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Search Results: 1 - 10 of 1983 matches for " Jai-Kyung Pyun "
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Improvement of Upper Extremity Lymphedema after Delayed Breast Reconstruction with an Extended Latissimus Dorsi Myocutaneous Flap
Kyeong Tae Lee,So-Young Lim,Jai-Kyung Pyun,Goo-Hyun Mun
Archives of Plastic Surgery , 2012, DOI: http://dx.doi.org/10.5999/aps.2012.39.2.154
Abstract: Lymphedema is a common complication after mastectomy in breast cancer patients. Manytreatment options are available, but no treatment results in a complete cure. We report acase of lymphedema that occurred after modified radical mastectomy in a breast cancerpatient who showed objective improvement after delayed breast reconstruction with anlatissimus dorsi myocutaneous flap. A 41-year-old female patient with left breast cancer hadundergone modified radical mastectomy with axillary lymph node dissection and postoperativeradiotherapy 12 years previously. Four years after surgery, lymphedema developed andincreased in aggravation despite conservative treatment. Eight years after the first operation,the patient underwent delayed breast reconstruction using the extended latissimus dorsimyocutaneous flap method. After reconstruction, the patient’s lymphedema symptomsshowed dramatic improvement by subjective measures including tissue softness and feeling oflightness, and by objective measures of about 7 mL per a week, resulting in near normal rangesof volume. At a postoperative follow-up after 3 years, no recurrence was observed. Delayedbreast reconstruction with extended latissimus dorsi myocutaneous flaps may be helpful topatients with lymphedema after mastectomy. This may be a good option for patients who areworried about the possibility of the occurrence or aggravation of secondary lymphedema.
A Method for Polarizing More Number of Impurity-Vacancy Dipoles  [PDF]
Jai Prakash, Devendra Prasad
Journal of Applied Mathematics and Physics (JAMP) , 2016, DOI: 10.4236/jamp.2016.42051
Abstract: Free rotating impurity-vacancy (IV) dipoles in an alkali halide matrix are polarized to the extent of 1/3 of the total number of IV dipoles. An experimental procedure is suggested in this article which will help in the polarization of IV dipoles to the extent of 2/3 of the total number of IV dipoles. In the suggested experimental procedure, the electric field will be applied at first in one direction and then will be applied in succession in opposite direction. Ionic thermocurrent technique is employed to ascertain the increase in polarization of IV dipoles.
A Neurotoxic Phosphoform of Elk-1 Associates with Inclusions from Multiple Neurodegenerative Diseases
Anup Sharma,Linda M. Callahan,Jai-Yoon Sul,Tae Kyung Kim,Lindy Barrett,Minsun Kim,James M. Powers,Howard Federoff,James Eberwine
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009002
Abstract: Neurodegenerative diseases are characterized by a number of features including the formation of inclusions, early synaptic degeneration and the selective loss of neurons. Molecules serving as links between these shared features have yet to be identified. Identifying candidates within the diseased microenvironment will open up novel avenues for therapeutic intervention. The transcription factor Elk-1 resides within multiple brain areas both in nuclear and extranuclear neuronal compartments. Interestingly, its de novo expression within a single dendrite initiates neuronal death. Given this novel regionalized function, we assessed whether extranuclear Elk-1 and/or phospho-Elk-1 (pElk-1) protein might be associated with a spectrum of human neurodegenerative disease cases including Lewy body Disease (e.g. Parkinson's), Alzheimer's disease, and Huntington's Disease. We first determined the importance of Elk-1 post-translational modifications on its ability to initiate regionalized cell death. We next screened human cases from three major neurodegenerative diseases to look for remarkable levels of Elk-1 and/or pElk-1 protein as well as their association with inclusions characteristic of these diseases. We compared our findings to age-matched control cases. We find that the ability of Elk-1 to initiate regionalized neuronal death depends on a specific phosphosite, T417. Furthermore, we find that T417+ Elk-1 uniquely associates with several types of inclusions present in cases of human Lewy body Disease, Alzheimer's disease, and Huntington's Disease. These results suggest a molecular link between the presence of inclusions and neuronal loss that is shared across a spectrum of neurodegenerative disease.
