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Search Results: 1 - 10 of 46042 matches for " Jau-Ching Wu "
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Academic Impact of a Public Electronic Health Database: Bibliometric Analysis of Studies Using the General Practice Research Database
Yu-Chun Chen, Jau-Ching Wu, Ingo Haschler, Azeem Majeed, Tzeng-Ji Chen, Thomas Wetter
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021404
Abstract: Background Studies that use electronic health databases as research material are getting popular but the influence of a single electronic health database had not been well investigated yet. The United Kingdom's General Practice Research Database (GPRD) is one of the few electronic health databases publicly available to academic researchers. This study analyzed studies that used GPRD to demonstrate the scientific production and academic impact by a single public health database. Methodology and Findings A total of 749 studies published between 1995 and 2009 with ‘General Practice Research Database’ as their topics, defined as GPRD studies, were extracted from Web of Science. By the end of 2009, the GPRD had attracted 1251 authors from 22 countries and been used extensively in 749 studies published in 193 journals across 58 study fields. Each GPRD study was cited 2.7 times by successive studies. Moreover, the total number of GPRD studies increased rapidly, and it is expected to reach 1500 by 2015, twice the number accumulated till the end of 2009. Since 17 of the most prolific authors (1.4% of all authors) contributed nearly half (47.9%) of GPRD studies, success in conducting GPRD studies may accumulate. The GPRD was used mainly in, but not limited to, the three study fields of “Pharmacology and Pharmacy”, “General and Internal Medicine”, and “Public, Environmental and Occupational Health”. The UK and United States were the two most active regions of GPRD studies. One-third of GRPD studies were internationally co-authored. Conclusions A public electronic health database such as the GPRD will promote scientific production in many ways. Data owners of electronic health databases at a national level should consider how to reduce access barriers and to make data more available for research.
Intervertebral Disc Rehydration after Lumbar Dynamic Stabilization: Magnetic Resonance Image Evaluation with a Mean Followup of Four Years
Li-Yu Fay,Jau-Ching Wu,Tzu-Yun Tsai,Tsung-Hsi Tu,Ching-Lan Wu,Wen-Cheng Huang,Henrich Cheng
Advances in Orthopedics , 2013, DOI: 10.1155/2013/437570
Abstract: Objective. To compare the clinical and radiographic outcomes in patients of different ages who underwent the Dynesys stabilization. Methods. This retrospective study included 72 patients (mean age 61.4 years) with one- or two-level lumbar spinal stenosis who underwent laminectomy and the Dynesys (Zimmer Spine, Minneapolis) dynamic stabilization system. Thirty-seven patients were younger than 65-year old while the other 35 were older. Mean followup was 46.7 months. Pre- and postoperative radiographic and clinical evaluations were analyzed. Results. The mean calibrated disc signal (CDS) at the index level was significantly improved from preoperatively to postoperatively ( ). Screw loosening occurred in 22.2% of patients and 5.1% of screws. The improvement in CDS at index level was seen to be significant in younger patients but not in older patients. Overall, the mean visual analogue scale (VAS) of back pain, VAS of leg pain, and the Oswestry disability index (ODI) scores improved significantly after operation. There were no significant differences in pre- and postoperative VAS and ODI and screw loosening rates between the younger and older patients. Conclusions. There is significant clinical improvement after laminectomy and dynamic stabilization for symptomatic lumbar spinal stenosis. Intervertebral disc rehydration was seen in younger patients. 1. Introduction Instrumented spinal fusion is the treatment of choice for degenerative spondylosis with instability refractory to conservative treatment [1, 2]. Spine surgeons have also used modern biologics such as recombinant human bone morphogenetic protein-2 to increase the rate of spinal fusion in selected patients [3–7]. However, using biologics to enhance spinal fusion has been sometimes reported with complications postoperatively and during followup. Moreover, even autograft has been repeatedly reported with adverse events, such as donor site morbidity. Not to mention that loss of segmental motion and subsequent adjacent segmental degeneration have also been concerned for the spinal fusion surgery [8–10]. In the recent years, there is the emerging option of dynamic stabilization to spare spinal fusion and still yield satisfactory outcomes in the surgical management of lumbar spondylosis and back pain. Fischgrund and colleagues reported application of the Dynesys (Zimmer Spine, Minneapolis, USA), a pedicle-based lumbar dynamic stabilization system, as an effective alternative to treat lumbar spondylosis in 1994 [11–16]. Theoretically Dynesys can unload the intervertebral disc while providing a restricted
