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Search Results: 1 - 10 of 2448 matches for " Jeff Barrett "
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Outcomes of usual chiropractic, harm & efficacy, the ouch study: study protocol for a randomized controlled trial
Bruce F Walker, Barrett Losco, Brenton R Clarke, Jeff Hebert, Simon French, Norman J Stomski
Trials , 2011, DOI: 10.1186/1745-6215-12-235
Abstract: One hundred and eighty participants will be randomly allocated to either usual chiropractic care or a sham intervention group. To be considered for inclusion the participants must have experienced non-specific spinal pain for at least one week. The study will be conducted at the clinics of registered chiropractors in Western Australia. Participants in each group will receive two treatments at intervals no less than one week. For the usual chiropractic care group, the selection of therapeutic techniques will be left to the chiropractors' discretion. For the sham intervention group, de-tuned ultrasound and de-tuned activator treatment will be applied by the chiropractors to the regions where spinal pain is experienced. Adverse events will be assessed two days after each appointment using a questionnaire developed for this study. The efficacy of short term chiropractic care for spinal pain will be examined at two week follow-up by assessing pain, physical function, minimum acceptable outcome, and satisfaction with care, with the use of the following outcome measures: Numerical Rating Scale, Functional Rating Index, Neck Disability Index, Minimum Acceptable Outcome Questionnaire, Oswestry Disability Index, and a global measure of treatment satisfaction. The statistician, outcome assessor, and participants will be blinded to treatment allocation.Australia and New Zealand Clinical Trials Register (ANZCTR): ACTRN12611000542998The success of any therapy is often based on the questions "Is it safe? Is it effective?". For chiropractic therapy there has been some research to ascertain effectiveness [1] and also for spinal manipulation [2] but there has been very little to document its safety. The safety profile of any therapy is a cornerstone of modern practice as it provides protection for the public and informs the consumer consent process. Trials of chiropractic therapy have shown mixed results which, together with its current use for multiple indications, make research int
YFitter: Maximum likelihood assignment of Y chromosome haplogroups from low-coverage sequence data
Luke Jostins,Yali Xu,Shane McCarthy,Qasim Ayub,Richard Durbin,Jeff Barrett,Chris Tyler-Smith
Quantitative Biology , 2014,
Abstract: Low-coverage short-read resequencing experiments have the potential to expand our understanding of Y chromosome haplogroups. However, the uncertainty associated with these experiments mean that haplogroups must be assigned probabilistically to avoid false inferences. We propose an efficient dynamic programming algorithm that can assign haplogroups by maximum likelihood, and represent the uncertainty in assignment. We apply this to both genotype and low-coverage sequencing data, and show that it can assign haplogroups accurately and with high resolution. The method is implemented as the program YFitter, which can be downloaded from http://sourceforge.net/projects/yfitter/
It’s a Matter of Time  [PDF]
Robert A. Barrett Jr.
Journal of Modern Physics (JMP) , 2015, DOI: 10.4236/jmp.2015.66081
Abstract: This paper describes a universe consisting only of time dilation and compares it to the one which we observe.
