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Search Results: 1 - 10 of 157869 matches for " Jan B Howes "
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Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer
Jan B Howes, Paul L de Souza, Leanne West, Li Huang, Laurence G Howes
BMC Pharmacology and Toxicology , 2011, DOI: 10.1186/1472-6904-11-1
Abstract: The pharmacokinetics of phenoxodiol was studied following a single intravenous (iv) bolus dose and during a continuous intravenous infusion. Three men with prostate cancer and 3 women with breast cancer received IV bolus phenoxodiol (5 mg/kg) and plasma was sampled for free and total phenoxodiol levels. On a separate occasion 5 of the same patients received a continuous intravenous infusion of phenoxodiol (2 mg/kg/h) and plasma was again sampled for free and total phenoxodiol levels. Phenoxodiol was measured using gradient HPLC with ultraviolet detection.Following bolus injection, free and total phenoxodiol appeared to follow first order pharmacokinetics. The elimination half-lives for free and total phenoxodiol were 0.67 ± 0.53 h and 3.19 ± 1.93 h, respectively, while the total plasma clearance rates were 2.48 ± 2.33 L/h and 0.15 ± 0.08 L/h, respectively. The respective apparent volumes of distribution were 1.55 ± 0.69 L/kg and 0.64 ± 0.51 L/kg. During continuous intravenous infusion, free phenoxodiol accumulated rapidly to reach a mean concentration at steady state of 0.79 ± 0.14 μg/ml after 0.87 ± 0.18 h. The apparent accumulation half-life of free phenoxodiol was 0.17 ± 0.04 h while the plasma clearance during continuous infusion was 1.29 ± 0.23 L/h.Phenoxodiol has a short plasma half-life, particularly in the free form, leading to a rapid attainment of steady state levels during continuous intravenous infusion.Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12610000334000Phenoxodiol (PXD, NV-06) is an isoflavone derivative that has been demonstrated in vitro and in vivo to possess anti-cancer activity [1-9]. Phenoxodiol is a synthetic analogue of genistein with unknown mechanism of action. It appears to have pleiotropic actions such as inhibition of tyrosine kinases, inhibition of topoisomerase II in a dose-dependent manner and inhibition of the X-linked inhibitor of apoptosis [2,10-12] but the predominant mode of action remains to be elucidated.
Influences of Confucianism on Chinese Parents’ Experience with Early Childhood Education  [PDF]
Shaohua Hong, Andrew Howes
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.27007
Abstract: Confucian concepts have long been seen as reflecting the main component of Chinese cultural civilization, which started in around 500 B.C. after Confucius passed away. There have been two significant Confucian movements. The earlier one appeared in the 12th century, during the regime of the Song Dynasty, and the later one started in the 20th century. These movements were both generally called new Confucian or Neo-Confucian. The rise of neo-Confucian thinking affects people from various aspects, including the way Chinese parents experience their child’s early childhood education. This paper attempts to understand how Confucianism influences Chinese parents’ experience with Early Childhood Education (ECE) by drawing upon a longitudinal study with a father from Urumqi, North-West of China, who sent his child to a local Confucian concept kindergarten, analysing tensions and contradictions within his experience. A series of in-depth interviews have been held with him over a period of a year, in particular relating to his selection of kindergarten and on-going perspectives. It has been revealed from this father’s testimony that his experience is a process of going through a hybrid of cultural influences, which are Confucianism, Positivism and Western concepts. It has also been proved that his constant learning of Confucianism had an unavoidable influence on his experience. Moreover, his growth to personal maturity was also intertwined together with Confucianism, which therefore strengthened his commitment to Confucianism.
Fontes sagradas e profanas de esperan?a para uma sociedade pós-moderna
Howes, Graham;
Estudos Avan?ados , 2012, DOI: 10.1590/S0103-40142012000200016
Abstract: this paper will attempt to evaluate -critically - some of the sacred and secular expressions of hope currently identifiable within many contemporary, "post-modern", societies, where, as one philosopher of religion has recently described it, "all frameworks of narrative description embodied in their history and interpretation are currently dissolved in the acids of modernity". particular attention will be paid to four distinctive yet interconnected contexts" where specific "strategies for hope" - in both theory and praxis can be identified and evaluated these are: 1) urban regeneration and community development - symbolising and securing hope for a viable urban future; 2) the ecological imperative - optimizing hope for the perpetuation of "planet earth"; 3) re-sacralizing the secular - re-investing "post-religious" secular social theory with overtly religious norms and values; 4) the aesthetic imperative -utilizing the visual arts- both elite and popular- as a mechanism for social and personal transformation. all four case studies embody explicit sources of "hope" for 21st century individuals, communities and societies. yet all four also demonstate how the "cognitive distance" between "is" and "ought", between "rhetoric" and "reality" remains as visible, intractable and seemingly permanent as ever .hence the re-constitution of "hope" at the normative epicentre of post-modern thought and action, although a theoretical possibility, may prove, in practice, little more than "hoping against hope".
