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Fabrication and evaluation of oral tablets using natural mucoadhesive agent from seeds of Caesalpinia pulcherrima (L.) SW
Jeevanandham S,Dhachinamoorthi D,Senthil V,Chandra Sekhar K
Asian Journal of Pharmaceutics , 2010,
Abstract: Oral mucoadhesive sustained drug delivery systems of salbutamol sulfate were formulated using an isolated natural agent from the seeds of Caesalpinia pulcherrima. The isolated material was evaluated for various parameters, such as, melting point, viscosity, pH, elemental analysis, swelling index, phytochemical constituents, and solubility studies. The mucoadhesive characters of the isolated substance were identified by a comparative study with hydroxyl propyl cellulose and sodium alginate, by various in vitro methods, such as, Shear stress measurement, Wilhelmy′s method, Falling sphere method, and Detachment force measurement. Formulation and evaluation of mucoadhesive oral tablets of salbutamol sulfate (100 mg), using isolated natural materials in different proportions, and in vitro release studies, were carried out for three different formulations according to the U.S.P apparatus two (paddle method). Each 100 mg tablet was taken in 900 ml of acid buffer 1.2 and maintained at 37 C. After two hours the filtrate was collected and replaced in buffer 7.4. In vitro releases of three different formulations for nine hours were studied, which showed the sustained action of drug release with increasing the concentration of the isolated natural mucoadhesive agent in the formulations.
Formulation and evaluation of naproxen sodium orodispersible tablets - A sublimation technique
Jeevanandham S,Dhachinamoorthi D,Chandra Sekhar K,Muthukumaran M
Asian Journal of Pharmaceutics , 2010,
Abstract: The rationale of this investigation was to develop fast dissolving tablets of naproxen sodium using camphor as a subliming agent. Orodispersible tablets of naproxen sodium were prepared by the wet granulation technique using camphor as a subliming agent and sodium starch glycolate together with crosscarmellose sodium as superdisintegrants. Camphor was sublimed from the granules by exposing the granules to vacuum. The porous granules were then compressed into tablets. Alternatively, tablets were first prepared and later exposed to vacuum. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, and in vitro dissolution. All the formulations showed low weight variation with dispersion time less than 55 s and rapid in vitro dissolution. Sublimation of camphor from tablets resulted in superior tablets as compared with the tablets prepared from granules that were exposed to vacuum. The results revealed that the tablets containing the subliming agent had a good dissolution profile. The drug content of all the formulations was within the acceptable limits of the United States Pharmacopoeia XXVII. The optimized formulation showed good release profile with maximum drug being released at all time intervals. It was concluded that fast dissolving tablets with improved naproxen sodium dissolution could be prepared by sublimation of tablets containing a suitable subliming agent. This work helped in understanding the effect of formulation processing variables especially the subliming agent on the drug release profile.
Robust design of decentralized power system stabilizers using meta-heuristic optimization techniques for multimachine systems
Jeevanandham Arumugam,Thanushkodi Gowder Keppana
Serbian Journal of Electrical Engineering , 2009, DOI: 10.2298/sjee0901089j
Abstract: In this paper a classical lead-lag power system stabilizer is used for demonstration. The stabilizer parameters are selected in such a manner to damp the rotor oscillations. The problem of selecting the stabilizer parameters is converted to a simple optimization problem with an eigen value based objective function and it is proposed to employ simulated annealing and particle swarm optimization for solving the optimization problem. The objective function allows the selection of the stabilizer parameters to optimally place the closed-loop eigen values in the left hand side of the complex s-plane. The single machine connected to infinite bus system and 10-machine 39-bus system are considered for this study. The effectiveness of the stabilizer tuned using the best technique, in enhancing the stability of power system. Stability is confirmed through eigen value analysis and simulation results and suitable heuristic technique will be selected for the best performance of the system.
Degree Splitting of Root Square Mean Graphs  [PDF]
S. S. Sandhya, S. Somasundaram, S. Anusa
Applied Mathematics (AM) , 2015, DOI: 10.4236/am.2015.66086
Abstract: Let \"\" be an injective function. For a vertex labeling f, the induced edge labeling \"\" is defined by, \"\" or \"\"; then, the edge labels are distinct and are from \"\". Then f is called a root square mean labeling of G. In this paper, we prove root square mean labeling of some degree splitting graphs.
