The next generation of submillimetre/millimetre instruments will provide us with a deeper insight into the mechanisms that rule galaxy formation. As the brightest starbursts are thought to be heavily obscured at optical wavelengths, the opening of this new window will complement the present observations, and enable a detailed investigation of the hierarchical merging of galaxies at remote epochs. In this context, we will present preliminary results of simulations currently developed for deep galaxy surveys with FIRST. N-body simulations of galaxy mergers are being developed to produce realistic morphologies and star formation histories. A Schmidt law is used to account for the evolution of the stellar and gas content of each particle. These simulations will be gathered in a library, including the temporal information with a timestep of 10 Myr. We then build consistent spectra accounting for this star formation history at each resolution element of the simulations. These morphologies will be included in the framework of the GalICS hybrid model of hierarchical galaxy formation, which reproduces the main observational constraints. We intend to present synthetic maps with the characteristics of the FIRST PACS/SPIRE instruments and discuss the optimal strategy for deep surveys complemented with the ground-based ALMA project.
Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples
Laura E. MacConaill,Catarina D. Campbell,Sarah M. Kehoe,Adam J. Bass,Charles Hatton,Lili Niu,Matt Davis,Keluo Yao,Megan Hanna,Chandrani Mondal,Lauren Luongo,Caroline M. Emery,Alissa C. Baker,Juliet Philips,Deborah J. Goff,Michelangelo Fiorentino,Mark A. Rubin,Kornelia Polyak,Jennifer Chan,Yuexiang Wang,Jonathan A. Fletcher,Sandro Santagata,Gianni Corso,Franco Roviello,Ramesh Shivdasani,Mark W. Kieran,Keith L. Ligon,Charles D. Stiles,William C. Hahn,Matthew L. Meyerson,Levi A. Garraway
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0007887
Abstract: Detection of critical cancer gene mutations in clinical tumor specimens may predict patient outcomes and inform treatment options; however, high-throughput mutation profiling remains underdeveloped as a diagnostic approach. We report the implementation of a genotyping and validation algorithm that enables robust tumor mutation profiling in the clinical setting.
Power-Laws and the Conservation of Information in discrete token systems: Part 1 General Theory
Les Hatton
Mathematics , 2012,
Abstract: The Conservation of Energy plays a pivotal part in the development of the physical sciences. With the growth of computation and the study of other discrete token based systems such as the genome, it is useful to ask if there are conservation principles which apply to such systems and what kind of functional behaviour they imply for such systems. Here I propose that the Conservation of Hartley-Shannon Information plays the same over-arching role in discrete token based systems as the Conservation of Energy does in physical systems. I will go on to prove that this implies power-law behaviour in component sizes in software systems no matter what they do or how they were built, and also implies the constancy of average gene length in biological systems as reported for example by Lin Xu et al (10.1093/molbev/msk019). These propositions are supported by very large amounts of experimental data extending the first presentation of these ideas in Hatton (2011, IFIP / SIAM / NIST Working Conference on Uncertainty Quantification in Scientific Computing, Boulder, August 2011).
Power-laws and the Conservation of Information in discrete token systems: Part 2 The role of defect
Les Hatton
Quantitative Biology , 2012,
Abstract: In a matching paper (arXiv:1207.5027), I proved that Conservation of Size and Information in a discrete token based system is overwhelmingly likely to lead to a power-law component size distribution with respect to the size of its unique alphabet. This was substantiated to a very high level of significance using some 55 million lines of source code of mixed provenance. The principle was also applied to show that average gene length should be constant in an animal kingdom where the same constraints appear to hold, the implication being that Conservation of Information plays a similar role in discrete token-based systems as the Conservation of Energy does in physical systems. In this part 2, the role of defect will be explored and a functional behaviour for defect derived to be consistent with the power-law behaviour substantiated above. This will be supported by further experimental data and the implications explored.
Altering gait by way of stimulation of the plantar surface of the foot: the immediate effect of wearing textured insoles in older fallers
Anna L Hatton, John Dixon, Keith Rome, Julia L Newton, Denis J Martin
Journal of Foot and Ankle Research , 2012, DOI: 10.1186/1757-1146-5-11
Abstract: Thirty older adults >65?years (21 women, mean [SD] age 79.0 [7.1]), with self-reported history of ≥2 falls in the previous year, conducted tests of level-ground walking over 10?m (GAITRite system), and double-limb standing with eyes open and eyes closed over 30 seconds (Kistler force platform) under two conditions: wearing textured insoles (intervention) and smooth (control) insoles in their usual footwear.Wearing textured insoles caused significantly lower gait velocity (P?=?0.02), step length (P?=?0.04) and stride length (P?=?0.03) compared with wearing smooth insoles. No significant differences were found in any of the balance parameters (P?>?0.05).A textured insole worn by older adults with a history of falls significantly lowers gait velocity, step length and stride length, suggesting that this population may not have an immediate benefit from this type of intervention. The effects of prolonged wear remain to be investigated.
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