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Search Results: 1 - 10 of 223906 matches for " Jean Le D? "
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Ichtyonymie bretonne, un atlas linguistique de la faune marine de Bretagne
Iwan Le Berre,Jean Le D,Jacques Grall,Michel Le Duff
M@ppemonde , 2009,
Abstract: Chercheur en linguistique, Alan-Gwenog Berr a consacré une grande partie de sa vie à la collecte de données décrivant la faune marine de Bretagne. Au cours des années 1950 et 1970, dans 129 ports de Basse-Bretagne, les enquêtes lui ont permis de rassembler les noms locaux de plus de 500 espèces. Faute de moyens de traitement adaptés, ce recueil de données n’a pu faire l’objet d’une exploitation systématique. Grace au travail d’une équipe de chercheurs de l’Université de Bretagne occidentale, soutenue par la Région Bretagne, ces données ont été numérisées et intégrées dans une base qui, exploitée à l’aide d’un logiciel développé en parallèle, permet de les cartographier et d’en effectuer une interprétation géolinguistique. Au-delà des perspectives de recherche qu’il ouvre, notre projet vise également à diffuser plus largement ce travail de référence sous forme d’un atlas linguistique.
Release of Cardiac Biomarkers during a Cycling Race  [PDF]
Caroline Le Goff, Jean-Fran?ois Kaux, Stéphanie D’Otreppe, Sébastien Goffaux, Marianne Fillet, Jean-Paul Chapelle, Etienne Cavalier
World Journal of Cardiovascular Diseases (WJCD) , 2016, DOI: 10.4236/wjcd.2016.68032
Abstract: Objectives: Over the past two decades, a large interest in cardiac marker elevations has developed in endurance sports events. The intense effort is not without risk. We aimed to see if the relatively cardiospecific biomarkers could show the damage on cardiac muscle cells. Methods: Fourteen cyclists were recruited for an international race (177 km). We studied different cardiac biomarkers, renal function markers and blood cytology. The subjects were submitted to three blood test: one before (T0), one just after (T1) and the last one 3 hours after the race (T3). Results: Blood cytology markers, namely erythrocytes, hemoglobin, hematocrit, and average hemoglobin concentration, were found to evolve in a similar way. Renal function markers, such as creatinin, cystatin C and uric acid, showed a post effort increase that might be related to renal blood flow depletion during exercise. Cardiac and muscular markers were all increased at T1. Conclusions: Physiological stress induced by an international cycling race certainly has consequences on cardiac muscle cells. Fortunately, those blood concentration variations are more representative of a transitional state, due to an imbalance created by an intense aerobic effort maintained during several hours, rather than an irreversible injury.
Improving Municipal Solid Waste Land Filling Disposal Process: Experiments with a Laboratory Scale Rotary Kiln  [PDF]
Jean Fidèle Nzihou
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.48087
Abstract:

Developing countries often face the challenge of managing continuously growing quantity of municipal waste. Waste is often disposed of by stockpiling and land filling because these have been found the cheapest waste disposal methods in the world. Unfortunately, these waste disposal methods are often source of visual pollution, water contamination and greenhouse effect gas emissions. Waste disposal by incineration has been found effective and now is one of the mostly used waste disposal method in several developed countries. Nevertheless, setting up appropriate waste incinerator requires a good of the combustion process. Unfortunately, direct studies on industrial facilities are not easily feasible because of technical issues and financial limitations. Studies and throughout testing frequently need to be carried out at laboratory scale. Work herein reported first overviewed operation conditions of the landfill facility in the town of Ouagadougou. In the second time for incineration simulation, batch experiments are carried out with a rotary kiln furnace to study the effects of the residence time on emissions of NO, NO2, CO, CO2 and SO2 in the atmosphere. For each rotation speed, emissions of NO, NO2, CO, CO2 and SO2 from the incineration of a household combustible fraction model waste consisting of wood (53%), cardboard (25%) and plastics (22%) have been recorded. The lifespan of the land filling facility with incineration has been estimated. Our work show that it may be improved up to roughly three times that of simple land filling. Visual pollution maybe drastically reduced and atmospheric pollution reduced

True Lies: The Double Life of the Nucleotide Excision Repair Factors in Transcription and DNA Repair
Nicolas Le May,Jean-Marc Egly,Frédéric Coin
Journal of Nucleic Acids , 2010, DOI: 10.4061/2010/616342
