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Search Results: 1 - 10 of 2094 matches for " Javed Iqbal "
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Transthyretin—A Key Gene Involved in Regulating Learning and Memory in Brain, and Providing Neuroprotection in Alzheimer Disease via Neuronal Synthesis of Transthyretin Protein  [PDF]
Javed Iqbal
Journal of Behavioral and Brain Science (JBBS) , 2018, DOI: 10.4236/jbbs.2018.82005
Abstract: Transthyretin (TTR), a carrier protein present in the liver and choroid plexus of the brain, has been shown to be responsible for binding thyroid hormone thyroxin (T4) and retinol in plasma and cerebrospinal fluid (CSF). TTR aids in sequestering of beta-amyloid peptides Aβ deposition, and protects the brain from trauma, ischemic stroke and Alzheimer disease (AD). Accordingly, hippocampal gene expression of TTR plays a significant role in learning and memory as well as in simulation of spatial memory tasks. TTR via interacting with transcription factor CREB regulates this process and decreased expression leads to memory deficits. By different signaling pathways, like MAPK, AKT, and ERK via Src, TTR provides tropical support through megalin receptor by promoting neurite outgrowth and protecting the neurons from traumatic brain injury. TTR is also responsible for the transient rise in intracellular Ca2+ via NMDA receptor, playing a dominant role under excitotoxic conditions. In this review, we tried to shed light on how TTR is involved in maintaining normal cognitive processes, its role in learning and memory, under memory deficit conditions; by which mechanisms it promotes neurite outgrowth; and how it protects the brain from Alzheimer disease (AD).
The Professional Medical Journal , 2004,
Abstract: Objective: To determine incidence of different causes of upperGastrointestinal (UGI) bleeding in reference to UGI endoscopy in one hundred patients and to comparethe results with similar studies conducted globally. Design: Prospective, comparative study. Place andduration of Study: The department of medicine, Combined Military Hospital Peshawar during theperiod of one year from June 2002 to June 2003. Patients and Methods: First consecutive one hundredpatients were selected with symptoms and signs of UGI bleeding and endoscopy was performed within48 hours of start of symptoms. Results of the study were compared with similar studies conducted atother centers in Pakistan and abroad. Results: Major cause of UGI bleeding was found to be esophagealvarices (39%) followed by duodenal ulcer (19%), gastric ulcer (9%), superficial mucosal lesion (20%),neoplasia (4%). In 9% patients no cause of UGI bleeding was found on endoscopy. Conclusion: Majorcause of UGI bleeding in our set up is esophageal varices while peptic ulcer is less common comparedwith western world. This reflects high prevalence of chronic liver disease due to viral hepatitis.
The Professional Medical Journal , 2009,
Abstract: All the conventional scabicidal drugs are used topically and have poor compliance. In several reports and studies, ivermectin, an oral antiparasitic drug, has been shown to be an effective scabicide without any major side effect. Objective: To evaluate the efficacy and safety of oral ivermectin in the treatment of scabies. Design: An open, randomized clinical trial (convenience sampling). Settings: Dermatology Department, Divisional Headquarters (DHQ) and Allied Hospitals, Punjab Medical College, Faisalabad, Pakistan, from 1st September 2002 to 28th February 2003. Material and methods: The study comprised of 100 outdoor patients of scabies, 5-60 years of age, diagnosed on history, clinical examination and light microscopy. They and their affected family members were given a single oral dose of ivermectin 200 g /kg body weight. Patients were followed up at intervals of 1, 2, 4 and 8 weeks. Results: Fifty-seven patients (57%) had complete recovery at 2 weeks whereas 93 patients (93%) had complete recovery at 4 weeks. Seven (7%) failure cases were given a second dose all of which had complete recovery at 8 weeks. No patient developed any major adverse effect. Blood, urine examinations and liver function tests did not show any significant abnormality. Conclusion: Oral ivermectin, in a single dose of 200 g/kg body weight, was effective and safe in the treatment of scabies and could be a useful substitute to conventional topical antiscabietics. However further large scale studies are required to further evaluate its safety.
Production of Carbon Nanotubes by Different Routes-A Review  [PDF]
Muhammad Musaddique Ali Rafique, Javed Iqbal
Journal of Encapsulation and Adsorption Sciences (JEAS) , 2011, DOI: 10.4236/jeas.2011.12004
Abstract: Carbon Nanotubes are one the most important materials of future. Discovered in 1991, they have reached a stage of attracting the interests of many companies world wide for their large scale production. They possess remarkable electrical, mechanical, optical, thermal and chemical properties, which make them a perfect “fit” for many engineering applications. In this paper various methods of production of carbon nanotubes are discussed outlining their capabilities, efficiencies and possible exploitation as economic large scale production methods. Chemical vapor disposition (CVD) is proposed as a potential method for economic large scale production of carbon nanotubes due to its relative simplicity of operation, process control, energy efficiency, raw materials used, capability to scale up as large unit operation, high yield and purity.