A Parameter Estimation Model of G-CSF: Mathematical Model of Cyclical Neutropenia  [PDF]
S. Balamuralitharan, S. Rajasekaran
American Journal of Computational Mathematics (AJCM) , 2012, DOI: 10.4236/ajcm.2012.21002
Abstract: We investigate the FFT (Fast Fourier Transform) model and G-CSF (granulocyte colony-stimulating factor) treatment of CN (Cyclical Neutropenia). We collect grey collies and normal dog’s data from CN and analyze the G-CSF treatment. The model develops the dynamics of circulating blood cells before and after the G-CSF treatment. This is quite natural and useful for the collection of laboratory data for investigation. The proposed interventions are practical. This reduces the quantity of G-CSF required for potential maintenance. This model gives us good result in treatment. The changes would be practical and reduce the risk side as well as the cost of treatment in G-CSF.
Synthesis, Thermal Behaviour, XRD, and Luminescent Properties of Lighter Lanthanidethiodipropionate Hydrates Containing Aminogunidine as Neutral Ligand  [PDF]
S. Packiaraj, S. Govindarajan
Open Journal of Inorganic Chemistry (OJIC) , 2014, DOI: 10.4236/ojic.2014.43006
Abstract:
Aminoguanidine lanthanide thiodipropionate hydrates of composition [Ln(Agun)2(tdp)3·nH2O], Agun = Aminoguanidine, tdp = thiodipropionic acid, where Ln = La, Pr, Nd and Sm if n = 2, have been prepared and characterized by physic-chemical techniques.
How to Check If a Number Is Prime Using a Finite Definite Integral  [PDF]
Jesús Sánchez
Journal of Applied Mathematics and Physics (JAMP) , 2019, DOI: 10.4236/jamp.2019.72028
Abstract: In the history of mathematics different methods have been used to detect if a number is prime or not. In this paper a new one will be shown. It will be demonstrated that if the following equation is zero for a certain number p, this number p would be prime. And being m an integer number higher than (the lowest, the most efficient the operation). \"\" . If the result is an integer, this result will tell us how many permutations of two divisors, the input number has. As you can check, no recurrent division by odd or prime numbers is done, to check if the number is prime or has divisors. To get to this point, we will do the following. First, we will create a domain with all the composite numbers. This is easy, as you can just multiply one by one all the integers (greater or equal than 2) in that domain. So, you will get all the composite numbers (not getting any prime) in that domain. Then, we will use the Fourier transform to change from this original domain (called discrete time domain in this regards) to the frequency domain. There, we can check, using Parseval’s theorem, if a certain number is there or not. The use of Parseval’s theorem leads to the above integral. If the number p that we want to check is not in the domain, the result of the integral is zero and the number is a prime. If instead, the result is an integer, this integer will tell us how many permutations of two divisors the number p has. And, in consequence information how many factors, the number p has. So, for any number p lower than 2m?- 1, you can check if it is prime or not, just making the numerical definite integration. We will apply this integral in a computer program to check the efficiency of the operation. We will check, if no further developments are done, the numerical integration is inefficient computing-wise compared with brute-force checking. To be added, is the question regarding the level of accuracy needed (number of decimals and number of steps in the numerical integration) to have a reliable result for large numbers. This will be commented on the paper, but a separate study will be needed to have detailed conclusions. Of course,
Bir Bibliyografik Kontrol Merkezi Yay nlar : al ma ekli ve Sat Metodu
?. S.
Türk Kütüphanecili?i , 1967,
Abstract:
Rain Attenuation at Terahertz  [PDF]
S. Ishii
Wireless Engineering and Technology (WET) , 2010, DOI: 10.4236/wet.2010.12014
Abstract: Rain attenuation values were calculated using empirical raindrop-size distributions, which were, Marshall-Palmer (M-P), Best, Polyakova-Shifrin (P-S) and Weibull raindrop-size distributions, and also calculated using a specific rain attenuation model for prediction methods recommended by ITU-R. Measurements of Terahertz wave taken at 313 GHz (0.96 mm) were compared with our calculations. Results showed that the propagation experiment was in very good agreement with a calculation from the specific attenuation model for use in prediction methods by ITU-R.
Frucht Graph is not Hyperenergetic  [PDF]
S. PIRZADA
Intelligent Information Management (IIM) , 2009, DOI: 10.4236/iim.2009.12017
Abstract: If are the eigen values of a p-vertex graph , the energy of is . If , then is said to be hyperenergetic. We show that the Frucht graph, the graph used in the proof of well known Frucht’s theorem, is not hyperenergetic. Thus showing that every abstract group is isomorphic to the automorphism group of some non-hyperenergetic graph. AMS Mathematics Subject Classification: 05C50, 05C35
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