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Search Results: 1 - 10 of 14081 matches for " Jan Jasiewicz "
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NMR Spectra of Sparteine N1-oxide and α-Isosparteine N-oxide
Beata Jasiewicz
Molecules , 2008, DOI: 10.3390/molecules13010003
Abstract: Sparteine N1-oxide and α-isosparteine N-oxide were prepared and theirstructures determined for the first time by 1H- and 13C-NMR spectroscopy using twodimensionaltechniques. The N-oxide effects were also calculated.
Guest Editorial: Smart rehabilitation for the 21st century: The Tampa Smart Home for veterans with traumatic brain injury
Jan Jasiewicz, PhD,William Kearns, PhD,Jeffrey Craighead, PhD,James L. Fozard, PhD
Journal of Rehabilitation Research and Development , 2011,
Abstract: In this editorial, we report on the development of a smart-home-based cognitive prosthetic that will deliver 24/7 rehabilitation at the James A. Haley Veterans' Hospital Polytrauma Transitional Rehabilitation Program (PTRP) facility in Tampa, Florida. The Tampa Smart Home was designed to address two weaknesses identified by PTRP clinicians in the rehabilitation process for patients with traumatic brain injury (TBI): (1) patient safety and (2) inadequate timing and repetition of prompts used to overcome TBI-related cognitive and memory deficits.
Telephone reliability of the Frenchay Activity Index and EQ-5D amongst older adults
Steven McPhail, Paul Lane, Trevor Russell, Sandra G Brauer, Steven Urry, Jan Jasiewicz, Peter Condie, Terry Haines
Health and Quality of Life Outcomes , 2009, DOI: 10.1186/1477-7525-7-48
Abstract: Patients aged >65 (n = 53) who had been discharged to the community following an acute hospital admission underwent telephone administration of the FAI and EQ-5D instruments seven days prior to attending a hospital outpatient appointment where they completed a face-to-face administration of these instruments.Overall, 40 subjects' datasets were complete for both assessments and included in analysis. The FAI items had high levels of agreement between the two modes of administration (item kappa's ranged 0.73 to 1.00) as did the EQ-5D (item kappa's ranged 0.67–0.83). For the FAI, EQ-5D VAS and EQ-5D utility score, intraclass correlation coefficients were 0.94, 0.58 and 0.82 respectively with paired t-tests indicating no significant systematic difference (p = 0.100, p = 0.690 and p = 0.290 respectively).Telephone administration of the FAI and EQ-5D instruments provides comparable results to face-to-face administration amongst older adults deemed to have cognitive functioning intact at a basic level, indicating that this is a suitable alternate approach for collection of this information.Improving functional independence and health-related quality of life are two common and inter-related goals of health care services. These objectives are particularly important for services that cater for the needs of older adults. Evaluation of these services and ongoing monitoring of their patients requires that participation in functional activities and health-related quality of life be measured with an approach that is amenable to the clinical context. [1-3] A difficulty with evaluating these constructs is that many older adults find it difficult to attend hospitals or other health care settings for appointments. This is often due to the difficulty associated with travelling to, within and from a hospital facility for the purpose of a face-to-face assessment.[4,5] A viable alternative may be to complete relevant survey instruments via a telephone interview.Different modes of administr
Mass Spectrometry of Bis-Quinolizidine Alkaloids: FAB-MS of Oxo-Substituted Sparteines
Beata Jasiewicz,El?bieta Wyrzykiewicz
International Journal of Analytical Chemistry , 2011, DOI: 10.1155/2011/652589
Abstract: The unpublished in the literature FAB mass spectral fragmentation of seven oxosparteines (i.e., 2-oxosparteine, 15-oxosparteine, 17-oxosparteine, 2,17-dioxosparteine, 2,13-dioxosparteine, 2-oxo-13-hydroxysparteine, and 2-oxo-17-hydroxysparteine) is investigated. Fragmentation pathways, elucidation of which was assisted by FAB/collision-induced dissociation (CID) mass spectra measurements, are discussed. The data obtained create the basis for distinguishing positional isomers. 1. Introduction Bis-quinolizidine alkaloids produced by Lupine species have generated much interest because of their valuable pharmacological properties. Both pharmacological and toxicological properties of these alkaloids are well known [1, 2]. Sparteine appears to offer protection to plants from Leguminosae family against insects and grazing mammals [3, 4]. Several bis-quinolizidine alkaloids (sparteine, lupanine, 17-oxosparteine, 13-hydroxylupanine, angustifoline, etc.) show antihypertensive, antipyretic, anti-inflammatory, antiarrhythmic, diuretic, hypoglicemic, hypotensive, antidiabetic, respiratory depressant and stimulant, and uterotonic properties [5, 6]. The mass spectrometry study of bis-quinolizidine alkaloids has been stimulated by the evidence of the method’s ability to distinguish their stereoisomers, metamers, and positional isomers [7–14]. The main characteristic of the so-called “hard” electron-impact induced ionization (EI) of mass fragmentation of bis-quinolizidine alkaloid molecular ions is the dependence of the fragmentation pathway of the bis-quinolizidine skeleton on the stereochemistry of the A/B and C/D ring junctions. The stereochemical effects that are encountered with dissociations of stereoisomers incorporating saturated heterocycles rings are due to the ability of chemical bonds to be broken or formed. Mass spectrometry includes a broad range of techniques that have allowed us to prove the detailed structures of organic compounds in a variety of ways. Fast atom bombardment ionization (FAB) is classified as a soft ionization technique in mass spectrometry and is well suited to organic compounds which contain a basic functional group. Those compounds tend to run well in positive ion mode. In the positive FAB technique a high velocity, rare gas atom molecular beam was produced in the ionization source, and directed onto the sample which was in solution (in the matrix) on a target, thus causing desorption of protonated molecular ions from the sample. Generally, positive FAB produces protonated molecular ions M+H?