OALib Journal期刊

ISSN: 2333-9721




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匹配条件: “James Hicks” ,找到相关结果约20911条。
Bringing the Stories Home: Wafaa Bilal’s War on the Public Narrative of War
James Hicks
Caracteres : Estudios Culturales y Críticos de la Esfera Digital , 2012,
Abstract: The aim of the present article is to examine some artistic representations that persuade us to read the complexity of the narratives of war. To focus this issue, we will analyze Wafaa Bilal’s Domestic Tension exhibition, work which could be defined as a translation of war self-experience into an artistic frame. In this context Domestic Tension configures a space to examine the effects of war violence in modern societies. Under this perspective, art become more than a simple and empty representation of war, but further more the only possible response to human violence.
Future medical applications of single-cell sequencing in cancer
Nicholas Navin, James Hicks
Genome Medicine , 2011, DOI: 10.1186/gm247
Abstract: The value of molecular methods for cancer medicine stems from the enormous breadth of information that can be obtained from a single tumor sample. Microarrays assess thousands of transcripts, or millions of single nucleotide polymorphisms (SNPs), and next-generation sequencing (NGS) can reveal copy number and genetic aberrations at base pair resolution. However, because most applications require bulk DNA or RNA from over 100,000 cells, they are limited to providing global information on the average state of the population of cells. Solid tumors are complex mixtures of cells including non-cancerous fibroblasts, endothelial cells, lymphocytes, and macrophages that often contribute more than 50% of the total DNA or RNA extracted. This admixture can mask the signal from the cancer cells and thus complicate the inter- and intra-tumor comparisons, which are the basis of molecular classification methods.In addition, solid tumors are often composed of multiple clonal subpopulations [1-3], and this heterogeneity further confounds the analysis of clinical samples. Single-cell genomic methods have the capacity to resolve complex mixtures of cells in tumors. When multiple clones are present in a tumor, molecular assays reflect an average signal of the population, or, alternatively, only the signal from the dominant clone, which may not be the most malignant clone present in the tumor. This becomes particularly important as molecular assays are employed for directing targeted therapy, as in the use of ERBB2 (Her2-neu) gene amplification to identify patients likely to respond to Herceptin (trastuzumab) treatment in breast cancer, where 5% to 30% of all patients have been reported to exhibit such genetic heterogeneity [4-7].Aneuploidy is another hallmark of cancer [8], and the genetic lineage of a tumor is indelibly written in its genomic profile. While whole genomic sequencing of a single cell is not possible using current technology, copy number profiling of single cells using s
Regeneration of Hyaline Cartilage Using a Mechanically-Tuned Chondrocyte-Seeded Biomimetic Tissue-Engineered 3D Scaffold: A Theoretical Approach  [PDF]
Addie Hicks
Advances in Bioscience and Biotechnology (ABB) , 2014, DOI: 10.4236/abb.2014.57074

The limited ability of cartilage tissue to repair itself poses a functionally impairing health problem. While many treatment methods are available, full restoration of the tissue to its original state is rare. Often, complete joint replacement surgery is required to obtain long-term relief. Tissue engineering approaches, however, provide new opportunities for cartilage replacement. They seek to provide mechanisms to repair or replace lost tissue or function. A theoretical method is presented here for regenerating hyaline cartilage in vitro using a chondrocyte-seeded three-dimensional biomimetic engineered scaffold with mechanical properties similar to those occurring naturally. The scaffold composition, type II collagen, aggrecan, hyaluronan, hyaluronan binding protein (for link protein), and BMP-7, were chosen to encourage synthesis of hyaline cartilage by providing a more native environment and signaling cue for the seeded chondrocytes. The scaffold components mimic the macrofibrillar collagen network found in articular cartilage. Type II collagen provides tensile strength, and aggrecan, the predominant proteoglycan, provides compressive strength.