Paradoxical response during antituberculous therapy in a patient discontinuing infliximab: a case report
Young Kyung Yoon, Jeong Yeon Kim, Jang Wook Sohn, Min Ja Kim, Ja Seol Koo, Jai Hyun Choi, Dae Won Park
Journal of Medical Case Reports , 2009, DOI: 10.1186/1752-1947-3-6673
Abstract: A 38-year-old Korean man with severe Crohn's disease presented with fever and diffuse abdominal pain. Infliximab had been started 2 months before admission. A chest X-ray and abdominal computed tomography scan revealed numerous miliary nodules in both lung fields and microabscesses in the spleen. Given the diagnosis of disseminated tuberculosis, the infliximab therapy was discontinued and antituberculosis therapy was promptly started. Over the next 3 months, the patient was diagnosed with tuberculosis lymphadenitis on a right supraclavicular lymph node and surgical excision of the lesion was performed. With the diagnosis of a paradoxical response, anti-tuberculous therapy was continued for 12 months.Our case suggests that patients who develop tuberculosis after infliximab exposure are at an increased risk of developing a paradoxical reaction. The current recommendation of discontinuing infliximab during tuberculosis treatment should be re-evaluated.In 1998, the drug infliximab, developed from a murine-human chimeric anti-tumor necrosis factor (TNF) monoclonal antibody that binds diverse TNF moieties, was approved by the US Food and Drug Administration for the treatment of Crohn's disease [1]. However, infliximab poses a risk for reactivation of latent granulomatous infections by disrupting established granulomas; this occurs due to the neutralization of soluble TNF that is essential for the formation and maintenance of a granuloma [2]. As a result, granulomas fail to serve as physical barriers to mycobacterial dissemination in patients with latent tuberculous infections.A paradoxical deterioration during anti-tubercular therapy is defined as a transient worsening of disease, at a pre-existing site, or the development of new tuberculous lesions in a patient who initially improved on anti-tubercular therapy. This phenomenon is more commonly associated with extrapulmonary tuberculosis [3]. A paradoxical exacerbation of the signs and symptoms of tuberculosis may occur n
A Single-Center, Randomized Double-Blind Placebo-Controlled Study Evaluating the Effects of Poly-Gamma-Glutamate on Human NK Cell Activity after an 8-Week Oral Administration in Healthy Volunteers
Kyung-Soo Kim,Tae-Young Lee,Jang-Hee Hong,Ahrom Kim,Sung-Jin Kim,Jai-Chul Choi,Moon-Hee Sung,Haryoung Poo
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/635960
Abstract: A randomized double-blind placebo-controlled immunity study involving 99 healthy volunteers was performed to investigate the effect of poly-γ-glutamate (γ-PGA) on human natural killer (NK) cell activity in peripheral blood. The volunteers were randomly assigned to one of three groups and orally treated with solutions (25?mL) containing 0?mg (placebo), 250?mg (low dosage), or 500?mg (high dosage) of γ-PGA. Each volunteer took one dose every 12 hours for 8 weeks. Blood samples were drawn before the initial treatment and at the 4th and the 8th weeks of treatment. NK cell activity was assessed by measuring its degranulation, cytokine production, and cytotoxicity against the K562 cell line. Our results revealed that the cytotoxic activities of NK cells from the high-dosage γ-PGA group were significantly higher ( for all comparisons) compared to the low dosage and placebo groups at weeks 4 and 8 after the initial treatment. This increase in the NK cell activity among peripheral blood mononuclear cells (PBMCs) of healthy individuals was also confirmed in vitro (as assessed by the degranulation and cytokine production). These results suggest that the oral administration of γ-PGA induces a cell-mediated immunity by increasing the NK cell activity in humans. 1. Introduction Poly-γ-glutamate (γ-PGA), which is naturally secreted from Bacillus, is a safe and edible polymer in which the α-amino and γ-carboxy groups of D- or L-glutamic acid are linked by isopeptide bonds [1]. We previously reported that oral administration of high-molecular-mass γ-PGA (average MW 2,000?kDa) isolated from Bacillus subtilis sp. Chungkookjang (a traditional Korean food) confers more significant antitumor effects than lower-molecular-mass (10?kDa) γ-PGA by inducing interleukin-12 (IL-12) and interferon-gamma (IFN-γ) production and activating natural killer (NK) cells in a mouse model system [2, 3]. These antitumor effects were elicited by the TLR4-dependent stimulation of immune cells (e.g., NK cells), activation of macrophages, and maturation of dendritic cells [3]. As part of their innate effector functions, NK cells possess a potent cytotoxic activity against tumor cells, virus-infected cells, and intracellular parasites [4–9]. NK cells destroy targets, including tumor cells, by various mechanisms, and they may be regulated by IL-12 secreted from activated macrophages or dendritic cells [10]. The effects of γ-PGA on the antitumor activity of human NK cells has not yet been reported. In the present study, we investigated the effect of oral administration of high-molecular-weight γ-PGA
Genetic heterogeneity of Oguchi′s disease
Singh Jai
Indian Journal of Ophthalmology , 1990,
Abstract: An analysis of the cases reported in Punjab, India, indicates the presence of genetic heterogeneity of Oguchi′s disease, for which autosomal recessive inheritance has been documented earlier. The autosomal dominant inheritance pattern of this disease is associated with incomplete penetrance and a distinct sex bias towards females. This recognition is important for genetic counselling.
