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Search Results: 1 - 10 of 33079 matches for " Jae Do Kim "
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Quality of Life (QOL) in Long-Term Survivors of Osteosarcoma  [PDF]
Jae Do Kim, Jae Man Kwak, So Hak Chung
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.41018

We conducted this study to analyze the quality of life using the SF-36 health questionnaire and the MSTS scores depending on surgical method and the primary site of occurrence. On the surgical method, the limb salvage had more excellent outcomes (60.9) than the amputation (46.3). The tumor prosthetic replacement had notably higher scores (62.5) than any other methods. For the correlation coefficients on the MSTS and SF-36, the Physical Function had the highest degree of correlation. Excellent functions of the extremities would lead to a good quality of life.

Treatment Outcome of Pelvic Osteosarcoma a 20 Year Experience in a Single Institution  [PDF]
Jae Do Kim, Cheung Kue Kim, So Hak Chung
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.41037

Purpose: Osteosarcoma of limbs shows excellent therapeutic results due to development of diagnostic and treatment methods. However, osteosarcoma of pelvic bone is known to have lower incidence than those of limbs and poorer prognosis. This study is performed to research the diagnosis, treatment, treatment outcomes, and complications of osteosarcoma of pelvic bone and propose standards for adequate treatment. Objective and Method: 16 cases that were diagnosed as osteosarcoma of pelvic bone from January 1988 to October 2010 in Kosin University Gospel Hospital were analyzed. Follow-up periods were at least 2 months up to 60 months. There were 6 cases of male and 10 cases of female, and mean age was 44.3 (14 ~ 74) years old. 5 cases were accompanied by pulmonary metastasis at the time of the diagnosis. Surgical treatment including preoperative and postoperative chemotherapy was performed in 9 cases, and only chemotherapy and radiation were performed in 1 case. Among 9 cases having undergone surgical treatment, 3 cases were performed with biological reconstruction using autogenous bone graft and total hip replacement together, 1 case was performed with extracorporeal irradiated recycled autogenous bone graft, 1 case was performed with reconstruction using tumor prosthesis, and 4 cases were performed with wide excision. Retrospective review was done about diagnostic procedures, treatment methods and results, and complications. Results: Mean period from the onset of symptoms to the time of the diagnosis was 6.3 (3 ~ 12) months, and the symptoms were 7 cases of hip pain, each 3 cases of lumbar pain and radiating pain to lower limbs, pelvic mass, each 2 cases of inguinal pain, and each 1 case of thigh pain, Among the 9 cases performed with preoperative and postoperative chemotherapy and surgical treatment, there were 6 cases of T-10 protocol, 2 cases of T-20 protocol, and 1 case of IA (Intraarterial) Cis protocol. In the 1 case that haven’t undergone surgical treatment, T-10 protocol was performed. 13 of the 16 cases were expired, with the mean time of 15 (2 ~ 47 months) from the time of the diagnosis to death. Complications were 4

Long-Term Results of Ewing’s Sarcoma—In a Single Institution  [PDF]
Jae Do Kim, Tae Hun Kim, So Hak Chung
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.41039

Purpose: This study analyzed oncological and functional outcomes of treatment for Ewing’s sarcoma, as well as its significant risk factors through long-term follow up. Objective and Method: Between September 1990 and April 2009, 20 cases that were diagnosed and treated as Ewing’s sarcoma in Kosin University Gospel Hospital were entered onto the study. Mean follow-up period was 45.4 (12 - 108) months. There were 7 cases of male and 13 cases of female, and mean age was 19.9 (5 - 48) years old. Retrospective review was done about treatment outcomes, complications, and significant risk factors. Results: In terms of oncologic results, there were 9 cases of CDF (continuous disease free), 1 case of NED (no evidence of disease), 4 cases of AWD (alive with disease), 5 cases of DOD (dead of disease), and 1 case of DWOD (dead with other disease). Five-year overall survival rate of all the patients was 70.0% and event-free survival rate was 50.0%. The mean MSTS (Musculoskeletal Tumor Society) score was 15.9 (53%) points at last follow-up. Among prognostic factors of age at diagnosis, Enneking stage, size of tumor, site of primary lesion, and distant metastasis, 5-year survival rate of groups without metastasis were 90.9%, nevertheless 44.4% in other group with the metastasis showing statistical significance (p = 0.020). Postoperative complications were 3 cases of infection, each 2 cases of ankylosis and metal failure, and each 1 case of leg length discrepancy, periprosthetic fracture, and local recurrence. Conclusion: Five-year survival rate of this study was similar to that of multicenter studies in America and Europe. Among the prognostic factors, distant metastasis was proven to be most significant. Enneking stage, size of tumor and site of primary lesion are also important and could be statistically significant if with more cases.

