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Search Results: 1 - 10 of 11627 matches for " Je Sung You "
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An Equation to Estimate the Concentration of Serum Apolipoprotein B
You-Cheol Hwang, Hong-Yup Ahn, Woo Je Lee, Cheol-Young Park, Sung-Woo Park
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0051607
Abstract: Background Several large prospective studies have demonstrated that apolipoprotein B (apoB) has greater value in predicting cardiovascular risk than any other lipid measurements. Currently, however, serum apoB levels are not routinely measured, because of the additional cost. The aim of this study was to develop an equation to estimate apoB from conventional lipid measurements including total cholesterol, HDL cholesterol, and triglycerides. Methods Data from a total of 78,127 subjects (47,057 men and 31,070 women), aged 15 to 88 years (mean age 41.8 years) were reviewed to develop an apoB equation. Additional datasets from the same institution and the NHANES obtained in 2007–2008 were used for internal (n = 73,445) and external validation (n = 3,097), respectively. Results We developed an apoB equation based on a linear regression model that contains total cholesterol, triglycerides, and HDL cholesterol as terms (model 1). To more precisely estimate the serum apoB level, we adjusted mode1 1 using a cutoff serum triglyceride value of 270 mg/dl (model 2). Model 2 showed more randomly distributed residuals in patients with diabetes, atherogenic dyslipidemia, and those taking lipid-lowering agents than model 1. The residuals in the development, internal validation, and external validation datasets were also randomly distributed around 0 with no clear trends. Conclusion The new equation we developed to estimate serum apoB concentrations is accurate and can be used in diverse subgroups of patients including those with diabetes, atherogenic dyslipidemia, and those taking lipid-lowering agents.
Diagnostic Radiation Exposure of Injury Patients in the Emergency Department: A Cross-Sectional Large Scaled Study
Je Sung You, Hye-Jeong Lee, Yong Eun Chung, Hye Sun Lee, Myo Jeong Kim, Sung Phil Chung, Myeong-Jin Kim, Incheol Park, Ki Whang Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0084870
Abstract: In contrast to patients with underlying cancer or chronic disease, injury patients are relatively young, and can be expected to live their natural lifespan if injuries are appropriately treated. Multiple and repeated diagnostic scans might be performed in these patients during admission. Nevertheless, radiation exposure in injury patients has been overlooked and underestimated because of the emergent nature of such situations. Therefore, we tried to assess the cumulative effective dose (cED) of injury patients in the emergency department. We included patients who visited the emergency department (ED) of a single tertiary hospital due to injury between February 2010 and February 2011. The cED for each patient was calculated and compared across age, sex and injury mechanism. A total of 11,676 visits (mean age: 28.0 years, M:F = 6,677:4,999) were identified. Although CT consisted of only 7.8% of total radiologic examinations (n=78,025), it accounted for 87.1% of the total cED. The mean cED per visit was 2.6 mSv. A significant difference in the cED among injury mechanisms was seen (p<0.001) and patients with traffic accidents and fall down injuries showed relatively high cED values. Hence, to reduce the cED of injury patients, an age-, sex- and injury mechanism-specific dose reduction strategy should be considered.
RFID Anti-Counterfeiting for Retailing Systems  [PDF]
Duy-Thinh Tran, Sung Je Hong
Journal of Applied Mathematics and Physics (JAMP) , 2015, DOI: 10.4236/jamp.2015.31001
Abstract:

Counterfeiting is one of the most serious problems in the consumer market. One promising approach for anti-counterfeiting is to attach a low-cost Radio-frequency Identification (RFID) tag to the product authentication. In this paper, we propose an RFID system for detecting counterfeiting products. This RFID system consists of the tag authentication protocol and the database correction protocol. We use the tag authentication protocol for authenticating tags without revealing their sensitive information. This protocol also allows the customer to freely inquire the tag. To prevent the widespread of the counterfeit products, we use the tag status information along with tag identity information. Meanwhile, the database correction protocol guarantees the correctness of the tag status. Our anti-counterfeiting system is the first work considering the seller who plays an important role in the consumer product supply chain. Finally, we show that anti-counterfeiting system is quite secure against counterfeiting and the tag authentication protocol is lightweight enough to be implemented in RFID-based applications.

