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Search Results: 1 - 10 of 1208 matches for " Jai Seup Ro "
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Inhibitory Effect of Inflexinol on Nitric Oxide Generation and iNOS Expression via Inhibition of NF- Activation
Jae Woong Lee,Moon Soon Lee,Tae Hun Kim,Hwa Jeong Lee,Seong Su Hong,Young Hee Noh,Bang Yeon Hwang,Jai Seup Ro,Jin Tae Hong
Mediators of Inflammation , 2007, DOI: 10.1155/2007/93148
Abstract: Inflexinol, an ent-kaurane diterpenoid, was isolated from the leaves of Isodon excisus. Many diterpenoids isolated from the genus Isodon (Labiatae) have antitumor and antiinflammatory activities. We investigated the antiinflammatory effect of inflexinol in RAW 264.7 cells and astrocytes. As a result, we found that inflexinol (1, 5, 10 μM) suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) as well as the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells and astrocytes. Consistent with the inhibitory effect on iNOS and COX-2 expression, inflexinol also inhibited transcriptional and DNA binding activity of NF-κB via inhibition of IκB degradation as well as p50 and p65 translocation into nucleus. These results suggest that inflexinol inhibits iNOS and COX-2 expression through inhibition of NF-κB activation, thereby inhibits generation of inflammatory mediators in RAW 264.7 cells and astrocytes, and may be useful for treatment of inflammatory diseases.
Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L
Dae Kim, Gwan Hong, Jai Ro
Journal of Neuroinflammation , 2011, DOI: 10.1186/1742-2094-8-25
Abstract: We co-cultured human U87 glioblastoma (U87) and human mast cell-1 (HMC-1) cell lines, and mouse cerebral cortices-derived astrocytes and mouse bone marrow-derived mast cells (BMMCs). Intracellular Ca2+ ([Ca2+]i) was measured by confocal microscopy; CD40 siRNA by Silencer Express Kit; small GTPases by GTP-pull down assay; PKCs, MAPKs, CD40, CD40L, Jak1/2, STAT1, TNF receptor 1 (TNFR1) by Western blot; NF-κB and AP-1 by EMSA; cytokines by RT-PCR. An experimental allergic encephalomyelitis (EAE) model was induced using myelin oligodendrocyte glycoprotein (MOG) peptide and pertussis toxin in mice. Co-localization of TNFR1 and astrocytes in EAE brain tissues was determined by immunohistochemistry.Each astrocyte co-culture had increases in [Ca2+]i levels, release of cytokines and chemokines; activities of Rho-family GTPases, NF-κB/AP-1/STAT1727, and Jack1/2, STAT1701. These effects were inhibited by anti-CD40 antibody or CD40 siRNA, and signaling pathways for Jak1/2 were inhibited by anti-TNFR1 antibody. EAE score, expression of TNFR1, and co-localization of TNFR1 and astrocytes were enhanced in brain of the EAE model. Anti-CD40 antibody or 8-oxo-dG pretreatment reduced these effects in EAE model.These data suggest that astrocytes activated by the CD40-CD40L interaction in co-culture induce inflammatory cytokine production via small GTPases, and the secreted cytokines re-activate astrocytes via Jak/STAT1701 pathways, and then release more cytokines that contribute to exacerbating the development of EAE. These findings imply that the pro-inflammatory mediators produced by cell-to-cell cross-talk via interaction of CD40-CD40L may be as a promising therapeutic target for neurodegenerative diseases like MS.Astrocytes, which are known as a major glial cell type, have important physiological properties in central nerve system (CNS) homeostasis. Astrocytes have a dynamic role in regulating neuronal function [1], and play an active and dual role in CNS inflammatory diseases such
Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells
Dae Kim, Eun Kwon, Gwan Hong, Yun Lee, Seung-Hyo Lee, Jai Ro
Respiratory Research , 2011, DOI: 10.1186/1465-9921-12-49