The Risk of Stroke after Percutaneous Vertebroplasty for Osteoporosis: A Population-Based Cohort Study
Ching-Lan Wu, Jau-Ching Wu, Wen-Cheng Huang, Hung-Ta H. Wu, Hong-Jen Chiou, Laura Liu, Yu-Chun Chen, Tzeng-Ji Chen, Henrich Cheng, Cheng-Yen Chang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031405
Abstract: Purpose To investigate the incidence and risk of stroke after percutaneous vertebroplasty in patients with osteoporosis. Methods A group of 334 patients with osteoporosis, and who underwent percutaneous vertebroplasty during the study period, was compared to 1,655 age-, sex- and propensity score-matched patients who did not undergo vertebroplasty. All demographic covariates and co-morbidities were deliberately matched between the two groups to avoid selection bias. Every subject was followed-up for up to five years for stroke. Adjustments using a Cox regression model and Kaplan-Meier analyses were conducted. Results A total of 1,989 osteoporotic patients were followed up for 3,760.13 person-years. Overall, the incidence rates of any stroke, hemorrhagic stroke and ischemic stroke were 22.6, 4.2 and 19.6 per 1,000 person-years, respectively. Patients who underwent vertebroplasty were not more likely to have any stroke (crude hazard ratio = 1.13, p = 0.693), hemorrhagic stroke (HR = 2.21, p = 0.170), or ischemic stroke (HR = 0.96, p = 0.90). After adjusting for demographics, co-morbidities and medications, the vertebroplasty group had no significant difference with the comparison group in terms of any, hemorrhagic and ischemic strokes (adjusted HR = 1.22, 3.17, and 0.96, p = 0.518, 0.055, and 0.91, respectively). Conclusions Osteoporotic patients who undergo percutaneous vertebroplasty are not at higher risk of any stroke in the next five years after the procedure.
Age, Sex, and Socio-Economic Status Affect the Incidence of Pediatric Spinal Cord Injury: An Eleven-Year National Cohort Study
Li-Chien Chien, Jau-Ching Wu, Yu-Chun Chen, Laura Liu, Wen-Cheng Huang, Tzeng-Ji Chen, Peck-Foong Thien, Su-Shun Lo, Henrich Cheng
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039264
Abstract: Background Few studies focus on pediatric spinal cord injury (SCI) and there is little information regarding the cause, anatomic level, and high risk population of SCI in children. This study aims to investigate the incidence and risk factors of pediatric SCI. Methods A nationwide cohort of 8.7 million children aged<18 years in an 11-year period was analyzed for causes, age at injury, anatomic sites, disability, and familial socio-economic factors. Incidence rates and Cox regression analysis were conducted. Results A total of 4949 SCI patients were analyzed. The incidence rates of cervical, thoracic, lumbar, and other SCI were 4.06, 0.34, 0.75, and 0.85 per 100,000 person-years, respectively. The proportional composition of gender, age, and socio-economic status of SCI patients were significantly different than those of non-SCI patients (all p<0.001). Male children were significantly more likely to have SCI than females in both the cervical and the other SCI groups [Incidence rate ratio (IRR) = 2.03 and 1.52; both p<0.001]. Young adults and teenagers were also significantly more likely to have SCI than pre-school age children in the cervical SCI (IRR = 28.55 and 10.50, both p<0.001) and other SCI groups (IRR = 18.8 and 7.47, both p<0.001). Children in families of lower socio-economic status were also significantly more likely to have SCI (p<0.05). Conclusions In the pediatric population, the overall SCI incidence rate is 5.99 per 100,000 person-years, with traumatic cervical SCI accounting for the majority. The incidence rate increases abruptly in male teenagers. Gender, age, and socio-economic status are independent risk factors that should be considered.
State Derivation of a 12-Axis Gyroscope-Free Inertial Measurement Unit
Jau-Ching Lu,Pei-Chun Lin
Sensors , 2011, DOI: 10.3390/s110303145
Abstract: The derivation of linear acceleration, angular acceleration, and angular velocity states from a 12-axis gyroscope-free inertial measurement unit that utilizes four 3-axis accelerometer measurements at four distinct locations is reported. Particularly, a new algorithm which derives the angular velocity from its quadratic form and derivative form based on the context-based interacting multiple model is demonstrated. The performance of the system was evaluated under arbitrary 3-dimensional motion.
Secretome-Based Identification of ULBP2 as a Novel Serum Marker for Pancreatic Cancer Detection
Ya-Ting Chang,Chih-Ching Wu,Yi-Ming Shyr,Tse-Ching Chen,Tsann-Long Hwang,Ta-Sen Yeh,Kai-Ping Chang,Hao-Ping Liu,Yu-Ling Liu,Ming-Hung Tsai,Yu-Sun Chang,Jau-Song Yu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0020029
Abstract: To discover novel markers for improving the efficacy of pancreatic cancer (PC) diagnosis, the secretome of two PC cell lines (BxPC-3 and MIA PaCa-2) was profiled. UL16 binding protein 2 (ULBP2), one of the proteins identified in the PC cell secretome, was selected for evaluation as a biomarker for PC detection because its mRNA level was also found to be significantly elevated in PC tissues.
