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Search Results: 1 - 10 of 6051 matches for " Jane Lindschou Hansen "
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The Effect of Interpersonal Psychotherapy and other Psychodynamic Therapies versus ‘Treatment as Usual’ in Patients with Major Depressive Disorder
Janus Christian Jakobsen,Jane Lindschou Hansen,Erik Simonsen,Christian Gluud
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019044
Abstract: Major depressive disorder afflicts an estimated 17% of individuals during their lifetimes at tremendous suffering and costs. Interpersonal psychotherapy and other psychodynamic therapies may be effective interventions for major depressive disorder, but the effects have only had limited assessment in systematic reviews.
The Effects of Cognitive Therapy versus ‘No Intervention’ for Major Depressive Disorder
Janus Christian Jakobsen,Jane Lindschou Hansen,Ole Jakob Storeb?,Erik Simonsen,Christian Gluud
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0028299
Abstract: Major depressive disorder afflicts an estimated 17% of individuals during their lifetimes at tremendous suffering and costs. Cognitive therapy may be an effective treatment option for major depressive disorder, but the effects have only had limited assessment in systematic reviews.
The Effects of Cognitive Therapy Versus ‘Treatment as Usual’ in Patients with Major Depressive Disorder
Janus Christian Jakobsen,Jane Lindschou Hansen,Ole Jakob Storeb?,Erik Simonsen,Christian Gluud
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0022890
Abstract: Major depressive disorder afflicts an estimated 17% of individuals during their lifetimes at tremendous suffering and costs. Cognitive therapy may be an effective treatment option for major depressive disorder, but the effects have only had limited assessment in systematic reviews.
Relationship between Adaptive Capability and Strategic Orientation: An Empirical Study in a Brazilian Company  [PDF]
Cristiano Kaehler, Franciele Busatto, Grace V. Becker, Peter Bent Hansen, Jane Lucia S. Santos
iBusiness (IB) , 2014, DOI: 10.4236/ib.2014.61001
Abstract:

The main purpose of this article is to examine the relationship between adaptive capability and strategic orientations in the organizational context. In order to achieve this, an empirical study was carried out in a Brazilian agency for maritime services, via a survey of 160 employees. The results show a positive correlation between all of the strategic orientation variables and their respective adaptive capability. That is, the findings show that the company’s strategic orientations affect its adaptive capability, and also suggest that the stronger the respondents’ perception of the companys dynamic capability, the higher its organizational adaptive capability in its market of operation.

A semiparametric spatio-temporal model for solar irradiance data
Joshua Patrick,Jane Harvill,Clifford Hansen
Statistics , 2015,
Abstract: Design and operation of a utility scale photovoltaic (PV) power plant depends on accurate modeling of the power generated, which is highly correlated with aggregate solar irradiance on the plant's PV modules. At present, aggregate solar irradiance over the area of a typical PV power plant cannot be measured directly. Rather, irradiance measurements are typically available from a few, relatively small sensors and thus aggregate solar irradiance must be estimated from these data. As a step towards finding more accurate methods for estimating aggregate irradiance from avaialble measurements, we evaluate semiparametric spatio-temporal models for global horizontal irradiance. Using data from a 1.2 MW PV plant located in Lanai, Hawaii, we show that a semiparametric model can be more accurate than simple intepolation between sensor locations. We investigate spatio-temporal models with separable and nonseparable covariance structures and find no evidence to support assuming a separable covariance structure.
