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Search Results: 1 - 10 of 37299 matches for " Javier Rodríguez Velásquez "
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Teoría de conjuntos aplicada a la caracterización matemática de unión de péptidos al HLA clase II
Rodríguez Velásquez,Javier;
Revista Ciencias de la Salud , 2008,
Abstract: antigen presentation contains the molecular basis for antigenic identification and immune responses. the set theory and experimental data were used in order to develop an union core region mathematic characterization through the definition of 8 laws associated to hla class ii binding. the laws were applied to 4 promiscuous peptides, 25 natural peptides sequences of core region: 13 binding peptides and 12 no binding peptides; and 19 synthetic peptides looking to differentiate peptides. only one peptide was not rightly characterized. this methodology may be used to choose key peptides in the development of vaccine.
COMPORTAMIENTO FRACTAL DEL REPERTORIO T ESPECíFICO CONTRA EL ALERGENO Poa p9
Rodríguez Velásquez,Javier;
Revista Facultad de Medicina de la Universidad Nacional de Colombia , 2005,
Abstract: background: based on a linguistic analogy applied to the immune specific b and t repertoires the immune system it has been characterized by the degree of fractal complexity like the one observed in the natural languages. material and methods: this study is the application of a mathematical law to the immune repertoire. the zipf-mandelbrot law, observed in the natural languages, was applied to the study of the specific t repertoire against the allergen poa p9. results: the scale behavior of the law was observed in the specific repertoire from an allergic patient, with a without alfa interferon, like in th cells clones. conclusion: complexity degree of t repertoire against poa p9 allergen can be identified by fractal dimension, as a appropriate mathematical parameter to characterize the physiology of the immune system, this fractal behavior has general implications for the immunology.
COMPORTAMIENTO FRACTAL DEL REPERTORIO T ESPECíFICO CONTRA EL ALERGENO Poa p9 Fractal behavior of T specify repertory against Poa p9 alergeno
Javier Rodríguez Velásquez
Revista Facultad de Medicina de la Universidad Nacional de Colombia , 2005,
Abstract: Antecedentes: basados en una analogía lingüística aplicada al repertorio inmune B y T específicos, el sistema inmune se puede caracterizar por su grado de complejidad como se hace con los lenguajes naturales. Material y métodos: este estudio es la aplicación de una ley matemática al repertorio inmune. Se aplicó la ley de Zipf-Mandelbrot, observada en los lenguajes naturales, al estudio del repertorio T específico contra el alergeno Poa p9. Resultados: se observó un comportamiento a escala de la ley en el repertorio específico para el alergeno obtenido de un paciente alérgico en presencia y ausencia de interferón á, y en los clones de células Th. Los repertorios T en presencia y ausencia de interferón á se comportanfractalmente, con una dimensión fractal de 0.661165 y 0.923895 respectivamente. Conclusión: el grado de complejidad del repertorio T contra el alergeno Poa p9 es una medida matemática objetiva y reproducible del repertorio inmune, la dimensión fractal es un parámetro matemático apropiado para caracterizar la fisiología del sistema inmune. Este comportamiento fractal puede tener implicaciones generales para la inmunología. Background: based on a linguistic analogy applied to the immune specific B and T repertoires the immune system it has been characterized by the degree of fractal complexity like the one observed in the natural languages. Material and methods: this study is the application of a mathematical law to the immune repertoire. The Zipf-Mandelbrot law, observed in the natural languages, was applied to the study of the specific T repertoire against the allergen Poa p9. Results: the scale behavior of the law was observed in the specific repertoire from an allergic patient, with a without alfa interferon, like in Th cells clones. Conclusion: complexity degree of T repertoire against Poa p9 allergen can be identified by fractal dimension, as a appropriate mathematical parameter to characterize the physiology of the immune system, this fractal behavior has general implications for the immunology.