Abstract: BALB/c mice were sensitized and challenged by OVA to induce asthma, and bone marrow-derived mast cells (BMMCs) were stimulated with antigen/antibody reaction. Mice or BMMCs were exposed to cigarette smoke or CSE solution for 1 mo or 6 h, respectively. The recruitment of inflammatory cells into BAL fluid or lung tissues was determined by Diff-Quik or H&E staining, collagen deposition by Sircol assay, penh values by a whole-body plethysmography, co-localization of tryptase and Smad3 by immunohistochemistry, IgE and TGF-β level by ELISA, expressions of Smads proteins, activities of signaling molecules, or TGF-β mRNA by immunoblotting and RT-PCR.Cigarette smoke enhanced OVA-specific IgE levels, penh values, recruitment of inflammatory cells including mast cells, expressions of smad family, TGF-β mRNA and proteins, and cytokines, phosphorylations of Smad2 and 3, and MAP kinases, co-localization of tryptase and Smad3, and collagen deposition more than those of BAL cells and lung tissues of OVA-induced allergic mice. CSE solution pretreatment enhanced expressions of TGF-β, Smad3, activities of MAP kinases, NF-κB/AP-1 or PAI-1 more than those of activated-BMMCs.The data suggest that smoke exposure enhances antigen-induced mast cell activation via TGF-β/Smad signaling pathways in mouse allergic asthma, and that it exacerbates airway inflammation and remodeling.Cigarette smoke contains many toxic substances and a strong pro-inflammatory stimulus [1-3]. It is widely recognized as a significant risk factor for a number of diseases including emphysema, chronic obstructive pulmonary disease, cardiovascular disease, lung cancer and allergic diseases [1].Effects of smoke on allergic airway inflammation in mice have reported both exacerbation [4-8] and attenuation [9-11], although these studies could not be directly compared due to differences in the various factors used, such as mouse strain, the routes and manners of allergen sensitization and smoke exposure. Smoke also enhanced a
A Method for Polarizing More Number of Impurity-Vacancy Dipoles  [PDF]
Jai Prakash, Devendra Prasad
Journal of Applied Mathematics and Physics (JAMP) , 2016, DOI: 10.4236/jamp.2016.42051
Abstract: Free rotating impurity-vacancy (IV) dipoles in an alkali halide matrix are polarized to the extent of 1/3 of the total number of IV dipoles. An experimental procedure is suggested in this article which will help in the polarization of IV dipoles to the extent of 2/3 of the total number of IV dipoles. In the suggested experimental procedure, the electric field will be applied at first in one direction and then will be applied in succession in opposite direction. Ionic thermocurrent technique is employed to ascertain the increase in polarization of IV dipoles.
Awareness and Utilisation of Information Resources Among Polytechnic Lecturers In Nigeria
RO Opeke, RO Odunlade
Samaru Journal of Information Studies , 2011,
Abstract: This study examined the relationship between awareness of existence of information resources and its utilisation among Polytechnic lecturers in Nigeria. The descriptive survey research design involving the use of questionnaire as the research instrument was adopted. Data were analysed using frequencies, percentages, means, standard deviations, and simple correlation. The study found that majority of Polytechnic lecturers had awareness of most of the information resources identified in the study. Among the mostly utilised resources were textbooks (93.5%), journals (80.4%), conference proceedings (56.5%), and encyclopedias (52.2%). A weak positive correlation (r=0.37, p=0.012<0.05) existed between awareness and utilisation of resources. Deliberate efforts by Polytechnic librarians in creating awareness on various information resources available for teaching was suggested as the way forward.
Genetic heterogeneity of Oguchi′s disease
Singh Jai
Indian Journal of Ophthalmology , 1990,
Abstract: An analysis of the cases reported in Punjab, India, indicates the presence of genetic heterogeneity of Oguchi′s disease, for which autosomal recessive inheritance has been documented earlier. The autosomal dominant inheritance pattern of this disease is associated with incomplete penetrance and a distinct sex bias towards females. This recognition is important for genetic counselling.
