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Search Results: 1 - 10 of 219459 matches for " Jancic C "
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On Semi-Periods
A. C. Avram,E. Derrick,D. Jancic
Mathematics , 1995, DOI: 10.1016/0550-3213(96)00149-6
Abstract: The periods of the three-form on a Calabi-Yau manifold are found as solutions of the Picard-Fuchs equations; however, the toric varietal method leads to a generalized hypergeometric system of equations which has more solutions than just the periods. This same extended set of equations can be derived from symmetry considerations. Semi-periods are solutions of this extended system. They are obtained by integration of the three-form over chains; these chains can be used to construct cycles which, when integrated over, give periods. In simple examples we are able to obtain the complete set of solutions for the extended system. We also conjecture that a certain modification of the method will generate the full space of solutions in general.
Thioperamide induces CD4+ CD25+ Foxp3+ regulatory T lymphocytes in the lung mucosa of allergic mice through its action on dendritic cells
Amaral MM,Alvarez CA,Langellotti C,Jancic C
Journal of Asthma and Allergy , 2011,
Abstract: Maria Marta Amaral1*, Carolina A Alvarez1*, Cecilia Langellotti2, Carolina Jancic1, Gabriela Salamone1, Jorge Geffner1, Mónica Vermeulen1,1Institute of Hematologic Research, National Academy of Medicine, Buenos Aires, Argentina; 2Institute of Virology, CICVyA, INTA, Castelar, Argentina *Authors contributed equally to this workBackground: Histamine is an important mediator in the development of allergic reactions. The biological effects of histamine are mediated through four histaminergic receptors. In recent years, an important role has been assigned to the proinflammatory functions of histamine regarding the H4 receptor. Previously, we have demonstrated that injection of immature dendritic cells treated with histamine into allergic mice promotes an increase in CD8+ Tc2 lymphocytes, which are involved in the worsening of allergy symptoms during the chronic phase of the disease. The aim of this study was to evaluate the role of the H3/H4 receptor antagonist, thioperamide, in allergy.Methods: Ovalbumin-allergized mice and nonallergized mice were injected with phosphate-buffered saline, dendritic cells, or thioperamide-treated dendritic cells. After treatment, the lungs of the mice were obtained and analyzed for changes in the populations of dendritic cells and T lymphocytes, as well as the expression of H and H4 receptors in mononuclear lung cells.Results: We found an increase in regulatory T cells in the lungs of allergic mice intratracheally injected with dendritic cells which had their H3/H4 receptors blocked with thioperamide. We also found an increase in the production of interleukin-10 by dendritic cells of the lung. Finally, we observed a decrease in serum levels of specific anti-IgE and a reduction of eosinophils in bronchoalveolar lavage from allergic mice.Conclusion: Thioperamide induces a significant improvement in symptoms of allergic reaction perhaps via induction of regulatory T lymphocytes. These findings may become relevant in the understanding of type 1 hypersensivity reactions.Keywords: dendritic cells, regulatory T lymphocytes, thioperamide, histamine, allergy
On the Connectedness of the Moduli Space of Calabi--Yau Manifolds
A. C. Avram,P. Candelas,D. Jancic,M. Mandelberg
Mathematics , 1995, DOI: 10.1016/0550-3213(96)00058-2
Abstract: We show that the moduli space of all Calabi-Yau manifolds that can be realized as hypersurfaces described by a transverse polynomial in a four dimensional weighted projective space, is connected. This is achieved by exploiting techniques of toric geometry and the construction of Batyrev that relate Calabi-Yau manifolds to reflexive polyhedra. Taken together with the previously known fact that the moduli space of all CICY's is connected, and is moreover connected to the moduli space of the present class of Calabi-Yau manifolds (since the quintic threefold P_4[5] is both CICY and a hypersurface in a weighted P_4, this strongly suggests that the moduli space of all simply connected Calabi-Yau manifolds is connected. It is of interest that singular Calabi-Yau manifolds corresponding to the points in which the moduli spaces meet are often, for the present class, more singular than the conifolds that connect the moduli spaces of CICY's.
