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Search Results: 1 - 10 of 2956 matches for " Jacqueline Barrett "
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Pathways to the diagnosis of lung cancer in the UK: a cohort study
Jacqueline Barrett, William Hamilton
BMC Family Practice , 2008, DOI: 10.1186/1471-2296-9-31
Abstract: Three main routes to diagnosis emerged. The first was the expected route of outpatient referral; 150 (61% of the cohort) of patients took this route, although only 110 (45% of the whole cohort, 73% of those referred to outpatients) were referred to a respiratory department. 56 (23%) were admitted as an emergency, having previously described a lung cancer symptom to their doctor. 26 patients (11%) had no symptom of lung cancer reported before their diagnosis. The interval from first symptom to referral was similar across the different pathways. However, the referral to diagnosis interval was longer in patients misdirected to other outpatient departments (66 days, interquartile range 37,110) than those sent to respiratory clinics (29 days, 17,61) or admitted as an emergency (16 days 8,40); p < 0.001.Only a minority of lung cancer patients follow the traditional route to diagnosis. Clinical and research efforts need to consider the alternative routes if they are to maximise their impact on speed of diagnosis.Over 37,000 new lung cancers are diagnosed each year in the UK [1]. Mortality is very high, with lung cancer the leading cause of cancer deaths in the UK [1]. The poor survival reflects the intrinsically aggressive nature of the tumour, with the shortest doubling time of the common cancers, plus the fact that symptoms occur relatively late in the growth of the cancer [2]. Many patients also delay presenting their symptoms to their doctor, and the duration of symptoms is now recognised to be longer than previously thought [3,4]. Thus few patients are diagnosed at a stage when they could be offered curative surgery [5]. Furthermore, no screening test has been found to be effective, and none is near to implementation, though trials are in progress using spiral CT [5]. Most lung cancers present with symptoms, and in the UK, most of these patients present initially to their general practitioner (GP) [6].Unlike for most other common cancers, there exists a primary care i
Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome
Jacqueline S Barrett, Kim EK Canale, Richard B Gearry, Peter M Irving, Peter R Gibson
World Journal of Gastroenterology , 2008,
Abstract: AIM: To determine whether Lactobacillus casei strain Shirota (Yakult ) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome (IBS).METHODS: 18 patients with IBS (Rome II criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale.RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of first rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no significant improvement in the symptom score with probiotic therapy, except for wind (P = 0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median final score 5.3 (IQR 3.9-5.9), 55% reduction; n = 6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18].CONCLUSION: Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these findings awaits a randomised, controlled trial.
It’s a Matter of Time  [PDF]
Robert A. Barrett Jr.
Journal of Modern Physics (JMP) , 2015, DOI: 10.4236/jmp.2015.66081
Abstract: This paper describes a universe consisting only of time dilation and compares it to the one which we observe.
The Pedagogy of Visual Discourse: An Analytical Approach to Teaching and Evaluating the Rhetorical Image  [PDF]
Jacqueline Irwin
Art and Design Review (ADR) , 2014, DOI: 10.4236/adr.2014.22003

As the area of visual rhetoric develops and evolves, the approaches that critics take in evaluating images must be scrutinized for the overall exploration of the discipline. Incorporating areas of analytical criticism from rhetoric to aesthetics to design should be combined to create the best possible way of evaluating imagery. By expanding on the traditional analytical approach to rhetorical criticism, this paper explores how the additional understanding of aesthetic and design theory will help the critic to reach a fuller understanding of the image. The twelve major principles of design being line, shape and form, space, texture, value, color, repetition, variety, rhythm, balance, emphasis, and economy are combined to create the strategy of the visual aesthetic that works to compliment the existing rhetorical strategies. The more complete understanding of how visuals are created and how people interpret them will allow for a more complete development of the visual rhetorical approach to communication.

