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Search Results: 1 - 10 of 192512 matches for " Janet G Shaw "
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Genetic influences on right ventricular systolic pressure (RVSP) in chronic obstructive pulmonary disease (COPD)
Janet G Shaw, Annette G Dent, Linda H Passmore, Darryl J Burstow, Rayleen V Bowman, Paul V Zimmerman, Kwun M Fong, Ian A Yang
BMC Pulmonary Medicine , 2012, DOI: 10.1186/1471-2466-12-25
Abstract: In patients with COPD, we genotyped 7 SNPs in 6 candidate PH genes (NOS3, ACE, EDN1, PTGIS, SLC6A4, VEGFA). We tested for association with right ventricular systolic pressure (RVSP), spirometry and gas transfer, and hypoxemia.580 COPD patients were recruited, 341 patients had a transthoracic echocardiogram, with RVSP measurable in 278 patients (mean age 69?years, mean FEV1 50% predicted, mean RVSP 44?mmHg, median history of 50 pack-years). Of the 7 tested SNPs, the NOS3-VNTR polymorphism was significantly associated with RVSP in a dose-dependent fashion for the risk allele: mean RVSP for a/a and a/b genotypes were 52.0 and 46.6?mmHg respectively, compared to 43.2?mmHg for b/b genotypes (P?=?0.032). No associations were found between RVSP and other polymorphisms. ACE II or ID genotypes were associated with a lower FEV1% predicted than the ACE DD genotype (P?=?0.028). The NOS3-298 TT genotype was associated with lower KCO % predicted than the NOS3-298 GG or GT genotype (P?=?0.031).The NOS3-VNTR polymorphism was associated with RVSP in patients with COPD, supporting its involvement in the pathogenesis of PH in COPD. ACE and NOS3 genotypes were associated with COPD disease severity, but not with the presence of PH. Further study of these genes could lead to the development of prognostic and screening tools for PH in COPD.Pulmonary hypertension (PH) is a serious complication of chronic obstructive pulmonary disease (COPD) and develops in 30% to 70% of patients with COPD, increasing their morbidity and mortality [1]. PH is progressive in COPD, with mean pulmonary arterial pressure increasing over time [2,3]. Understanding variations in susceptibility to PH in patients with COPD could significantly enhance diagnosis, risk stratification and therapy for these patients.Vascular remodelling is the main pathological feature in PH and is mediated via vasoactive molecules [4]. Genes encoding these mediators contain genetic polymorphisms that potentially affect their function and
Jacobi evolution of structure functions: convergence and stability
G. Shaw
Physics , 1999, DOI: 10.1016/S0375-9474(00)00219-0
Abstract: The Jacobi evolution method has been widely used in the QCD analysis of structure function data. However a recent paper claims that there are serious problems with its convergence and stability. Here we briefly review the evidence for the adequate convergence of the method; and show that there are errors in the above paper which undermine its conclusions.
Introduction to Diffractive Photoprocesses
G. Shaw
Physics , 2000, DOI: 10.1063/1.1402820
Abstract: The objectives of my talk are to provide a very brief introduction to diffractive photoprocesses in general and the colour dipole model in particular; and to comment on possible gluon saturation effects at HERA and beyond.
Physical activity and dietary behaviors of health clinic workers trying to lose weight  [PDF]
Tan Leng Goh, Trever Ball, Janet M. Shaw, James C. Hannon
Health (Health) , 2012, DOI: 10.4236/health.2012.48079
Abstract: Health clinic workers are potential agents of change for weight loss to patients, yet their behaviors are not well known. This study examined physical activity (PA) levels and dietary habits of health clinic workers who were and who were not trying to lose weight. Participants were 64 community health clinic workers (58 females and 6 males). Moderate-to-vigorous intensity (MVI) time spent in PA was assessed by triaxial accelerometry over 7 consecutive days. Dietary habits and weight loss efforts were determined by a food frequency questionnaire. Differences in MVI and nutrition variables were assessed by One-way ANOVA, comparing those trying to lose weight and those not trying to lose weight. 48 out of 64 health clinic workers (approximately 75%) indicated that they were currently trying to lose weight. There were significant differences (p < 0.05) in Body Mass Index (BMI), daily energy (Kcal) and fat (g) intake between those trying to lose weight and those not trying to lose weight. There were no significant differences in MVI, daily sugar intake (g), vegetable and fruit servings, and daily fiber intake (g) between groups. Health clinic workers trying to lose weight appear to be engaging in some appropriate dietary but not PA behaviors.
[Diphenyldi(pyrazol-1-yl)methane]dinitratocobalt(II)
Janet L. Shaw,Bruce C. Noll
Acta Crystallographica Section E , 2010, DOI: 10.1107/s1600536810000565
Abstract: In the title compound, [Co(NO3)2(C19H16N4)], the diphenyldipyrazolylmethane ligand coordinates to CoII in a bidentate fashion forming a six-membered ring with an approximate boat configuration. The mean planes of the two pyrazolyl rings are separated by an angle of 39.6 (2)°. The coordination at the CoII center is best described as distorted octahedral with two NO3 anions serving as bidentate ligands for charge balance. The dihedral angle between the mean planes of the two nitrate rings is 85.0 (1)° and that between the mean planes of the two phenyl rings is 73.7 (1)°. The crystal structure is stabilized by weak intermolecular C—H...O and intramolecular C—H...N hydrogen-bond interactions.
