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Search Results: 1 - 10 of 466125 matches for " JULIO A; "
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The Value of Combined Large Format Histopathology Technique to Assess the Surgically Removed Breast Tissue following Neoadjuvant Chemotherapy: A Single Institution Study of 40 Cases
Julio A. Ibarra
International Journal of Breast Cancer , 2012, DOI: 10.1155/2012/361707
Abstract: Historically, neoadjuvant chemotherapy has been used to treat patients with advanced breast disease in an attempt to convert them into candidates for breast conservation surgery. The ultimate goal of histopathologic examination of the specimens removed after neoadjuvant chemotherapy is the identification of either residual disease or positive identification of the tumor bed. We report a series of 40 patients treated with neoadjuvant chemotherapy and evaluation of the surgical specimens by a combination of standard histopathology and the use of large format histopathology techniques. 1. Introduction The use of preoperative systemic therapy has increased in the last several years. Originally this therapy was used predominantly for patients with locally advanced breast cancer without systemic disease; the purpose was to convert these inoperable patients into candidates for breast conservation surgery [1–3]. However, neoadjuvant chemotherapy has also been extended to patients without locally advanced breast cancer that traditionally were subjected to surgery as the primary treatment modality [4–7]. The definition of pathologic complete response (pCR) was proposed in the NSABP B18 and B27 protocols; it is defined as the complete absence of invasive carcinoma both in the breast and in the axillary lymph nodes. The presence of residual duct carcinoma in situ (DCIS) was acceptable for the definition of pCR in these original studies. This definition has been challenged by others, some of which include small areas of residual tumor [8] or noninvasive disease in the pathologic complete response group [9]. Regardless of the definition used, the role of the pathologist in the evaluation of the resected specimens, whether it is a mastectomy or a partial mastectomy, is the identification of residual viable tumor or documenting the presence of the tumor bed and the absence of residual tumor in cases with pathologic complete response. In order to accomplish this task, the pathologist has to work in close cooperation with the radiologist in order to determine whether there was a residual “mass” or the fiducial clip placed by the radiologist before the start of therapy. A comprehensive review on the evaluation of pathology specimens after neoadjuvant therapy was published by Sneige and Page [10]. They indicate the importance of radiology and the fact that “extensive” sampling is required for complete pathologic evaluation. There are, however, no strict guidelines regarding the volume of tissue recommended for investigation as long as the tumor bed or residual tumor are
Ergosterol biosynthesis and drug development for Chagas disease
Urbina, Julio A;
Memórias do Instituto Oswaldo Cruz , 2009, DOI: 10.1590/S0074-02762009000900041
Abstract: this article presents an overview of the currently available drugs nifurtimox (nfx) and benznidazole (bzn) used against trypanosoma cruzi, the aetiological agent of chagas disease; herein we discuss their limitations along with potential alternatives with a focus on ergosterol biosynthesis inhibitors (ebi). these compounds are currently the most advanced candidates for new anti-t. cruzi agents given that they block de novo production of 24-alkyl-sterols, which are essential for parasite survival and cannot be replaced by a host's own cholesterol. among these compounds, new triazole derivatives that inhibit the parasite's c14± sterol demethylase are the most promising, as they have been shown to have curative activity in murine models of acute and chronic chagas disease and are active against nfx and bzn-resistant t. cruzi strains; among this class of compounds, posaconazole (schering-plough research institute) and ravuconazole (eisai company) are poised for clinical trials in chagas disease patients in the short term. other t. cruzi-specific ebi, with in vitro and in vivo potency, include squalene synthase, lanosterol synthase and squalene epoxidase-inhibitors as well as compounds with dual mechanisms of action (ergosterol biosynthesis inhibition and free radical generation), but they are less advanced in their development process. the main putative advantages of ebi over currently available therapies include their higher potency and selectivity in both acute and chronic infections, activity against nfx and bzn-resistant t. cruzi strains, and much better tolerability and safety profiles. limitations may include complexity and cost of manufacture of the new compounds. as for any new drug, such compounds will require extensive clinical testing before being introduced for clinical use, and the complexity of such studies, particularly in chronic patients, will be compounded by the current limitations in the verification of true parasitological cures for t. cruzi infecti
Indicadores de discapacidad en la Encuesta de Discapacidades, Deficiencias y Estado de Salud
Cabrero García,Julio;
Revista Espa?ola de Salud Pública , 2007, DOI: 10.1590/S1135-57272007000200007
Abstract: background: the measurement and meaning of disability depend on the indicators used. in this study the indicators of dependency and severe residual disability are examined on two levels: in each of the 14 selected activities of daily living (adl) and also as a summary score of the activities count. methods: the data are extracted of the disability, impairment and health survey (ine, 1999). the sample is composed of 8.779 entries corresponding to people over 65 years old with disability in some of the 14 selected adl. tables of proportions and contingency have been elaborated, statistics of association and agreement has been calculated and the dimensionality of the aggregated measures had been analyzed through the full information factor analysis. results: the main discrepancies between the indicators are concentrated on the mobility activities (kappa coefficients ranged between 0,50 to 0,75 for mobility activities and between 0,73 to 0,87 for domestic activities and self-care). severe residual disability (indicator selected by the national institute of statistics) compared to dependency more inability includes more mobility disabled people and excludes more disabled people in domestic activities and self-care. dependency more inability is the indicator with the highest validity as a summary measure of disability (two eigenvalues: 8,37 and 1,91, the first factor accounted for 56,3% of the variance, the saturations of the first factor ranged between 0,58 to 0,87). conclusions: dependency more inability is more valid than severe residual disability as main indicator of disability.