The Hand Eczema Trial (HET): design of a randomised clinical trial of the effect of classification and individual counselling versus no intervention among health-care workers with hand eczema
Kristina Ibler, Tove Agner, Jane Hansen, Christian Gluud
BMC Dermatology , 2010, DOI: 10.1186/1471-5945-10-8
Abstract: We describe the design of a randomised clinical trial to investigate the effects of classification of hand eczema plus individual counselling versus no intervention. The trial includes health-care workers with hand eczema identified from a self-administered questionnaire delivered to 3181 health-care workers in three Danish hospitals. The questionnaire identifies the prevalence of hand eczema, knowledge of skin-protection, and exposures that can lead to hand eczema. At entry, all participants are assessed regarding: disease severity (Hand Eczema Severity Index); self-evaluated disease severity; number of eruptions; quality of life; skin protective behaviour, and knowledge of skin protection. The patients are centrally randomised to intervention versus no intervention 1:1 stratified for hospital, profession, and severity score. The experimental group undergoes patch and prick testing; classification of the hand eczema; demonstration of hand washing and appliance of emollients; individual counselling, and a skin-care programme. The control group receives no intervention. All participants are reassessed after six months. The primary outcome is observer-blinded assessment of disease severity and the secondary outcomes are unblinded assessments of disease severity; number of eruptions; knowledge of skin protection; skin-protective behaviour, and quality of life.The trial is registered in ClinicalTrials.Gov, NCT01012453.Hand eczema (HE) is a long-lasting disease with a point prevalence of 9.7% in the background population [1] and an incidence reported to be 5.5 to 8.8 per 1000 person-years [2,3]. Occupational hand eczema (OHE) is the most frequently recognized occupational disease in Denmark with an incidence of approximately 0.32 per 1000 person-years [4]. Other studies have revealed that the annual incidence of new reports of occupational skin diseases is 0.7 to 0.8 per 1,000 employees [5,3] and the number of unreported occupational skin conditions are many times greate
Micronutrient intake in relation to all-cause mortality in a prospective Danish cohort
Nina Roswall,Anja Olsen,Jane Christensen,Louise Hansen
Food & Nutrition Research , 2012, DOI: 10.3402/fnr.v56i0.5466
Abstract: Background: Few studies have considered source-specific micronutrient intake in relation to mortality under the consideration that dietary and supplemental intake could exhibit different effects. Objective: To evaluate the association between intake of vitamin C, E, folate, beta-carotene from diet and supplements, and overall mortality. Furthermore, to examine effect modification by smoking, alcohol intake, and BMI and to investigate if the effect of supplement use differs with dietary micronutrient intake. Methods and Material: In a prospective cohort study of 55,453 middle-aged Danes, information regarding diet, supplement use, and lifestyle was collected through questionnaires. During follow-up, 6,767 deaths were identified and incidence rate ratios (IRRs) of mortality related to micronutrient intake were calculated using Cox proportional hazards models. Results: The present study found no effect of dietary vitamin C, E, folate, or beta-carotene in relation to mortality. In contrast, supplemental folic acid was associated with a significantly increased mortality, whereas no other micronutrient supplement was associated with mortality. Effect modification by smoking and alcohol intake, but not BMI, was suggested in relation to some dietary micronutrients. The effect of supplements did not differ in groups defined by dietary micronutrient intake. Conclusion: This study suggests no effect of dietary micronutrients in relation to overall mortality. Supplemental folic acid was found to be associated with increased mortality, but further studies are required. No other supplemental micronutrient was associated with mortality.
A Preliminary Study of Barriers to Bank Financing of Ethnic Chinese Entrepreneurs in the UK  [PDF]
Jane Zhang
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.37018
Abstract:

Ethnic minority entrepreneurship has been a growing research interest, however, little has been known about financial barriers to start up and run a business venture from the perspectives of UK ethnic Chinese entrepreneurs. The aim of this study is to explore the financial barriers of ethnic Chinese entrepreneurs in starting up and running a business in the UK. Through semi-structured interviews with 12 ethnic Chinese entrepreneurs who run businesses in the UK, this study has preliminarily found: 1) ethnic Chinese businesses in the UK have increasingly faced difficulties to get access to bank finance since the global financial crisis; 2) the difficulties are largely caused by a lack of communication and understanding between the entrepreneurs and financial institutions; 3) the traditional perceptions of Chinese businesses have disadvantaged ethnic Chinese entrepreneurs in the UK when they apply for bank credits. This study offers a number of implications. For policy-makers, an understanding of the characteristics of ethnic Chinese businesses and financing barriers to ethnic Chinese in business start-ups and running is important for the development of policy that encourages and supports ethnic Chinese businesses. For banks in the UK to expand their business, there is a need to develop tailored products and services specifically for ethnic Chinese entrepreneurs.

Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?