Thioperamide induces CD4+ CD25+ Foxp3+ regulatory T lymphocytes in the lung mucosa of allergic mice through its action on dendritic cells
Amaral MM, Alvarez CA, Langellotti C, Jancic C, Salamone G, Geffner J, Vermeulen M
Journal of Asthma and Allergy , 2011, DOI: http://dx.doi.org/10.2147/JAA.S23507
Abstract: peramide induces CD4+ CD25+ Foxp3+ regulatory T lymphocytes in the lung mucosa of allergic mice through its action on dendritic cells Original Research (2552) Total Article Views Authors: Amaral MM, Alvarez CA, Langellotti C, Jancic C, Salamone G, Geffner J, Vermeulen M Published Date September 2011 Volume 2011:4 Pages 93 - 102 DOI: http://dx.doi.org/10.2147/JAA.S23507 Maria Marta Amaral1*, Carolina A Alvarez1*, Cecilia Langellotti2, Carolina Jancic1, Gabriela Salamone1, Jorge Geffner1, Mónica Vermeulen1, 1Institute of Hematologic Research, National Academy of Medicine, Buenos Aires, Argentina; 2Institute of Virology, CICVyA, INTA, Castelar, Argentina *Authors contributed equally to this work Background: Histamine is an important mediator in the development of allergic reactions. The biological effects of histamine are mediated through four histaminergic receptors. In recent years, an important role has been assigned to the proinflammatory functions of histamine regarding the H4 receptor. Previously, we have demonstrated that injection of immature dendritic cells treated with histamine into allergic mice promotes an increase in CD8+ Tc2 lymphocytes, which are involved in the worsening of allergy symptoms during the chronic phase of the disease. The aim of this study was to evaluate the role of the H3/H4 receptor antagonist, thioperamide, in allergy. Methods: Ovalbumin-allergized mice and nonallergized mice were injected with phosphate-buffered saline, dendritic cells, or thioperamide-treated dendritic cells. After treatment, the lungs of the mice were obtained and analyzed for changes in the populations of dendritic cells and T lymphocytes, as well as the expression of H and H4 receptors in mononuclear lung cells. Results: We found an increase in regulatory T cells in the lungs of allergic mice intratracheally injected with dendritic cells which had their H3/H4 receptors blocked with thioperamide. We also found an increase in the production of interleukin-10 by dendritic cells of the lung. Finally, we observed a decrease in serum levels of specific anti-IgE and a reduction of eosinophils in bronchoalveolar lavage from allergic mice. Conclusion: Thioperamide induces a significant improvement in symptoms of allergic reaction perhaps via induction of regulatory T lymphocytes. These findings may become relevant in the understanding of type 1 hypersensivity reactions.
Action of Shiga Toxin Type-2 and Subtilase Cytotoxin on Human Microvascular Endothelial Cells
María M. Amaral, Flavia Sacerdoti, Carolina Jancic, Horacio A. Repetto, Adrienne W. Paton, James C. Paton, Cristina Ibarra
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070431
Abstract: The hemolytic uremic syndrome (HUS) associated with diarrhea is a complication of Shiga toxin (Stx)-producing Escherichia coli (STEC) infection. In Argentina, HUS is endemic and responsible for acute and chronic renal failure in children younger than 5 years old. The human kidney is the most affected organ due to the presence of very Stx-sensitive cells, such as microvascular endothelial cells. Recently, Subtilase cytotoxin (SubAB) was proposed as a new toxin that may contribute to HUS pathogenesis, although its action on human glomerular endothelial cells (HGEC) has not been described yet. In this study, we compared the effects of SubAB with those caused by Stx2 on primary cultures of HGEC isolated from fragments of human pediatric renal cortex. HGEC were characterized as endothelial since they expressed von Willebrand factor (VWF) and platelet/endothelial cell adhesion molecule 1 (PECAM-1). HGEC also expressed the globotriaosylceramide (Gb3) receptor for Stx2. Both, Stx2 and SubAB induced swelling and detachment of HGEC and the consequent decrease in cell viability in a time-dependent manner. Preincubation of HGEC with C-9 ?a competitive inhibitor of Gb3 synthesis-protected HGEC from Stx2 but not from SubAB cytotoxic effects. Stx2 increased apoptosis in a time-dependent manner while SubAB increased apoptosis at 4 and 6 h but decreased at 24 h. The apoptosis induced by SubAB relative to Stx2 was higher at 4 and 6 h, but lower at 24 h. Furthermore, necrosis caused by Stx2 was significantly higher than that induced by SubAB at all the time points evaluated. Our data provide evidence for the first time how SubAB could cooperate with the development of endothelial damage characteristic of HUS pathogenesis.