El desarrollo de la sociología en el Perú: notas introductorias
Navarrete, Julio Mejía;
Sociologias , 2005, DOI: 10.1590/S1517-45222005000200012
Abstract: this work is a synthesis of the evolution of sociology in peru since its incorporation as a university cathedra in 1896. a discourse is build in order to link to the changes that are typical of the developments of modernity in the country and, at the same time, it is supported on the theoretical debate resulting from the slow process of institutionalization of the discipline and the emergence of a higher awareness of the plurality of paradigms, methodological perspectives, and interpretive possibilities on social reality in recent years.
Ciudades nuevas sostenibles en las regiones del Caribe y Orinoquía
Carrizosa Uma?a,Julio;
Revista de Ingeniería , 2009,
Abstract: a regional policy of new towns development is proposed in order to obtain a better quality of life, a more rational use of energy, water and soil resources and alleviation of population pressure in the large cities, lower costs of contamination management and mitigation of impacts of urban population on ecosystems. geographic, historic, social and economic obstacles in contamination management are noted and the case of the capital is analyzed. engineering roles in obtaining sustainable cities are outlined. priority in the development of new towns in the caribe and orinoquía is recommended.
Especies nuevas de abejas de Cuba y La Espa?ola (Hymenoptera: Colletidae, Megachilidae, Apidae)
Genaro,Julio A.;
Revista de Biología Tropical , 2001,
Abstract: five new species of antillean bees are described and illustrated: colletes granpiedrensis n. sp. (cuba) (colletidae) is charaterized as follows: head and mesosoma black, legs and metasoma brown. dense brown hairs on head and mesosoma; white on frons and metasomal terga. clypeus, frons and mesosoma with large punctures, lesser on vertex and metasoma. malar space more wide than long. male and female slightly similar, except in the apical margin of clypeus, supraclipeal area, and color of the pubescence on legs and sterna; osmia (diceratosmia) stangei n. sp. (dominican republic) (megachilidae) is charaterized as follows: dark metallic green, metasoma black with metallic green reflections. pubescence light; body with large, closed punctures. female with violet reflections in tergum iii and mandible tridentate; coelioxys (cyrtocoelioxys) alayoi n. sp. (cuba) (megachilidae) is charaterized as follows: female black, except basal area of mandibles, tegula, legs, lateral area of tergum i and sterna, reddish brown. posterior margin of scutellum rounded. apex of tergum vi with spine curved up. sternum vi fringed with short, closed setae, and the apex with short spine; coelioxys (boreocoelioxys) sannicolarensis n. sp. (cuba) (megachilidae) is charaterized as follows: black, except antenna and tegula brown; legs and sterna reddish brown. clypeal margin straight in profile. gradular grooves on metasomal terga ii and iii distinct medially. fovea on metasomal tergum ii of male deep and short, and triepeolus nisibonensis n. sp. (dominican republic) (apidae) is charaterized as follows: dorsal pubescence (short and dense) on mesosoma and metasoma from white to yellow, according to specimen; ventral pubescence white. tergal bands of hairs interrupted medially; two spots of light pubescence on tergum ii. male metasomal sternum vii with anterior margin v-shaped and basal constriction narrow
Parasitismo entre especies (Diptera, Hymenoptera) en los nidos de Stictia signata (Hymenoptera: Sphecidae)
Genaro,Julio A.;
Revista de Biología Tropical , 1999,
Abstract: stictia signata is one of the most frequently observed sand wasps in the cuban keys and coasts. females build their nests in the sand and supply them with flies to feed offspring. here, i describe the behavior of two species, liohippelates n. sp. near collusor (diptera: chloropidae) and hexacola sp. (hymenoptera: eucoilidae), which enter the nests of s. signata. the observations were carried out from 1989 through 1991 in caimito beach, southern havana province, cuba. liohippelates inhabited 100% of the nests. its necrofagous larvae fed on the remnants of prey left by the larva of s. signata, without affecting the larva. only in one case did the larva show signs of mortality because, apart from the high number of immature cleptoparasites, there were 53 adult flies feeding on prey body fluids. hexacola sp. parasitized the larvae of liohippelates within the cells. in spite of high cleptoparasitism, the sphecid population remained high during the observation years.
Alimentación artificial en el lactante sano
JULIO A. BAUZA
Revista chilena de pediatría , 1942,
Abstract:
El desarrollo de la sociología en el Perú: notas introductorias
Navarrete Julio Mejía
Sociologias , 2005,
Abstract: El trabajo es una síntesis de la evolución de la sociología en el Perú desde su incorporación como cátedra universitaria en 1896. Se elabora un discurso que busca vincularse con los avatares propios del desarrollo de la modernidad en el país y, al mismo tiempo, se apoya en el debate teórico resultado del lento proceso de institucionalización de la disciplina y de la emergencia de una mayor conciencia, en los últimos a os, acerca de la pluralidad de paradigmas, perspectivas metodológicas y posibilidades interpretativas de la realidad social.
Del papel a la pantalla, de la utopía a la realidad
Julio A. Juncal
Panace@ : Revista de Medicina, Lenguaje y Traducción , 2009,
Abstract: La evolución en la práctica de la traducción, desde la modalidad tradicional hasta la traducción asistida por ordenador, en la experiencia del autor durante más de cuarenta a os. Una rese a de útiles y recursos para la traducción, incluidos el reconocimiento del habla, la búsqueda de texto íntegro y la traducción automática. ------------------------------------------ From paper to screen — From utopia to reality. The evolution of translation practice, from traditional techniques to Computer Aided Translation, based on the author's experience over more than 40 years. A review of computer tools and resources for translators, including speech recognition, full-text search and machine translation.
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