Effects of a Building''s Density on Flow in Urban Areas

Jae-Jin KIM,Do-Yong KIM,

大气科学进展 , 2009,
Abstract: The effects of a building's density on urban flows are investigated using a CFD model with the RNG k - ε turbulence closure scheme. Twenty-seven cases with different building's density parameters (e.g., building and street-canyon aspect ratios) are numerically simulated. As the building's density parameters vary, different flow regimes appear. When the street canyon is relatively narrow and high, two counterrotating vortices in the vertical direction are generated. The wind speed along streets is mainly affected by the building's length. However, it is very difficult to find or generalize the characteristics of the street-canyon flows in terms of a single building's density parameter. This is because the complicated flow patterns appear due to the variation of the vortex structure and vortex number. Volume-averaged vorticity magnitude is a very good indicator to reflect the flow characteristics despite the strong dependency of flows on the variation of the building's density parameters. Multi-linear regression shows that the volume-averaged vorticity magnitude is a strong function of the building's length and the streetcanyon width. The increase in the building's length decreases the vorticity of the street-canyon flow, while, the increase in the street-canyon width increases the vorticity.
Effect of Curing Poly(p-Phenylene Sulfide) on Thermal Properties and Crystalline Morphologies  [PDF]
Sungho Lee, Do-Hwan Kim, Jae-Ha Park, Min Park, Han-Ik Joh, Bon-Cheol Ku
Advances in Chemical Engineering and Science (ACES) , 2013, DOI: 10.4236/aces.2013.32017

Commercial poly(p-phenylene sulfide) (PPS) was thermally cured, which resulted in an increase of molecular weight due to cross-linking. Non-isothermal crystallization studies of samples cured for up to 7 days at 250?C showed a monotonous increase of crystallization temperature compared to pure PPS. However, a further increase of curing time decreased the crystallization temperature. The change in the half-crystallization time (t1/2) was similar to the crystallization temperature. Thus, the cross-linking of PPS affected crystallization behaviors significantly. To a certain extent, crosslinks acted as nucleation agents, but excessive cross-linking hindered the crystallization. Morphologies observed by polarized optical microscopy suggested that thermal curing for as little as 1 day contributed to the spherulitic structure having a smaller size, that was not observed with pure PPS.

