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Search Results: 1 - 10 of 169856 matches for " JUDITH E; "
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Multiple osteochondromas
Judith VMG Bovée
Orphanet Journal of Rare Diseases , 2008, DOI: 10.1186/1750-1172-3-3
Abstract: Multiple Osteochondromas (MO) MIM 133700Hereditary Multiple Exostoses (HME), Multiple Hereditary Exostoses (MHE), EXT, diaphyseal aclasis, (multiple hereditary) osteochondromatosis, multiple cartilaginous exostosesOsteochondroma (osteocartilaginous exostosis) is a cartilage capped bony projection arising on the external surface of bone containing a marrow cavity that is continuous with that of the underlying bone [1]. A diagnosis of MO can be made when radiologically at least two osteochondromas of the juxta-epiphyseal region of long bones are observed. In the majority of patients a positive family history and/or mutation in one of the EXT genes can be detected [2,3].The prevalence of MO is estimated at 1:50,000 persons within the general population [4] and seems to be higher in males (male-to-female ratio 1.5:1) [2,5]. This is probably due to the fact that females tend to have a milder phenotype and are therefore more easily overlooked [2]. The solitary (sporadic) form of osteochondroma is approximately six times more common than the occurrence within the context of MO. Approximately 62% of the patients with multiple osteochondromas have a positive family history [2].Osteochondromas develop and increase in size in the first decade of life, ceasing to grow when the growth plates close at puberty. They are pedunculated or sessile (broad base) and can vary widely in size. The majority are asymptomatic and located in bones that develop from cartilage, especially the long bones of the extremities, predominantly around the knee (Figures 1 and 2A). The facial bones are not affected. The number of osteochondromas may vary significantly within and between families, the mean number of locations is 15–18 [6]. In addition, in MO patients a variety of orthopaedic deformities can be found like deformities of the forearm (shortening of the ulna with secondary bowing of radius) (39–60%) [4,6,7] (Figure 2C), inequality in limb length (10–50%) [4,7], varus or valgus angulation of th
A más de 30 a?os: otra mirada a la tecnología lítica de Las Buitreras 1 (cuenca del río Gallegos, Santa Cruz)
Charlin,Judith E.;
Intersecciones en antropolog?-a , 2009,
Abstract: this article is a re-examination of the lithic artifacts of las buitreras 1 cave, güer aike departament, santa cruz province, focused on the explotation of lithic raw materials for the manufacture of artifacts. the procurement strategies for rocks at the site are also discussed. the sample includes lithics from layers iv to i, which correspond to the last 4000 years bp. the explotation of nearby lithic raw materials, the predominance of tools/debris, the scarcity of primary and secondary flakes/debris, the small size of flakes and the reutilization of blanks, suggest a low investment in the procurement of rocks and the manufacture of artifacts. these results agree with the previously proposed marginal land-use model of the gallegos river basin during the late holocene.
Materias primas líticas y uso del espacio en las nacientes del Río Gallegos: el caso de Laguna Cóndor (Estancia Glencross, Santa Cruz, Argentina)
CHARLIN,JUDITH E;
Magallania (Punta Arenas) , 2012, DOI: 10.4067/S0718-22442012000100010
Abstract: the analysis of stone tool from the surface of laguna cóndor (estancia glencross, santa cruz, argentina), located in the upper basin of the gallegos river, in an area known as los morros, is presented. the methodology applied, denominated minimun analitical nodules analysis (larson y kornfel 1997), has the advantage of grouping the artifacts and ecofacts by rock nodule, which is more useful than clustering them by class or type of lithic raw material. this method allows us to doing a major resolution analysis and a more detailed quantification. the results shown the predominance of nodules represen-ted by only one piece of debitage, in some cases in non-local raw materials, and by sets of debitage in immediately available lithic raw materials. according to the organization models proposed as framework to this methodology, the results point out, at frst, the resharpening of tools manufactured and discarded in another place and with a minor rate, in situ manufacture and maintenance of tools, removed of the site and transported far away. this pattern, together with other lines of evidences, suggests a logistic landscape use, at least in historic times, according to the available radiocarbon dating.