Muhammad Javed Iqbal
The Professional Medical Journal , 1998,
Abstract: OBJECTIVE: To highlight the mortality in various groups of acute myocardial infarction. DESIGN:Retrospective study. SETTING: Coronary care Unit DHQ Hospital Faisalabad.PERIOD: January 1995to December 1995.PATIENTS AND METHODS: Total number of patients were 275, males 223, female52. Mean age was 54.85 ± 13.57 years, mean age of males was 53.52 ± 13.61 and for females 60.55 ± 11.91years. Presented with typical chest pain of Ischaemic heart disease for more than 30 minutes. Diagnosed byhistory, physical examination, 12 lead electrocardiography and ride of cardiac enzymes. RESULTS: Fromthe 275 patients, 102 were from inferior wall, 109 from anteroseptal and 64 were from extensive anteriorwall myocardial infarction. Forty two (15%) patients expired during hospital stay, 13(12.74%), 14(12.80%)patients expired from inferior, anteroseptal and extensive anterior wall myocardial infarction respectively.CONCLUSIONS: Mortality associated with acute anteroseptal MI and extensive anterior wall myocardialinfarction was significantly higher, so these patients be monitored and managed more aggressively.
The Challenges to Political Stability in Pakistan (1947-2012)
Zafar Iqbal Javed
International Journal of Asian Social Science , 2012,
Abstract: Political stability is a valve of any government. If the valve is closed, a government is blocked. Pakistan came into existence on the bases of two-nation theory. Quiad -i- Azam wanted Pakistan to be a democratic state whereas all citizens enjoyed equal rights with out any discrimination. After the death of Quaid -i- Azam and the assassination of Liaquat Ali Khan, the Pakistan Muslim League and its successors had lost its prestige among the people that promoted the culture of palace intrigues, intimidation, squabbling and chair-politics. The governor-generals with the annexes of military-bureaucratic establishment dominated in decision-making process. The breaking and formulation of the governments were started that initiated the military to take over. The military governments introduced various forms of government. Moreover, to achieve economic and military assistance from USA military adopted some suicidal policies. The civilians and military regimes badly failed to address the main challenges (the role of Islam in politics, center-provinces relations, division of powers, sovereign parliament, free and fair elections, transparency and a comprehensive accountability of corrupt politicians) to political stability in Pakistan.
Life Long Education: A Conceptual Debate
Muhammad Javed Iqbal
Seminar.net , 2009,
Abstract: This paper deals with the nature of a concept of lifelong education. Lifelong education can be provided through informal, formal and non-formal education processes. Hence, lifelong education can be defined as a process of both deliberate and unintentional opportunities influencing learning throughout one’s life span. Dimensions of lifelong education have also been detailed along with its goals. Pre-requisites of lifelong education, concept of integration, flexibility and diversity and lifelong education as a master concept are also given due consideration.
Optimizing Plant Density Cum Weed Control Method For Puccinial Rust Management and Yield in Garlic
Shabeer Ahmad,Javed Iqbal
Asian Journal of Plant Sciences , 2002,
Abstract: Seven different plant densities ( 0.44, 0.53, 0.67, 0.8, 1.0, 1.3 and 2.0 million plants ha-1) and two weed control methods (manual and chemical), compared with no weeding as control, were evaluated in different combinations to find the best interaction for effective rust control and high production in garlic. The lowest value (65.33) of area under disease progress curve (AUDPC) was recorded in treatment where plant population @ 1 million ha-1 and hand weeding were used. Yield (14 t ha-1) and bulb index (4.6 cm) in this treatment were statistically at par with their respective highest values indicating that its performance was better than other treatments in rust control and garlic yield.
Impact of Trade Openness on Output Growth for pakistan: An Empirical Investigation
Aamir Hussain Siddiqui,Javed Iqbal
Market Forces , 2005,
Muhammad Javed Iqbal,Mumtaz Ahmad
The Turkish Online Journal of Distance Education , 2010,
Abstract: Education is the driving force for economic and social development in any country. Considering this, it is necessary to find ways to make quality education, accessible and affordable to all, using the latest technology available. Unfortunately, Pakistan has not been able to take advantage of the possibilities offered by e-learning. Major reasons for this are institutional and technical infrastructure, culture, computer literacy and access. Although government’s commitment to promote e-learning in the country is encouraging and initiatives such as the establishment of the Virtual University (VU) are commendable, Pakistan has yet to go a long way in reaching the unique socio-economic benefits of e-learning. Allama Iqbal Open University is providing ‘Education for All’ through distance education from basic (functional) literacy to higher education (PhD) level. The aim of this paper is to present the case study of Allama Iqbal Open University in accordance with the strategies and adoption of e-learning. This case study focuses on different dimensions including concept and rational of e-learning, its significance and quality education, efforts made by Allama Iqbal Open University for the enhancing quality of education through e-learning.
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