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Gelucires : Pharmaceutical Applications
Namdeo Jadhav,Sanjeev Gubbi,Hanmantrao Kadam
Pharmaceutical Reviews , 2008,
Abstract: The major problems affecting design of any dosage form are related with the solubility and stability of drug substances. And hence to solve these problems carriers like polyethylene glycol (PEG), polyvinyl pyrollidone (PVP), poloxamers, polyols, organic acid and hydrotropes helping the dissolution enhancement of poorly soluble drugs are used.1 But now a days new type of excipients which are polyethylene glycol glycerides composed of mono-, di- and triglycerides and mono- and diesters of polyethylene glycol (PEG) called as gelucire are used. They are a group of inert semi-solid waxy amphiphilic excipients, which are surface active in nature and disperse or solubilize in aqueous media forming micelles, microscopic globules or vesicles. They have been widely studied as controlled release matrices as well as for improvement of physicochemical properties of drug. They are identified with respect to their melting point and HLB value 2.
Crystallo-co-agglomeration: A novel particle engineering technique
Paradkar Anant,Pawar Atmaram,Jadhav Namdeo
Asian Journal of Pharmaceutics , 2010,
Abstract: Crystallo-co-agglomeration (CCA) is a novel particle engineering/design technique developed by Kadam et al, to overcome the limitations of spherical crystallization (SC). Basically, it′s single step process used for size enlargement of single, two or more, small dose or large dose drugs, in combination with or without diluent. The process of CCA involves simultaneous crystallization and agglomeration of drug/s with/without excipients/s from good solvent and/or bridging liquid by addition of a non-solvent. Till date CCA has been applied for spherical agglomeration of talc, bromhexine hydrochloride-talc, ibuprofen-talc, ibuprofen-paracetamol, and naproxen-starch. The spherical agglomerates obtained by CCA can be used as intact beads (encapsulated spansules) or directly compressible tablet intermediates having satisfactory micromeritic (flowability), mechanical (friability, crushing), compressional (compressibility, compactibility), and drug release properties. Modified drug release from agglomerates and compacts thereof can be achieved using suitable polymer composition in the process design. Thus, it can be concluded that, CCA is a simple and cost effective process, which can be tailor-made for particle design of all majority of drugs and combinations thereof.
Drug Delivery and Therapeutic Applications of Ion Exchange Resins: An update
Jadhav Namdeo,Mrs. Neela M. Bhatia,Mr. Namdeo R. Jadhav,Mr. Mayuresh Shinde
Pharmaceutical Reviews , 2007,
Abstract: Ion exchange resins are vinyl, divinyl benzene and polystyrene copolymers available as high molecular weight polyelectrolytes having extensive charged functional sites.1They are insoluble in nature and exchange their exchangeable ions with same charge ions in the surrounding ionic medium.1-2 Mainly, resins are of two types; weak and strong cationic and anionic resins respectively.1Apart from taste masking, resins have been used in modified drug release 3 drug stabilization 4 tablet disintegration 3-4 and even in therapeutics too.4 Long term physico-chemical stability 3-4 and safety 4 of ion exchange resins have provided an additional benefit to consider them as drug carriers for wide array of applications.
Glass transition temperature: Basics and application in pharmaceutical sector
Jadhav Namdeo,Gaikwad Vinod,Nair Karthik,Kadam Hanmantrao
Asian Journal of Pharmaceutics , 2009,
Abstract: Glass transition temperature (Tg) is an important tool used to modify physical properties of drug and polymer molecules. Tg is shown by certain crystalline as well as amorphous solids. During the process of heating, some solid gets melted and if quench cooled, instead of crystallizing, gets converted to amorphous solid form appearing as that of glass. This glass formation is seen because of the dynamic arrest of molecules forming a disordered state at Tg. The molecules/atoms in glassy state are subject to only vibration and not translational and rotational motion. Mainly, at Tg, conversion of glassy (vitrified, amorphous) solid to rubbery (viscous liquid) takes place. Numerous factors like structural change in molecules, cooling rate and incorporation of additives alter the Tg. Techniques like differential scanning calorimetry, elastic modulus, broad-line NMR are used to measure the Tg of substances. The change in Tg has been carried out to improve dissolution and bioavailability, processing and handling qualities of the material.