Medical Informatics For Medical Students And Medical Practitioners
International e-Journal of Science, Medicine & Education , 2010,
Abstract: The importance of incorporating medical (or health)informatics into the education of medical students andmedical practitioners is being increasingly recognised.The advances in information and communicationtechnology and the pervasion of the Internet intoeveryday life have important implications forhealthcare services and medical education.Students and practitioners should learn to utilisebiomedical information for problem solving anddecision making based on evidence. The extensiveintroduction of electronic health information systemsinto hospitals and clinics and at the enterprise level inMalaysia and elsewhere is driving a demand for healthprofessionals who have at least basic skills in andappreciation of the use of these technologies.The essential clinical informatics skills have beenidentified and should be incorporated into theundergraduate medical curriculum. It is recommendedthat these be introduced in stages and integrated intoexisting programmes rather than taught as a separatemodule. At the same time, medical schools shouldsupport the integration of e-learning in the educationalprocess in view of the numerous potential benefits.
Lagrangian Velocity Correlations and Absolute Dispersion in the Midlatitude Troposphere
Jai Sukhatme
Physics , 2004, DOI: 10.1175/JAS3560.1
Abstract: Employing daily wind data from the ECMWF, we perform passive particle advection to estimate the Lagrangian velocity correlation functions (LVCF) associated with the midlatitude tropospheric flow. In particular we decompose the velocity field into time mean and transient (or eddy) components to better understand the nature of the LVCF's. A closely related quantity, the absolute dispersion (AD) is also examined. Given the anisotropy of the flow, meridional and zonal characteristics are considered separately. The zonal LVCF is seen to be non-exponential. In fact, for intermediate timescales it can either be interpreted as a power law of the form $\tau^{-\alpha}$ with $ 0<\alpha<1$ or as the sum of exponentials with differing timescales - both interpretations being equivalent. More importantly the long time correlations in the zonal flow result in a superdiffusive zonal AD regime. On the other hand, the meridional LVCF decays rapidly to zero. Before approaching zero the meridional LVCF shows a region of negative correlation - a consequence of the presence of planetary scale Rossby waves. As a result the meridional AD, apart from showing the classical asymptotic ballistic and diffusive regimes, displays transient subdiffusive behaviour.
Probability Density Functions of Decaying Passive Scalars in Periodic Domains : An Application of Sinai-Yakhot Theory
Jai Sukhatme
Physics , 2004, DOI: 10.1103/PhysRevE.69.056302
Abstract: Employing the formalism introduced by Sinai and Yakhot [PRL, 63(18), p. 1962, 1989], we study the probability density functions (pdf's) of decaying passive scalars in periodic domains under the influence of smooth large scale velocity fields. The particular regime we focus on is one where the normalized scalar pdf's attain a self-similar profile in finite time, i.e., the so called strange or statistical eigenmode regime. In accordance with the work of Sinai and Yakhot, the central regions of the pdf's are power laws. But the details of the pdf profiles are dependent on the physical parameters in the problem. Interestingly, for small Peclet numbers the pdf's {\it resemble} stretched or pure exponential functions, whereas in the limit of large Peclet numbers, there emerges a universal Gaussian form for the pdf. Numerical simulations are used to verify these predictions.
Automated Test Case Generation using Petri Nets
Jai Manral
Computer Science , 2015,
Abstract: Software testing is the process of determining the precision, quality, completeness and security of the software systems. An important step in testing software is the generation of test cases, whose quality plays a vital role in determining the time for testing and subsequently its cost. In this research, it is shown that both structural and behavioural diagrams can be used to represent specifications in a single model using High Level Petri Nets (HLPN). This research focuses on automated generation of test models from Petri nets. Moreover, generating consistent formal models (HLPN) from informal models (UML) is the highlight of this research.
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