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Search Results: 1 - 10 of 40811 matches for " James Q. Yin "
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Gene expression regulators —MicroRNAs
Fang Chen,James Q. Yin
Chinese Science Bulletin , 2005, DOI: 10.1360/982005-573
Abstract: A large class of non-coding RNAs found in small molecule RNAs are closely associated with the regulation of gene expression, which are called microRNA (miRNA). MiRNAs are coded in intergenic or intronic regions and can be formed into foldback hairpin RNAs. These transcripts are cleaved by Dicer, generating mature miRNAs that can silence their target genes in different modes of action. Now, research on small molecule RNAs has gotten breakthrough advance in biology. To discover miRNA genes and their target genes has become hot topics in RNA research. This review attempts to look back the history of miRNA discovery, to introduce the methods of screening miRNAs, to localize miRNA loci in genome, to seek miRNA target genes and the biological function, and to discuss the working mechanisms of miRNAs. Finally, we will discuss the potential important roles of miRNAs in modulating the genesis, development, growth, and differentiation of organisms. Thus, it can be predicted that a complete understanding of miRNA functions will bring us some new concepts, approaches and strategies for the study of living beings.
A Novel Biosensor to Detect MicroRNAs Rapidly
Jie-Ying Liao,James Q. Yin,Jia-Chang Yue
Journal of Sensors , 2009, DOI: 10.1155/2009/671896
Abstract: -free 01-ATPase within chromatophore was constructed as a novel biosensor to detect miRNA targets. Specific miRNA probes were linked to each rotary subunits of 01-ATPase. Detection of miRNAs was based on the proton flux change induced by light-driven rotation of -free 01-ATPase. The hybridization reaction was indicated by changes in the fluorescent intensity of pH-sensitive CdTe quantum dots. Our results showed that the assay was attomole sensitivities (1.2×10?18 mol) to target miRNAs and capable of distinguishing among miRNA family members. Moreover, the method could be used to monitor real-time hybridization without any complicated fabrication before hybridization. Thus, the rotary biosensor is not only sensitive and specific to detect miRNA target but also easy to perform. The -free 01-ATPase-based rotary biosensor may be a promising tool for the basic research and clinical application of miRNAs.
Alu-directed transcriptional regulation of some novel miRNAs
Tong J Gu, Xiang Yi, Xi W Zhao, Yi Zhao, James Q Yin
BMC Genomics , 2009, DOI: 10.1186/1471-2164-10-563
Abstract: We present a comprehensive exploration of the Alu-directed transcriptional regulation of some new miRNAs. Using a new computational approach, a variety of Alu-related sequences from multiple sources were pooled and filtered to obtain a subset containing Alu elements and characterized miRNA genes for which there is clear evidence of full-length transcription (embedded in EST). We systematically demonstrated that 73 miRNAs including five known ones may be transcribed by Pol-III through Alu or MIR. Among the new miRNAs, 33 were determined by high-throughput Solexa sequencing. Real-time TaqMan PCR and Northern blotting verified that three newly identified miRNAs could be induced to co-express with their upstream Alu transcripts by heat shock or cycloheximide.Through genomic analysis, Solexa sequencing and experimental validation, we have identified candidate sequences for Alu-related miRNAs, and have found that the transcription of these miRNAs could be governed by Pol-III. Thus, this study may elucidate the mechanisms by which the expression of a class of small RNAs may be regulated by their upstream repeat elements.MicroRNAs (miRNAs) are a class of small non-coding RNAs (ncRNAs) about 22 nt in length. They control fundamental cellular activities such as differentiation, proliferation, apoptosis and others in different species by regulating gene expression [1-3]. Although miRNAs were discovered more than a decade ago, their transcription remains insufficiently understood. They are believed to be transcribed by polymerase II (Pol-II) [4-6]. However, new research on ncRNA transcription indicates that polymerase III (Pol-III) may participate in this process [7-9]. Pol-III is usually recognized as transcribing housekeeping ncRNAs and short interspersed nuclear elements (SINEs) such as tRNAs, 5s-rRNAs and Alu [7,10,11]. In 2004, a study revealed that the exogenous Pol-III promoter can initiate miRNA transcription [12]. Since then, several lines of evidence have shown that P
Music in Terms of Science
James Q. Feng
Physics , 2012,
Abstract: To many people, music is a mystery. It is uniquely human, because no other species produces elaborate, well organized sound for no particular reason. It has been part of every known civilization on earth. It has become a very part of man's need to impose his will upon the universe, to bring order out of chaos and to endow his moments of highest awareness with enduring form and substance. It is a form of art dealing with the organization of tones into patterns. Despite of cultural differences, music from different civilizations seems to consist of some building blocks that are universal: melody, harmony, rhythm, etc. Almost all musical systems are based on scales spanning an octave---the note that sounds the same as the one you started off with, but at a higher or lower pitch. It was discovered by Pythagoras, a Greek philosopher who lived around 500 BC, that the note an octave higher than another has a frequency twice high. The notes that sound harmonious together have simple rational number ratios between their frequencies. It is those implicit structures and relationships in apparently mysterious musical experience that I am interested in exploring here. As a scientist by training with a consistent passion for classical guitar playing, I would like make an attempt to explain the musical experience in terms of science and mathematics, hoping to fill some gaps between the knowledge of scientists and artistic intuition of musicians.