Division Technique Training Tool for Problem Solving Methods of IPR  [PDF]
Gil Su Yoon, You Heon Kim, Sung Ju Lim
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.38205
Abstract: We have developed a training tool of division technique among 5 techniques in ASIT for problem solving method for Intellectual Property Right. Even though with its good capability, there were not yet an applicable training tool to use for division training because of its easy disassembled shape with small disturbance. To develop a division technique training tool, we have applied ASIT to game T. We have chosen game shape parts with magnetic rubber and board as the plate coated with zinc. The adhesive strength of the game shape parts to board is enough to keep fixed position even in turn down. Developed division training tool is expected to be used for the e-learning of problem solving training for student education and lifelong education. It is under Korean utility model application. E-learning with open resources including beneficial training for solving problem will be developed together with the foundation of life-long education. This division training device is proposed to younger generation as the educational auxiliary training tool for problem solving method. We are looking for the international cooperation with this division training tool. With the encouragement of this division training tool we have patented Korean patent of the lifting method of methane hydrate which can be extended to various fields of IPR.
Division Technique Training Tool for Problem Solving Methods of IPR  [PDF]
Gil Su Yoon, You Heon Kim, Sung Ju Lim
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.38B027
Abstract: We have developed a training tool of division technique among 5 techniques in ASIT for problem solving method for Intellectual Property Right.  Even though with its good capability, there were no applicable training tool to use for division training because of its easy disassembled shape with small disturbance. To develop a division technique training tool, we have applied ASIT to game T. We have chosen game shape parts with magnetic rubber and board as the plate coated with zinc. The adhesive strength of the game shape parts to board is enough to keep fixed position even in turn down. Developed tool is expected to use for the e-learning of problem solving training for student education and lifelong education. It is under Korean utility model application. E-learning with open resources including beneficial training for solving problem will develop together in foundation of life-long education. This division training device is proposed to younger generation as the educational auxiliary training tool for problem solving method. We have applied for Korean patent of the lifting method of methan hydrate which can be extended to various fields of IPR.
The Chevrel phase In4.07Mo15S11.87Se7.13 with mixed chalcogenide occupancy
You-Soon Lee,Sung Kwon Kang
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809007351
Abstract: The single-crystal of the title compound, indium pentadecamolybdenum nonadeca(sulfide/selenide), was obtained by solid state reaction with an S/Se mixture. It adopts the structure type of In3Mo15Se19 and In3.7Mo15S19, which are non-substituted Chevrel phases in the space group P63/m. The Mo, one S/Se and two In sites have point symmetry m.. and two S/Se and one In atoms are in 3.. sites. This compound contains isolated Mo6 and Mo9 clusters. The shapes of clusters are octahedral and confacial bioctahedral, respectively, face-capped by chalcogen atoms over each triangle face. The Mo—X bonds (X = S, Se) play an important role for the constitution of the framework. The Mo—X distances of 2.479 (2)–2.6687 (9) are within the ranges of average values of Mo—S and Mo—Se distances. The In atoms located on sites with m.. symmetry are partially occupied.
General Nonlinear Random Equations with Random Multivalued Operator in Banach Spaces
Heng-You Lan,Yeol Je Cho,Wei Xie
Journal of Inequalities and Applications , 2009, DOI: 10.1155/2009/865093
Abstract: We introduce and study a new class of general nonlinear random multivalued operator equations involving generalized m-accretive mappings in Banach spaces. By using the Chang's lemma and the resolvent operator technique for generalized m-accretive mapping due to Huang and Fang (2001), we also prove the existence theorems of the solution and convergence theorems of the generalized random iterative procedures with errors for this nonlinear random multivalued operator equations in q-uniformly smooth Banach spaces. The results presented in this paper improve and generalize some known corresponding results in iterature.