Método para la predicción de la dinámica temporal de la malaria en los municipios de Colombia
Velásquez,Javier Oswaldo Rodríguez;
Revista Panamericana de Salud Pública , 2010, DOI: 10.1590/S1020-49892010000300008
Abstract: objective: to develop a methodology for forecasting the seasonal dynamic of malaria outbreaks in the municipalities of colombia. methods: epidemiologic ranges were defined by multiples of 50 cases for the six municipalities with the highest incidence, 25 cases for the municipalities that ranked 10th and 11th by incidence, 10 for the municipality that ranked 193rd, and 5 for the municipality that ranked 402nd. the specific probability values for each epidemiologic range appearing in each municipality, as well as the s/k value-the ratio between entropy (s) and the boltzmann constant (k)- were calculated for each three-week set, along with the differences in this ratio divided by the consecutive sets of weeks. these mathematical ratios were used to determine the values for forecasting the case dynamic, which were compared with the actual epidemiologic data from the period 2003-2007. results: the probability of the epidemiologic ranges appearing ranged from 0.019 and 1.00, while the differences in the s/k ratio between the sets of consecutive weeks ranged from 0.23 to 0.29. three ratios were established to determine whether the dynamic corresponded to an outbreak. these ratios were corroborated with real epidemiological data from 810 colombian municipalities. conclusions: this methodology allows us to forecast the malaria case dynamic and outbreaks in the municipalities of colombia and can be used in planning interventions and public health policies.
Geometrical Evaluation of Cervical Cells. Fractal and Euclidean Diagnostic Methodology of Clinical Application  [PDF]
Javier Rodríguez Velásquez, Miguel Sánchez Cárdenas, Freddy Andrés Barrios Arroyave, Yolanda Soracipa Mu?oz
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.63009
Abstract: Background: The concomitant use of fractal and Euclidian measurements has led to the development of new methodologies of cell evaluation, including a diagnosis of cervical cells that set up differences between normality and various degrees of lesion, to carcinoma. Aim: To confirm the diagnostic capacity of the methodology based on fractal and Euclidian geometry for the mathematical diagnosis through a blind study of normal cells and with different types of lesion, as atypia of undetermined significance (ASCUS), low grade squamous intra-epithelial lesion (LGSIL) and high grade squamous intra-epithelial lesion (HGSIL). Methods: 100 cells of Papanicolaou tests were analyzed and divided into 4 groups according to conventional parameters: 25 normal, 25 ASCUS, 25 LGSIL and 25 HGSIL. By means of the Box-counting Fractal Space, we calculated the fractal dimension and occupying spaces of the border and surface in pixels of the cell nucleus and cytoplasm. The diagnostic parameters of the previously developed methodology were applied and compared with the conventional diagnosis, setting up sensibility, specificity, negative likelihood ratio and Kappa coefficient. Results: The values of the occupation of the border and surface of the cell nucleus and cytoplasm were consistent with the values found by the diagnostic methodology previously found. The subtraction of the nucleus and cytoplasm frontiers presented values between: 189 and 482 for normality; 159 and 432 for ASCUS; 126 to 401 for LGSIL and 39 to 122 for HGSIL. A sensitivity and specificity of 100%, and a Kappa coefficient of 1 were obtained. Conclusions: The capacity of the methodology to diagnose quantitatively the different stages in the evolution of the cervical cells observed in Papanicolaou tests was confirmed, from normality to HGSIL.
Set Theory Applied to the Mathematical Characterization of HLA Class II Binding Peptides
Javier Rodríguez Velásquez, MD, esp.1
Revista Ciencias de la Salud , 2008,
Abstract: Antigen presentation contains the molecularbasis for antigenic identification and immuneresponses. The set theory and experimental datawere used in order to develop an union core regionmathematic characterization through the definitionof 8 laws associated to HLA class II binding.The laws were applied to 4 promiscuous peptides,25 natural peptides sequences of core region: 13binding peptides and 12 no binding peptides; and19 synthetic peptides looking to differentiate peptides.Only one peptide was not rightly characterized.This methodology may be used to choose keypeptides in the development of vaccine.
Diagnóstico matemático de ecocardiografías pediátricas con medidas de dimensión fractal evaluadas con armonía matemática intrínseca
Rodríguez-Velásquez,Javier O; Prieto,Signed E; Ortiz,Liliana; Ronderos,Miguel; Correa,Catalina;
Revista Colombiana de Cardiología , 2010,
Abstract: background and objectives: geometry allows the objective mathematical characterization of forms. fractal geometry characterizes irregular objects. the left ventricle dynamical states form observed through echocardiography can be objectively evaluated through fractal dimension measures. methods: a measurement of fractal dimension was performed using the box-counting method of three defined objects in 28 echocardiographic images, 16 from normal children (group a) and 12 ill children (group b), in order to establish differences between health and illness from its comparison with the fractal dimensions of 2 normality prototypes and 2 disease prototypes. results: a new diagnostic, clinical application methodology was developed based in the "intrinsic mathematical harmony" (imh) concept, and it was observed that the fractal dimensions of the defined objects for an abnormal echocardiogram show similarity to its fourth significant number, thus demonstrating the possibility of following up the evolution from normality towards disease. according to the performed calculations, 68.75% of the cases in group a could be better evaluated with the developed diagnostic methodology, and the ill ones could be diagnosed more effectively. conclusions: the pediatric echocardiography images can be objectively characterized with fractal dimension measurements, thus enabling the development of a clinical diagnostic methodology of echocardiography in children from the imh concept.
