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Search Results: 1 - 10 of 23866 matches for " Jean-Jacques Cassiman "
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Molecular Diagnostics
Jean-Jacques Cassiman
Human Genomics , 2011, DOI: 10.1186/1479-7364-5-3-208
Abstract: Genetic testing/screening makes use of a variety of technologies to identify inherited or acquired modifi-cations in the genetic information of an individual. The technologies used can be cytogenetic, as well as biochemical and immunochemical, to verify the composition of DNA, RNA, proteins, carbohydrates and lipids.The result of this testing can yield different types of information, such as: (1) confirmation or exclusion of the diagnosis of a specific disease; (2) the magnitude of the risk, or its absence, of developing a disease or reacting adversely to drugs and environmental factors; (3) the magnitude of the risk of biological descendants inheriting a defect.The tests can be performed on individuals, or on nuclear or extended families. The term 'screening' is usually reserved for the systematic testing of the members of defined populations or high-risk population subgroups for one or more inherited modifications of the genome. As the technology improves and its cost decreases, the genome of individuals may also be screened for a series of related or unrelated inherited variants. Since the composition of the chromosomes and the DNA of an individual are fixed at fertilisation, most tests can be done at any stage of life, either before or after birth (pre-implantation diagnosis, all forms of prenatal diagnosis and neonatal and adult testing). In most genetics centres, the testing of children will be strictly limited to those cases in which a diagnosis is important for management or therapy.As a result, the possibilities for testing and screening for the genes involved in inherited diseases or susceptibility to diseases have increased spectacularly. In addition, modulators of gene expression -- other genes, non-coding DNA sequences, proteins involved in the three-dimensional organisation of DNA and acquired (epigenetic) modifications of DNA -- are being ident-ified. This has led to the surprising realisation that even environmental factors, such as food components,
Testing the Long Run Neutrality of Money in Developing Economies: Evidence from EMCCA  [PDF]
Jean-Jacques Tony Ekomie
Modern Economy (ME) , 2013, DOI: 10.4236/me.2013.41006

We examine the long run neutrality of money, (LMN, hereafter), in the Economic and Monetary Community of Central Africa (EMCCA) countries, applying Fisher and Seater (1993) Autoregressive Integrated Moving Average (ARIMA) methodology, using different monetary aggregates, money supply in the strict sense (M1), money supply in the large sense (M2) and domestic credit (credit to private sector) during the period 1978-2008. Tests consistently reject the LMN hypothesis. It is found that monetary aggregates have significant and positive impacts on real Gross Domestic Product (GDP) for all EMCCA countries. The results are robust under various sub-periods and the estimated coefficients are stable under two breakpoints corresponding to the dates of central bank reforms and devaluation of the local currency.

A Multivariate Long-Run Money Neutrality Investigation: Empirical Evidence for CAMEU  [PDF]
Jean-Jacques Tony Ekomie
Modern Economy (ME) , 2013, DOI: 10.4236/me.2013.45040

We examine the long run neutrality of money, in Central Africa Monetary and Economic Union (CAMEU) economies applying the multivariate methodology of King and Watson, using M2 and real output during the period 1970-2008. Tests consistently reject the long run money neutrality hypothesis. It is found that M2 has significant and positive impacts on real output of all CAMEU countries except for Gabon. The results are robust under other monetary aggregate variables and various sub-periods. In addition, the estimated coefficients are stable under two breakpoints corresponding to the dates of central bank reforms and devaluation of the local currency.

Business Cycle: The Case of Gabon  [PDF]
Jean-Jacques Tony Ekomie
Modern Economy (ME) , 2013, DOI: 10.4236/me.2013.44035

This article identifies cycles of Gabon GDP, those of its main components (consumption, investment, government spending, exports and imports), and their characteristics (duration, severity and depth), using a band-pass filter and according to the algorithm of Bry and Boschan. Synchronization and the concordance of the cycles of GDP and those of its components are highlighted. Similarly, the contributions of cycles of variables that make up the GDP to the cycles of this greatness are studied according to Stock and Watson’s way (1998).