Abstract: Nucleotide excision repair (NER) is a major DNA repair pathway in eukaryotic cells. NER removes structurally diverse lesions such as pyrimidine dimers, arising upon UV irradiation or bulky chemical adducts, arising upon exposure to carcinogens and some chemotherapeutic drugs. NER defects lead to three genetic disorders that result in predisposition to cancers, accelerated aging, neurological and developmental defects. During NER, more than 30 polypeptides cooperate to recognize, incise, and excise a damaged oligonucleotide from the genomic DNA. Recent papers reveal an additional and unexpected role for the NER factors. In the absence of a genotoxic attack, the promoters of RNA polymerases I- and II-dependent genes recruit XPA, XPC, XPG, and XPF to initiate gene expression. A model that includes the growth arrest and DNA damage 45 protein (Gadd45 ) and the NER factors, in order to maintain the promoter of active genes under a hypomethylated state, has been proposed but remains controversial. This paper focuses on the double life of the NER factors in DNA repair and transcription and describes the possible roles of these factors in the RNA synthesis process. 1. Introduction A number of DNA repair pathways protect us from the deleterious effects of DNA damage. The importance of these mechanisms is highlighted by the existence of genetic disorders in which impaired DNA repair mechanisms predispose patients to cancer and early onset of aging. A major advance in our understanding of these DNA repair mechanisms has been to uncover the tangled connection existing between these systems and other fundamental cellular processes such as DNA replication and transcription. These cellular processes are not only highly connected with DNA repair pathways but they also share common factors with them. This complexity leads to new hypothesis about the cause of the phenotypes displayed by patients suffering from DNA repair disorders and may even force us to re-evaluate the place of the repair factors in cellular homeostasis. 2. The NER Pathway: The Fountain of Youth of Our Genome We do not live forever young. We all have to experience aging, a functional decline coupled to an increased mortality risk from diseases such as cancer. The molecular origins of aging can be sought, at least in part, in an alteration of the expression of our genes that results from the physicochemical constitution of DNA, which does not guarantee life-long stability (for reviews see [1, 2]). Over time, DNA accumulates a tremendous diversity of lesions that, if unrepaired, lead to mutations that
Hernioplastia inguinal con técnica Prolene hernia system: Evaluación de los resultados a largo plazo Long term results of inguinal hernia repair with prolene hernia system technique
JEAN MICHEL BUTTE B,FRANCISCA LEóN G,NICOLETTE VAN SINT JAN D,CAMILA HEVIA S
Revista Chilena de Cirugía , 2007,
Abstract: Introducción: En múltiples trabajos se han evaluado los resultados a corto y mediano plazo de la reparación de la hernia inguinal con la técnica prolene hernia system PHS). Sin embargo, en pocos estudios se han reportado resultados a largo plazo. Objetivos: Evaluar los resultados a largo plazo de la reparación de la hernia inguinal con la técnica PHS. Material y método: Se realizó un estudio prospectivo de 62 enfermos operados con la técnica PHS entre 2001 y 2002. Las complicaciones inmediatas y el dolor fueron evaluadas en todos los enfermos. Se completaron 4 a os de seguimiento en 53 pacientes que se analizan en este trabajo (90,1%). Se evaluó la recurrencia hemiaria, la presencia de dolor crónico (en reposo y en actividad), el rechazo de la malla y la satisfacción con la operación. Resultados: El grupo está formado por 50 hombres (94%) y 3 mujeres (6%), con una edad de 53,2 + 8,5 a os. En 52 enfermos (98%) la hernia inguinal fue asintomática. Se repararon 58 hernias en 53 enfermos. Dos enfermos (2,5%) presentaron complicaciones inmediatas. En el seguimiento a largo plazo, no se ha observado recurrencia, dolor crónico, rechazo de la malla y todos los enfermos están satisfechos con los resultados obtenidos. Conclusiones: La hernioplastia inguinal con técnica PHS presenta buenos resultados en el seguimiento a largo plazo, sin recidiva ni dolor crónico. Los pacientes se encuentran satisfechos con los resultados obtenidos Background: Short and mid-term results of inguinal hernia repair with Prolene Hernia System (PHS) have been evaluated. However, few studies have reported long-term recurrence rates. Aim: To evaluate long-term outcomes among patients who underwent inguinal hernia repair with Prolene Hernia System technique. Material and Methods: A prospective study of 62 patients operated with PHS from 2001 to 2002. Pain and immediate complications were evaluated in all patients. Four years follow-up was completed in 53 (90.1%) patients, who are the analyzed group. The evaluated issues were hernia recurrence, chronic pain (at rest and in activity), alteration in sexual behavior, mesh rejection and overall satisfaction with the procedure. Results: Fifty men (94%) and three women (6%), aged 53.2 + 8.5 years were analyzed. In 52 patients (98%), inguinal hernia was symptomatic. Fifty eight hernias were repaired on the 53 patients. On immediate follow-up, postoperative complications were observed in two patients (2.5%). In long-term follow-up, no patient had hernia recurrence, chronic pain or alterations in sexual behavior. Conclusions: Inguinal hernia repair
RHYTHM-AF: design of an international registry on cardioversion of atrial fibrillation and characteristics of participating centers
Crijns Harry JGM,Bash Lori D,Chazelle Fran?ois,Le Heuzey Jean-Yves
BMC Cardiovascular Disorders , 2012, DOI: 10.1186/1471-2261-12-85