Diffusion-Controlled Quasi-Stationary Mass Transfer for an Isolated Spherical Particle in an Unbounded Medium
James Q. Feng
Physics , 2011,
Abstract: A consolidated mathematical formulation of the spherically symmetric mass-transfer problem is presented, with the quasi-stationary approximating equations derived from a perturbation point of view for the leading-order effect. For the diffusion-controlled quasi-stationary process, a mathematically complete set of the exact analytical solutions is obtained in implicit forms to cover the entire parameter range. Furthermore, accurate explicit formulas for the particle radius as a function of time are also constructed semi-empirically for convenience in engineering practice. Both dissolution of a particle in a solvent and growth of it by precipitation in a supersaturated environment are considered in the present work.
Vapor Transport of a Volatile Solvent for a Multicomponent Aerosol Droplet
James Q. Feng
Physics , 2015, DOI: 10.1080/02786826.2015.1072262
Abstract: This work presents analytical formulas derived for evaluating vapor transport of a volatile solvent for an isolated multicomponent droplet in a quiescent environment, based on quasi-steady-state approximation. Among multiple solvent components, only one component is considered to be much more volatile than the rest such that other components are assumed to be nonvolatile remaining unchanged in the droplet during the process of (single-component) volatile solvent evaporation or condensation. For evaporating droplet, the droplet size often initially decreases following the familiar "d^2 law" at an accelerated rate. But toward the end, the rate of droplet size change diminishes due to the presence of nonvolatile cosolvent. Such an acceleration-deceleration reversal behavior is unique for evaporating multicomponent droplet, while the droplet of pure solvent has an accelerated rate of size change all the way through the end. This reversal behavior is also reflected in the droplet surface temperature evolution as "S-shaped" curves. However, a closer mathematical examination of conditions for acceleration-deceleration reversal indicates that the acceleration phase may disappear when the amount of nonvolatile cosolvent is relatively small and ambient vapor pressure is relatively high. Because the net effect of adding nonvolatile cosolvent is to reduce the mole fraction of the volatile solvent such that the saturation vapor pressure is lowered, vapor condensation onto the multicomponent droplet is predicted to occur when the ambient vapor pressure is subsaturated with respect to that for the pure volatile solvent. In this case, the droplet will grow asymptotically toward a finite size. But when the ambient vapor pressure becomes supersaturated with respect to that for the pure volatile solvent, the condensation growth of droplet can continue indefinitely without bound.
Existence of Saddle Points in Discrete Markov Games and Its Application in Numerical Methods for Stochastic Differential Games
Q. S. Song,G. Yin
Mathematics , 2006,
Abstract: This work establishes sufficient conditions for existence of saddle points in discrete Markov games. The result reveals the relation between dynamic games and static games using dynamic programming equations. This result enables us to prove existence of saddle points of non-separable stochastic differential games of regime-switching diffusions under appropriate conditions.
Spatial Search Techniques for Mobile 3D Queries in Sensor Web Environments
Junjun Yin,James D. Carswell
ISPRS International Journal of Geo-Information , 2013, DOI: 10.3390/ijgi2010135
Abstract: Developing mobile geo-information systems for sensor web applications involves technologies that can access linked geographical and semantically related Internet information. Additionally, in tomorrow’s Web 4.0 world, it is envisioned that trillions of inexpensive micro-sensors placed throughout the environment will also become available for discovery based on their unique geo-referenced IP address. Exploring these enormous volumes of disparate heterogeneous data on today’s location and orientation aware smartphones requires context-aware smart applications and services that can deal with “information overload”. 3DQ (Three Dimensional Query) is our novel mobile spatial interaction (MSI) prototype that acts as a next-generation base for human interaction within such geospatial sensor web environments/urban landscapes. It filters information using “Hidden Query Removal” functionality that intelligently refines the search space by calculating the geometry of a three dimensional visibility shape (Vista space) at a user’s current location. This 3D shape then becomes the query “window” in a spatial database for retrieving information on only those objects visible within a user’s actual 3D field-of-view. 3DQ reduces information overload and serves to heighten situation awareness on constrained commercial off-the-shelf devices by providing visibility space searching as a mobile web service. The effects of variations in mobile spatial search techniques in terms of query speed vs. accuracy are evaluated and presented in this paper.
Option pricing in a regime-switching model using the fast Fourier transform
R. H. Liu,Q. Zhang,G. Yin
International Journal of Stochastic Analysis , 2006, DOI: 10.1155/jamsa/2006/18109
Abstract: This paper is concerned with fast Fourier transform (FFT) approach to option valuation, where the underlying asset price is governed by a regime-switching geometric Brownian motion. An FFT method for the regime-switching model is developed first. Aiming at reducing computational complexity, a near-optimal FFT scheme is proposed when the modulating Markov chain has a large state space. To test the FFT method, a novel semi-Monte Carlo simulation algorithm is developed. This method takes advantage of the observation that the option value for a given sample path of the underlying Markov chain can be calculated using the Black-Scholes formula. Finally, numerical results are reported.
Impiications for the timing of terrestrial accretion and core formation from97Tc-97Mo and182Hf182W chronometers
Q. Z. Yin,S. B. Jacobsen
Chinese Science Bulletin , 1998, DOI: 10.1007/BF02891648
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