Materias primas líticas y uso del espacio en las nacientes del Río Gallegos: el caso de Laguna Cóndor (Estancia Glencross, Santa Cruz, Argentina) Lithic raw materials and landscape use in the upper Gallegos River: The case of Laguna Cóndor, (Estancia Glencross, Santa Cruz, Argentina)
JUDITH E CHARLIN
Magallania , 2012,
Abstract: Se presenta el análisis de los materiales líticos de superficie recuperados en la margen noreste de la laguna Cóndor (Estancia Glencross, Santa Cruz, Argentina), localizada en las nacientes del río Gallegos, en un área conocida localmente como los Morros. La metodología implementada, denominada Minimun Analitical Nodules Analysis (Larson y Kornfel 1997), permite agrupar los artefactos y ecofactos por nódulo de roca, lo cual posibilita un análisis de mayor resolución y una cuantificación más precisa de las materias primas líticas explotadas que la agrupación genérica por clase o tipo de roca. Los resultados alcanzados muestran el predominio de nódulos representados por un desecho aislado, en muchos casos en materias primas no-locales, y por conjuntos de desechos en materias primas disponibles en la inmediata vecindad. De acuerdo con los modelos de organización tecnológica propuestos como marco de esta metodología de análisis, los resultados indican, en primer lugar, la reactivación de instrumentos manufacturados y descartados en otro lado que transitaron por el sitio y, en menor proporción, la manufactura y mantenimiento de artefactos in situ que fueron transportados fuera del sitio. Este patrón, junto con otras evidencias, sugieren un uso logístico de este sector del espacio, al menos en momentos históricos, según las dataciones radiocarbónicas disponibles hasta la fecha. The analysis of stone tool from the surface of laguna Cóndor (Estancia Glencross, Santa Cruz, Argentina), located in the upper basin of the Gallegos river, in an area known as los Morros, is presented. The methodology applied, denominated Minimun Analitical Nodules Analysis (Larson y Kornfel 1997), has the advantage of grouping the artifacts and ecofacts by rock nodule, which is more useful than clustering them by class or type of lithic raw material. This method allows us to doing a major resolution analysis and a more detailed quantification. The results shown the predominance of nodules represen-ted by only one piece of debitage, in some cases in non-local raw materials, and by sets of debitage in immediately available lithic raw materials. According to the organization models proposed as framework to this methodology, the results point out, at frst, the resharpening of tools manufactured and discarded in another place and with a minor rate, in situ manufacture and maintenance of tools, removed of the site and transported far away. This pattern, together with other lines of evidences, suggests a logistic landscape use, at least in historic times, according to the available radiocarb
A más de 30 a os: otra mirada a la tecnología lítica de Las Buitreras 1 (cuenca del río Gallegos, Santa Cruz) MORE THAN THIRTY YEARS LATER: A REVIEW OF LAS BUITRERAS CAVE LITHIC TECHNOLOGY, GALLEGOS RIVER BASIN, SANTA CRUZ PROVINCE
Judith E. Charlin
Intersecciones en Antropología , 2009,
Abstract: En este trabajo se presenta un reanálisis de la colección de artefactos líticos de Las Buitreras 1 (Departamento Güer Aike, provincia de Santa Cruz), poniendo la atención en la forma en que se utilizaron las materias primas líticas para la manufactura de artefactos. Asimismo, se discuten las estrategias de aprovisionamiento de rocas que se implementaron en el sitio. La muestra analizada comprende las capas IV a I, las cuales corresponden a los últimos ca. 4000 a os AP. El aprovechamiento de materias primas disponibles en la inmediata vecindad del sitio, el predominio de artefactos formatizados/desechos de talla, la escasez de lascas primarias y secundarias/total de desechos, el tama o peque o de los mismos y la reutilización de formas-base para la manufactura de artefactos indican una baja inversión en el abastecimiento de rocas y en la manufactura de artefactos. Estos resultados apoyan las propuestas previas de un uso marginal de la cuenca del río Gallegos para el Holoceno tardío. This article is a re-examination of the lithic artifacts of Las Buitreras 1 Cave, Güer Aike Departament, Santa Cruz Province, focused on the explotation of lithic raw materials for the manufacture of artifacts. The procurement strategies for rocks at the site are also discussed. The sample includes lithics from layers IV to I, which correspond to the last 4000 years BP. The explotation of nearby lithic raw materials, the predominance of tools/debris, the scarcity of primary and secondary flakes/debris, the small size of flakes and the reutilization of blanks, suggest a low investment in the procurement of rocks and the manufacture of artifacts. These results agree with the previously proposed marginal land-use model of the Gallegos river basin during the late Holocene.
Locomotor sensitization to EtOH: contribution of β-Endorphin
Stephani Dempsey,Judith E. Grisel
Frontiers in Molecular Neuroscience , 2012, DOI: 10.3389/fnmol.2012.00087
Abstract: Alcohol use disorders, like all drug addictions, involve a constellation of adaptive changes throughout the brain. Neural activity underlying changes in the rewarding properties of alcohol reflect changes in dopamine transmission in mesolimbic and nigrostriatal pathways and these effects are modulated by endogenous opioids such as β-Endorphin. In order to study the role of β-Endorphin in the development of locomotor sensitization to repeated EtOH exposure, we tested transgenic mice that vary in their capacity to synthesize this peptide as a result of constitutive modification of the Pomc gene. Our results indicate that mice deficient in β-Endorphin show attenuated locomotor activation following an acute injection of EtOH (2.0 g/kg) and, in contrast to wildtype mice, fail to demonstrate locomotor sensitization after 12 days of repeated EtOH injections. These data support the idea that β-Endorphin modulates the locomotor effects of EtOH and contributes to the neuroadaptive changes associated with chronic use.
