Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2020 ( 10 )

2019 ( 539 )

2018 ( 628 )

2017 ( 662 )

Custom range...

Search Results: 1 - 10 of 345201 matches for " Jean-Sébastien Hardy "
All listed articles are free for downloading (OA Articles)
Page 1 /345201
Display every page Item
La question de la question : en réponse à Lyotard
Jean-Sébastien Hardy
Phares : Revue Philosophique étudiante de l’Université Laval , 2006,
Immanence: langage, connaissance
Hardy, Jean-Sébastien
Phares : Revue Philosophique étudiante de l’Université Laval , 2007,
Pharmacogenomics and personalized medicine: lost in translation?
Jean-Sébastien Hulot
Genome Medicine , 2010, DOI: 10.1186/gm134
Abstract: The Sixth Joint Cold Spring Harbor/Wellcome Trust Centre Conference reported on new improvements that could affect 'personalized medicine' for the treatment of various diseases. Even though the term 'pharmacogenetics' was coined over 40 years ago, personalized medicine has become increasingly recognized in the past few years. The basic concept is to prescribe drugs according to genetic profiles or other tests that give evidence for tailoring treatments to patients, potentially improving care and saving money. It has been recognized for a long time that there is considerable inter-individual variation in the level of therapeutic responses to most drugs [1,2], and the same applies to the occurrence of adverse drug reactions. Some experts believe that most drugs currently on the market work for only a portion of the patients who take them, while countless patients are exposed to useless and/or toxic medications. This situation is a drawback of the 'one size fits all' approach of conventional phase 3 studies in which the treatment that seems to be superior on average will then be recommended for all patients with the same disease. This is a global rather than individual evaluation that determines the best treatment for a group of patients without distinguishing the fortunate few who will really benefit from it.Although individualization of certain treatments had been carried out in the pre-genomic era, recent progress in personalized medicine follows advances in molecular diagnostics and genomic technologies. In the past 4 years, genome-wide association studies (GWASs) have emerged as a powerful tool to identify disease-related genes for many common human disorders [3]. This hypothesis-free approach now provides useful information in the context of drug safety and efficacy. Data from the National Human Genome Research Institute (NHGRI) GWAS catalog http://genome.gov/gwastudies webcite show that the number of published GWASs exceeded 400 in September 2009. Careful analys
Asistencia y cuidados cotidianos de los ni os discapacitados mentales. Diagnósticos profanos y grupos domésticos Asistencia y cuidados cotidianos de los ni os discapacitados mentales. Diagnósticos profanos y grupos domésticos
Jean-sébastien Eideliman
Política y Sociedad , 2007, DOI: -
Abstract: This article is based on a long-lasting ethnographic enquiry on families taking care of a mentally disabled child. It proposes to unfold the stakes and mechanisms of the daily care for these children, which is based not only on the institutions chosen for their education, but also on a daily practical organization. This organization is here grasped through the determination of the community which takes care of the child, named “maisonnée” ( household), and of the different viewpoints on the child, named uninitiated diagnoses. The complex articulation between these two sorts of production –material and cognitive– is illustrated here by a monography of one exemplary family. The combination between family history, uninitiated diagnoses and “maisonnée” dynamics allows to account for the specific type of care which is observed at the time of the field work. This article aims to examine the articulation between these different elements. Este artículo propone actualizar, a partir de una investigación etnográfica de larga duración con familias donde un hijo es discapacitado mental, los desafíos y mecanismos de la asistencia y los cuidados cotidianos de estos ni os, que se basan no sólo en elecciones de establecimientos donde escolarizarlos, sino también en una organización material de todos los días. Esta organización es comprendida a partir de la determinación del colectivo que se hace cargo del ni o, llamado grupo doméstico ( maisonnée), y de los diferentes puntos de vista sobre el ni o, llamados diagnósticos profanos. La articulación compleja de estas dos producciones, material y cognitiva, es ilustrada aquí a partir de la monografía de una familia. La conjugación de la historia familiar, los diferentes diagnósticos profanos y las lógicas de grupos domésticos permite dar cuenta de la asistencia y los cuidados cotidianos observados en el momento de la investigación. El presente artículo se dedica a examinar la articulación de estos diferentes elementos.
Comment on `Revisiting the Exact Dynamical Structure Factor of the Heisenberg Antiferromagnetic Model' by A. H. Bougourzi
Jean-Sébastien Caux
Physics , 2014,
Abstract: We point out the erroneous reasoning and disprove the conclusions contained in a recent preprint by A. H. Bougourzi (arxiv:1402.3855v1) concerning the spin structure factor of the Heisenberg model at zero field in the thermodynamic limit, as calculated using the vertex operator approach.
Local activation of cannabinoid CB1 receptors in the urinary bladder reduces the inflammation-induced sensitization of bladder afferents
Jean-Sébastien Walczak, Fernando Cervero
Molecular Pain , 2011, DOI: 10.1186/1744-8069-7-31