Stage III and IV Head and Neck Cancer: Does Everyone Need Chemotherapy?  [PDF]
Gaurav Marwaha, William L. Barrett
International Journal of Otolaryngology and Head & Neck Surgery (IJOHNS) , 2014, DOI: 10.4236/ijohns.2014.31006

Objectives: Definitive treatment of Stage III and IV squamous cell carcinoma can be with surgical resection, definitive radiation therapy alone or combined radiation therapy with chemotherapy. Radiation and concomitant platinum-based chemotherapy are the accepted gold standard. The purpose of this study was to determine how often patients treated with radiation therapy alone developed locoregionally recurrent disease that in retrospect possibly could have been prevented with the addition of chemotherapy. Methods: 116 consecutive patients with known Stage III and Stage IV head and neck cancers were treated with curative intent with radiation therapy alone. Results of the treatment were retrospectively reviewed. Results: Of the 116 patients treated with radiation alone, 11 (9.48%) died from locally recurrent disease, 6 (5.17%) died from local disease and were never disease-free, 7 (6.03%) died from metastatic disease, 9 (7.75%) died from disease NOS, 6 (5.17%) died from secondary malignancy, 10 (8.62%) died from ICD (2 oropharynx; 8 larynx), 6 (5.17%) died from uncertain causes, 51 (43.96%) are alive and disease-free, and 10 (8.62%) patients’ final outcome data were not recoverable. Conclusions: Cure rates in selected patients with advanced head and neck cancer may be similar with radiation alone compared to radiation with the addition of chemotherapy.

Eradication versus control: the economics of global infectious disease policies
Bulletin of the World Health Organization , 2004, DOI: 10.1590/S0042-96862004000900010
Abstract: a disease is controlled if, by means of a public policy, the circulation of an infectious agent is restricted below the level that would be sustained by individuals acting independently to control the disease. a disease is eliminated if it is controlled sufficiently to prevent an epidemic from occurring in a given geographical area. control and elimination are achieved locally, but a disease can only be eradicated if it is eliminated everywhere. eradication is plainly a more demanding goal, but it has two advantages over control. first, the economics of eradication can be very favourable when eradication not only reduces infections but also avoids the need for vaccinations in future. indeed, when eradication is feasible, it will either pay to control it to a fairly low level or to eradicate it. this suggests that, from an economics perspective, diseases that are eliminated in high-income countries are prime candidates for future eradication efforts. second, the incentives for countries to participate in an eradication initiative can be strong; indeed they can be even stronger than an international control programme. moreover, high-income countries typically benefit so much that they will be willing to finance elimination in developing countries. full financing of an eradication effort by nation-states is not always guaranteed, but it can be facilitated by a variety of means. hence, from the perspective of economics and international relations, eradication has a number of advantages over control. the implications for smallpox and polio eradication programmes are discussed.
Introductory Editorial (Immunotherapy Insights)
John Barrett
Immunotherapy Insights , 2012,
Abstract: Introductory Editorial by Dr John Barrett, Allogeneic Stem Cell Transplantation, Bethesda, Maryland, U.S.A.
“What I say will not be understood”: Intertextuality as a subversive force in Nadine Gordimer’s Burger’s Daughter
E-rea : Revue électronique d’études sur le Monde Anglophone , 2004, DOI: 10.4000/erea.491
Abstract: In 1963 the South African government passed The Publications and Entertainment Act which made it possible to ban not only works which were considered blasphemous or obscene but also any work which “brings any section of the inhabitants into ridicule or contempt, is harmful to the relations between any sections of the inhabitants; is prejudicial to the safety of the State, the general welfare or the peace and good order” (Essential Gesture, 61). Under this act almost 9 000 works were banned in...
The Shadow
Lindsay Barrett
Cultural Studies Review , 2011,
Abstract: ‘The Shadow’ is a reflection on the destruction of the city of Hiroshima by an atomic bomb in 1945. It uses personal observation of the extant traces of the event in the contemporary city of Hiroshima, along with a number of historical sources, in order to understand this particular catastrophe as part of the wider experience of modernity in the twentieth century.
The Case for Daylighting in Architecture
Richard Barrett
Archnet-IJAR : International Journal of Architectural Research , 2009,
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