Governance for Resilience: CALFED as a Complex Adaptive Network for Resource Management
David E. Booher,Judith E. Innes
Ecology and Society , 2010,
Abstract: A study of California’s water planning and management process, known as CALFED, offers insights into governance strategies that can deal with adaptive management of environmental resources in ways that conventional bureaucratic procedures cannot. CALFED created an informal policy-making system, engaging multiple agencies and stakeholders. The research is built on data from 5 years of field work that included interviews with participants, review of documents, and observation of meetings. We argue that CALFED can be seen as a self-organizing complex adaptive network (CAN) in which interactions were generally guided by collaborative heuristics. The case demonstrates several innovative governance practices, including new practices and norms for interactions among the agents, a distributed structure of information and decision making, a nonlinear planning method, self-organizing system behavior, and adaptation. An example of a resulting policy innovation, a method to provide real-time environmental use of water while protecting a reliable supply of water for agricultural and urban interests, is described. We outline how ideas about complex adaptive network governance differ from ideas about traditional governance. These differences result in ongoing tension and turbulence as they do for other self-organizing governance processes that operate in a context of traditional governance.
Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia
Judith E Karp,Jeffrey E Lancet
Biologics: Targets and Therapy , 2008,
Abstract: Judith E Karp1, Jeffrey E Lancet21Division of Hematologic Malignancies, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA; 2H. Lee Moffitt Comprehensive Cancer Center, Tampa, Florida, USAAbstract: Farnesyltransferase inhibitors (FTIs) represent a new class of signal transduction inhibitors that block the processing of cellular polypeptides that have cysteine terminal residues and, by so doing, interdict multiple pathways involved in proliferation and survival of diverse malignant cell types. Tipifarnib is an orally bioavailable, nonpeptidomimetic methylquinolone FTI that has exhibited clinical activity in patients with myeloid malignancies including elderly adults with acute myelogenous leukemia (AML) who are not candidates for traditional cytotoxic chemotherapy, patients with high-risk myelodysplasia, myeloproliferative disorders, and imatinib-resistant chronic myelogenous leukemia. Because of its relatively low toxicity profile, tipifarnib provides an important alternative to traditional cytotoxic approaches for elderly patients who are not likely to tolerate or even benefit from aggressive chemotherapy. In this review, we will focus on the clinical development of tipifarnib for treatment of newly diagnosed AML, both as induction therapy for elderly adults with poor-risk AML and as maintenance therapy following achievement of first complete remission following induction and consolidation therapies for poor-risk AML. As with all other malignancies, the optimal approach is likely to lie in rational combinations of tipifarnib with cytotoxic, biologic and/or immunomodulatory agents with non-cross-resistant mechanisms of action. Gene expression profi ling has identified networks of differentially expressed genes and gene combinations capable of predicting response to single agent tipifarnib. The clinical and correlative laboratory trials in progress and under development will provide the critical foundations for defining the optimal roles of tipifarnib and in patients with AMl and other hematologic malignancies.Keywords: farnesylation, farnesyltransferase inhibitor, acute myelogenous leukemia (AML), signal transduction, gene expression, tipifarnib
Similarity and Diversity in Macrophage Activation by Nematodes, Trematodes, and Cestodes
Stephen J. Jenkins,Judith E. Allen
Journal of Biomedicine and Biotechnology , 2010, DOI: 10.1155/2010/262609
Abstract: This review summarizes current knowledge of macrophages in helminth infections, with a focus not only on delineating the striking similarities in macrophage phenotype between diverse infections but also on highlighting the differences. Findings from many different labs illustrate that macrophages in helminth infection can act as anti-parasite effectors but can also act as powerful immune suppressors. The specific role for their alternative (Th2-mediated) activation in helminth killing or expulsion versus immune regulation remains to be determined. Meanwhile, the rapid growth in knowledge of alternatively activated macrophages will require an even more expansive view of their potential functions to include repair of host tissue and regulation of host metabolism.
Evolution of Th2 Immunity: A Rapid Repair Response to Tissue Destructive Pathogens
Judith E. Allen ,Thomas A. Wynn
PLOS Pathogens , 2011, DOI: 10.1371/journal.ppat.1002003
Abstract:
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