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Search Results: 1 - 10 of 401358 matches for " Jeanette M. Jerrell "
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Utility of Two PANSS 5-Factor Models for Assessing Psychosocial Outcomes in Clinical Programs for Persons with Schizophrenia
Jeanette M. Jerrell,Stephanie Hrisko
Schizophrenia Research and Treatment , 2013, DOI: 10.1155/2013/705631
Abstract: Using symptom factors derived from two models of the Positive and Negative Syndrome Scale (PANSS) as covariates, change over time in consumer psychosocial functioning, medication adherence/compliance, and treatment satisfaction outcomes are compared based on a randomized, controlled trial assessing the effectiveness of antipsychotic medications for 108 individuals diagnosed with schizophrenia. Random effects regression analysis was used to determine the relative performance of these two 5-factor models as covariates in estimating change over time and the goodness of fit of the regression equations for each outcome. Self-reported psychosocial functioning was significantly associated with the relief of positive and negative syndromes, whereas patient satisfaction was more closely and significantly associated with control of excited/activation symptoms. Interviewer-rated psychosocial functioning was significantly associated with relief of positive and negative symptoms, as well as excited/activation and disoriented/autistic preoccupation symptoms. The VDG 5-factor model of the PANSS represents the best “goodness of fit” model for assessing symptom-related change associated with improved psychosocial outcomes and functional recovery. Five-factor models of the syndromes of schizophrenia, as assessed using the PANSS, are differentially valuable in determining the predictors of psychosocial and satisfaction changes over time, but not of improved medication adherence/compliance. 1. Introduction Recovery from a serious mental illness is now widely endorsed as a guiding principle of mental health policy and brings new rules for services, for example, user involvement and person-centered care, as well as participatory approaches to evidence-based medicine and policy. Recovery is determined to varying degrees by the severity of psychopathology and cognitive deficits, objective social variables such as marital status and living situation, previous psychosocial functioning, course of illness variables such as age of onset or duration, and personal risk factors such as gender or race [1, 2]. Cognitive function, encompassing all aspects of perceiving, thinking, reasoning, and remembering, is a key predictor of functional recovery [3]. Whether pharmacotherapy or psychosocial interventions are being investigated, treatment studies for persons with schizophrenia typically encompass a range of outcomes, including symptoms, psychosocial functioning, quality of life, treatment adherence or compliance, or satisfaction with the treatment received [2, 4]. Previous research has
El orientador en la red de escuelas asociadas a la UNESCO (PEAU) y la inclusión social
Educere , 2006,
Abstract: the point of this article is to present a working experience initiating in the school year 2002-2003 from the moment the counselor takes on the responsibility of coordinating the schools associated to unesco’s plan, which makes it a participant of this net at the same time. the school plan is a ministry of education and sports-dependant program which pretends to make education stronger to promote comprehension and international peace, and allows contact and interchange between schools worldwide. this way, social inclusion is allowable not only within a specific context or particular area, but it is a worldwide referent answering to technological breakthroughs and globalization. an experience which allows the counselor’s edification and growing, and it does the same for the people involved in the project like teachers, and, specially, students.
Estimation of SM backgrounds to SUSY search in the 1-lepton + jets + MET channel
Jeanette M. Lorenz
Physics , 2011,
Abstract: The ATLAS Collaboration has reported the first results of the search for SUSY particles in 1-lepton + 3 jets + MET final states. An essential ingredient for these results is a reliable background estimation in the signal region, in particular of the ttbar, W+jets and QCD backgrounds. The estimation of these three backgrounds is explained in this paper. The ttbar and W+jets backgrounds are obtained from a background dominated control region and extrapolated to the signal region, whereas for the estimation of the QCD background a matrix method is used.