+ with a little fragmentation, and so the
"Individual and social determinants of human development. The positive psychology perspective"
Maria Czerwińska-Jasiewicz, Ludwika Wojciechowska
Polish Psychological Bulletin , 2011, DOI: 10.2478/v10059-011-0023-9
The effect of bottom sediment supplement on heavy metals content in plants (Zea mays) and soil
Baran A.,Jasiewicz C.,Tarnawski M.
E3S Web of Conferences , 2013, DOI: 10.1051/e3sconf/20130104008
Abstract: Important aspect of bottom sediments is the problem of their management or disposal after their extraction from the bottom of rivers, dam reservoirs, ports, channels or ponds. The research aimed at an assessment of potential environmental management of bottom sediment used as an admixture to light soil basing on its effect on contents of heavy metals in plants and soil. The research was conducted on light soil with granulometric structure of weakly loamy sand. The bottom sediment was added to light soil in the amount of 0 (control) 5, 10, 30 i 50%. The test plant was maize (Zea mays), “Bora” c.v. The sediment applied in the presented research revealed high share of silt and clay fractions, alkaline pH and low contents of heavy metals, therefore it may be used as an admixture to the above mentioned soils to improve their productivity. The applied bottom sediment to the soil affected a decreased in Zn, Cd and Pb content in maize in comparison with the treatment without the deposit whereas increased content of Cu, Cr and Ni. No exceeded permissible content of heavy metals concerning plant assessment in view of their forage usability were registered in maize biomass.
Spine deformities in patients with Ehlers-Danlos syndrome, type IV - late results of surgical treatment
Barbara Jasiewicz, Tomasz Potaczek, Maciej Tesiorowski, Krzysztof Lokas
Scoliosis , 2010, DOI: 10.1186/1748-7161-5-26
Abstract: This is a retrospective study of the records of 11 patients with Ehlers-Danlos syndrome type IV, treated surgically between 1990 and 2007. All patients underwent surgical treatment for spinal deformity. Duration of operation, type of instrumentation, intraoperative blood loss, complications and number of additional surgeries were noted. Radiographic measurement was performed on standing AP and lateral radiographs acquired before surgery, just after and at final follow up.The mean follow up period was 5.5 ± 2.9 years (range 1-10 years). The mean preoperative thoracic and lumbar curve were 109.5 ± 19.9° (range 83° - 142°) and 75.6 ± 26.7° (range 40° - 108°) respectively. Posterior spine fusion alone was performed on 6 patients and combined anterior and posterior fusion (one- or two stage) on 5 cases. Posterior segmental spinal instrumentation was applied with use of hooks, screws and wires. The mean postoperative thoracic and lumbar curve improved to 79.3 ± 16.1° (range 56° - 105°) and 58.5 ± 27.7° (range 10° - 95°) respectively, with a slight loss of correction during follow up. The average thoracic and lumbar correction was 26.4 ± 14.9% (range 5.3 - 50.4%) and 26.3 ± 21.2% (range 7.9 - 75%). Postoperatively, the mean kyphosis was 79.5 ± 40.3° (range 21° -170°), and lordosis was 50.8 ± 18.6° (range 20° -79°). Hyperkyphosis increased during follow up while lordosis remained stable. Mean Th12-L2 angle was -3.5 ±9.9° (range -19° - 15°) postoperatively and did not change significantly during follow up.Huge spinal deformities in patients with Ehlers-Danlos syndrome require complex and extensive surgery. There is a big risk of sagittal imbalance in this group.Ehlers-Danlos syndrome is a group of different inherited diseases caused by various defects of collagen metabolism [1]. It is characterized by joint hypermobility and joint laxity. From the description of the first patient by van Meckeren in 1682, it had to pass over 200 years until Ehlers and Danlos published their w
Aneta G?dek,Leszek Wojnar,Maciej T?siorowski,Barbara Jasiewicz
Image Analysis and Stereology , 2003, DOI: 10.5566/ias.v22.p183-191
Abstract: A new method for quantification of bone regenerate on the basis of computer-aided analysis of digitized Xray images is presented and its applicability in bone lengthening using Ilizarov method is demonstrated. In contrary to classical methods the internal part of the bone image is taken into consideration instead of the bone edges. Theoretical background of this concept is presented and experimentally verified. Experimental results show that the method proposed allows us for assessment of the bone regenerate, precise choice of the moment of external fixator removal as well as prediction of abnormalities in the osteogenesis process (excluding overall decalcification). However, the rules of interpretation of the results are not discussed in details.
