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Search Results: 1 - 10 of 22029 matches for " Jae-Bong Kim "
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Hedgehog Signaling Regulates the Survival of Gastric Cancer Cells by Regulating the Expression of Bcl-2
Myoung-Eun Han,Young-Suk Lee,Sun-Yong Baek,Bong-Seon Kim,Jae-Bong Kim,Sae-Ock Oh
International Journal of Molecular Sciences , 2009, DOI: 10.3390/ijms10073033
Abstract: Gastric cancer is the second most common cause of cancer deaths worldwide. The underlying molecular mechanisms of its carcinogenesis are relatively poorly characterized. Hedgehog (Hh) signaling, which is critical for development of various organs including the gastrointestinal tract, has been associated with gastric cancer. The present study was undertaken to reveal the underlying mechanism by which Hh signaling controls gastric cancer cell proliferation. Treatment of gastric cancer cells with cyclopamine, a specific inhibitor of Hh signaling pathway, reduced proliferation and induced apoptosis of gastric cancer cells. Cyclopamine treatment induced cytochrome c release from mitochondria and cleavage of caspase 9. Moreover, Bcl-2 expression was significantly reduced by cyclopamine treatment. These results suggest that Hh signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2.
Direct Response Elements of BMP within the PV.1A Promoter Are Essential for Its Transcriptional Regulation during Early Xenopus Development
Hyun-Shik Lee, Sung-Young Lee, Hyosang Lee, Yoo-Seok Hwang, Sang-Wook Cha, Soochul Park, Jae-Yong Lee, Jae-Bong Park, SungChan Kim, Mae Ja Park, Jaebong Kim
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0022621
Abstract: Xvent homeobox genes encode transcription factors that repress organizer genes and are essential for dorsoventral specification during early embryogenesis in Xenopus. In contrast to the Xvent-2 gene subfamily, Xvent-1 subfamily members, including PV.1A, have been proposed as indirect targets of Bone Morphogenetic Protein-4 (BMP-4) signaling. Because PV.1A is a critical downstream mediator of, and tightly regulated by, BMP-4 signaling, we hypothesized that its promoter contains a direct BMP-4 response element to effect this transcriptional regulation. We demonstrate that direct regulation by BMP-4 is necessary for transcription of PV.1A: its proximal promoter contains cis-acting binding elements for Smads and Oaz crucial to induction in response to BMP-4 signaling. In addition to these direct cis-acting BMP-4 responsive elements, an indirect Xvent-2 response element and several repressive elements exist in the PV.1A promoter to regulate its transcription. In summary, PV.1A undergoes combinatorial regulation during early Xenopus development as both the direct target of BMP-4 signaling and as the direct and indirect target of positive and negative regulatory factors.
Regulation of cerebrospinal fluid production by caffeine consumption
Myoung-Eun Han, Hak-Jin Kim, Young-Suk Lee, Dong-Hyun Kim, Joo-Taek Choi, Chul-Sik Pan, Sik Yoon, Sun-Yong Baek, Bong-Seon Kim, Jae-Bong Kim, Sae-Ock Oh
BMC Neuroscience , 2009, DOI: 10.1186/1471-2202-10-110
Abstract: In the present study we found that the long-term consumption of caffeine can induce ventriculomegaly; this was observed in 40% of the study rats. In the caffeine-treated rats with ventriculomegaly, there was increased production of CSF, associated with the increased expression of Na+, K+-ATPase and increased cerebral blood flow (CBF). In contrast to the chronic effects, acute treatment with caffeine decreased the production of CSF, suggesting 'effect inversion' associated with caffeine, which was mediated by increased expression of the A1 adenosine receptor, in the choroid plexus of rats chronically treated with caffeine. The involvement of the A1 adenosine receptor in the effect inversion of caffeine was further supported by the induction of ventriculomegaly and Na+, K+-ATPase, in A1 agonist-treated rats.The results of this study show that long-term consumption of caffeine can induce ventriculomegaly, which is mediated in part by increased production of CSF. Moreover, we also showed that adenosine receptor signaling can regulate the production of CSF by controlling the expression of Na+, K+-ATPase and CBF.Methylxanthine caffeine is present in many common beverages, and is widely consumed worldwide [1,4]. Caffeine consumption has been estimated to be 76 mg per person per day worldwide, as high as 238 mg per person per day in the United States and Canada, and more than 400 mg per person per day in Sweden and Finland [5,6]. Caffeine is absorbed rapidly after oral administration and distributed to various organs and tissues. In the liver, caffeine is metabolized to dimethyl- and monomethylxanthines, dimethyl and monomethyl uric acids, trimethyl- and dimethylallantoin, and uracil derivatives. Some metabolites of caffeine including 1,3-dimethylxanthine (theophylline) and 1,7-dimethylxanthine (paraxanthine) have pharmacological activity similar to caffeine [4]. The half-life of caffeine is ~5 hours in humans and ~1 hour in rats [4,7].The main mechanism of action of caffei