Uptake and Intracellular Trafficking of Superantigens in Dendritic Cells
María B. Ganem, Mauricio C. De Marzi, María J. Fernández-Lynch, Carolina Jancic, Mónica Vermeulen, Jorge Geffner, Roy A. Mariuzza, Marisa M. Fernández, Emilio L. Malchiodi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066244
Abstract: Bacterial superantigens (SAgs) are exotoxins produced mainly by Staphylococcus aureus and Streptococcus pyogenes that can cause toxic shock syndrome (TSS). According to current paradigm, SAgs interact directly and simultaneously with T cell receptor (TCR) on the T cell and MHC class II (MHC-II) on the antigen-presenting cell (APC), thereby circumventing intracellular processing to trigger T cell activation. Dendritic cells (DCs) are professional APCs that coat nearly all body surfaces and are the most probable candidate to interact with SAgs. We demonstrate that SAgs are taken up by mouse DCs without triggering DC maturation. SAgs were found in intracellular acidic compartment of DCs as biologically active molecules. Moreover, SAgs co-localized with EEA1, RAB-7 and LAMP-2, at different times, and were then recycled to the cell membrane. DCs loaded with SAgs are capable of triggering in vitro lymphocyte proliferation and, injected into mice, stimulate T cells bearing the proper TCR in draining lymph nodes. Transportation and trafficking of SAgs in DCs might increase the local concentration of these exotoxins where they will produce the highest effect by promoting their encounter with both MHC-II and TCR in lymph nodes, and may explain how just a few SAg molecules can induce the severe pathology associated with TSS.
Increased Levels of Hyaluronic Acid in Bronchoalveolar Lavage from Patients with Interstitial Lung Diseases, Relationship with Lung Function and Inflammatory Cells Recruitment  [PDF]
Glenda Ernst, Jancic Carolina, Auteri Santiago, Rodriguez Moncalvo Juan, Galíndez Fernando, Grynblat Pedro, E. Hajos Silvia
Modern Research in Inflammation (MRI) , 2014, DOI: 10.4236/mri.2014.32004
Abstract: Purpose: Interstitial Lung Diseases (ILD) are characterized by inflammation and fibrosis. It described the role of hyaluronic acid (HA) as an immune-regulator. It is not known if HA contributes to the recruitment of inflammatory cells associated with ILD. If this hypothesis was correct, then concentrations of HA in bronchoalveolar lavage (BAL) should correlate with the severity of ILD. Methods: We collected BAL from 22 ILD patients and 15 control subjects. We determined HA and cytokine levels by ELISA. In vitro chemotaxis assays were performed by using a transwell system. Results: We found that ILD patients showed a significant increase in HA, IL-6 levels and the amount of cells in BAL compared to control subjects. We detected a significant positive correlation between HA and IL-6 levels (r = 0.53 and p < 0.001) and an inverse relationship between HA levels and diffusion capacity (r = -0.59, p < 0.01). In vitro, HA induced migration of macrophages and monocytes through a CD44-dependent process. BAL from patients with ILD stimulated macro-phage migration and this was abrogated by hyaluronidase. Conclusions: Our results support the hypothesis that HA contributes to the recruitment of monocytes towards the alveolar space, leading to exacerbation of lung inflammation in ILD patients.
ENDOCRINE BASIS OF THE BENIGN BREAST DISORDERS
Dragan Zecevic,Vuka Kati?,Mileva Milosavljevic,Sne?ana Jancic
Acta Medica Medianae , 2000,
Abstract: There are solid clinic proofs that the benign breast disorders, primarily the pain,the creation of small nodes and cysts, are caused by the hormonal disorders duringthe woman's reproductive cycle. Some new findings have stressed the importance ofthe dynamic hormonal changes as well as of the chronobiological rhythm, namely,daily, menstrual and season one. The newly-gained knowledge in science is reportedthis time in order to suggest the directions to be taken for the sake of discoveringetiology of the benign breast disorders.
The use of image analysis for the study of interfacial bonding in solid composite propellant
JASMINA DOSTANIC,GORDANA USCUMLIC,TATJANA VOLKOV–HUSOVIC,RADMILA JANCIC–HEINEMANN
Journal of the Serbian Chemical Society , 2007,
Abstract: In the framework of this research, the program Image Pro Plus was applied for determining the polymer–oxidizer interactions in HTPB-based composite propellants. In order to improve the interactions, different bonding agents were used, and their efficiency was analyzed. The determination of the quantity, area and radius of non-bonded oxidizer crystals is presented. The position of formed cracks in the specimen and their area has a great influence on the mechanical properties of composite propellant. The preparation of the composite propellant in order to enable the photographing of their structure by means of stereoscopic and metallographic microscopes with the digital camera is also described as well.
On Periods for String Compactifications
P. Berglund,E. Derrick,T. Hübsch,D. Jancic
Physics , 1993, DOI: 10.1016/0550-3213(94)90381-6
Abstract: Motivated by recent developments in the computation of periods for string compactifications with $c=9$, we develop a complementary method which also produces a convenient basis for related calculations. The models are realized as Calabi--Yau hypersurfaces in weighted projective spaces of dimension four or as Landau-Ginzburg vacua. The calculation reproduces known results and also allows a treatment of Landau--Ginzburg orbifolds with more than five fields.
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