Neuronal Function and Dysfunction of Drosophila dTDP
Meng-Jau Lin, Ching-Wei Cheng, C.-K. James Shen
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0020371
Abstract: Background TDP-43 is an RNA- and DNA-binding protein well conserved in animals including the mammals, Drosophila, and C. elegans. In mammals, the multi-function TDP-43 encoded by the TARDBP gene is a signature protein of the ubiquitin-positive inclusions (UBIs) in the diseased neuronal/glial cells of a range of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-U). Methodology/Principal Findings We have studied the function and dysfunction of the Drosophila ortholog of the mammalian TARDBP gene, dTDP, by genetic, behavioral, molecular, and cytological analyses. It was found that depletion of dTDP expression caused locomotion defect accompanied with an increase of the number of boutons at the neuromuscular junctions (NMJ). These phenotypes could be rescued by overexpression of Drosophila dTDP in the motor neurons. In contrast, overexpression of dTDP in the motor neurons also resulted in reduced larval and adult locomotor activities, but this was accompanied by a decrease of the number of boutons and axon branches at NMJ. Significantly, constitutive overexpression of dTDP in the mushroom bodies caused smaller axonal lobes as well as severe learning deficiency. On the other hand, constitutive mushroom body-specific knockdown of dTDP expression did not affect the structure of the mushroom bodies, but it impaired the learning ability of the flies, albeit moderately. Overexpression of dTDP also led to the formation of cytosolic dTDP (+) aggregates. Conclusion/Significance These data together demonstrate the neuronal functions of dTDP, and by implication the mammalian TDP-43, in learning and locomotion. The effects of mis-expression of dTDP on Drosophila NMJ suggest that eukaryotic TDP-43 guards against over development of the synapses. The conservation of the regulatory pathways of functions and dysfunctions of Drosophila dTDP and mammalian TDP-43 also shows the feasibility of using the flies as a model system for studying the normal TDP-43 function and TDP-43 proteinopathies in the vertebrates including human.
Improvement of Fixing Problems in Lin et al.`s OSPA Protocol
Jau-Ji Shen,Ching-Ying Lin,Hung-Wen Yang
Journal of Applied Sciences , 2006,
Abstract: Recently, Yoon et al. proposed an improved scheme to solve the problems of replay attack and denial of service attack in the Lin et al.`s OSPA scheme. Their scheme can simply update user password, provides mutual authentication between the user and remote server and has more efficient performance by reducing the number of hash operations. In this study, an improved scheme is shown to be vulnerable to the insider attack and smart card loss problem and propose an enhancement of the protocol to solve these problems.
Cryptanalysis of a New Efficient MAKEP for Wireless Communications
Jau-Ji Shen,Ching-Ying Lin,Hung-Wen Yang
International Journal of Network Security , 2005,
Abstract: In 2001, Wong and Chan proposed two mutual authentication and key exchange protocols (MAKEP) for low power wireless communications, which were suitable for establishing secure communications between a low-power wireless device and a powerful base station. Unfortunately, Shim pointed out Wong and Chan's schemes were incurred the unknown key-shared attack, then he proposed an improved scheme to overcome this weakness. Later, Jan and Chen found that the improved scheme was vulnerable to the man-in-the-middle attack. Then, they also proposed a new efficient MAKEP in spirit of Girault's method to withstand the above weakness. However, in this paper, we shall show that Jan and Chen's scheme suffered from the forgery attack and the man-in-the-middle attack.
Reproducible Hepatic Dysfunction Following Separate Anesthesia with Sevoflurane and Desflurane
Peter Chi-Ho Chung,Shyh-Ching Chiou,Jau-Min Lien,Allen H. Li
Chang Gung Medical Journal , 2003,
Abstract: Both desflurane and sevoflurane have individually been reported to induce hepatic dysfunction;however hepatic dysfunction after administration of both of them separately in asingle patient has not previously been reported. As their metabolites differ in nature, weconsidered that it would be unlikely that their combined use would cause sensitization andinduce hepatic dysfunction. We report on the first patient with reproducible liver dysfunctionafter sevoflurane and desflurane. This 54-year-old man sequentially received 3 anestheticsover a 1-year period. The first anesthetic was isoflurane, and the course wasuneventful. The second anesthetic was sevoflurane, and this resulted in fever with chills andelevated aspartate aminotransferase (543 U/l) 17 days later. The third anesthetic was desfluranewhich resulted in a similar clinical picture after 17 days. The symptoms improved, andthe serum transaminase level returned to normal after conservative therapy. The similartime interval between the operation date and the onset of hepatic dysfunction, after excludingother possibilities, made us highly suspicious that the hepatic dysfunction was inducedby sevoflurane on 1 occasion and desflurane on the other. We suggest that inhaled anestheticsshould be totally replaced by intravenous anesthetics for future operations in patientswith such a diagnosis.
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