Medical Informatics For Medical Students And Medical Practitioners
International e-Journal of Science, Medicine & Education , 2010,
Abstract: The importance of incorporating medical (or health)informatics into the education of medical students andmedical practitioners is being increasingly recognised.The advances in information and communicationtechnology and the pervasion of the Internet intoeveryday life have important implications forhealthcare services and medical education.Students and practitioners should learn to utilisebiomedical information for problem solving anddecision making based on evidence. The extensiveintroduction of electronic health information systemsinto hospitals and clinics and at the enterprise level inMalaysia and elsewhere is driving a demand for healthprofessionals who have at least basic skills in andappreciation of the use of these technologies.The essential clinical informatics skills have beenidentified and should be incorporated into theundergraduate medical curriculum. It is recommendedthat these be introduced in stages and integrated intoexisting programmes rather than taught as a separatemodule. At the same time, medical schools shouldsupport the integration of e-learning in the educationalprocess in view of the numerous potential benefits.
Lagrangian Velocity Correlations and Absolute Dispersion in the Midlatitude Troposphere
Jai Sukhatme
Physics , 2004, DOI: 10.1175/JAS3560.1
Abstract: Employing daily wind data from the ECMWF, we perform passive particle advection to estimate the Lagrangian velocity correlation functions (LVCF) associated with the midlatitude tropospheric flow. In particular we decompose the velocity field into time mean and transient (or eddy) components to better understand the nature of the LVCF's. A closely related quantity, the absolute dispersion (AD) is also examined. Given the anisotropy of the flow, meridional and zonal characteristics are considered separately. The zonal LVCF is seen to be non-exponential. In fact, for intermediate timescales it can either be interpreted as a power law of the form $\tau^{-\alpha}$ with $ 0<\alpha<1$ or as the sum of exponentials with differing timescales - both interpretations being equivalent. More importantly the long time correlations in the zonal flow result in a superdiffusive zonal AD regime. On the other hand, the meridional LVCF decays rapidly to zero. Before approaching zero the meridional LVCF shows a region of negative correlation - a consequence of the presence of planetary scale Rossby waves. As a result the meridional AD, apart from showing the classical asymptotic ballistic and diffusive regimes, displays transient subdiffusive behaviour.
Probability Density Functions of Decaying Passive Scalars in Periodic Domains : An Application of Sinai-Yakhot Theory
Jai Sukhatme
Physics , 2004, DOI: 10.1103/PhysRevE.69.056302
Abstract: Employing the formalism introduced by Sinai and Yakhot [PRL, 63(18), p. 1962, 1989], we study the probability density functions (pdf's) of decaying passive scalars in periodic domains under the influence of smooth large scale velocity fields. The particular regime we focus on is one where the normalized scalar pdf's attain a self-similar profile in finite time, i.e., the so called strange or statistical eigenmode regime. In accordance with the work of Sinai and Yakhot, the central regions of the pdf's are power laws. But the details of the pdf profiles are dependent on the physical parameters in the problem. Interestingly, for small Peclet numbers the pdf's {\it resemble} stretched or pure exponential functions, whereas in the limit of large Peclet numbers, there emerges a universal Gaussian form for the pdf. Numerical simulations are used to verify these predictions.
Automated Test Case Generation using Petri Nets
Jai Manral
Computer Science , 2015,
Abstract: Software testing is the process of determining the precision, quality, completeness and security of the software systems. An important step in testing software is the generation of test cases, whose quality plays a vital role in determining the time for testing and subsequently its cost. In this research, it is shown that both structural and behavioural diagrams can be used to represent specifications in a single model using High Level Petri Nets (HLPN). This research focuses on automated generation of test models from Petri nets. Moreover, generating consistent formal models (HLPN) from informal models (UML) is the highlight of this research.
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