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Search Results: 1 - 10 of 462202 matches for " Jaclyn A. Jeffries "
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Embracing Pharmacy E-Learning: Models of Success
Jaclyn A. Jeffries,Pamela R. Jeffries,John B. Hertig,Kyle E. Hultgren
Pharmacy , 2013, DOI: 10.3390/pharmacy1010043
Abstract: Traditionally, education has revolved around the idea of a learner being taught in a physical classroom setting. With recent technological developments and the “immediate results” world we now live in, elearning has become much more common. Students and professionals are now able to access and acquire lectures, tests, certifications and degrees online. The Purdue University College of Pharmacy’s Center for Medication Safety Advancement has developed three eresources to enhance medication safety: The Veterans Affairs Yellow Belt Lean Certification Course, the Medication Safety Essentials Continuing Education Modules, and the Virtual Clean Room Simulation Certificate. These three modalities offer valuable content for additional knowledge, training and certification at a convenient location—your computer.
The Chemical Synthesis of Tetrodoxin: An Ongoing Quest
Jaclyn Chau,Marco A. Ciufolini
Marine Drugs , 2011, DOI: 10.3390/md9102046
Abstract: This contribution reviews all the synthetic work on tetrodotoxin that has appeared in the literature through June 2011.
Is Hypothyroidism Overlooked in Cardiac Surgery Patients?  [PDF]
Aarne Jyrala, Robert E. Weiss, Robin A. Jeffries, Gregory L. Kay
Open Journal of Thoracic Surgery (OJTS) , 2012, DOI: 10.4236/ojts.2012.22009
Abstract: Objectives: to analyze adequacy of preoperative thyroid screening of cardiac surgery patients (pts) with hypothyroidism (HT) and compare with pts without HT by demographic data, EuroSCORE (ES) scores, early and late outcomes. Patients: From 1000 cardiac surgery pts from Jan 1999 through May 2000 pts with HT were identified (Group 1, n = 80). 920 pts (Group 2) had no HT. Results Group 1 pts were older (p < 0.0001), had more females (p < 0.0001), more pts with CHF p < 0.0001, more pts in NYHA class III-IV (p = 0.01) and higher ES risk scores by both algorithms (p = 0.003 and p < 0.0001 consecutively) than Group 2 pts. ES variables demonstrated higher number of pts >60 years (p = 0.004), more females (p < 0.0001) and higher number of other than CABG surgery pts (p = 0.01) in Group 1. 47 (58.8%) had adequate laboratory tests. 15 (18.8%) had no tests and 18 (22.5%) inadequate tests. 10 (12.5%) pts had no replacement therapy. There was no operative mortality in Group 1 and 14 (1.5%) in Group 2 (p = 0.70). Hospital mortality was higher in Group 1 (6/7.5% vs 37/4.5%), p = 0.03. Stay in postoperative intensive care unit and hospital were similar (p = 0.66 and 0.53). More pts in Group 1 needed prolonged ICU and LOS (p < 0.0001 for both). Occurrence of postoperative AF was higher in Group 1, p < 0.02. Seventeen pts (23.0%) were not discharged home in Group 1 and 87 (10.2%) in Group 2, (p = 0.002). Follow-up mortality was higher in Group 1 (45/58.1% vs 378/43.5%, p = 0.02). Conclusions HT is overlooked in cardiac surgery patients. Long-term mortality is higher in pts with HT. Resource utilization is higher in pts with HT.
A lithium depletion boundary age of 21 Myr for the Beta Pictoris moving group
A. S Binks,R. D. Jeffries
Physics , 2013, DOI: 10.1093/mnrasl/slt141
Abstract: Optical spectroscopy is used to confirm membership for 8 low-mass candidates in the young Beta Pic moving group (BPMG) via their radial velocities, chromospheric activity and kinematic parallaxes. We searched for the presence of the Li I 6708A resonance feature and combined the results with literature measurements of other BPMG members to find the age-dependent lithium depletion boundary (LDB) -- the luminosity at which Li remains unburned in a coeval group. The LDB age of the BPMG is 21 +/- 4 Myr and insensitive to the choice of low-mass evolutionary models. This age is more precise, likely to be more accurate, and much older than that commonly assumed for the BPMG. As a result, substellar and planetary companions of BPMG members will be more massive than previously thought.
