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Search Results: 1 - 10 of 224521 matches for " Jennifer C Peleshok "
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Neurotrophic factor changes in the rat thick skin following chronic constriction injury of the sciatic nerve
Jennifer C Peleshok, Alfredo Ribeiro-da-Silva
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-1
Abstract: We observed a decrease in peptidergic fiber innervation at 1 week after the application of a chronic constriction injury (CCI) to the sciatic nerve, followed by a recovery, correlating with TrkA protein levels. ProNGF expression in CCI animals was significantly higher than in sham-operated controls from 1-4 weeks post-CCI. ProNGF immunoreactivity was increased in mast cells at 1 week post-CCI and, at later time points, in keratinocytes. P75 expression within the dermis and epidermis was significantly higher in CCI-operated animals than in controls and these changes were localized to neuronal and non-neuronal cell populations using specific markers for each.We describe proNGF expression by non-neuronal cells over time after nerve injury as well as the association of NGF-responsive fibers to proNGF-expressing target tissues. ProNGF expression increases following nerve injury in those cell types previously suggested to express it.Nerve growth factor (NGF) is a 13 kDa neurotrophin [1]. Its roles within the peripheral nervous system include the maintenance of the adult sensory afferents and sympathetic post-ganglionic efferents [2,3]. During embryonic development, its expression is essential for the normal development and maturation of the sympathetic nervous system [4]. Mice engineered to over-express NGF in keratinocytes were associated with increased peptidergic fiber density as well as inappropriate innervation by sympathetic efferents [5,6]. These mice were also shown to have heightened sensitivity to applied heat and mechanical stimuli [7]. We have previously demonstrated that following nerve injury, there was an increase in sympathetic and peptidergic innervation in skin, comparable to that occurring following the overexpression of NGF [8-12]. We have also shown that an increase in sympathetic and peptidergic innervation occurs following application of nerve injury models [8-10]. These observed changes in NGF-responsive sympathetic and sensory fibers have been pro
Conservative Management of Placenta Accreta in a Multiparous Woman
Jennifer C. Hunt
Journal of Pregnancy , 2010, DOI: 10.1155/2010/329618
Abstract: Placenta accreta refers to any abnormally invasive placental implantation. Diagnosis is suspected postpartum with failed delivery of a retained placenta. Massive obstetrical hemorrhage is a known complication, often requiring peripartum hysterectomy. We report a case of presumed placenta accreta in a patient following failed manual removal of a retained placenta. We describe an attempt at conservative management with methotrexate in a stable patient desiring future fertility. Treatment was unsuccessful and led to the development of a disseminated intrauterine infection complicated by a bowel obstruction, requiring both a hysterectomy and small bowel resection. In hemodynamically stable patients, conservative management of placenta accreta may involve leaving placental tissue in situ with subsequent administration of methotrexate. However, ongoing close observation is required to identify complications. 1. Introduction Placenta accreta is an obstetrical complication associated with significant maternal morbidity and mortality. It is caused by a defect in the decidua basalis resulting in an abnormally invasive placental implantation [1]. This disruption is often related to previous uterine scars, including caesarean sections and prior uterine curettage [2]. Other risk factors associated with placenta accreta are multiparity ( > 6 pregnancies); placenta previa; prior intrauterine infections; elevated maternal serum alpha-fetoprotein; and maternal age over 35 years [2–4]. Histologically, placenta accreta is identified by trophoblastic invasion of the myometrium in the absence of intervening decidua [1]. The spectrum includes invasion of the superficial myometrium (accreta), invasion into deeper myometrial layers (increta), and invasion through the serosa and/or adjacent pelvic organs (percreta) [5]. Ideally, the diagnosis might be evaluated antenatally in high-risk pregnancies and suspected using ultrasound [1]. This could allow for predelivery planning to reduce maternal morbidity and mortality. Unfortunately, most cases are identified only at the time of delivery when forcible attempts at manual removal of the placenta are unsuccessful [6]. Severe postpartum hemorrhage may result and may lead to complications such as massive transfusion of blood products; DIC; acute renal failure; infectious morbidities; ARDS; loss of fertility [1]. Mortality is as high as 7% [7]. Traditionally, caesarean hysterectomy at the time of delivery has been the preferred management strategy for placenta accreta [1]. Not only does this approach preclude future fertility, but it
The Open Knowledge Foundation: Open Data Means Better Science
Jennifer C. Molloy
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1001195
Gravelle,Jennifer C.;
Revista de Economía Institucional , 2011,
Abstract: this paper reviews the current evidence on the incidence of the corporate tax from harberger-type general equilibrium models, with special attention to the open economy. the analysis identifies the major drivers of the results from open-economy models and compares estimates from four major studies that have examined corporate tax incidence in an open economy. adjusting estimates from the studies to reflect central empirical estimates of key elasticities suggests that capital bears the majority of the corporate tax burden. the paper also presents an alternative method, based on the new view of property tax incidence, for allocating the corporate tax burden that distinguishes between the global effects of corporate taxes and excise effects that vary among nations.
