oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 14 )

2018 ( 25 )

2017 ( 20 )

2016 ( 30 )

Custom range...

Search Results: 1 - 10 of 8306 matches for " JOSE DARIAS "
All listed articles are free for downloading (OA Articles)
Page 1 /8306
Display every page Item
SECONDARY METABOLITES FROM MARINE PENICILLIUM BREVICOMPACTUM
JUANA ROVIROSA,ANA DIAZ-MARRERO,JOSE DARIAS,KARIN PAINEMAL
Journal of the Chilean Chemical Society , 2006,
Abstract: In a screening of Basidiomycete cultures isolated from marine invertebrates collected along the Chilean coastline for the production of antibiotics we identified a Penicillium brevicompactum strain as a producer of metabolites inhibiting the growth of bacteria and fungi. Bioactivity guided purification resulted in the isolation of four known metabolites. Their structures were elucidated by spectroscopic methods
Coordinated gene expression during gilthead sea bream skeletogenesis and its disruption by nutritional hypervitaminosis A
Ignacio Fernández, Maria Darias, Karl B Andree, David Mazurais, Jose Zambonino-Infante, Enric Gisbert
BMC Developmental Biology , 2011, DOI: 10.1186/1471-213x-11-7
Abstract: During gilthead sea bream larval development, specific expression profiles for each gene were tightly regulated during fish morphogenesis and correlated with specific morphogenetic events and tissue development. Dietary hypervitaminosis A during early larval development disrupted the normal gene expression profile for genes involved in RA signalling (RARA), VA homeostasis (RBP) and several genes encoding ECM proteins that are linked to skeletogenesis, such as bglap and mgp.Present data reflects the specific gene expression patterns of several genes involved in larval fish RA signalling and skeletogenesis; and how specific gene disruption induced by a nutritional VA imbalance underlie the skeletal deformities. Our results are of basic interest for fish VA signalling and point out some of the potential molecular players involved in fish skeletogenesis. Increased incidences of skeletal deformities in gilthead sea bream fed with hypervitaminosis A were the likely ultimate consequence of specific gene expression disruption at critical development stages.Skeletogenesis is a critical process in vertebrates during which the skeleton develops in a genetically programmed manner, leading to normal anatomy that provides support and protection for the internal organs. In mammals, this process includes the differentiation and proliferation of different cell types, such as chondrocytes, osteoblasts, osteocytes and osteoclasts, which determine the size, shape and mineral composition of bone structures. The expression of specific genes deeply underlies these processes of cell proliferation and differentiation, which are also controlled by biotic and abiotic factors as well as individual genetic characteristics. Thus, determining factors and conditions that control and perturb those processes at the transcriptional level could be useful for deciphering the specific mechanisms behind these processes.Teleost fish are considered to be the first vertebrate group to develop a bony skeleto
SECONDARY METABOLITES FROM MARINE PENICILLIUM BREVICOMPACTUM
ROVIROSA,JUANA; DIAZ-MARRERO,ANA; DARIAS,JOSE; PAINEMAL,KARIN; SAN MARTIN,AURELIO;
Journal of the Chilean Chemical Society , 2006, DOI: 10.4067/S0717-97072006000100004
Abstract: in a screening of basidiomycete cultures isolated from marine invertebrates collected along the chilean coastline for the production of antibiotics we identified a penicillium brevicompactum strain as a producer of metabolites inhibiting the growth of bacteria and fungi. bioactivity guided purification resulted in the isolation of four known metabolites. their structures were elucidated by spectroscopic methods
A systems biology approach to analyse amplification in the JAK2-STAT5 signalling pathway
Julio Vera, Julie Bachmann, Andrea C Pfeifer, Verena Becker, Jose A Hormiga, Nestor Darias, Jens Timmer, Ursula Klingmüller, Olaf Wolkenhauer
BMC Systems Biology , 2008, DOI: 10.1186/1752-0509-2-38