Abstract: Compared to untreated animals, afferent fiber activity in inflamed bladders was increased for intravesical pressures between 10 and 40 mmHg. Local treatment with a non selective cannabinoid agonist (AZ12646915) significantly reduced the afferent activity at intravesical pressures above 20 mmHg. This effect was blocked by AM251 but not by AM630 (selective for CB1 and CB2 respectively). Finally, CB1 was co-expressed with TRPV1 in control and inflamed bladders.These results demonstrate that sensitization of bladder afferents induced by inflammation is partly suppressed by intravesical activation of cannabinoid receptors, an effect that appears to be mediated by CB1 receptors. Also, TRPV1 positive fibers were found to co-express CB1, supporting the hypothesis of a direct action of the cannabinoid agonist on nociceptive afferents. Taken together, these results indicate a peripheral modulation by the cannabinoid system of bladder hypersensitivity during inflammation.The role of the cannabinoid system in the regulation of bladder function has attracted considerable interest in the last few years [1]. Several studies have reported the presence of cannabinoid receptors CB1 or CB2 mRNA and/or protein in the bladder of rats [2], mice [3], monkeys[4] and humans[5]. The localization of CB1 receptors has been described in the urothelium and in nerve fiber structures of the suburothelium and the detrusor [3,6,7]. Another study did not find CB1 immunoreactivity in the urothelium and nerve fibers but reported the expression of CB2 in these structures [4]. However, most previous studies have looked only at the efferent functions of the bladder when studying the functional activity of cannabinoid receptors. For instance, electrically-evoked contractions of bladder preparations in mice are reduced by CB1 activation [8,9]. The release of CGRP evoked by capsaicin and ATP is also reduced by activation of CB1 and CB2 in rats [6]. And cystometric studies have shown that systemic administrat
The Clinical Impact of who Standardization of PSA Assays
Jean-Sébastien Blanchet, Thomas Brinkmann
Journal of Medical Biochemistry , 2008, DOI: 10.2478/v10011-008-0010-7
Abstract: The determination of serum level of the prostate specific antigen (PSA) is widely used for detection and management of prostate cancer. Analytical variability between the various PSA assays on the market has been reported. This discrepancy in the PSA results was shown to be related to non-equimolar detection of total PSA (tPSA) but also to a lack of assay standardization and could have serious clinical repercussions on the diagnostic performance of PSA testing. The recalibration of equimolar assays to common reference preparations (tPSA WHO 96/670 and fPSA 96/668) was thought to promote standardization of PSA assays and limit the clinical implication of assay variability. Comparison studies have demonstrated that PSA assay calibration to the WHO standard certainly improves the harmonisation of PSA testing, but differences between assays remain. Recent evaluations of the clinical impact of analytical variations induced by a calibration to the WHO standard reported that 15% to 30% of prostate cancer could be missed if the historical tPSA cut-off was used. In order to avoid unacceptable erosion of the clinical diagnostic performance of PSA determination for the detection of prostate cancer with WHO calibrated assays, it is critical to define new specific clinical decision points.
Proteasome inhibitor (MG132) rescues Nav1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx5cv mice
Jean-Sébastien Rougier,Hugues Abriel
Frontiers in Physiology , 2013, DOI: 10.3389/fphys.2013.00051
Abstract: The cardiac voltage-gated sodium channel, Nav1.5, plays a central role in cardiac excitability and impulse propagation and associates with the dystrophin multiprotein complex at the lateral membrane of cardiomyocytes. It was previously shown that Nav1.5 protein content and the sodium current (lNa) were both decreased in cardiomyocytes of dystrophin-deficient mdx5cv mice. In this study, wild-type and mdx5cv mice were treated for 7 days with the proteasome inhibitor MG132 (10 μg/Kg/24 h) using implanted osmotic mini pumps. MG132 rescued both the total amount of Nav1.5 protein and lNa but, unlike in previous studies, de novo expression of dystrophin was not observed in skeletal or cardiac muscle. This study suggests that the reduced expression of Nav1.5 in dystrophin-deficient cells is dependent on proteasomal degradation.
Relaxation dynamics in the gapped XXZ spin-1/2 chain
Jorn Mossel,Jean-Sébastien Caux
Physics , 2010, DOI: 10.1088/1367-2630/12/5/055028
Abstract: We study the dynamics of a quench-prepared domain wall state released into a system whose unitary time evolution is dictated by the Hamiltonian of the Heisenberg spin-1/2 gapped antiferromagnetic chain. Using exact wavefunctions and their overlaps with the domain wall state allows us to describe the release dynamics to high accuracy, up to the long-time limit, for finite as well as infinite systems. The results for the infinite system allow us to rigorously prove that the system in the gapped regime ($\Delta >1$) cannot thermalize in the strict sense.
Equilibrium thermodynamic properties of interacting two-component bosons in one dimension
Antoine Klauser,Jean-Sébastien Caux
Physics , 2011, DOI: 10.1103/PhysRevA.84.033604
Abstract: The interplay of quantum statistics, interactions and temperature is studied within the framework of the bosonic two-component theory with repulsive delta-function interaction in one dimension. We numerically solve the thermodynamic Bethe Ansatz and obtain the equation of state as a function of temperature and of the interaction strength, the relative chemical potential and either the total chemical potential or a fixed number of particles, allowing to quantify the full crossover behaviour of the system between its low-temperature ferromagnetic and high-temperature unpolarized regime, and from the low coupling decoherent regime to the fermionization regime at high interaction.
Page 1 /345201
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.