On the odour of the soul; Spatial representation and olfactory classification in Eastern Indonesia and Western Melanesia
David Howes
Bijdragen tot de Taal-, Land- en Volkenkunde , 1988,
Abstract:
Handelinge se uitbeelding van die rol van vroue in die vroe kerk
Llewellyn Howes
HTS Theological Studies/Teologiese Studies , 2009, DOI: 10.4102/hts.v61i4.481
Abstract: Acts and the role of women in the early church The aim of this article is to determine what the role of women in the church of the first century was according to Acts. Amongst other things it pertains to the situation of women within the community of believers on a daily basis. It not only includes their contribution to faith services and the faith community as a whole, but also how the faith community perceived them. What part did they play and what positions of leadership did they hold? Did their gender exclude them from exercising certain leadership roles? What was the gender-specific view of Christians? Establishing the historicity of every pericope in Acts is not the main aim. However, the article subscribe to the historicity of the overall picture of the role women played in the early church.
An analytic method for bounding $ψ(x)$
Jan Büthe
Mathematics , 2015,
Abstract: In this paper we present an analytic altorithm which calculates almost sharp bounds for the normalized error term $(t-\psi(t))/\sqrt{t}$ for $t\leq x$ in expected run time $O(x^{1/2+\varepsilon})$ for every $\varepsilon>0$. The method has been implemented and used to calculate the bound $|\psi(t) - t| \leq 0.94 \sqrt{t}$ for $11< t\leq 10^{19}$. In particular, this bound implies that $\operatorname{li}(t) - \pi(t) > 0$ for $t\in [2,10^{19}]$, which gives an improved lower bound for the Skewes number.
A method for proving the completeness of a list of zeros of certain L-functions
Jan Büthe
Mathematics , 2013, DOI: 10.1090/S0025-5718-2015-02922-6
Abstract: When it comes to partial numerical verification of the Riemann Hypothesis, one crucial part is to verify the completeness of a list of pre-computed zeros. Turing developed such a method, based on an explicit version of a theorem of Littlewood on the average of the argument of the Riemann zeta function. In a previous paper we suggested an alternative method based on the Weil-Barner explicit formula. This method asymptotically sacrifices fewer zeros in order to prove the completeness of a list of zeros with imaginary part in a given interval. In this paper, we prove a general version of this method for an extension of the Selberg class including Hecke and Artin L-series, L-functions of modular forms, and, at least in the unramified case, automorphic L-functions. As an example, we further specify this method for Hecke L-series and L-functions of elliptic curves over the rational numbers.
An improved analytic Method for calculating $π(x)$
Jan Büthe
Mathematics , 2014,
Abstract: We present an improved version of the analytic method for calculating $\pi(x)$, the number of prime numbers not exceeding $x$. We implemented this method in cooperation with J. Franke, T. Kleinjung and A. Jost and calculated the value $\pi(10^{25})$.
Estimating $π(x)$ and related functions under partial RH assumptions
Jan Büthe
Mathematics , 2014,
Abstract: The aim of this paper is to give a direct interpretation of the validity of the Riemann hypothesis up to a certain height $T$ in terms of the prime-counting function $\pi(x)$. This is done by proving the well-known explicit Schoenfeld bound on the RH to hold as long as $4.92 \sqrt{x/\log(x)} \leq T$. Similar statements are proven for the Riemann prime-counting function and the Chebyshov functions $\psi(x)$ and $\vartheta(x)$. Apart from that, we also improve some of the existing bounds of Chebyshov type for the function $\psi(x)$.
A Brun-Titchmarsh inequality for weighted sums over prime numbers
Jan Büthe
Mathematics , 2014, DOI: 10.4064/aa166-3-5
Abstract: We prove explicit upper bounds for weighted sums over prime numbers in arithmetic progressions with slowly varying weight functions. The results generalize the well-known Brun-Titchmarsh inequality.
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