From Deep Inelastic Scattering to Photoproduction: A Unified Approach
G. Kerley,G. Shaw
Physics , 1997, DOI: 10.1103/PhysRevD.56.7291
Abstract: The strikingly different high energy behaviours of real photoabsorption cross-sections with Q^2 = 0 and the low x proton structure function at large Q^2 are studied from a laboratory frame viewpoint, in which the x and Q^2 dependence reflects the space-time structure of the interaction. This is done using a simple model which incorporates hadron dominance, but attributes the striking enhancement observed at HERA at very low x and high Q^2 to contributions from heavy long-lived fluctuations of the incoming photon. Earlier published predictions of the model for the then unknown behaviour of the structure function at small x and intermediate Q^2 are shown to be strikingly confirmed by recent experimental data. A simultaneous analysis of real photoabsorption data and structure function data for 0 <= x < 0.1 and 0 <= Q^2 <= 15 GeV^2 is then reported. An excellent fit is obtained, with all parameters in the restricted ranges allowed by other physical requirements.
Nuclear shadowing and rho photoproduction
A. Pautz,G. Shaw
Physics , 1997, DOI: 10.1103/PhysRevC.57.2648
Abstract: Rho photoproduction on complex nuclei is re-examined using a generalised vector dominance model which succesfully predicts the observed nuclear shadowing in real photoabsorption and deep inelastic scattering. This model is shown to give a good fit to rho photoproduction data on both nucleons and complex nuclei, in which the well-known disagreement between the measured gamma-rho coupling and the gamma-rho coupling required by the simple vector dominance model is eliminated. The rho N total cross-sections required are similar to those predicted by the additive quark model; and the magnitude of the correction to simple vector dominance is consistent with that inferred from the analysis of real photoabsorption and deep inelastic scattering.
The 2012 and 2014 Olympic Doping Scandals: A Critical Analysis of the Effectiveness of Anti-Doping Mechanisms in Sports Law and the Necessity of Global Unity and Rehabilitation in Enforcing Anti-Doping Measures  [PDF]
Anthony G. A. Shaw
Beijing Law Review (BLR) , 2019, DOI: 10.4236/blr.2019.104038
Abstract: This paper critically assesses the effectiveness of Olympic anti-doping measures, will consider the way in which the difficulties inherent in the detection of doping may cause infringements on rule of law principles, and discusses approaches to further encourage a mutually beneficial global culture of cooperation and compliance between nations, which must serve as the fundamental basis for the modern development of anti-doping practices. This paper further highlights how the positive steps Russian bodies have taken in response to this scandal and the tangible improvements made to their regulation of doping behaviors are a positive indicator of sports law’s capacity to enact change. Moreover, this paper will argue that an approach to anti-doping that seeks to rehabilitate and encourage positive behaviors is ultimately necessary to ensure international sport’s role in peacefully facilitating international cooperation, as approaches that vilify and permanently ostracize states that have been found in violation of anti-doping laws are ultimately ineffective at facilitating compliance.
Regulating the Pollution of Queensland’s Waterways from Natural Resource Extraction: Potential Pathways to Law Reform Inspired by Recent Chinese Developments in Environmental Law  [PDF]
Anthony G. A. Shaw
Beijing Law Review (BLR) , 2019, DOI: 10.4236/blr.2019.104039
Abstract: This research paper critically evaluates the status of natural resources law in Australia in relation to its capacity to disincentivize the capacity for mining and natural resource extraction related activities to pollute essential water sources. This paper articulates the historical development of the law protecting waterways from pollution within Australia and Queensland and identifies the deficiencies in this development. This paper then investigates mechanisms for improving the capacity of the law to incentivize environmentally sound practices from groups that carry out natural resource extraction. This topic warrants investigation due to the vital nature of water for sustainable growth and development in Queensland, particularly with Australia and Queensland’s dependence on waterways such as the Murray-Darling basin for agricultural and ecological sustainability. This paper investigates the complicated relationship between the necessity of water for facilitating mining infrastructure projects such as coal seam gas extraction, alongside the potential for waterways to become polluted through these processes and negatively impact the livelihood of local populations. This research looks toward jurisdictions who have recently made law reform attempts to address similar issues relating to pollutants from mining practices in waterways such as the recent reforms made by the People’s Republic of China. In studying these reforms, this paper critically assesses the capacity for these law reforms to provide solutions to address pollution caused by natural resource extraction in Australian waterways.
Transforming scientific evidence into better consumer choices
Janet G Bauer,Francesco Chiappelli
Bioinformation , 2011,
Abstract: Translational research using evidence-based and comparative effectiveness research continues to evolve, becoming a useful tool in improving informed consent and decision-making in the clinical setting. While in development, emerging technologies, including cellular and molecular biology, are leading to establishing evidence-based dental practices. One emerging technology, which conjoins bench proteomic findings to clinical decision-making for treatment intervention, is the Translational Evidence Mechanism. This mechanism was developed to be a foundation for a compact between researcher, translational researcher, clinician, and patient. The output of such a mechanism is the clinical practice guideline (CPG), an interactive tool for dentists and patients to game evidence in reaching optimum clinical decisions that correspond to individual patient preferences and values. As such, the clinical practice guideline requires the vesting of decision, utility, and cost best evidence. Evidence-based research provides decision data, a first attempt at supporting decision-making by providing best outcome data. Since then comparative effectiveness research has emerged, using systematic review analysis to compare similar treatments or procedures in maximizing the choice of the most effective cost/benefit option within the context of best evidence. With innovation in the clinical practice guideline for optimizing efficacy and comparative effectiveness research, evidence-based practices will shape a new approach to health-based systems that adhere to shared decision-making between bench scientists, healthcare providers and patients.
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