Abstract: Background Atrial fibrillation is a serious public health problem posing a considerable burden to not only patients, but the healthcare environment due to high rates of morbidity, mortality, and medical resource utilization. There are limited data on the variation in treatment practice patterns across different countries, healthcare settings and the associated health outcomes. Methods/design RHYTHM-AF was a prospective observational multinational study of management of recent onset atrial fibrillation patients considered for cardioversion designed to collect data on international treatment patterns and short term outcomes related to cardioversion. We present data collected in 10 countries between May 2010 and June 2011. Enrollment was ongoing in Italy and Brazil at the time of data analysis. Data were collected at the time of atrial fibrillation episode in all countries (Australia, Brazil, France, Germany, Italy, Netherlands, Poland, Spain, Sweden, United Kingdom), and cumulative follow-up data were collected at day 60 (±10) in all but Spain. Information on center characteristics, enrollment data, patient demographics, detail of atrial fibrillation episode, medical history, diagnostic procedures, acute treatment of atrial fibrillation, discharge information and the follow-up data on major events and rehospitalizations up to day 60 were collected. Discussion A total of 3940 patients were enrolled from 175 acute care centers. 70.5% of the centers were either academic (44%) or teaching (26%) hospitals with an overall median capacity of 510 beds. The sites were mostly specialized with anticoagulation clinics (65.9%), heart failure (75.1%) and hypertension clinics (60.1%) available. The RHYTHM-AF registry will provide insight into regional variability of antiarrhythmic and antithrombotic treatment of atrial fibrillation, the appropriateness of such treatments with respect to outcomes, and their cost-efficacy. Observations will help inform strategies to improve cardiovascular outcomes in patients with atrial fibrillation. Trial registration Clinical trials NCT01119716
Brain neuropeptides in central ventilatory and cardiovascular regulation in trout
Jean-Claude Le Mével,Frédéric Lancien,Nagi Mimassi,J. Michael Conlon
Frontiers in Endocrinology , 2012, DOI: 10.3389/fendo.2012.00124
Abstract: Many neuropeptides and their G-protein coupled receptors (GPCRs) are present within the brain area involved in ventilatory and cardiovascular regulation but only a few mammalian studies have focused on the integrative physiological actions of neuropeptides on these vital cardio-respiratory regulations. Because both the central neuroanatomical substrates that govern motor ventilatory and cardiovascular output and the primary sequence of regulatory peptides and their receptors have been mostly conserved through evolution, we have developed a trout model to study the central action of native neuropeptides on cardio-ventilatory regulation. In the present review, we summarize the most recent results obtained using this non-mammalian model with a focus on PACAP, VIP, tachykinins, CRF, urotensin-1, CGRP, angiotensin-related peptides, urotensin-II, NPY, and PYY. We propose hypotheses regarding the physiological relevance of the results obtained.
Statistics on parallelogram polyominoes and a q,t-analogue of the Narayana numbers
Jean-Christophe Aval,Michele D'Adderio,Mark Dukes,Angela Hicks,Yvan Le Borgne
Mathematics , 2013,
Abstract: We study the statistics area, bounce and dinv on the set of parallelogram polyominoes having a rectangular m times n bounding box. We show that the bi-statistics (area, bounce) and (area, dinv) give rise to the same q,t-analogue of Narayana numbers which was introduced by two of the authors in [arXiv:1208.0024]. We prove the main conjectures of that paper: the q,t-Narayana polynomials are symmetric in both q and t, and m and n. This is accomplished by providing a symmetric functions interpretation of the q,t-Narayana polynomials which relates them to the famous diagonal harmonics.
Two operators on sandpile configurations, the sandpile model on the complete bipartite graph, and a Cyclic Lemma
Jean-Christophe Aval,Michele D'Adderio,Mark Dukes,Yvan Le Borgne
Mathematics , 2013,
Abstract: We introduce two operators on stable configurations of the sandpile model that provide an algorithmic bijection between recurrent and parking configurations. This bijection preserves their equivalence classes with respect to the sandpile group. The study of these operators in the special case of the complete bipartite graph ${K}_{m,n}$ naturally leads to a generalization of the well known Cyclic Lemma of Dvoretsky and Motzkin, via pairs of periodic bi-infinite paths in the plane having slightly different slopes. We achieve our results by interpreting the action of these operators as an action on a point in the grid $\mathbb{Z}^2$ which is pointed to by one of these pairs of paths. Our Cyclic lemma allows us to enumerate several classes of polyominoes, and therefore builds on the work of Irving and Rattan (2009), Chapman et al. (2009), and Bonin et al. (2003).
Parallel Sparse Matrix Solver on the GPU Applied to Simulation of Electrical Machines
Antonio Wendell De Oliveira Rodrigues,Frédéric Guyomarch,Yvonnick Le Menach,Jean-Luc Dekeyser
Computer Science , 2010,
Abstract: Nowadays, several industrial applications are being ported to parallel architectures. In fact, these platforms allow acquire more performance for system modelling and simulation. In the electric machines area, there are many problems which need speed-up on their solution. This paper examines the parallelism of sparse matrix solver on the graphics processors. More specifically, we implement the conjugate gradient technique with input matrix stored in CSR, and Symmetric CSR and CSC formats. This method is one of the most efficient iterative methods available for solving the finite-element basis functions of Maxwell's equations. The GPU (Graphics Processing Unit), which is used for its implementation, provides mechanisms to parallel the algorithm. Thus, it increases significantly the computation speed in relation to serial code on CPU based systems.
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