BRCA1-mediated repression of select X chromosome genes
Amir A Jazaeri, Gadisetti VR Chandramouli, Olga Aprelikova, Ulrike A Nuber, Christos Sotiriou, Edison T Liu, H Hilger Ropers, Cindy J Yee, Jeff Boyd, J Carl Barrett
Journal of Translational Medicine , 2004, DOI: 10.1186/1479-5876-2-32
Abstract: The mechanisms by which mutations in BRCA1 and BRCA2 tumor suppressor genes lead to carcinogenesis are incompletely understood. It remains to be established whether pathways involved in BRCA1 and BRCA2-associated tumorigenesis are also altered in sporadic cancers. Two recent reports demonstrated that BRCA1 and BRCA2-associated tumors have distinct expression profiles in both breast [1] and ovarian [1,2] cancers. With respect to ovarian cancers, two additional novel patterns of gene expression were observed. First, the same set of genes that distinguished BRCA1 and BRCA2-associated tumors also segregated the sporadic (not BRCA1 or BRCA2-associated) ovarian cancers into 2 subgroups consisting of "BRCA1-like" and "BRCA2-like" gene expression profiles. This observation lends support to the hypothesis that the same or similar dichotomous molecular pathways are affected in major subgroups of both hereditary and sporadic ovarian tumors. Second, a disproportionate number of genes located on the Xp11 locus showed statistically significant higher expression in the BRCA1-associated tumors when compared to sporadic tumors. Related to this observation, Ganesan and colleagues recently demonstrated that BRCA1 colocalizes with XIST RNA covering the inactive X chromosome [3]. These investigators showed that repression of BRCA1 led to the increased expression of a green fluorescent protein (GFP) transgene targeted to the inactive X chromosome. However, it remains unknown whether BRCA1 mediates any changes in expression of normal X chromosome genes and whether any such changes are global (affecting the entire X chromosome) or specific to certain genes.The goal of this study was to investigate further the influence of BRCA1 on the expression of transcripts mapped to the X chromosome. For this purpose the BRCA-associated and sporadic ovarian cancer gene expression data set was analyzed with respect to the expression of 178 transcripts mapped to the X chromosome. Additional in vivo and i
Stage III and IV Head and Neck Cancer: Does Everyone Need Chemotherapy?  [PDF]
Gaurav Marwaha, William L. Barrett
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2014, DOI: 10.4236/ijohns.2014.31006

Objectives: Definitive treatment of Stage III and IV squamous cell carcinoma can be with surgical resection, definitive radiation therapy alone or combined radiation therapy with chemotherapy. Radiation and concomitant platinum-based chemotherapy are the accepted gold standard. The purpose of this study was to determine how often patients treated with radiation therapy alone developed locoregionally recurrent disease that in retrospect possibly could have been prevented with the addition of chemotherapy. Methods: 116 consecutive patients with known Stage III and Stage IV head and neck cancers were treated with curative intent with radiation therapy alone. Results of the treatment were retrospectively reviewed. Results: Of the 116 patients treated with radiation alone, 11 (9.48%) died from locally recurrent disease, 6 (5.17%) died from local disease and were never disease-free, 7 (6.03%) died from metastatic disease, 9 (7.75%) died from disease NOS, 6 (5.17%) died from secondary malignancy, 10 (8.62%) died from ICD (2 oropharynx; 8 larynx), 6 (5.17%) died from uncertain causes, 51 (43.96%) are alive and disease-free, and 10 (8.62%) patients’ final outcome data were not recoverable. Conclusions: Cure rates in selected patients with advanced head and neck cancer may be similar with radiation alone compared to radiation with the addition of chemotherapy.

Australian Consumer Attitudes and Decision Making on Renewable Energy Technology and Its Impact on the Transformation of the Energy Sector  [PDF]
Jeff Sommerfeld, Laurie Buys
Open Journal of Energy Efficiency (OJEE) , 2014, DOI: 10.4236/ojee.2014.33009
Abstract: This paper critically examines research on consumer attitudes and behavior towards solar photovoltaic (PV) and renewable energy technology in Australia. The uptake of renewable energy technology by residential consumers in Australia in the past decade has transformed the electricity supply and demand paradigm. Thus, this paper reviews Australian research on consumer behavior, understanding and choices in order to identify gaps in knowledge. As the role of the consumer transforms, there is a critical need to understand the ways that consumers may respond to future energy policies to mitigate unforeseen negative social and economic consequence of programs designed to achieve positive environmental outcomes.
