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Search Results: 1 - 10 of 11487 matches for " Jaime Flores-Riveros "
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An Anti-Inflammatory Sterol Decreases Obesity-Related Inflammation-Induced Insulin Resistance and Metabolic Dysregulation
Chris L. Reading,Jaime Flores-Riveros,Dwight R. Stickney,James M. Frincke
Mediators of Inflammation , 2013, DOI: 10.1155/2013/814989
Abstract:
5-Androstenediol Ameliorates Pleurisy, Septic Shock, and Experimental Autoimmune Encephalomyelitis in Mice
Ferdinando Nicoletti,Dominick L. Auci,Katia Mangano,Jaime Flores-Riveros,Sonia Villegas,James M. Frincke,Christopher L. Reading,Halina Offner
Autoimmune Diseases , 2010, DOI: 10.4061/2010/757432
Abstract: Androstenediol (androst-5-ene-3 ,17 -diol; 5-AED), a natural adrenal steroid, has been shown to suppress experimental autoimmune encephalomyelitis (EAE) in female SJL/J mice. We here report that 5-AED limits inflammation and proinflammatory cytokines including TNF in murine models of carrageenan-induced pleurisy and lippopolysaccaride- (LPS) induced septic shock. 5-AED binds to and transactivates sex steroid receptors with the same general rank order of potency (ERβ > ERα ? AR). 5-AED provides benefit in EAE in a dose-dependent fashion, even when treatment is delayed until onset of disease. The minimally effective dose may be as low as 4?mg/kg in mice. However, benefit was not observed when 5-AED was given in soluble formulation, leading to a short half-life and rapid clearance. These observations suggest that treatment with 5-AED limits the production of pro-inflammatory cytokines in these animal models and, ultimately, when formulated and administered properly, may be beneficial for patients with multiple sclerosis and other Th1-driven autoimmune diseases. 1. Introduction Nonglucocorticoid steroids are subjects of intense scientific investigation as perturbations are associated with various diseases including the pathogenesis of autoimmunity [1]. The “gender gap” [2] with respect to incidence and severity of autoimmune disease has been the focus of efforts to uncover new therapies. For example, estrogens [3] and androgens [4, 5] are protective in several autoimmune disease models, including experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS). Recent work has dissociated the anti-inflammatory effect from the neuroprotective effect of estrogen treatment in EAE and has shown that its neuroprotective effects do not necessarily depend on anti-inflammatory properties [6]. Specifically, an estrogen receptor (ER) agonist reduced central nervous system inflammation, whereas an ER agonist treatment did not, but instead, was neuroprotective. Preliminary clinical results were encouraging. In a pilot trial, oral estriol treatment of relapsing remitting multiple sclerosis patients caused significant decreases in enhancing lesions on brain magnetic resonance imaging [7]. However, sex steroid therapy involves serious risks. For example, estrogen treatment involves increased risk for breast cancer in women [8]. Because such estrogen-related toxicities are mediated almost exclusively through ER , ER ligand treatment has been suggested as a potentially safer neuroprotective strategy in multiple sclerosis and other
Study of the Reactivity of (100) Felodipine Surface Model Based on DFT Concepts  [PDF]
Carlos Tepech-Carrillo, Roxana Licona-Ibarra, J. Francisco Rivas-Silva, Antonio Flores-Riveros
Open Journal of Physical Chemistry (OJPC) , 2019, DOI: 10.4236/ojpc.2019.91001
Abstract: In this study, Density Functional Theory including a dispersion correction is employed to model and analyze the structural, electronic and local reactivity of the (100) surface of felodipine. The surface energy calculated at the Generalized Gradient Approximation (GGA) level, along with plane waves as basis set and ultrasoft pseudopotentials, shows that the (100) surface is the most stable as compared to the (010) and (110) ones. In particular, we have focused on performing a quantitative study of the reactivity of the surface by means of the Fukui function and through the HOMO and LUMO populations. Our results can be related to some applications in the pharmaceutical chemistry of this compound.