Lithium abundances from the 6104A line in cool Pleiades stars
A. Ford,J. Jeffries,B. Smalley
Physics , 2002, DOI: 10.1051/0004-6361:20020779
Abstract: Lithium abundances determined by spectral synthesis from both the 6708A resonance line and the 6104 subordinate line are reported for 11 late-type Pleiades stars, including spectra previously analysed by Russell (1996). We report a 0.7 dex scatter in the abundances from 6708A, and a scatter at least as large from the 6104A line. We find a reasonable correllation between the 6104A and 6708A Li abundances, although four stars have 6104A-determined abundances which are significantly larger than the 6708-determined values, by up to 0.5 dex, suggesting problems with the homogeneous, one-dimensional atmospheres being used. We show that these discrepancies can be explained, although probably not uniquely, by the presence of star spots with plausible coverage fractions. The addition of spots does not significantly reduce the apparent scatter in Li abundances, leaving open the possibility that at least some of the spread is caused by real star-to-star differences in pre-main- sequence Li depletion.
Spectroscopic confirmation of M-dwarf candidate members of the Beta Pictoris and AB Doradus Moving Groups
A. S. Binks,R. D. Jeffries
Physics , 2015, DOI: 10.1093/mnras/stv2431
Abstract: Optical spectroscopic observations are reported for 24 and 23, nearby, proper-motion-selected M-dwarf candidate members of the Beta Pictoris and AB Doradus moving groups (BPMG and ABDMG). Using kinematic criteria, the presence of both Halpha emission and high X-ray-to-bolometric luminosity, and position in absolute colour-magnitude diagrams, 10 and 6 of these candidates are confirmed as likely members of the BPMG and ABDMG respectively. Equivalent widths or upper limits for the Li I 6708A line are reported and the lithium depletion boundary (LDB) age of the BPMG is revisited. Whilst non-magnetic evolutionary models still yield an estimated age of 21 +/- 4 Myr, models that incorporate magnetic inhibition of convection imply an older age of 24 +/- 4 Myr. A similar systematic increase would be inferred if the stars were 25 per cent covered by dark magnetic starspots. Since young, convective M-dwarfs are magnetically active and do have starspots, we suggest that the original LDB age estimate is a lower limit. The LDB age of the ABDMG is still poorly constrained -- non-magnetic evolutionary models suggest an age in the range 35-150 Myr, which could be significantly tightened by new measurements for existing candidate members.
Establishing a gold standard for manual cough counting: video versus digital audio recordings
Jaclyn A Smith, John E Earis, Ashley A Woodcock
Cough , 2006, DOI: 10.1186/1745-9974-2-6
Abstract: We studied 8 patients with chronic cough, overnight in laboratory conditions (diagnoses were 5 asthma, 1 rhinitis, 1 gastro-oesophageal reflux disease and 1 idiopathic cough). Coughs were recorded simultaneously using a video camera with infrared lighting and digital sound recording.The numbers of coughs in each 8 hour recording were counted manually, by a trained observer, in real time from the video recordings and using audio-editing software from the digital sound recordings.The median cough frequency was 17.8 (IQR 5.9–28.7) cough sounds per hour in the video recordings and 17.7 (6.0–29.4) coughs per hour in the digital sound recordings. There was excellent agreement between the video and digital audio cough rates; mean difference of -0.3 coughs per hour (SD ± 0.6), 95% limits of agreement -1.5 to +0.9 coughs per hour. Video recordings had poorer sound quality even in controlled conditions and can only be analysed in real time (8 hours per recording). Digital sound recordings required 2–4 hours of analysis per recording.Manual counting of cough sounds from digital audio recordings has excellent agreement with simultaneous video recordings in laboratory conditions. We suggest that ambulatory digital audio recording is therefore ideal for validating future cough monitoring devices, as this as this can be performed in the patients own environment.For more than 40 years there has been an interest in making objective measurements of cough frequency. The original published systems consisted of reel-to-reel tape recorders with patients confined to a single room containing a microphone [1-3]. Coughs were manually counted by listening to the sound recordings. The major problems with these systems were the laborious nature of the manual cough counting and the restriction of the patients; hence these static systems never became established.In the 1990s ambulatory devices using analogue sound recordings combined with EMG were devised; coughs were identified manually from the
Data reduction for cough studies using distribution of audio frequency content
Antony Barton, Patrick Gaydecki, Kimberley Holt, Jaclyn A Smith
Cough , 2012, DOI: 10.1186/1745-9974-8-12