The Function of Heterodimeric AP-1 Comprised of c-Jun and c-Fos in Activin Mediated Spemann Organizer Gene Expression
Sung-Young Lee, Jaeho Yoon, Hyun-Shik Lee, Yoo-Seok Hwang, Sang-Wook Cha, Chul-Ho Jeong, Jong-Il Kim, Jae-Bong Park, Jae-Yong Lee, SungChan Kim, Mae Ja Park, Zigang Dong, Jaebong Kim
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021796
Abstract: Background Activator protein-1 (AP-1) is a mediator of BMP or FGF signaling during Xenopus embryogenesis. However, specific role of AP-1 in activin signaling has not been elucidated during vertebrate development. Methodology/Principal Findings We provide new evidence showing that overexpression of heterodimeric AP-1 comprised of c-jun and c-fos (AP-1c-Jun/c-Fos) induces the expression of BMP-antagonizing organizer genes (noggin, chordin and goosecoid) that were normally expressed by high dose of activin. AP-1c-Jun/c-Fos enhanced the promoter activities of organizer genes but reduced that of PV.1, a BMP4-response gene. A loss of function study clearly demonstrated that AP-1c-Jun/c-Fos is required for the activin-induced organizer and neural gene expression. Moreover, physical interaction of AP-1c-Jun/c-Fos and Smad3 cooperatively enhanced the transcriptional activity of goosecoid via direct binding on this promoter. Interestingly, Smad3 mutants at c-Jun binding site failed in regulation of organizer genes, indicating that these physical interactions are specifically necessary for the expression of organizer genes. Conclusions/Significance AP-1c-Jun/c-Fos plays a specific role in organizer gene expression in downstream of activin signal during early Xenopus embryogenesis.
Transcortical Alterations in - ATPase and Microtubule-Associated Proteins Immunoreactivity in the Rat Cortical Atrophy Model Induced by Hypoxic Ischemia
Jun-Gyo Suh,Sung-Jin An,Jae-Bong Park,Zae-Young Ryoo,Jeong Woong Lee,Yang-Seok Oh,Moo Ho Won,Tae-Cheon Kang
Neural Plasticity , 2002, DOI: 10.1155/np.2002.135
Abstract: To identify the chronological transcortical change in the contralateral hemisphere following ischemic insults, we investigated the changes in microtubule associated protein (MAP) and Na
Biodegradable stent  [PDF]
Doo Yeon Kwon, Jae Il Kim, Da Yeon Kim, Hwi Ju Kang, Bong Lee, Kang Woo Lee, Moon Suk Kim
Journal of Biomedical Science and Engineering (JBiSE) , 2012, DOI: 10.4236/jbise.2012.54028
Abstract: The bare metal stent (BMS) used in the blood vessel caused the restenosis after the operation due to formation and proliferation of neointimal. Recently, as a method to overcome the problems of BMS, drug eluting stent (DES) is developed and being applied to human body which has drug reducing restenosis applied on the metal surface. DES has the advantage of greatly reducing the restenosis after the operation; however, metal stent remains in the body after the drug is released causing issues such as late thrombosis and restenosis so that currently the attention is increasing for biodegradable materials that reduce restenosis and thrombosis by degrading as a certain amount of time passes after the drug is released by the stent material. In this review, the study trend of biodegradable stent will be explained.
Enhanced stability of nano-emulsified paclitaxel  [PDF]
Ju Young Lee, Da Yeon Kim, Gyeong Hae Kim, Kkot Nim Kang, Byoung Hyun Min, Bong Lee, Jae Ho Kim, Moon Suk Kim
Journal of Biomedical Science and Engineering (JBiSE) , 2011, DOI: 10.4236/jbise.2011.45044
Abstract: The main goal of this work was to develop an optimal self-microemulsifying paclitaxel prepared with PLGA and solubilizer such as tetraglycol, Cremophor ELP, and Labrasol. The prepared PTx-loaded SMES showed the size of the range of 80–130 nm by dy-namic light scattering and a spherical shape by atomic force microscopy. In experiment of storage stability in deionized water (DW) or blood condition, PTx-loaded SMES showed good stability in DW and comparable stability in blood condition at 37oC for 7 days. In addition, PTx-loaded SMES showed a sig-nificant inhibitory effect on B16F10 melanoma proli-feration. In conclusion, we confirmed that the for-mulations tried in this study could be used as admin-istration form for animal trials of PTx.
Evaluation the Properties of Titanium Matrix Composites by Melting Route Synthesis

Bong-Jae Choi,Si-Young Sung,Myoung-Gyun Kim,Young-Jig Kim,

材料科学技术学报 , 2008,
Abstract: The main purpose of this study is an in-situ synthesis of (TiB TiC) hybrid titanium matrix composites (TMCs) by vacuum induction melting method and to verify its mechanical properties. The melting route was adopted to synthesize the commercial pure titanium (cp Ti) and granular boron carbide (B4C). The reinforcements, the fraction of 10 vol. pct, were formed by adding 1.88 wt pct B4C to cp Ti. After in-situ synthesis of TMCs, electron probe micro-analysis elemental mapping was carried out to confirm the distribution and shape of reinforcements. The cone-on-disk type sliding wear test was also done for the identification of TMCs. It is concluded that (TiB TiC) hybrid TMCs can be in-situ synthesized and has better wear properties than H13.