Obituary - Jürgen Stock
Gustavo Bruzual,M. Jeanette Stock
Revista mexicana de astronomía y astrofísica , 2004,
Are premenstrual symptoms associated with health anxiety in nursing graduates?  [PDF]
Yinghui Xu, Russell Noyes, Arthur J. Hartz, Barcey T. Levy, Jeanette M. Daly, Susan R. Johnson
Open Journal of Psychiatry (OJPsych) , 2011, DOI: 10.4236/ojpsych.2011.13014
Abstract: Objective: This study examined retrospectively the relationship between premenstrual symptoms and health anxiety. Methods: Premenstrual symptoms of nursing school graduates were assessed in 1985 and again in 1991 using the Premenstrual Assessment Form (PAF). A total of 571 women completed the survey in 1991, along with items relating to their physical and mental health. The latter included depression, anxiety, and panic attacks. Health anxiety was also assessed using the Whiteley Index (WI). After women who were amenorrheic for any reason were excluded, a final sample of 410 women aged 25 to 52 years was obtained. Factor analyses yielded 57 items that were useful for calculating a total PAF score. A stepwise multivariate linear regression model was used to find the association of PAF scores with various participant characteristics. Results: Thirty-kone of the 410 (7.6%) women had WI scores of ≥5 and were considered to have significant health-related anxiety. The PAF score had statistically significant associations with health anxiety, as well as depression and anxiety. Conclusions: Our results suggest that the premenstrual symptoms often coexist with health anxiety as well as other psychological symptoms. Clinicians should be alert to the fact that PMS may be associated with treatable psychiatric conditions.
The Glucocorticoid Receptor: A Revisited Target for Toxins
Jeanette I. Webster Marketon,Esther M. Sternberg
Toxins , 2010, DOI: 10.3390/toxins2061357
Abstract: The hypothalamic-pituitary-adrenal (HPA) axis activation and glucocorticoid responses are critical for survival from a number of bacterial, viral and toxic insults, demonstrated by the fact that removal of the HPA axis or GR blockade enhances mortality rates. Replacement with synthetic glucocorticoids reverses these effects by providing protection against lethal effects. Glucocorticoid resistance/insensitivity is a common problem in the treatment of many diseases. Much research has focused on the molecular mechanism behind this resistance, but an area that has been neglected is the role of infectious agents and toxins. We have recently shown that the anthrax lethal toxin is able to repress glucocorticoid receptor function. Data suggesting that the glucocorticoid receptor may be a target for a variety of toxins is reviewed here. These studies have important implications for glucocorticoid therapy.
Alternative health care consultations in Ontario, Canada: A geographic and socio-demographic analysis
Allison M Williams, Peter Kitchen, Jeanette Eby
BMC Complementary and Alternative Medicine , 2011, DOI: 10.1186/1472-6882-11-47
Abstract: Data is drawn from the Canadian Community Health Survey (CCHS Cycle 3.1, 2005) for people aged 18 or over (n = 32,598) who had a consultation with an alternative health care provider. Four groups of consultations are examined: (1) all consultations (2) massage therapy (3) acupuncture, and (4) homeopath/naturopath. Descriptive statistics, mapping and logistic regression modeling are employed to analyze the data and to compare modalities of alternative health care use.In 2005, more than 1.2 million adults aged 18 or over consulted an alternative health care provider, representing about 13% of the total population of Ontario. The analysis revealed a varied geographic pattern of consultations across the province. Consultations were fairly even across the urban to rural continuum and rural residents were just as likely to consult a provider as their urban counterparts. From a health perspective, people with a chronic condition, lower health status and self-perceived unmet health care needs were more likely to see an alternative health provider. Women with chronic conditions such as fibromyalgia, high blood pressure, chronic fatigue syndrome and chemical sensitivities were more likely to see an alternative provider if they felt their health care needs were not being met.The analysis revealed that geography is not a factor in determining alternative health care consultations in Ontario. By contrast, there is a strong association between these consultations and socio-demographic characteristics particularly age, sex, education, health and self-perceived unmet health care needs. The results underscore the importance of women's health needs as related to alternative care use. The paper concludes that there is a need for more place-specific research that explores the reasons why people use specific types of alternative health care as tied to socio-economic status, health, place of residence, and knowledge of these treatments.In Canada and other developed countries, the use of
Formación por competencias para los programas directores
Díaz,Judith; Márquez,Jeanette;
Investigación y Postgrado , 2007,
Abstract: the objective of this research was to determine the training requirements under competence profi les for the teaching staff that executes the lead programs in the department of psychology and the orientation center of the university of zulia. the rationale was based on the competence approach. the work was done with a population census, composed of 34 subjects. the methodology was based on a non-experimental transectional design. the technique used was the observation, and the instrument was a questionnaire of sociometric scale. it was concluded that a) the teachers subjected to the research have more developed generic competences than the technical competences; b) they require training for the technical and generic competences; c) regarding the training strategies, it was observed a slight preference to the mode of individual work; d) in the strategies there was a higher predominance for the case study and self-evaluation, which are related with individual work.