Abstract: 20 subjects were recruited (5 healthy smokers and non-smokers, 5 chronic cough, 5 chronic obstructive pulmonary disease and 5 asthma), fitted with an ambulatory recording system and recorded for 24 hours. The recordings produced were divided into 15 min segments and counted. Periods of inactive audio in each segment were removed using the median frequency and power of the audio signal and the resulting files re-counted.The median resultant segment length was 13.9 s (IQR 56.4 s) and median 24 hr recording length 62.4 min (IQR 100.4). A median of 0.0 coughs/h (IQR 0.0-0.2) were erroneously removed and the variability in the resultant cough counts was comparable to that between manual cough counts. The largest error was seen in asthmatic patients, but still only 1.0% coughs/h were missed.These data show that a system which measures signal activity using the median audio frequency can substantially reduce record lengths without significantly compromising the coughs contained within them.Cough is the commonest symptom reported by patients to doctors and presents as part of the symptom complex of many respiratory diseases [1,2]. Until recent years the study of cough has been restricted by a lack of useful measurement tools, relying mainly upon subjective reporting of cough severity. The development of portable digital sound recording devices has allowed the number of cough sounds to be counted over extended time periods, providing an objective measure of cough rate and new insights into its determinants [3-6]. However, at present, sufficiently accurate algorithms are not in place to allow reliance upon fully automated detection systems. Patient recordings require laborious manual counting with confirmation of cough sounds by experienced observers. To enable studies of a meaningful size, either the present method of manual counting must be made more efficient, or for large studies an automatic system must be developed. The amount of data generated by larger cough studies r
Myeloid cell leukemia-1 (Mc1-1) is a candidate target gene of hypoxia-inducible factor-1 (HIF-1) in the testis
Palladino Michael A,Shah Anoop,Tyson Rebecca,Horvath Jaclyn
Reproductive Biology and Endocrinology , 2012, DOI: 10.1186/1477-7827-10-104
Abstract: Background Spermatic cord torsion can lead to testis ischemia (I) and subsequent ischemia-reperfusion (I/R) causing germ cell-specific apoptosis. Previously, we demonstrated that the hypoxia-inducible factor-1 (HIF-1) transcription factor, a key regulator of physiological responses to hypoxia, is abundant in Leydig cells in normoxic and ischemic testes. We hypothesize that testicular HIF-1 activates the expression of antiapoptotic target genes to protect Leydig cells from apoptosis. In silico analysis of testis genes containing a consensus hypoxia response element (HRE, 5’-RCGTG-3’) identified myeloid cell leukemia-1 (Mcl-1) as a potential HIF-1 target gene. The purpose of this study was to determine whether HIF-1 shows DNA-binding activity in normoxic and ischemic testes and whether Mcl-1 is a target gene of testicular HIF-1. Methods The testicular HIF-1 DNA-binding capacity was analyzed in vitro using a quantitative enzyme-linked immunosorbent assay (ELISA) and electrophoretic mobility shift assays (EMSA). MCL-1 protein expression was evaluated by immunoblot analysis and immunohistochemistry. The binding of testicular HIF-1 to the Mcl-1 gene was examined via chromatin immunoprecipitation (ChIP) analysis. Results The ELISA and EMSA assays demonstrated that testicular HIF-1 from normoxic and ischemic testes binds DNA equally strongly, suggesting physiological roles for HIF-1 in the normoxic testis, unlike most tissues in which HIF-1 is degraded under normoxic conditions and is only activated by hypoxia. MCL-1 protein was determined to be abundant in both normoxic and ischemic testes and expressed in Leydig cells. In a pattern identical to that of HIF-1 expression, the steady-state levels of MCL-1 were not significantly affected by I or I/R and MCL-1 co-localized with HIF-1α in Leydig cells. Chromatin immunoprecipitation (ChIP) analysis using a HIF-1 antibody revealed sequences enriched for the Mcl-1 promoter. Conclusions The results demonstrated that, unlike what is observed in most tissues, HIF-1 displays DNA-binding activity in both normoxic and ischemic testes, and Mcl-1 may be a key target gene of testicular HIF-1 with potential roles in the antiapoptotic protection of Leydig cells.
On the image of the Galois representation associated to a non-CM Hida family
Jaclyn Lang
Mathematics , 2014,
Abstract: Fix a prime $p > 2$. Let $\rho : \text{Gal}(\overline{\mathbb{Q}}/\mathbb{Q}) \to \text{GL}_2(\mathbb{I})$ be the Galois representation coming from a non-CM irreducible component $\mathbb{I}$ of Hida's $p$-ordinary Hecke algebra. Assume the residual representation $\bar{\rho}$ is absolutely irreducible. Under a minor technical condition we identify a subring $\mathbb{I}_0$ of $\mathbb{I}$ containing $\mathbb{Z}_p[[T]]$ such that the image of $\rho$ is large with respect to $\mathbb{I}_0$. That is, $\text{Im} \rho$ contains $\text{ker}(\text{SL}_2(\mathbb{I}_0) \to \text{SL}_2(\mathbb{I}_0/\mathfrak{a}))$ for some non-zero $\mathbb{I}_0$-ideal $\mathfrak{a}$. This paper builds on recent work of Hida who showed that the image of such a Galois representation is large with respect to $\mathbb{Z}_p[[T]]$. Our result is an $\mathbb{I}$-adic analogue of the description of the image of the Galois representation attached to a non-CM classical modular form obtained by Ribet and Momose in the 1980s.
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