Characterization of the Structure and Immunostimulatory Activity of a Vaccine Adjuvant, De-O-Acylated Lipooligosaccharide
Ji Eun Han, Seo Ri Wui, Kwang Sung Kim, Yang Je Cho, Wan Je Cho, Na Gyong Lee
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0085838
Abstract: Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative bacteria. LPS elicits strong immunopathological responses during bacterial infection, and the lipid A moiety of LPS is responsible for this immunostimulatory activity. Lipid A exerts its biological activity by sending signals via TLR4 present on immune cells, and TLR4 agonists have been a target for vaccine adjuvant. Previously, we demonstrated an adjuvant activity of deacylated lipooligosaccharide (dLOS) to viral and bacterial antigens. In this study, we characterized the chemical structure of dLOS and evaluated its immunostimulatory activity on mouse and human immune cells in comparison with monophosphoryl lipid A (MPL). dLOS consists of a core oligosaccharide lacking the terminal glucose residue, a glucosamine disaccharide with two phosphate groups, and two N-linked acyl groups. dLOS was similar to MPL in induction of cytokine production in mouse peritoneal macrophages, but was a more potent activator in human monocytes and dendritic cells (DCs). Results of an analysis of allogeneic T cell responses revealed that dLOS induces Th1, Th2, and Th17-type immune responses in a dose-dependent manner. The immunostimulatory activities of dLOS were completely abrogated in TLR4?/? mice, which confirms its TLR4-dependency. These results suggest that in the presence of the core oligosaccharide, O-linked acyl groups of LPS are dispensable for activating the TLR4 signaling pathway. dLOS did not cause any pathological effects or death at 0.25, 0.5, or 1 mg per kg body weight in mice in the acute toxicity tests. This result suggests that dLOS has a low toxicity. dLOS should be considered for further development as a safe and effective adjuvant for human vaccines.
Nanofluidic Refractive-Index Sensors Formed by Nanocavity Resonators in Metals without Plasmons
Shih-Pin Tsai,Yao-Feng Ma,Ming-Je Sung,Ding-Wei Huang
Sensors , 2011, DOI: 10.3390/s110302939
Abstract: Nanocavity resonators in metals acting as nanofluidic refractive-index sensors were analyzed theoretically. With the illumination of transverse electric polarized light, the proposed refractive index sensor structure acts as a pure electromagnetic resonator without the excitation of surface plasmons. The reflected signal from the nanocavity resonators can be very sensitive to the refractive index of the fluids inside the nanocavities due to the enhancement of the electric field of the resonant mode inside the cavities. Such a sensor configuration can be a useful tool for probing the refractive index change of the fluid inside the nanocavities using the spectral, angular or intensity interrogation schemes. The wavelength sensitivity of 430 nm/RIU, angular sensitivity of 200–1,000 deg/RIU and intensity sensitivity of 25.5 RIU?1 can be achieved in the proposed sensor configuration.
Bisdemethoxycurcumin Induces Apoptosis in Activated Hepatic Stellate Cells via Cannabinoid Receptor 2
Phil Jun Lee,Seung Je Woo,Jun-Goo Jee,Sang Hyun Sung,Hong Pyo Kim
Molecules , 2015, DOI: 10.3390/molecules20011277
Abstract: Activated Hepatic Stellate Cells (HSCs), major fibrogenic cells in the liver, undergo apoptosis when liver injuries cease, which may contribute to the resolution of fibrosis. Bisdemethoxycurcumin (BDMC) is a natural derivative of curcumin with anti-inflammatory and anti-cancer activities. The therapeutic potential of BDMC in hepatic fibrosis has not been studied thus far in the context of the apoptosis in activated HSCs. In the current study, we compared the activities of BDMC and curcumin in the HSC-T6 cell line and demonstrated that BDMC relatively induced a potent apoptosis. BDMC-induced apoptosis was mediated by a combinatory inhibition of cytoprotective proteins, such as Bcl 2 and heme oxygenase-1 and increased generation of reactive oxygen species. Intriguingly, BDMC-induced apoptosis was reversed with co-treatment of sr144528, a cannabinoid receptor (CBR) 2 antagonist, which was confirmed with genetic downregulation of the receptor using siCBR2. Additionally, incubation with BDMC increased the formation of death-induced signaling complex in HSC-T6 cells. Treatment with BDMC significantly diminished total intracellular ATP levels and upregulated ATP inhibitory factor-1. Collectively, the results demonstrate that BDMC induces apoptosis in activated HSCs, but not in hepatocytes, by impairing cellular energetics and causing a downregulation of cytoprotective proteins, likely through a mechanism that involves CBR2.
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