Third Grade Reading Performance and Teacher Perceptions of the Scott Foresman Reading Street Program in Title I Schools in South Mobile County
Ladnier-Hicks, Jamie,McNeese, Rose M.,Johnson, James T.
Journal of Curriculum and Instruction , 2010,
Abstract: This study was conducted to determine if third grade reading performance improved as a result of first year implementation of the Scott Foresman Reading Street program, obtain the overall satisfaction level of the certified instructional personnel using the new curriculum, and identify predictors that may improve future student performance. Reading performance was measured using the Stanford Achievement Test-10 (SAT-10). Although slight improvements in student outcome data were noted during the initial implementation year, no statistically significant differences between the performance of third grade participants before and after the implementation of Reading Street were found. A literature review revealed that it is common for reading achievement to remain the same or decrease following curriculum change. These findings appear characteristic of the reported curvilinear nature of reading curriculum implementation. Questionnaire data indicated that educators were very satisfied with Reading Street, and no specific predictors that may improve future performance within the participating population were revealed.
Identification of Novel Small RNAs and Characterization of the 6S RNA of Coxiella burnetii
Indu Warrier, Linda D. Hicks, James M. Battisti, Rahul Raghavan, Michael F. Minnick
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0100147
Abstract: Coxiella burnetii, an obligate intracellular bacterial pathogen that causes Q fever, undergoes a biphasic developmental cycle that alternates between a metabolically-active large cell variant (LCV) and a dormant small cell variant (SCV). As such, the bacterium undoubtedly employs complex modes of regulating its lifecycle, metabolism and pathogenesis. Small RNAs (sRNAs) have been shown to play important regulatory roles in controlling metabolism and virulence in several pathogenic bacteria. We hypothesize that sRNAs are involved in regulating growth and development of C. burnetii and its infection of host cells. To address the hypothesis and identify potential sRNAs, we subjected total RNA isolated from Coxiella cultured axenically and in Vero host cells to deep-sequencing. Using this approach, we identified fifteen novel C. burnetii sRNAs (CbSRs). Fourteen CbSRs were validated by Northern blotting. Most CbSRs showed differential expression, with increased levels in LCVs. Eight CbSRs were upregulated (≥2-fold) during intracellular growth as compared to growth in axenic medium. Along with the fifteen sRNAs, we also identified three sRNAs that have been previously described from other bacteria, including RNase P RNA, tmRNA and 6S RNA. The 6S regulatory sRNA of C. burnetii was found to accumulate over log phase-growth with a maximum level attained in the SCV stage. The 6S RNA-encoding gene (ssrS) was mapped to the 5′ UTR of ygfA; a highly conserved linkage in eubacteria. The predicted secondary structure of the 6S RNA possesses three highly conserved domains found in 6S RNAs of other eubacteria. We also demonstrate that Coxiella’s 6S RNA interacts with RNA polymerase (RNAP) in a specific manner. Finally, transcript levels of 6S RNA were found to be at much higher levels when Coxiella was grown in host cells relative to axenic culture, indicating a potential role in regulating the bacterium’s intracellular stress response by interacting with RNAP during transcription.
Physician-assisted suicide: a review of the literature concerning practical and clinical implications for UK doctors
Madelyn Hicks
BMC Family Practice , 2006, DOI: 10.1186/1471-2296-7-39
Abstract: Most deaths by physician-assisted suicide are likely to occur for the illness of cancer and in the elderly. GPs will deal with most requests for assisted suicide. The UK is likely to have proportionately more PAS deaths than Oregon due to the bill's wider application to individuals with more severe physical disabilities. Evidence from other countries has shown that coercion and unconscious motivations on the part of patients and doctors in the form of transference and countertransference contribute to the misapplication of physician-assisted suicide. Depression influences requests for hastened death in terminally ill patients, but is often under-recognized or dismissed by doctors, some of whom proceed with assisted death anyway. Psychiatric evaluations, though helpful, do not solve these problems. Safeguards that are incorporated into physician-assisted suicide criteria probably decrease but do not prevent its misapplication.The UK is likely to face significant clinical problems arising from physician-assisted suicide if it is legalized. Terminally