Diagnóstico matemático de ecocardiografías pediátricas con medidas de dimensión fractal evaluadas con armonía matemática intrínseca Mathematical diagnosis of pediatric echocardiograms with fractal dimension measures evaluated through intrinsic mathematical harmony
Javier O Rodríguez-Velásquez,Signed E Prieto,Liliana Ortiz,Miguel Ronderos
Revista Colombiana de Cardiología , 2010,
Abstract: Antecedentes y objetivos: la geometría permite la caracterización matemática objetiva de las formas; la geometría fractal caracteriza objetos irregulares. La forma de los estados dinámicos del ventrículo izquierdo que se observa mediante eco-cardiografía, puede evaluarse de manera objetiva a partir de medidas de dimensiones fractales. Métodos: se midió la dimensión fractal a través del método de Box-Counting de tres objetos definidos en 28 imágenes eco-cardiográficas, 16 de infantes normales (grupo A) y 12 enfermos (grupo B), a fin de establecer diferencias entre salud y estados patológicos a partir de su comparación con las dimensiones fractales de dos prototipos de normalidad y dos de enfermedad. Resultados: se desarrolló una nueva metodología diagnóstica de aplicación clínica basada en el concepto de "armonía matemática intrínseca", y se halló que las dimensiones fractales de los objetos definidos para un ecocardiograma enfermo presentan similitudes hasta en su cuarta cifra significativa, con lo que se evidencia la posibilidad de seguir la evolución de normalidad a enfermedad. De acuerdo con los cálculos realizados 68,75% de los casos del grupo A podrían tener mejor evaluación con el diagnóstico desarrollado y los enfermos podrían diagnosticarse de modo más efectivo. Conclusiones: las imágenes ecocardiográficas pediátricas pueden caracterizarse de manera objetiva con medidas de dimensión fractal, lo cual permite desarrollar una metodología de diagnóstico clínico de la eco-cardiografía en menores de edad, a partir del concepto de armonía matemática intrínseca. Background and objectives: Geometry allows the objective mathematical characterization of forms. Fractal geometry characterizes irregular objects. The left ventricle dynamical states form observed through echocardiography can be objectively evaluated through fractal dimension measures. Methods: A measurement of fractal dimension was performed using the Box-counting method of three defined objects in 28 echocardiographic images, 16 from normal children (group A) and 12 ill children (group B), in order to establish differences between health and illness from its comparison with the fractal dimensions of 2 normality prototypes and 2 disease prototypes. Results: A new diagnostic, clinical application methodology was developed based in the "intrinsic mathematical harmony" (IMH) concept, and it was observed that the fractal dimensions of the defined objects for an abnormal echocardiogram show similarity to its fourth significant number, thus demonstrating the possibility of following up the evolution
Dinámica probabilista temporal de la epidemia de dengue en Colombia Temporary probabilistic dynamics of the dengue's epidemic in Colombia
Javier Rodríguez Velásquez,Sarith Vitery Erazo,Germán Puerta,Diana Mu?oz
Revista Cubana de Higiene y Epidemiología , 2011,
Abstract: En el estudio de las enfermedades epidémicas se han aplicado diferentes modelos, tanto matemáticos como epidemiológicos, orientados hacia la comprensión y predicción de la dinámica de estos fenómenos. Dichas aproximaciones se fundamentan en la búsqueda de relaciones causales, tales como el clima, la precipitación pluvial, los movimientos poblacionales, entre otros, lo cual dificulta la generalización de dichas predicciones. Partiendo de la construcción de dos espacios de probabilidad que cuantifican el número anual de infectados de dengue en Colombia en rangos de 5 000 y 10 000 infectados y del comportamiento probabilista de casos durante rangos de a os consecutivos, se realizó una predicción temporal del número de casos de dengue en Colombia.El número de casos de dengue predicho para el 2007 se encontró en el rango de 35 000-45 000 y de 37 500-42 500, valores calculados con los rangos de 10 000 y 5 000 respectivamente. Estos valores fueron corroborados con los datos del Instituto Nacional de Salud que corresponde, en la semana epidemiológica 52, a 43 564 casos en Colombia, lo que evidenció una autoorganización matemática de la dinámica de aparición de