Variational description of the 3-body Coulomb problem through a correlated Eckart-Gaussian wavefunction
Flores-Riveros, A.;Rivas-Silva, J. F.;
Brazilian Journal of Physics , 1999, DOI: 10.1590/S0103-97331999000300018
Abstract: the quantum mechanical problem posed by the internal motion of three particles subject to coulomb interactions is variationally solved by means of an eckart-gaussian (eg) ansatz that exhibits an exponential behavior with respect to the radial coordinates {r1,r2}, and a harmonic gaussian-type dependence on the interparticle distance r12, thereby providing explicit correlation. the proposed wavefunction is of the form (e-a1r1-b1r2 + e-b2r1 -a2r2) rl12 e-(g 2r1-u0)2, through which ground state energies are calculated for a few two-electron atoms-considering finite nuclear mass effects-and molecular ions corresponding to electronic and mesonic systems. the physical interpretation and advantages of the eg wavefunction are discussed in terms of the relative masses of the particles in the analyzed systems. a useful application of the variational method is presented where the underlying structure of the 3-body wavefunction combines an atomic- and a molecular-like description of the system. the obtained energies agree with the exact results within 10-4 - 10-2 hartrees.
Variational description of the 3-body Coulomb problem through a correlated Eckart-Gaussian wavefunction
Flores-Riveros A.,Rivas-Silva J. F.
Brazilian Journal of Physics , 1999,
Abstract: The quantum mechanical problem posed by the internal motion of three particles subject to Coulomb interactions is variationally solved by means of an Eckart-Gaussian (EG) ansatz that exhibits an exponential behavior with respect to the radial coordinates {r1,r2}, and a harmonic Gaussian-type dependence on the interparticle distance r12, thereby providing explicit correlation. The proposed wavefunction is of the form (e-alpha1r1-beta1r2 + e-beta2r1-alpha2r2) r l12 e-(g 2r1-u0)2, through which ground state energies are calculated for a few two-electron atoms-considering finite nuclear mass effects-and molecular ions corresponding to electronic and mesonic systems. The physical interpretation and advantages of the EG wavefunction are discussed in terms of the relative masses of the particles in the analyzed systems. A useful application of the variational method is presented where the underlying structure of the 3-body wavefunction combines an atomic- and a molecular-like description of the system. The obtained energies agree with the exact results within 10-4 - 10-2 Hartrees.
Variational and perturbative approaches to the confined hydrogen atom with a moving nucleus
Francisco M. Fernández,N. Aquino,A. Flores-Riveros
Physics , 2010, DOI: 10.1088/0143-0807/31/3/018
Abstract: We calculate the ground--state energy and other physical properties of the hydrogen atom inside a spherical box with an impenetrable wall. We apply the variational method and perturbation theory and compare both approximate results. We show that the total, kinetic and potential energies for the moving--nucleus model are greater than those for the case in which the nucleus is clamped at the box center.
H2+ ion in a strong magnetic field: Lowest gerade and ungerade electronic states
A. V. Turbiner,J. C. Lopez V.,A. Flores-Riveros
Physics , 2001,
Abstract: In the framework of a variational method with a single trial function an accurate study of the lowest gerade 1g and ungerade 1u electronic states of the molecular ion $H_2^+$ in a magnetic field is performed. Magnetic field ranges from 0 to 4.414x10^13 G and orientations of the molecular axis with respect to the magnetic line 0 \leq theta \leq 90 are considered. A one-parameter gauge dependent vector potential is used in the Hamiltonian, which is finally variationally optimized. A well pronounced minimum on the total energy surface of the (ppe) system in both 1g and 1u states is found for all magnetic fields and orientations studied. It is shown that for both states the parallel configuration (theta=0) at equilibrium always corresponds to the minimal total energy. It is found that for a given theta for both states the magnetic field growth is always accompanied by an increase in the total and binding energies as well as a shrinking of the equilibrium distance. We demonstrate that for B\gtrsim 1.8x10^11 G the molecular ion can dissociate, H2+ -> H + p, over a certain range of orientations (theta_cr \le theta \le 90), where the minimal thetaa_cr \simeq 25 occurs for the strongest magnetic field studied, B=4.414x10^13 G. For B<10^12 G the ion H2+ in 1g, 1u states is the most compact, being in the perpendicular configuration (theta=90), whereas for B\gtrsim 10^12 this occurs for an angle < 90. For the 1g state in any orientation, with the magnetic field growth at B \sim 10^11 G, a two-peak electronic distribution changes to single-peak one.
