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Search Results: 1 - 10 of 459087 matches for " JOSé M; AMPUERO "
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p53 Codon 72 Polymorphism and Risk of Cervical Cancer
JOSé M OJEDA,SANDRA AMPUERO,PATRICIO ROJAS,RODRIGO PRADO
Biological Research , 2003,
Abstract: Storey et al. (1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (CC) with the observation that the p53 protein is more efficiently inactivated by the E6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform. These authors further noted that in the United Kingdom, individuals homozygous for the arginine allele were several times more susceptible to HPV-associated tumorigenesis that proline/arginine heterozygotes. Subsequent studies in different countries failed to unanimously confirm this association. Motivated by the high incidence of CC in Chile, we undertook a case control study obtaining the following frequencies for genotypes PP, AP and AA in 60 ICC cases and 53 carefully selected controls: 0.067, 0.250, 0.683 and 0.075, 0.453, 0.472 respectively. A significant difference (X2 = 3.19 p < 0.02) and an odds ratio of 2.62 supported Storey et al (1998)'s results. In addition, rejecting previous hypotheses about the world distribution of the p53 codon 72 polymorphism, we conclude that this distribution most likely represents ancient human dispersal routes. Several methodological and biological explanations for the results obtained in previous negative association studies are briefly discussed.
p53 Codon 72 Polymorphism and Risk of Cervical Cancer
OJEDA,JOSé M; AMPUERO,SANDRA; ROJAS,PATRICIO; PRADO,RODRIGO; ALLENDE,JORGE E; BARTON,SARA A; CHAKRABORTY,RANAJIT; ROTHHAMMER,FRANCISCO;
Biological Research , 2003, DOI: 10.4067/S0716-97602003000200017
Abstract: storey et al. (1998) implicated the proline/argine polymorphism of the codon 72 of the tumor-suppressor gene p53 in the development of cervical cancer (cc) with the observation that the p53 protein is more efficiently inactivated by the e6 oncoprotein of human papillomavirus in p53 arginine as compared with its proline isoform. these authors further noted that in the united kingdom, individuals homozygous for the arginine allele were several times more susceptible to hpv-associated tumorigenesis that proline/arginine heterozygotes. subsequent studies in different countries failed to unanimously confirm this association. motivated by the high incidence of cc in chile, we undertook a case control study obtaining the following frequencies for genotypes pp, ap and aa in 60 icc cases and 53 carefully selected controls: 0.067, 0.250, 0.683 and 0.075, 0.453, 0.472 respectively. a significant difference (x2 = 3.19 p < 0.02) and an odds ratio of 2.62 supported storey et al (1998)'s results. in addition, rejecting previous hypotheses about the world distribution of the p53 codon 72 polymorphism, we conclude that this distribution most likely represents ancient human dispersal routes. several methodological and biological explanations for the results obtained in previous negative association studies are briefly discussed.
Degradation capability of the coastal environment adjacent to the Itata River in central Chile (36.5° S)
S. Pantoja, M. H. Gutiérrez, P. Ampuero,E. Tejos
Biogeosciences (BG) & Discussions (BGD) , 2011,
Abstract: The response of the coastal ocean influenced by both river discharges and inputs of photosynthetically derived organic carbon product of upwelling, was evaluated by estimating rates of microbial hydrolysis of macromolecules with the goal of estimating the potential degradation capability of the coastal ecosystem off central Chile. Extracellular enzymatic activity (EEA) in seawater was dominated by aminopeptidase activity on substrate L-leucine-4-methyl-7-coumarinylamide (MCA-leu) (1.2 to 182 nmol l 1 h 1) followed by 4-methylumbelliferyl- -D-glucoside (MUF-glu) (0.08–61 nmol l 1 h 1) and 4-methylumbelliferyl- -D-cellobiose (MUF-cel) (0.15–7 nmol l 1 h 1), with the highest rates measured during spring-summer. In riverine waters, extracellular enzymatic hydrolysis remained within the range of 45 to 131 nmol l 1 h 1 for MCA-leu and ca. 20 nmol l 1 h 1 for glucosidic substrates, year-round. Contrary to the EEA observed for the marine water column, surface sediment extracellular enzymatic hydrolysis of MCA-leu (0.04 to 6.13 nmol g 1 dw h 1) was in the same order of magnitude as the rates observed for MUF-cel (0.004 to 5.1 nmol g 1 dw h 1) and MUF-glu (0.007 to 10.5 nmol g 1 dw h 1). Moreover, hydrolysis in sediments was characterized by higher rates during winter compared with spring-summer in the coastal and estuarine zone. The five years of data allowed us to evaluate the potential capability of microbial processing of organic carbon in the coastal area adjacent to the Itata river discharge where the increase in primary production in the productive seasons is accompanied by the increase in hydrolysis of macromolecules.