casos de la epidemia de dengue de carácter predictivo. El estudio de las probabilidades durante la dinámica de la epidemia permite predecir la cantidad de infectados para el 2007 con predicciones simples, directamente comprobables y aplicables, lo cual evita el problema causal de los modelos matemáticos y establece predicciones más fáciles que economizan tiempo y recursos. Studying some epidemical diseases have been applied different models also mathematical like epidemiological, towards understand and predict the dynamical of this phenomena. These methodologies are founded in search for acausal relations, like climate, pluvial precipitation, demographic movements and more, which difficult to generalize these predictions. Starting from the construction of two sample spaces for probability, which quantify the annual infected number of dengue in Colombia in ranges of 5.000 and 10.000 infected, and from the probabilistic behaviour along consecutive group of years, it was made a temporal prediction about cases number of dengue in Colombia. The prediction for infected people for 2007 year was founded in the ranges 35000-45000 and 37500-42500, values calculated with the ranges of 10000 and 5000 respectively. These values ware corroborated with the National Health Institute data, for the accumulate value in the epidemiological week number 52, equals to 43564 cases in Colombia, it was evident a mathematical self-
DIAGNóSTICO MATEMáTICO DE LA MONITORíA FETAL APLICANDO LA LEY DE ZIPF-MANDELBROT Zipf-Mandelbrot law and mathematical approach in fetal cardiac monitoring diagnosis
Javier Rodríguez Velásquez,Signed Prieto Bohórquez,Liliana Ortíz Salamanca,Alejandro Bautista Charry
Revista Facultad de Medicina de la Universidad Nacional de Colombia , 2006,
Abstract: Antecedentes. El actual diagnóstico clínico de la monitoría fetal presenta problemas de objetividad y reproducibilidad, sin embargo el análisis físico y matemático del trazado lleva a caracterizaciones objetivas y reproducibles de la dinámica cardíaca fetal. Objetivo. Desarrollar una nueva metodología diagnóstica de la monitoría fetal aplicando las concepciones de la teoría de sistemas dinámicos y la ley de Zipf-Mandelbrot para evaluar la complejidad del trazado a partir de la aparición de Componentes Dinámicos del Sistema (CDS) Material y métodos. Se evaluaron 50 monitorias de mujeres gestantes divididas en dos grupos: grupo A, 40 gestantes con estados de interés en la práctica clínica durante el desarrollo del embarazo, por ende, diagnosticadas con enfermedades y grupo B, 10 mujeres con embarazo normal. Se definieron cuatro prototipos matemáticos de salud y enfermedad para la evaluación y diagnóstico de cualquier dinámica cardíaca y se evalúo su grado de complejidad aplicando la ley de Zipf-Mandelbrot. Resultados. Un feto sano presenta una autoorganización matemática caracterizada por una dimensión fractal mayor que cero, la ausencia de CDS invertidos pronunciados (CDSiP) y un valor mayor a 12 en la suma de apariciones de CDS con cambios de frecuencias entre 15 y 25 latidos por minuto. La enfermedad se caracteriza por la presencia de uno o más CDSiP o por la pérdida de complejidad en el grupo de CDS de altura 5 ó 10, o por la suma menor de 12 en las apariciones de CDS con alturas entre 15-25 latidos por minuto y por combinaciones de éstos parámetros. De acuerdo a las medidas obtenidas tres de cada diez embarazadas de los grupos A y B tienen un diagnóstico equivocado. Conclusión. Esta es una nueva metodología matemática de evaluación diagnóstica de la dinámica cardíaca fetal; objetiva y reproducible en la práctica clínica diaria. Background. Current clinical diagnosis of fetal monitoring lacks objectivity and reproducibility, nevertheless, physical and mathematical analysis of the tracing can help in the characterization of the fetal cardiac dynamics, obtaining by these way reproducible measurements. Objective. To develop a new diagnostic methodology of the fetal monitoring applying the dynamical systems conceptions and the Zipf-Mandelbrot law to evaluate the tracing complexity, starting of the Dynamical Components of the Systems (DSC) apparition. Materials and methods. We evaluated a set of 50 monitoring tests from pregnant women divided in two groups: group A, 40 women with abnormal pregnancy, and group B, 10 with normal pregnancy. Four mathematical p
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