Abstract: In this work we investigate the amplification and responsiveness of the JAK2-STAT5 pathway using a kinetic model. The recruitment of EpoR to the plasma membrane, activation by Epo, and deactivation of the EpoR/JAK2 complex are considered as well as the activation and nucleocytoplasmic shuttling of STAT5. Using qualitative biological knowledge, we first establish the structure of a general power-law model. We then generate a family of models from which we select suitable candidates. The parameter values of the model are estimated from experimental quantitative time-course data. The final model, whether it is conventional model with fixed predefined integer kinetic orders or a model with variable non-integer kinetic orders, is selected on the basis of a good agreement between simulations and the experimental data. The model is used to analyse the responsiveness and amplification properties of the pathway with sustained, transient, and oscillatory stimulation.The selected kinetic model predicts that the system acts as an amplifier with maximum amplification and sensitivity for input signals whose intensity match physiological values for Epo concentration and with duration in the range of one to 100 minutes. The response of the system reaches saturation for more intense and longer stimulation with Epo. We hypothesise that these properties of the system directly relate to the saturation of Epo receptor activation, its low recruitment to the plasma membrane and intense deactivation as predicted by the model.Cellular signal transduction is accomplished by networks of interacting proteins that detect, modulate and transfer cellular signals which control gene expression. A prime example of this is tumour progression and certain oncogenic processes, which directly relate to dysfunctions in signal transduction networks [1,2]. So far the use of mathematical modelling in cell signalling has been limited by the availability of suitable experimental data. However, the systematic d
LAS TRANSFORMACIONES SOCIO-ESPACIALES DE SAN SEBASTIáN DE LA GOMERA EN SIGLO XX: ENTRE LA AGRICULTURA Y LAS ACTIVIDADES TERCIARIAS
Luis Manuel Jerez Darias
Papeles de Geografía , 2008,
Abstract: Las principales transformaciones socio-espaciales producidas en el municipio de San Sebastián de La Gomera en el último siglo derivan de la actividad agrícola y de las inmobiliarias- turísticas. De su análisis se desprende el papel jugado por la propiedad del suelo, pilar que ha sostenido el edifi cio de la semifeudalidad en el campo gomero y de control del actual proceso inmobiliario-turístico.
El sello de correos, como medio informativo. La antigua Guinea espa ola, en su filatelia
Dr. Victoriano Darias
Revista Latina de Comunicación Social , 2001,
Abstract: A través de la observación detallada de las colecciones y catálogos filatélicos de un determinado país es posible obtener interesantes consideraciones históricas y periodísticas del mismo. Como ejemplo de ello proponemos en estas líneas el estudio de la faceta filatélica de la Guinea Espa ola, territorio africano discontinuo (islas y zona continental) que ocupó Espa a desde 1778, mediante la desafortunada expedición del conde de Argelejo.
La Guinea Ecuatorial, a través de sus medios de comunicación
Dr. Victoriano Darias
Revista Latina de Comunicación Social , 2001,
Abstract: Tras un ejemplar proceso emancipador, la Guinea Espa ola alcanza su prematura independencia el 12-X-1968, recibiendo de la antigua administración colonial una más que aceptable herencia mediática. En ella debe incluirse una flamante y potente emisora y estudios de TV inaugurados unos meses antes (12-VI-1968), dos excelentes emisoras de radio, Radio Fernando Poo, en Santa Isabel, actualmente Radio Nacional de Guinea Ecuatorial, y Radio Ecuatorial en Bata, tres dignos rotativos, ébano, Poto-Poto y la Hoja del Lunes de Fernando Poo de los que sus lectores, aún reconociendo sus limitaciones, se sentían orgullosos, amén de una serie de otras publicaciones de menor frecuencia entre las que es obligado destacar "La Guinea Espa ola" que venía siendo publicada desde abril de 1900 (1), donde velaron sus primeras armas informativas muchos de los futuros intelectuales y políticos guineanos (Nze Abuy, S. Ibongo, A. Ma é, S. Moto) y que constituía una auténtica memoria histórica del país.
Re-reading Cuba in London: Media and Identity in the Cuban Diaspora
Ivan Darias ALFONSO
Revista Roman? de Comunicare ?i Rela?ii Publice , 2012,