Korea National Long-Term Ecological Research: provision against climate change and environmental pollution (Review)
Ji Yoon Kim,Gea-Jae Joo,Yuno Do,Gu-Yeon Kim
Journal of Ecology and Field Biology , 2011,
Abstract: The Korea National Long-Term Ecological Research (KNLTER) was initiated in 2004 by the Korean Ministry of Environment. This project entered its third and final phase in 2010. Committee members have suggested that the project needs to be assessed in terms of its achievement and advised regarding its refinement. In this review, we recapitulated the last 7 years of KNLTER progress for developing further program improvements. We reviewed ecological research before the existing LTER, project initiation, the increase in the number of research sites, and research topics. Then, we briefly examine the status of KNLTER and discuss areas for improvement and avenues for further research. The KNLTER established 20 research sites covering 80 topics related to terrestrial, freshwater, coastal, and animal ecology. To strengthen its role in LTER research, KNLTER participants need to confirm standard protocols and data formats for an efficient interaction with other LTER programs. All participants should enhance communication at both the domestic and international levels to reach out and collaborate on research and multidisciplinary studies. Climate change and environmental pollution issues will be solved with a global research network and long-term research projects focusing on this issue.
Impact of Pelvic Radiotherapy on Gut Microbiota of Gynecological Cancer Patients Revealed by Massive Pyrosequencing
Young-Do Nam, Hak Jae Kim, Jae-Gu Seo, Seung Wan Kang, Jin-Woo Bae
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0082659
Abstract: Although pelvic irradiation is effective for the treatment of various cancer types, many patients who receive radiotherapy experience serious complications. Gut microbial dysbiosis was hypothesized to be related to the occurrence of radiation-induced complications in cancer patients. Given the lack of clinical or experimental data on the impact of radiation on gut microbiota, a prospective observational study of gut microbiota was performed in gynecological cancer patients receiving pelvic radiotherapy. In the current study, the overall composition and alteration of gut microbiota in cancer patients receiving radiation were investigated by 454 pyrosequencing. Gut microbial composition showed significant differences (P < 0.001) between cancer patients and healthy individuals. The numbers of species-level taxa were severely reduced after radiotherapy (P < 0.045), and the abundance of each community largely changed. In particular, the phyla Firmicutes and Fusobacterium were significantly decreased by 10% and increased by 3% after radiation therapy, respectively. In addition, overall gut microbial composition was gradually remolded after the full treatment course of pelvic radiotherapy. In this set of cancer patients, dysbiosis of the gut microbiota was linked to health status, and the gut microbiota was influenced by pelvic radiotherapy. Although further studies are needed to elucidate the relationship between dysbiosis and complications induced by pelvic radiotherapy, the current study may offer insights into the treatment of cancer patients suffering from complications after radiation therapy.
Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis
Jongmin Kim, Seok Hong, Eun Lim, Yun-Suk Yu, Seung Kim, Ji Roh, In-Gu Do, Jae-Won Joh, Dae Kim
Journal of Experimental & Clinical Cancer Research , 2009, DOI: 10.1186/1756-9966-28-20
Abstract: Frozen tumors and non-cancerous surrounding tissues from 120 patients with primary HCC were studied. Expressions of NNMT and internal control genes were measured by real-time reverse-transcription PCR (RT-PCR). The relationship of NNMT mRNA level with clinicopathologic parameters and clinical outcome was evaluated.NNMT mRNA level is markedly reduced in HCCs compared to non-cancerous surrounding tissues (P < 0.0001), and NNMT expression in tumors was significantly correlated with tumor stage (P = 0.010). Moreover, stratification of patients based on tumor NNMT mRNA levels revealed that the patients who expressed higher NNMT mRNA levels tended to have a shorter overall survival (OS) time (P = 0.053) and a significantly shorter disease-free survival (DFS) time (P = 0.016). Both NNMT expression (P = 0.0096) and tumor stage (P = 0.0017) were found to be significant prognostic factors for DFS in a multivariate analysis.The results of this study indicated that NNMT gene expression is associated with tumor stage and DFS time in HCC cases. Because of the broad substrate specificity of NNMT, which could alter the efficacy and adverse effects of chemotherapy, NNMT merits further investigation regarding its role as a prognostic factor with a larger cohort of HCC patients.Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the most common form of liver cancer, being responsible for 80% of primary malignant tumors in adults. HCC causes more than 600,000 deaths annually worldwide [1] and its endemic prevalence in Asia, including South Korea, makes HCC one of the top causes of death in this region. HCC is a type of tumor that is highly resistant to available chemotherapeutic agents, administered either alone or in combination [2]. Thus, in many cases, no effective therapy can be offered to patients with HCC. Therefore, it is of vital importance to identify important prognostic factors and novel molecular targets of HCC to develop targeted therapies, ultimat
Interaction of annexin A6 with alpha actinin in cardiomyocytes
Sumita Mishra, Vivek Chander, Priyam Banerjee, Jae G Oh, Ekaterina Lifirsu, Woo J Park, Do H Kim, Arun Bandyopadhyay
BMC Cell Biology , 2011, DOI: 10.1186/1471-2121-12-7
Abstract: To identify the putative binding partners of annexin A6 in the heart, ventricular extracts were subjected to glutathione S-transferase (GST)- annexin A6 pull down assay and the GST- annexin A6 bound proteins were identified by mass spectrometry. The pull down fractions of ventricular extracts with GST-full length annexin A6 as well as GST-C terminus deleted annexin A6 when immunoblotted with anti sarcomeric alpha (α)-actinin antibody showed the presence of α-actinin in the immunoblot which was absent when GST-N terminus deleted annexin A6 was used for pull down. Overexpression of green fluorescent protein (GFP) tagged full length annexin A6 showed z-line like appearance in cardiomyocytes whereas GFP-N termimus deleted annexin A6 was mostly localized to the nucleus. Overexpression of GFP-C terminus deleted annexin A6 in cardiomyocytes showed aggregate like appearance in the cytoplasm. Double immunofluorescent staining of cardiomyocytes with anti annexin A6 and anti sarcomeric α-actinin antibodies showed perfect co-localization of these two proteins with annexin A6 appearing like a component of sarcomere. Transient knockdown of annexin A6 in cardiomyocytes by shRNA significantly enhances the contractile functions but does not affect the z-band architecture, as revealed by α-actinin immunostaining in shRNA treated cells.In overall, the present study demonstrated for the first time that annexin A6 physically interacts with sarcomeric α-actinin and alters contractility of cardiomyocytes suggesting that it might play important role in excitation and contraction process.The annexins constitute a family of highly conserved proteins that are characterized by their Ca2+-dependent binding to phospholipids [1]. Annexins are expressed in a wide variety of tissues and implicated in various extra- and intracellular processes including mitogenic signal transduction, differentiation and membrane trafficking events [2]. However, the exact biological role of each annexin remains unkno
3D volume extraction of cerebrovascular structure on brain magnetic resonance angiography data sets  [PDF]
Do-Yeon Kim
Journal of Biomedical Science and Engineering (JBiSE) , 2012, DOI: 10.4236/jbise.2012.510070
Abstract: The use of computers in facilitating their processing and analysis has become necessary with the increaseing size and number of medical images. In particular, computer algorithms for the delineation of anatomical structures and other regions of interest, which are called image segmentation, play a vital role in numerous biomedical imaging applications such as the quantification of tissue volumes, diagnosis, localization of pathology, study of anatomical structure, treatment planning, and computer-integrated surgery. In this paper, a 3D volume extraction algorithm was proposed for segmentation of cerebrovascular structure on brain MRA data sets. By using a priori knowledge of cerebrovascular structure, multiple seed voxels were automatically identified on the initially thresholded image. In the consideration of the preserved voxel connectivity—which is defined as 6-connectivity with joint faces, 18-connectivity with joint edges, and 26-connectivity with joint corners— the seed voxels were grown within the cerebrovascular structure area throughout 3D volume extraction process. This algorithm provided better segmentation results than other segmentation methods such as manual, and histogram thresholding approach. This 3D volume extraction algorithm is also applicable to segment the tree-like organ structures such as renal artery, coronary artery, and airway tree from the medical imaging modalities.
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