Clinical management of smoking cessation: patient factors affecting a reward-based approach
Jeanette M Renaud, Michael T Halpern
Patient Preference and Adherence , 2010, DOI: http://dx.doi.org/10.2147/PPA.S8913
Abstract: ical management of smoking cessation: patient factors affecting a reward-based approach Review (4606) Total Article Views Authors: Jeanette M Renaud, Michael T Halpern Published Date December 2010 Volume 2010:4 Pages 441 - 450 DOI: http://dx.doi.org/10.2147/PPA.S8913 Jeanette M Renaud1, Michael T Halpern2 1RTI International, Research Triangle Park, NC, USA; 2RTI International, Washington, DC, USA Abstract: Although the majority of current smokers indicate they would like to quit, only about half of smokers make a quit attempt each year. Of those who attempt to quit, only about 5% are successful. Many effective products and programs are available to assist in smoking cessation; however those interested in quitting often do not make use of these resources. To increase use of cessation products in order to improve successful cessation rates, the Consumer Demand Roundtable has argued that smokers need to be viewed as consumers of cessation products rather than as patients needing treatment. With this consumer-based approach in mind, the current review examines how participant characteristics, perceptions, and behavior influence, and are influenced by, contingency management (CM) paradigms in various settings. Findings suggest that participant factors associated with success in these programs include demographic characteristics (eg, gender, marital status), self-efficacy, motivation to quit, and impulsivity. Overall, participants perceive incentives for successful cessation as motivating. However, such programs may involve greater withdrawal symptoms (eg, craving for cigarettes) initially, but these symptoms tend to decrease at a greater rate over time compared with nonincentive group participants. CM programs have also been shown to be successful across a number of settings (eg, communities, schools), including settings in which smokers are often considered difficult to treat (eg, substance abuse treatment centers). Overall, CM programs are perceived positively by participants and can increase rates of successful cessation. Furthermore, CM interventions have the flexibility to adapt to individual preferences and needs, leading to greater participation and likelihood of successful cessation. Thus, CM provides an important framework for addressing the need for consumer-focused smoking cessation interventions.
Negative Regulation of C/EBPbeta1 by Sumoylation in Breast Cancer Cells
Allison A. Atwood,Rachel Jerrell,Linda Sealy
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0025205
Abstract: Sumoylation is a post-translational modification that is oftentimes deregulated in diseases such as cancer. Transcription factors are frequent targets of sumoylation and modification by SUMO can affect subcellular localization, transcriptional activity, and stability of the target protein. C/EBPbeta1 is one such transcription factor that is modified by SUMO-2/3. Non-sumoylated C/EBPbeta1, p52-C/EBPbeta1, is expressed in normal mammary epithelial cells but not breast cancer cell lines and plays a role in oncogene-induced senescence, a tumor suppressive mechanism. Although p52-C/EBPbeta1 is not observed via immunoblot in breast cancer cell lines, higher molecular weight bands are observed when breast cancer cell lines are subjected to immunoblot analysis with a C/EBPbeta1-specific antibody. We show that exogenously expressed C/EBPbeta1 is sumoylated in breast cancer cells, and that the higher molecular weight bands we observe in anti-C/EBPbeta1 immunoblots of breast cancer cell lines is sumoylated C/EBPbeta1. Phosphorylation oftentimes enhances sumoylation, and phosphorylation cascades are activated in breast cancer cells. We demonstrate that phosphorylation of C/EBPbeta1Thr235 by Erk-2 enhances sumoylation of C/EBPbeta1 in vitro. In addition, sumoylated C/EBPbeta1 is phosphorylated on Thr235 and mutation of Thr235 to alanine leads to a decrease in sumoylation of C/EBPbeta1. Finally, using a C/EBPbeta1-SUMO fusion protein we show that constitutive sumoylation of C/EBPbeta1 completely blocks its capability to induce senescence in WI38 fibroblasts expressing hTERT. Thus, sumolylation of C/EBPbeta1 in breast cancer cells may be a mechanism to circumvent oncogene-induced senescence.
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