Functional interaction between TRP4 and CFTR in mouse aorta endothelial cells
Lin Wei, Marc Freichel, Martine Jaspers, Harry Cuppens, Jean-Jacques Cassiman, Guy Droogmans, Veit Flockerzi, Bernd Nilius
BMC Physiology , 2001, DOI: 10.1186/1472-6793-1-3
Abstract: MAEC cells express CFTR transcripts as shown by RT-PCR analysis. Application of a phosphorylating cocktail activated a Cl- current with characteristics similar to those of CFTR mediated currents in other cells types (slow activation by cAMP, absence of rectification, block by glibenclamide). The current is present in trp4 +/+ MAEC, but not in trp4 -/- cells, although the expression of CFTR seems unchanged in the trp4 deficient cells as judged from RT-PCR analysis.It is concluded that TRP4 is necessary for CFTR activation in endothelium, possibly by providing a scaffold for the formation of functional CFTR channels.The cystic fibrosis transmembrane conductance regulator (CFTR) is well described as a low-conductance, cyclic nucleotide-regulated Cl- channel in epithelial cells [1]. Only recently, CFTR has also been detected in vascular endothelium [2]. Endothelial cells (EC) form an anticoagulative barrier but also control many other functions, such as regulation of the vascular tone by secretion of vasoactive compounds such as bradykinin, and autocoids, such as nitric oxide and prostacyclin [3]. These functions are modulated by a diversity of ion channels among which Cl- channels [4,5]. Endothelial Cl- channels, the volume-regulated anion channel, VRAC, and Ca2+ activated Cl- channels, CaCC, have been shown to modulate EC electrogenesis, are possible mechano-sensors, serve as permeation pathways for amino acids and organic osmolytes and may be involved in regulation of the driving force for Ca2+ entry [for a review, see 6]. This list of Cl- channels has been extended with CFTR, which is functional in human umbilical vein endothelium and in human lung microvascular endothelial cells [1], but not in bovine pulmonary artery endothelial cells [6]. As we show in this work, it is also functional in mouse aorta endothelial cells.MAEC express different types of putative ion channel transcripts which are encoded by genes of the trp family, trp1, 2, 3, 4, and 6 [7,8]. TRP4 form
An indirect approach to the extensive calculation of relationship coefficients
Jean-Jacques Colleau
Genetics Selection Evolution , 2002, DOI: 10.1186/1297-9686-34-4-409
Abstract: (To access the full article, please see PDF)
Increased fracture rate in women with breast cancer: a review of the hidden risk
Jean-Jacques Body
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-384
Abstract: Fracture risk during treatment for breast cancer may be influenced by the rate of BMD loss and the consequent rapid alterations in bone microarchitecture, in addition to the established fracture risk factors in postmenopausal osteoporosis. The rapid decrease in BMD during adjuvant chemoendocrine therapy for breast cancer may necessitate more aggressive pharmacotherapy than is indicated for healthy postmenopausal women who develop osteoporosis. Over the last few years, clinical trials have established the effectiveness of bisphosphonates and other antiresorptive agents to preserve BMD during adjuvant therapy for early breast cancer. In addition, some bisphosphonates (eg, zoledronic acid) may also delay disease recurrence in women with hormone-responsive tumors, thereby providing an adjuvant benefit in addition to preserving BMD and potentially preventing fractures.It is likely that a combined fracture risk assessment (eg, as in the WHO FRAX algorithm) will more accurately identify both women with postmenopausal osteoporosis and women with breast cancer who require bone-protective therapy.Women with breast cancer (BC), even in the absence of skeletal metastases, are known to have a higher incidence of fractures than women of the same age without BC. A case control study performed before aromatase inhibitors (AIs) were part of standard medical practice showed that at the time of diagnosis, women with BC did not have a higher prevalence of vertebral fracture than controls. However, when followed after diagnosis, women with nonmetastatic BC had a higher rate of fractures compared with age- and weight-matched controls [1]. Fracture incidence was even higher (HR = 22.7; 95% CI = 9.1, 57.1; P < .0001) in women with recurrent disease but without skeletal metastases (Table 1) [1]. The increase in fracture incidence was maintained in analyses excluding women who eventually developed skeletal metastases (HR = 2.8; 95% CI = 1.3, 6.2). These data are rendered even more compelling
Construir um viver junto na democracia renovada
Schaller, Jean-Jacques;
Educa??o e Pesquisa , 2002, DOI: 10.1590/S1517-97022002000200011
Abstract: how do we - equals and different - build relations in a democracy in which individuals benefit from rights that protect them from the omnipotence of the apparatuses of cultural conformation? democracy is here defined as the respect for human and personal rights against the usurpation promoted by those apparatuses. it is the regime of freedom of expression, of freedom of association. it is a space for freedom of consciousness for people, and a space for the rights of the minorities. it is about promoting the construction of the agent in the tension between an integrative identity and a conflictual identity, pointing out that any recognition of the actor's action relies on its insertion in a social relation. the creation of spaces for debate by the actor will allow him to question his distancing from the conditions for the production of his life. those spaces for debate remind us of the need, in the middle of a society in transformation, of promoting the domains of adventure, the places of life, and not the places for living, where the other has its place, and the farthest from the violence that wants to reduce the other to the same. through debate, a factor of de-dramatization of everyday life, one deals with the recreation of the social relation having at its center everyone's ability to produce his/her life.
Identidad étnica y manipulación cultural: La indumentaria inca en la época colonial
Estudios atacame?os , 2005, DOI: 10.4067/S0718-10432005000100008
Abstract: precolonial andean dress such as the uncu, the liclla or the acso served to express ethnic identity and the status or condition of the individual. colonial powers tried, instead, to homogenize those differences through the imposition of a generic indigenous identity. this article considers the uses of dress as a semiotic expression of identity, and its manipulation in changing fields of reference. it intends to highlight the strategies used to express, control, conceal or transform the projection of a specific collective identity in contradictory social contexts.
Morte e ressurrei??o do capitalismo: a propósito de Schumpeter
Salomon, Jean-Jacques;
Estudos Avan?ados , 1991, DOI: 10.1590/S0103-40141991000300006
Abstract: the economical crisis and the emergence of the "new technologies" in the 70's brought a new popularity to the work of joseph schumpeter. in this article, the author discusses how recent history has danied schumpeter's predictions concerning the passage of capitalism to socialism. first of all, it has not been proved that rationalization of industrial progress redacts the level of inovation, extinguishing the roles of the entreprensur and the inventor. it is quite the opposite, for the aleatory character of inovation is such that a not-planned economy suits much better its nature. concerning the second aspect, the growing role of the state in the activities of research-development, the world scene of 1945 has changed drastically from the 70 's onward when the civil markets demand for high technology outweighted the public demands. the third point relates to the function of intellectuals. the expansion and simultaneous devaluation of superior education generate an exceeding number of individual who develop a critical view towards the system. but if such "hostility" is due only to resentment, as schumpeter believes, it will never have enought strength to put an end to capitalism. therefore, if there is nothing, from an economical point of view, that postulates the disappearance of capitalim, the sociological and psychological reasons expouded by schumpeter have the same weakness of ideological statements.
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