Comparison of Gut Microbiota between Sasang Constitutions
Bong-Soo Kim,Hyo Sang Bae,Chi-yeon Lim,Mi Jeong Kim,Jae-gu Seo,Jong Yeol Kim,Jai-eun Kim,Hojun Kim
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/171643
Abstract: The Sasang constitutional medicine has long been applied to diagnose and treat patients with various diseases. Studies have been conducted for establishment of scientific evidence supporting Sasang Constitutional (SC) diagnosis. Recent human microbiome studies have demonstrated individual variations of gut microbiota which can be dependent on lifestyle and health conditions. We hypothesized that gut microbial similarities and discrepancies may exist across SC types. We compared the difference of gut microbiota among three constitutions (So-Yang, So-Eum, and Tae-Eum), along with the investigation of anthropometric and biochemical parameters. Firmicutes and Bacteroidetes were predominant phyla in all SC types. The median plot analysis suggested that Firmicutes and Bacteroidetes appeared more abundant in SE and TE, respectively, in the male subjects of 20–29 years old. At the genus level, Bifidobacterium and Bacteroides manifested the difference between SE and TE types. For anthropometry, body weight, body mass index, and waist circumference of the TE type were significantly higher than those of the other types. Overall, findings indicated a possible link between SC types and gut microbiota within a narrow age range. Further investigations are deemed necessary to elucidate the influences of age, gender, and other factors in the context of SC types and gut microbiota. 1. Introduction Individualized treatment according to the patients’ “syndrome” pattern is one of the characteristics of traditional oriental medicine in the East Asian countries. The Sasang constitutional medicine, a holistic approach based on the unique constitutional typology, has long been applied to diagnose and treat patient with various diseases. Characteristics pertaining one’s physical, psychosomatic, and emotional aspects are integrated in the determination of Sasang constitutional (SC) types. The SCM deals with biological and psychological traits in individuals and explains individual differences in behavioral tendencies, physical characteristics, and varying levels of vulnerability to disease and responsiveness to environmental stimuli. Diagnosis under the SC typology divides human beings into four categories (Tae-Yang, Tae-Eum, So-Yang, and So-Eum) according to their inherited traits, including appearance, physiology, susceptibility to disease, and personality. Traditional Korean medical doctors classify patients using SC for diagnosis and treatment in clinics. However, like other forms of complementary and alternative medical systems worldwide, the identification of SC has been
High susceptibility of metastatic cells derived from human prostate and colon cancer cells to TRAIL and sensitization of TRAIL-insensitive primary cells to TRAIL by 4,5-dimethoxy-2-nitrobenzaldehyde
Hak-Bong Kim, Mi-Ju Kim, Dae-Young Kim, Jae-Won Lee, Jae-Ho Bae, Dong-Wan Kim, Chi-Dug Kang, Sun-Hee Kim
Molecular Cancer , 2011, DOI: 10.1186/1476-4598-10-46
Abstract: PC3-MM2 and KM12L4A cells with high level of c-Myc and DNA-PKcs were more susceptible to TRAIL than their poorly metastatic primary PC3 and KM12 cells, which was associated with down-regulation of c-FLIPL/S and Mcl-1 and up-regulation of the TRAIL receptor DR5 but not DR4 in both metastatic cells. Moreover, high susceptibility of these metastatic cells to TRAIL was resulted from TRAIL-induced potent activation of caspase-8, -9, and -3 in comparison with their primary cells, which led to cleavage and down-regulation of DNA-PKcs. Knockdown of c-Myc gene in TRAIL-treated PC3-MM2 cells prevented the increase of DR5 cell surface expression, caspase activation and DNA-PKcs cleavage and attenuated the apoptotic effects of TRAIL. Moreover, the suppression of DNA-PKcs level with siRNA in the cells induced the up-regulation of DR5 and active caspase-8, -9, and -3. We also found that 4,5-dimethoxy-2-nitrobenzaldehyde (DMNB), a specific inhibitor of DNA-PK, potentiated TRAIL-induced cytotoxicity and apoptosis in relatively TRAIL-insensitive PC3 and KM12 cells and therefore functioned as a TRAIL sensitizer.This study showed the positive relationship between c-Myc expression in highly metastatic human prostate and colon cancer cells and susceptibility to TRAIL-induced apoptosis and therefore indicated that TRAIL might be used as an effective therapeutic modality for advanced metastatic cancers overexpressing c-Myc and combination of TRAIL therapy with agent that inhibits the DNA-PKcs/Akt signaling pathway might be clinically useful for the treatment of relatively TRAIL-insensitive human cancers.Despite the improvement of therapeutic strategies against cancer, the acquisition of invasive/metastatic capabilities and the development of resistance to therapy in cancer cells are still critical problems for successful cancer therapy because recurrent or metastatic cancers that appear after the initial radiotherapy or chemotherapy are generally refractory to secondary therapies [1]. Som
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