Incidencia del impuesto de renta a las sociedades: revisión y análisis de las estimaciones de equilibrio general
Jennifer C. Gravelle
Revista de Economía Institucional , 2011,
Abstract: Este artículo revisa la evidencia actual sobre la incidencia del impuesto de renta a las sociedades anónimas a partir de modelos de equilibrio general tipo Harberger, con especial atención en la economía abierta. Identifica los principales inductores de los resultados de estos modelos y compara las estimaciones de cuatro importantes estudios que examinan la incidencia de este impuesto en una economía abierta. El ajuste de las estimaciones de los estudios para que reflejen las estimaciones empíricas centrales de las elasticidades claves sugiere que el capital soporta la mayor carga del impuesto. El artículo también presenta un método alternativo para asignar la carga del impuesto basado en la nueva visión de la incidencia del impuesto a la propiedad, que distingue los efectos globales de los impuestos a las sociedades y los efectos de los impuestos al consumo que varían entre naciones.
The Open Knowledge Foundation: Open Data Means Better Science
Jennifer C. Molloy
PLOS Biology , 2011, DOI: 10.1371/journal.pbio.1001195
Lens Masses and Distances from Microlens Parallax and Flux
Jennifer C. Yee
Physics , 2015,
Abstract: I present a novel method for measuring lens masses for microlensing events. By combining a measured lens flux with the microlens parallax vector pi_E, it is possible to derive the mass of the lens system without knowing the angular size of the Einstein ring, theta_E. This enables mass and distance measurements for single, luminous lenses, as well as binary and planetary lenses without caustic crossings. I discuss applications of this method in the contexts of the Spitzer, Kepler, and WFIRST microlensing missions.
Representation stability for the cohomology of the pure string motion groups
Jennifer C. H. Wilson
Mathematics , 2011, DOI: 10.2140/agt.2012.12.909
Abstract: The cohomology of the pure string motion group PSigma_n admits a natural action by the hyperoctahedral group W_n. Church and Farb conjectured that for each k > 0, the sequence of degree k rational cohomology groups of PSigma_n is uniformly representation stable with respect to the induced action by W_n, that is, the description of the groups' decompositions into irreducible W_n representations stabilizes for n >> k. We use a characterization of the cohomology groups given by Jensen, McCammond, and Meier to prove this conjecture. Using a transfer argument, we further deduce that the rational cohomology groups of the string motion group vanish in positive degree. We also prove that the subgroup of orientation-preserving string motions, also known as the braid-permutation group, is rationally cohomologically stable in the classical sense.
FI_W-modules and stability criteria for representations of the classical Weyl groups
Jennifer C. H. Wilson
Mathematics , 2013,
Abstract: In this paper we develop machinery for studying sequences of representations of any of the three families of classical Weyl groups, extending work of Church, Ellenberg, Farb, and Nagpal on the symmetric groups S_n to the signed permutation groups B_n and the even-signed permutation groups D_n. For each family W_n, we present an algebraic framework where a sequence V_n of W_n-representations is encoded into a single object we call an FI_W-module. We prove that if an FI_W-module V satisfies a simple finite generation condition then the structure of the sequence is highly constrained. One consequence is that the sequence is uniformly representation stable in the sense of Church-Farb, that is, the pattern of irreducible representations in the decomposition of each V_n eventually stabilizes in a precise sense. Using the theory developed here we obtain new results about the cohomology of generalized flag varieties associated to the classical Weyl groups, and more generally the r-diagonal coinvariant algebras. We analyze the algebraic structure of the category of FI_W-modules, and introduce restriction and induction operations that enable us to study interactions between the three families of groups. We use this theory to prove analogues of Murnaghan's 1938 stability theorem for Kronecker coefficients for the families B_n and D_n. The theory of FI_W-modules gives a conceptual framework for stability results such as these.
FI_W-modules and constraints on classical Weyl group characters
Jennifer C. H. Wilson
Mathematics , 2015,
Abstract: In this paper we study the characters of sequences of representations of any of the three families of classical Weyl groups W_n: the symmetric groups, the signed permutation groups (hyperoctahedral groups), or the even-signed permutation groups. Our results extend work of Church, Ellenberg, Farb, and Nagpal on the symmetric groups. We use the concept of an FI_W-module, an algebraic object that encodes the data of a sequence of W_n-representations with maps between them, defined in the author's recent work ArXiv:1309.3817. We show that if a sequence {V_n} of W_n-representations has the structure of a finitely generated FI_W-module, then there are substantial constraints on the growth of the sequence and the structure of the characters: for n large, the dimension of V_n is equal to a polynomial in n, and the characters of V_n are given by a character polynomial in signed-cycle-counting class functions, independent of n. We determine bounds the degrees of these polynomials. We continue to develop the theory of FI_W-modules, and we apply this theory to obtain new results about a number of sequences associated to the classical Weyl groups: the cohomology of complements of classical Coxeter hyperplane arrangements, and the cohomology of the pure string motion groups (the groups of symmetric automorphisms of the free group).
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