Claus Desler,Thomas Lau Hansen,Jane Bruun Frederiksen,Maiken Lise Marcker,Keshav K. Singh,Lene Juel Rasmussen
Journal of Aging Research , 2012, DOI: 10.1155/2012/192503
Abstract: Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserve respiratory capacity or spare respiratory capacity is used to describe the amount of extra ATP that can be produced by oxidative phosphorylation in case of a sudden increase in energy demand. Depletion of the reserve respiratory capacity has been related to a range of pathologies affecting high energy requiring tissues. During aging of an organism, and as a result of mitochondrial dysfunctions, the efficiency of oxidative phosphorylation declines. Based on examples from the energy requiring tissues such as brain, heart, and skeletal muscle, we propose that the age-related decline of oxidative phosphorylation decreases the reserve respiratory capacity of the affected tissue, sensitizes the cells to surges in ATP demand, and increases the risk of resulting pathologies. 1. Introduction In aerobic cells the majority of ATP is produced by oxidative phosphorylation. This process takes place in the mitochondria where electrons that are donated from the Krebs cycle are passed through the four complexes (complex I–IV) comprising the electron transport chain (ETC), eventually reducing oxygen and producing water. The flux of electrons creates an electrochemical potential between the inter-membrane space and the matrix of the mitochondria. This potential is utilized by the ATP synthase to phosphorylate ADP producing ATP. Many cells operate at a basal level that only requires a part of their total bioenergetic capability. The difference between ATP produced by oxidative phosphorylation at basal and that at maximal activity is termed “spare respiratory capacity” or “reserve respiratory capacity”, where the latter denomination will be used throughout this review. Under certain conditions a tissue can require a sudden burst of additional cellular energy in response to stress or increased workload. If the reserve respiratory capacity of the cells is not sufficient to provide the required ATP affected cells risk being driven into senescence or cell death. Exhaustion of the reserve respiratory capacity has been correlated with a variety of pathologies including heart diseases [1], neurodegenerative disorders [2, 3], and cell death in smooth muscle [4]. According to the mitochondrial theory of aging, functional alterations in mitochondria contribute to the aging process [5]. The mitochondrion is the only organelle in animal cells that
Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol
Lone Baandrup, Birgitte Fagerlund, Poul Jennum, Henrik Lublin, Jane L Hansen, Per Winkel, Christian Gluud, Bob Oranje, Birte Y Glenthoj
BMC Psychiatry , 2011, DOI: 10.1186/1471-244x-11-160
Abstract: Randomized, blinded, two-armed, parallel superiority trial. We plan to include 80 consenting outpatients diagnosed with schizophrenia or schizoaffective disorder, 18-55 years of age, treated with antipsychotic drug(s) and at least one benzodiazepine derivative for the last three months before inclusion. Exclusion criteria: currently under treatment for alcohol or drug abuse, aggressive or violent behavior, known mental retardation, pervasive developmental disorder, dementia, epilepsy, terminal illness, severe co morbidity, inability to understand Danish, allergy to melatonin, lactose, starch, gelatin, or talc, hepatic impairment, pregnancy or nursing, or lack of informed consent. After being randomized to prolonged-release melatonin (Circadin?) 2 mg daily or matching placebo, participants are required to slowly taper off their benzodiazepine dose. The primary outcome measure is benzodiazepine dose at 6 months follow-up. Secondary outcome measures include sleep, psychophysiological, and neurocognitive measures. Data are collected at baseline and at 6 months follow-up regarding medical treatment, cognition, psychophysiology, sleep, laboratory tests, adverse events, psychopathology, social function, and quality of life. Data on medical treatment, cognition, psychophysiology, adverse events, social function, and quality of life are also collected at 2 and 4 months follow-up.The results from this trial will examine whether melatonin has a role in withdrawing long-term benzodiazepine administration in schizophrenia patients. This group of patients is difficult to treat and therefore often subject to polypharmacy which may play a role in the reduced life expectancy of patients compared to the background population. The results will also provide new information on the association of chronic benzodiazepine treatment with sleep, psychophysiology, cognition, social function, and quality of life. Knowledge of these important clinical aspects is lacking in this group of patients
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