Abstract: This article examines issues of identity formation within Cubans in London and how news media figure in this process. It is argued that news media consumption plays a pivotal role in constructing knowledgeabout Cuba and how this new knowledge contributes to form notions of identity and nation amongst the emigrants. In diaspora, news media are used to validate a relationship with the emigrants' past and future. Past events are reviewed by a critical use of media, by acknowledging the potential bias of homeland media and the way Cuba was portrayed in the host country. I discuss how media influence the migrants' future, because notions of nation and culture gained from media access actively intervene in the emigrants' subject construction. The construction of knowledge through media represents an ongoing process that also influences identity formation. Accessedmedia reports can be internalised through renovated reading practices, especially for those who lacked the habit in the homeland, to re-define notions of belonging and claims of loyalties to Cuba.The article is based on a series of qualitative interviewing. From the data analysis, narratives of belonging and self-consciousness suggest that notions of nation and national identity are constructed differently in the Cuban diaspora than in the homeland.
Contribución al estudio de los medios de comunicación en la ex Guinea Espa ola
Victoriano Darias del Castillo,Victoriano Darias de las Heras
Revista Latina de Comunicación Social , 2001,
Abstract: Desde finales del S. XVIII (1778-79) y merced a los Tratados de S. Ildefonso y de El Pardo, Espa a obtuvo de Portugal en el Golfo de Guinea un territorio discontinuo (islas y continente) que le posibilitaba una fuente propia de mano de obra negra y una alternativa logística en la ruta a Filipinas. En aquella colonia espa ola en áfrica se originó un lento proceso de creación de medios informativos. Los autores hacen un aporte a la historia de estos.
Insulin allergy and resistance successfully treated by desensitisation with Aspart insulin
Victor Matheu, Eva Perez, Marta Hernández, Elisa Díaz, Ricardo Darias, Abel González, Jose C García, Inmaculada Sánchez, Laura Feliciano, Agueda Caballero, Fernando de la Torre
Clinical and Molecular Allergy , 2005, DOI: 10.1186/1476-7961-3-16
Abstract: Drug hypersensitivity reactions by IgE-mediated mechanisms during therapies have been reported elsewhere. Diagnosis is based in a meticulous clinical history, but many times needs to be supported by skin and/or serological tests and, even sometimes, drug provocation tests since drug preparations may contain multiple potential allergens that can trigger reactions, including drug itself, carrier proteins [1] or additives [2]. Among drugs triggering allergy reactions, insulin allergy might be one of the hot and controversial topics, since it is usually the only known treatment in the case of patients suffering type I diabetes. Although the prevalence of suspected insulin allergy have been reported as high as 2.5% [3], diagnosis should be more accurate since less than one third of patients are finally diagnosed of true insulin allergy [4].The patient is a 25-year-old builder with diabetes mellitus who was diagnosed at 23 years of age. Treatment with three daily injections of semi-synthetic human insulin was initially tolerated (Neutral protamine Hagedorn -NPH, Eli Lilly, Indianapolis, IN-: in the morning and in the evening and Lispro -Eli Lilly, Indianapolis, IN- in lunch-time). Glycosilated hemoglobin (HbA1c) controls were around 10%. He gradually started to develop wheals and flare local reactions following his injections of insulin. He was referred to Allergy Service of University Hospital NS Candelaria in April 2003. An initial exam at the Outpatient Clinic revealed strong sensitisation to Nickel Sulphate by patch test after 24, 48 and 96 hours. Separately, skin prick test (SPT) and intradermal test (ID) revealed sensitisation to Protamine (ID at 1:1000 dilution) but not to human insulin. Switch to Insulin without Protamine (Lispro -Eli Lilly, Indianapolis, IN) and subcutaneous insulin pump were both recommended. He did not observed any reaction for a 3-month period using Human regular insulin. Next, he started to notice local symptoms that progressively became wors
Page 1 /8306
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.