Insulinooporno u pacjentów z niewydolno ci serca jest zwi zana ze st eniem interleukiny 6 w surowicy - wyniki wst pne
Karol Adam Kamiński,Ma?gorzata Jasiewicz,Izabela Wojtkowska,Barbara Szepietowska
Polish Journal of Cardiology , 2008,
Abstract: Wprowadzenie: Interleukina 6 (IL-6) jest plejotropow cytokin uczestnicz c zarówno w odpowiedzi zapalnej organizmu, jak te w regulacji metabolizmu w glowodanów. Odgrywa ona istotn rol w regulacji insulinowra liwo ci poszczególnych tkanek. Wykazano i podwy szone st enie IL-6 u pacjentów z niewydolno ci serca (congestive heart failure - CHF) jest markerem z ego rokowania. Jednak mechanizm tego zjawiska nie zosta dotychczas wyja niony. Wyniki badań przeprowadzonych w ostatnich latach wykaza y zwi kszon insulinooporno chorych z CHF. Dotychczas nie wykazano czy mo e mie to zwi zek z podwy szonym st eniem IL-6. Cel pracy: Ocena zale no ci pomi dzy st eniem IL-6 a parametrami insulinooporno ci u pacjentów z CHF. Materia i metodyka: Pi tnastu pacjentów ze stabiln umiarkowan niewydolno ci serca w II i III klasie wg NYHA oraz 21 zdrowych ochotników zosta o w czonych do badania. Wykluczono osoby zwywiadem zaburzeń gospodarki w glowodanowej, zaktualn lub przebyt infekcj orazz przewlek ymi chorobami zapalnymi. Wszyscy uczestnicy badania mieli wykonany doustny test obci enia 75 g glukozy (or a lglucose tolerance test -OGTT), podczas którego oceniano st enie glukozy i insuliny w surowicy. Na tej podstawie wyliczono parametry insulinooporno ci: model homeostazy (homeostasis model assessment- HOMA), sumaryczne st enie insuliny (Sigma insulin), skorygowan odpowied insulinow (corrected insulin response - CIR). Oceniano równie st enie IL-6 w surowicy (ELISA firmy R'n'D). Wyniki: Chorzy z CHF mieli znamiennie wy sze st enie IL-6 w porównaniu do grupy kontrolnej (odpowiednio 3,1±2,2 pg/mL vs 1,8±1,1 pg/mL; p<0,05), jak te wy sz warto CIR (odpowiednio 8,7±4,9 vs -1,5±17,4; p<0,05). W tej grupie pacjentów obserwowano istotne korelacje pomi dzy st eniem IL-6 w surowicy a parametrami insulinooporno ci, takimi jak: HOMA (r=0,57; p<0,005), suma st eń insuliny (r=0,72; p=0,005) oraz st enie insuliny w 120 minucie OGTT (r=0,79; p<0,005). Wnioski: U pacjentów z CHF parametry oceniaj ce insulinooporno koreluj ze st eniem IL-6 w surowicy krwi. Jest to jeden z potencjalnych mechanizmów w jaki mo e doj do wzrostu insulinooporno ci u pacjentów z niewydolno ci serca.
A Longitudinal Analysis of the Stability of Household Money Demand  [PDF]
Jan Tin
Modern Economy (ME) , 2011, DOI: 10.4236/me.2011.23046
Abstract: Past aggregate time-series studies, conducted under the assumption of a representative economic agent, frequently show that the demand for narrowly defined M1, especially non-interest-yielding demand deposit, is unstable during periods of financial innovations. Whether this is longitudinally the case among life-cycle savers is unclear. This study utilizes longitudinal data to take another look and find that volatility in the demand for non-interest-earning checking accounts in the mid and late 1990s is attributable solely to the portion held for the transactions motive. When the conventional Baumol-Tobin model is extended to include human capital and family formation variables representing the life-cycle motive, equilibrium money demand is a stable function of both economic and demographic variables.
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