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Search Results: 1 - 10 of 226443 matches for " Jacque C. Young "
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Phage-Induced Expression of CRISPR-Associated Proteins Is Revealed by Shotgun Proteomics in Streptococcus thermophilus
Jacque C. Young, Brian D. Dill, Chongle Pan, Robert L. Hettich, Jillian F. Banfield, Manesh Shah, Christophe Fremaux, Philippe Horvath, Rodolphe Barrangou, Nathan C. VerBerkmoes
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038077
Abstract: The CRISPR/Cas system, comprised of clustered regularly interspaced short palindromic repeats along with their associated (Cas) proteins, protects bacteria and archaea from viral predation and invading nucleic acids. While the mechanism of action for this acquired immunity is currently under investigation, the response of Cas protein expression to phage infection has yet to be elucidated. In this study, we employed shotgun proteomics to measure the global proteome expression in a model system for studying the CRISPR/Cas response in S. thermophilus DGCC7710 infected with phage 2972. Host and viral proteins were simultaneously measured following inoculation at two different multiplicities of infection and across various time points using two-dimensional liquid chromatography tandem mass spectrometry. Thirty-seven out of forty predicted viral proteins were detected, including all proteins of the structural virome and viral effector proteins. In total, 1,013 of 2,079 predicted S. thermophilus proteins were detected, facilitating the monitoring of host protein synthesis changes in response to virus infection. Importantly, Cas proteins from all four CRISPR loci in the S. thermophilus DGCC7710 genome were detected, including loci previously thought to be inactive. Many Cas proteins were found to be constitutively expressed, but several demonstrated increased abundance following infection, including the signature Cas9 proteins from the CRISPR1 and CRISPR3 loci, which are key players in the interference phase of the CRISPR/Cas response. Altogether, these results provide novel insights into the proteomic response of S. thermophilus, specifically CRISPR-associated proteins, upon phage 2972 infection.
Identifying the Intellectual Virtues in a Demon World  [PDF]
M. C. Young
Open Journal of Philosophy (OJPP) , 2012, DOI: 10.4236/ojpp.2012.24036
Abstract: Within contemporary epistemology, notions of intellectual virtue have come to fulfill a prominent role in attempts to provide an account of knowledge. Notions of such virtue can vary, and one particular aspect of this variance concerns how to construe the relationship between the intellectual virtues and particular epistemic ends. The goal of this article is to defend an instrumental connection between the intellectual virtues and the epistemic end of true belief. One type of skeptical argument that attempts to sever this connection, a Cartesian Demon argument, is considered. This Cartesian Demon argument will be summarized, as well as three responses to it. The claim that truth-conduciveness is a tenable criterion for identifying the intellectual virtues is then defended. It is acknowledged that the possibility of a Cartesian Demon does initiate scepticism, but that this scepticism is directed toward identifying specific intellectual virtues and not toward the instrumental connection between intellectual virtue and true belief.
地质学报 , 1929,
Abstract: I.CHARACTEROFTHEDEPOSITSANDTHEMETHODOFPRESERVATIONOFTHEBONES.InMay1929Dr.V.K.TingpresentedmeanumberofbonedepositswhichhecollectedfromWu-chow,Kwangsiduringhisrecentgeologicaltripinsummer1928."Thedepositslooklikeakindotbrecciacon-
地质学报 , 1942,
Abstract: Duringthelatespringof1941,Messrs.M.N.Bien,T.H.Miandthepresentwriterwerefortunateenoughtodiscoverseverallocalitiesofvertebratefossils.Thegeologicalconditionwillbereportedinanotherpaper'andneednotberepeatedthere.Mostofthefossilswerederivedfromthehill
Uniqueness of solution of a singular heat equation
Eutiquio C. Young
International Journal of Mathematics and Mathematical Sciences , 1984, DOI: 10.1155/s0161171284000211
Abstract: Some uniqueness results for the singular heat equation are presented in this paper.
On Bellman-Bihari integral inequalities
Eutiquio C. Young
International Journal of Mathematics and Mathematical Sciences , 1982, DOI: 10.1155/s016117128200009x
Abstract: Integral inequalities of the Bellman-Bihari type are established for integrals involving an arbitrary number of independent variables.
Studies of the Virgo cluster based on the Virgo Photometry Catalogue
C. K. Young
Physics , 1997,
Abstract: The `Virgo Photometry Catalogue' (VPC) is the first independently calibrated general catalogue of galaxies to cover the Virgo cluster since the `Catalog of Galaxies and Clusters of Galaxies' of Zwicky et al. (1961,1963). It contains 1180 galaxies (including background objects) within a 23 square-degree region centred on the cluster's core. Photographic surface photometry is presented for 1067 galaxies in the U band, for 1020 galaxies in the B_J band and for 1020 galaxies in the R_C band. All total magnitudes and total colours are extrapolated according to a new system; denoted `t' to distinguish it from the `T' system already in use. This paper outlines: the scope of the VPC, the new extrapolation system, some recent findings based on the catalogue and further work in progress.
Yang-Yang Anomalies and Coexistence Diameters: Simulation of Asymmetric Fluids
Young C. Kim
Physics , 2005, DOI: 10.1103/PhysRevE.71.051501
Abstract: A general method for estimating the Yang-Yang ratio, ${\cal R}_{\mu}$, and the coexistence-curve diameter of a model fluid via Monte Carlo simulations is presented on the basis of data for a hard-core square-well (HCSW) fluid and the restricted primitive model (RPM) electrolyte. The isothermal minima of $Q_{L}\equiv< m^{2}>^{2}_{L}/< m^{4}>_{L}$ are evaluated at $T_{c}$ in an $L\times L\times L$ box where $m = \rho - <\rho>_{L}$ is the density fluctuation. The ``complete'' finite-size scaling theory for the $Q_{\scriptsize min}^{\pm}(T_{c};L)$ incorporates pressure mixing in the scaling fields, thereby allowing for a Yang-Yang anomaly.
Quantum loop algebras and l-root operators
C. A. S. Young
Mathematics , 2012,
Abstract: Let g be a simple Lie algebra and q transcendental. We consider the category C_P of finite-dimensional representations of the quantum loop algebra Uq(Lg) in which the poles of all l-weights belong to specified finite sets P. Given the data (g,q,P), we define an algebra A whose raising/lowering operators are constructed to act with definite l-weight (unlike those of Uq(Lg) itself). It is shown that there is a homomorphism Uq(Lg) -> A such that every representation V in C_P is the pull-back of a representation of A.
Young C. Y. NG
地质论评 , 2007,
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