ill patients with mental illness, especially depression, are particularly vulnerable to the misapplication of physician-assisted suicide despite guidelines and safeguards.A bill to legalize physician-assisted suicide in the UK recently progressed further than ever before in the British House of Lords. In 2005 Lord Joffe revised his Assisted Dying for the Terminally Ill Bill, originally written to legalize euthanasia and physician-assisted suicide (EAS), to narrow the focus to physician-assisted suicide (PAS) in England and Wales. The bill subsequently progressed to its second reading in the House of Lords in May 2006. Though peers voted to block the bill, Lord Joffe has declared his intention to continue reintroducing his bill to legalize PAS until it has proceeded through all parliamentary stages. Over the course of this legislative process, there has been little discussion of the clinical implications of physician-assis
Firming up the Foundations: Reflections on Verifying the 248 Quotations in a Historical Dict ionary, with Reference to "A Dictionary of South African English on Historical Principles"
S Hicks
Lexikos , 2010,
Abstract: A Dictionary of South African English on Historical Principles (DSAEHist) is rooted in quotation evidence. It contains just over 8 000 South African English entries, with about 45 000 citations to support those words included as headwords in the dictionary. Using the legacy electronic format in which DSAEHist was typeset, the Dictionary Unit for South African English embarked on a digitising process of DSAEHist, during which it became clear that the quotations would benefit from a full review involving the verification of all quotations against their original sources. This article examines the evolution of the quotation verification project from its beginnings as an entirely manual exercise to its current use of software developed for the purpose. Some of the project’s achievements, such as antedatings and primary source identification, are highlighted, and challenges, such as unverifiable quotations and sometimes highly convoluted research paths, are described. In addition to this, the article looks at the necessarily systematic nature of quotation handling and the main types of considerations determining methodology (for example, lexicographic, bibliographic and typographic requirements).
Pentaquark Searches
Hicks, Ken
High Energy Physics - Phenomenology , 2007,
Abstract: Current evidence does not favor the existence of the \thplus pentaquark, which was reported by several groups in the years after 2002. The question naturally arises: how could many groups could have seen fluctuations in their data at the level of 3-5 $\sigma$ statistical significance? An example of a statistical fluctuation is given and the number of $\sigma$'s necessary for claims of discovery are examined. Using this guideline, a possible answer to the above question is presented.
Sexuality and the ‘Relations of Ruling’: Using Institutional Ethnography to Research Lesbian and Gay Foster Care and Adoption.
Hicks, Stephen
Social Work and Society , 2009,
Abstract: This article makes use of institutional ethnography to research foster care and adoption by lesbians and gay men, drawing on the work of the feminist sociologist Dorothy E. Smith in order to demonstrate the investigation of social work institutional categories and the ‘relations of ruling’. Through an analysis of the ways in which ‘gender’ and the idea of the ‘gender role model’ is used within the assessment of gay and lesbian foster carers and adopters, the author shows how these categories are produced and used to police relationship forms and to identify ‘deviant instances’.
The Naueti relationship terminology: A new instance of asymmetric prescription from East Timor
David Hicks
Bijdragen tot de Taal-, Land- en Volkenkunde , 2008,
Abstract: Relationship terminologies of an asymmetric prescriptive character are widespread throughout mainland and insular Southeast Asia. Their western limit is marked by the Kachin of northern Burma (Leach 1961:28-53) while their eastern limit is marked by the Mambai people of central East Timor (Figures 1 and 2). Between these limits are such other instances as occur, for example, among the Lamet of Cambodia (Needham 1960), the various Batak groups of Sumatra (Rodgers 1984), and the Rindi of eastern Sumba (Forth 1981). The principal intention of the present paper is to establish the existence of a new asymmetric prescriptive terminology in East Timor, and by doing so provide empirical justification for adjusting the easternmost limits of nomenclatures of this kind. A subsidiary intent is to offer a contribution to current speculations regarding the transformation of relationship terminologies in eastern Indonesia (Guermonprez 1998; Smedal 2002).

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