Dual Wavelength Spectrophotometric Method for Simultaneous Estimation of Atorvastatin Calcium and Felodipine from Tablet Dosage Form
Namdeo R. Jadhav,Ramesh S. Kambar,Sameer J. Nadaf
Advances in Chemistry , 2014, DOI: 10.1155/2014/131974
Abstract: Atorvastatin calcium (ATR) and felodipine (FEL) are beneficial in combination for elderly people in management of hypertension and atherosclerosis. Aim of present study is to develop simple, accurate, and precise method for simultaneous quantitative estimation of ATR and FEL from combined tablet dosage form. Method involves simultaneous equation, using acetonitrile—double distilled water (70?:?30)—common solvent showing absorption maxima at 245 and 268?nm. Calibration curves determination for both drugs has been carried out in 0.1?N HCl, phosphate buffer pH 6.8, and acetonitrile (ACN)—water (70?:?30?V/V). Linearity range was observed in the concentration range of 2 to 12?μg/mL for FEL and 20 to 100?μg/mL for ATR. Percent concentration estimated for ATR and FEL was 100.12 ± 1.03 and 99.98 ± 0.98, respectively. The method was found to be simple, economical, accurate and precise and can be used for quantitative estimation of ATR and FEL. 1. Introduction Atorvastatin (ATR) is chemically described as [R-( , )]-2-(4-fluorophenyl)-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid (Figure 1). It is a member of the drug class known as statins, used for lowering blood cholesterol [1]. It also stabilizes plaque and prevents strokes through anti-inflammation and other mechanisms. It inhibits HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body. Inhibition of this enzyme stops the reduction of HMG-CoA to mevalonate, which is the rate-limiting step in hepatic cholesterol biosynthesis. Inhibition of the enzyme decreases cholesterol synthesis and ultimately increases expression of low-density lipoprotein receptors (LDL receptors) on hepatocytes [2, 3]. Figure 1: Structure of (I) atorvastatin, (II) felodipine. Felodipine (FEL) is a 1, 4 dihydropyridine derivative, that is, chemically described as ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(2,3 dichlorophenyl)-3,5-pyridinedicarboxylate. It is a dihydropyridine calcium channel blocker used mainly for the management of hypertension and angina pectoris like the other calcium channel blockers [4]. Literature survey reveals that spectrophotometric and chromatographic methods, and a stability-indicating LC method, have been reported for determination of ATR in pharmaceutical preparations in combination with other drugs [5–13]. Several chromatographic and spectrophotometric methods have been reported for felodipine assay [14–18]. However, most of the analytical methods developed for the
Methods of Carbon Nanotube and Nanohorn Synthesis: A Review
Namdeo Jadhav,Mr. Malay D. Shah.,Mr. Karthik Nair,Mr. Pramod Shirote
Pharmaceutical Reviews , 2007,
Abstract: Until 1985, only two forms of pure-carbon structures were known as diamond and graphite.But, Richard Smalley and Harry Kroto in November 1985, discovered C-60 (buckyball) during a series of experiments on the laser-vaporization of graphite.In 1990, Wolfgang Kratschmer and Donald Huffman used a carbon arc instead of laser to vaporize graphite1. This produced macroscopic amounts of C-60 marking milestone in the beginning of fullerene research.Mainly, Buckminster Fuller in 1985 from Rice University discovered carbon allotropes composed entirely of carbon in the form of a hollow sphere, ellipsoid, or tube. Spherical fullerenes were called as buckyball while cylindrical fullerenes as buckytubes or nanotubes2. Their structure is composed of graphite sheets having pentagonal, hexagonal and sometimes heptagonal rings that prevent the sheets from being planar2.
Network Traffic Management
Namdeo V. Kalyankar
Computer Science , 2009,
Abstract: The purposes of this paper have to discuss issues related to Network Traffic Management. A relatively new category of network management is fast becoming a necessity in converged business Networks. Mid-sized and large organizations are finding they must control network traffic behavior to assure that their strategic applications always get the resources they need to perform optimally. Controlling network traffic requires limiting bandwidth to certain applications, guaranteeing minimum bandwidth to others, and marking traffic with high or low priorities. This exercise is called Network Traffic Management.
SYNTHESIS OF SOME- 6- SUBSTITUTED- 6H- PYRROLO [3, 4-D] PYRIDAZINE DERIVATIVES AND THEIR EVALUATION FOR IN-VIVO ANTI-CONVULSANT ACTIVITY IN ALBINO RATS
Kamta P. Namdeo et al.
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Present studies on the synthesis and evaluation of anticonvulsant activity of some 6- Substituted- 6H- Pyrrolo [3, 4-d] Pyridazine derivatives. In the preliminary screening for anticonvulsant activity in albino rats, all the synthesized compounds were found to be active, even more than standard at dose 50mg/kg body weight.
Isostructural changes in h-YMnO3 by Fe-substitution: effects on multiferroicity
Sonu Namdeo,A. M. Awasthi
Physics , 2012,
Abstract: Iron-substitution in hexagonal YMnO3 causes isostructural intra-lattice changes exceeding those of the lattice cell, contrary to the effects of non-magnetic B-site dopants. Magnetization M(T) evidence antiferromagnetic (AFM) ordering of the specimens with little weak ferromagnetism, and the metrices of exchange interaction suppress with Fe-doping, attributed to the lengthening of the Mn-O planar bond lengths. Ferroelectric (FE) P-E hysteresis loops reflect subdued and conductive ferroelectricity with increased Fe-substitution, traced to the reduced polyhedral buckling. Dielectric {\epsilon}'(T) results showing highly doping-dependent anomaly at the N\'eel temperature signify strong magnetostrictive tunability and imply linear magneto-electric (ME) coupling. We recognize a correspondence of the structure-property changes versus Fe-doping, with the reported magnetostrictive effects upon cooling below TN. Correlations of AFM-FE-ME properties with their relevant microstructural attributes underline the spin-lattice-dipole coupling and provide significant characteristic figures.
A related fixed point theorem for three pairs of mappings on three complete metric spaces
R.K. Namdeo,Brian Fisher
Mathematical Sciences Quarterly Journal , 2010,
Abstract: A new related fixed point theorem for three pairs of mappings on three complete metric spaces is obtained.
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