Laser-Assisted Generation and Detection of Non-Nuclear Low-Energy Neutrino-Antineutrino Beams  [PDF]
Jeff W. Eerkens
Journal of Modern Physics (JMP) , 2018, DOI: 10.4236/jmp.2018.96077
Abstract: It is argued that conservation of energy, momentum, and spin, and QM transition probabilities, allow the generation and detection of low-energy (eV) neutrinos and antineutrinos in intra-atomic (non-nuclear) laser transitions. Two-quantum transitions between an upper and lower excited state in a lasing medium can support paired emissions of a neutrino and a recoiling counter-propagating anti-neutrino, each carrying half of the lasing transition energy. Their propagations are in opposite directions along the same axis as that of the intracavity laser beam in the lasing medium. Estimates show that the probability of this two-quantum event is on the order of 10−7 compared to a one-quantum stimulated emission of a laser photon. Absorptions or emissions of single antineutrinos or neutrinos by molecular/atomic matter are impossible because they carry spins s = ±h/2 which violates Δs = ±nh (n = integer) required for such processes. However, inside a laser, emissions of photons from excited states can be stimulated by neutrinos or anti-neutrinos passing through, provided their undulation frequency is resonant with the transition frequency. This is because in stimulated emissions, neutrinos or antineutrinos are not absorbed, and spin conservation violation is not an issue. Thus, detection of the passage of a laser-generated antineutrino or neutrino beam through a second “receiver” laser is possible provided that the transition energy in the second laser equals half the transition energy of the laser that emits the antineutrino-neutrino beam to be detected.
The Most Difficult Basic Skill Faced by Learners of English in First Year Undergraduate Classes at UEA/Bukavu, DR Congo  [PDF]
Ct Buhendwa Rubango Jeff
Creative Education (CE) , 2019, DOI: 10.4236/ce.2019.102033
Abstract: This article pursues three objectives: firstly, it aims at identifying the most difficult basic skill faced by learners of English in first year undergraduate classes at UEA, one of the major universities in Bukavu, DR Congo. Secondly, the author aims to find out its factors and thirdly, to propose possible solutions to such a problem. The study focused on 750 learners (259 female plus 491male) of English at UEA. The research was conducted in the first semester of the academic year 2015-2016. The sample was randomly selected in all the?faculties of UEA. The research instruments were a placement test, and class observations.Analytical and comparative methods were used to investigate on students’ English basic skill difficulties. The collected data were transformed into tables and calculated in percentage to facilitate the interpretation. The findings of the study revealed that speaking skill was the biggest problem (with the highest below average rate: 14.27%). Its main factors were low-backgrounds of learners, shyness and lack of interest in English language activities. Some strategies to tackle this challenge were notably: recitation of memory verses related to different fields of studies (Agronomy, Economics, Theology, Social Sciences and Medicine) at UEA, inspiring shy students self-confidence and self-esteem, making presentations in classrooms and in English clubs, attending the Language Resource Centre for practice, answering oral text comprehension in full and correct sentences, spoken English practice by holding dialogues and debates with classmates.
Eradication versus control: the economics of global infectious disease policies
Bulletin of the World Health Organization , 2004, DOI: 10.1590/S0042-96862004000900010
Abstract: a disease is controlled if, by means of a public policy, the circulation of an infectious agent is restricted below the level that would be sustained by individuals acting independently to control the disease. a disease is eliminated if it is controlled sufficiently to prevent an epidemic from occurring in a given geographical area. control and elimination are achieved locally, but a disease can only be eradicated if it is eliminated everywhere. eradication is plainly a more demanding goal, but it has two advantages over control. first, the economics of eradication can be very favourable when eradication not only reduces infections but also avoids the need for vaccinations in future. indeed, when eradication is feasible, it will either pay to control it to a fairly low level or to eradicate it. this suggests that, from an economics perspective, diseases that are eliminated in high-income countries are prime candidates for future eradication efforts. second, the incentives for countries to participate in an eradication initiative can be strong; indeed they can be even stronger than an international control programme. moreover, high-income countries typically benefit so much that they will be willing to finance elimination in developing countries. full financing of an eradication effort by nation-states is not always guaranteed, but it can be facilitated by a variety of means. hence, from the perspective of economics and international relations, eradication has a number of advantages over control. the implications for smallpox and polio eradication programmes are discussed.
Introductory Editorial (Immunotherapy Insights)
John Barrett
Immunotherapy Insights , 2012,
Abstract: Introductory Editorial by Dr John Barrett, Allogeneic Stem Cell Transplantation, Bethesda, Maryland, U.S.A.
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