Ion $H_2^+$ can dissociate in a strong magnetic field
Alexander V. Turbiner,Juan Carlos Lopez V.,Antonio Flores-Riveros
Physics , 2000, DOI: 10.1134/1.1368709
Abstract: In framework of a variational method the molecular ion $H_2^+$ in a magnetic field is studied. An optimal form of the vector potential corresponding to a given magnetic field (gauge fixing) is chosen variationally. It is shown that for any magnetic field strength as well as for any orientation of the molecular axis the system $(ppe)$ possesses a minimum in the potential energy. The stable configuration always corresponds to elongation along the magnetic line. However, for magnetic fields $B \gtrsim 5\times 10^{11} G$ and some orientations the ion $H_2^+$ becomes unstable decaying to $H{-atom} + p$.
GENOTIPO E3/3 DE APO E Y SU RELACIóN CON LA RESPUESTA DE LOS LIPIDOS SéRICOS AL COLESTEROL DIETARIO
Reyes S,María Soledad; Flores C,Ingrid; Riveros S,Claudia; Castillo V,Oscar; Arteaga Ll,Antonio; Acosta B,Ana María; Rozowski N,Jaime;
Revista chilena de nutrición , 2003, DOI: 10.4067/S0717-75182003000300006
Abstract: introduction: it has been described in the literature that dietary cholesterol produces only slight changes in serum cholesterol in healthy individuals. nevertheless, several studies have shown a marked heterogeneity in the response to a variation of cholesterol in the diet. one of the factors involved in this response is the apo e genotype, also singled as a risk factor for cardiovascular disease. there are no studies in chile that evaluate the response to dietary cholesterol in individuals and its relationship to the apo e genotype. objective: to evaluate the response to a cholesterol load in individuals and relate it to their apo e genotype. materials and methods: a prospective randomized and cross-over study was carried out in 36 male volunteers either normolipemics or isolated hypercholesterolemic aged 25-55 years old, who were given one egg/day for 4 weeks in addition to their normal diet. total, ldl, and hdl cholesterol were measured before and after the intervention, as well as apo b concentration and apo e genotype. results: apo e genotype was 79% e3/3 and 16% e 4/3 in this population. the addition of one egg to their normal diet did not change significantly any of the variables studied. conclusions: normocholesterolemic or hypercholesterolemic individuals did not respond to a load of cholesterol given in the form of one egg/day. the implications for population recommendations are discussed
El papel fundamental de Internet2 para el desarrollo de los entornos virtuales de aprendizaje y su impacto en la brecha digital
Mu?oz Flores, Jaime;
Revista mexicana de investigación educativa , 2010,
Abstract: this article presents elements that reveal the urgent need to reformulate public policies for the development of infrastructure, so that broad sectors of our communities of learning can incorporate internet2 from the early phases. such incorporation is recognized as the only way to prevent the generation of new digital gaps as internet2 expands rapidly in developed nations. latin america has already recognized the strategic advantage of virtual environments for developing communities of learning; however, this resource is still not used on a massive basis due to the enormous barrier of latin america's insufficient infrastructure for ict in schools and homes.
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