Degradation capability of the coastal environment adjacent to the Itata River in central Chile (36.5° S)
S. Pantoja,M. H. Gutiérrez,P. Ampuero,E. Tejos
Biogeosciences Discussions , 2011, DOI: 10.5194/bgd-8-1335-2011
Abstract: The response of the coastal ocean influenced by both river discharges and inputs of photosynthetically derived organic carbon product of upwelling, was evaluated by estimating rates of microbial hydrolysis of macromolecules with the goal of estimating the degradation capability of the coastal ecosystem off central Chile. Extracellular enzymatic hydrolysis in seawater was dominated by aminopeptidase activity on substrate MCA-leu (1.2 to 182 nM h 1), which surpassed that of substrates MUF-glu (0.08–61 nM h 1) and MUF-cel (0.15–6.8 nM h 1), with the fastest rates measured during spring-summer. In riverine waters, extracellular enzymatic hydrolysis remained within the range of 45 to 131 nM h 1 for MCA-leu and ca. 20 nM h 1 for glucosidic substrates, year-round. Contrary to the observed for the marine water column, surface sediment extracellular enzymatic hydrolysis of MCA-leu (0.04 to 6.13 nmol gdw 1 h 1) was in the same order of magnitude as the rates observed for MUF-cel (0.004 to 2.58 nmol gdw 1 h 1) and MUF-glu (0.007 to 10.5 nmol gdw 1 h 1). Moreover, hydrolysis was characterized by higher rates during winter compared with spring-summer in the coastal and estuarine zone. The five years of data allowed us to construct a carbon budget for winter and spring-summer in the coastal area adjacent to the Itata River discharge. The comparison of fluxes evidenced a deficit of photosynthetic carbon to fuel extracellular hydrolysis in the water column during both periods (winter 20% and spring-summer 35%). We estimated that the Itata River is a feasible source of dissolved organic carbon, specially during winter, in the form of macromolecules, although non-focal sources may be also significant for the area.
Analysis of 5382insC (BRCA1) and 6174delT (BRCA2) mutations in 382 healthy Chilean women with a family history of breast cancer
JARA,LILIAN; AMPUERO,SANDRA; SECCIA,LORENA; BUSTAMANTE,MARIO; BLANCO,RAFAEL; OJEDA,JOSé MANUEL;
Biological Research , 2002, DOI: 10.4067/S0716-97602002000100011
Abstract: breast cancer is the most common malignancy among women. chilean studies reveal that this cancer presents the third highest mortality rate. a family history of breast cancer is one of the major risk factors for the development of this disease. brca1 and brca2 are the two main hereditary breast cancer susceptibility genes, and mutations in these genes are related to inherited breast cancer. in specific populations only some mutations have been found to be associated with susceptibility. the purpose of this study was to establish the frequency of 5382insc (brca1) and 6174delt (brca2) germline mutations in 382 healthy chilean women with at least two relatives affected with breast cancer and in probands and their relatives from 8 high risk families for breast cancer, using mismatch pcr assay. the results obtained showed that 5382insc and 6174delt mutations were not found in either of the groups studied. the ethnic origin of the contemporary chilean population and the data reported in the literature suggest that these mutations may be absent or have a very low frequency in this population.. this genetic study is part of a breast cancer screening program that also includes annual mammography and clinical breast examination over a five-year period. strategies to reduce morbidity and mortality associated with breast cancer lie in early detection in women with genetic risk.
EL ALOE VERA (ALOE BARBADENSIS MILLER) COMO COMPONENTE DE ALIMENTOS FUNCIONALES
Vega G,Antonio; Ampuero C,Nevenka; Díaz N,Luis; Lemus M,Roberto;
Revista chilena de nutrición , 2005, DOI: 10.4067/S0717-75182005000300005
Abstract: because of the current population concern and interest about health conditions and life quality, the demand for natural products has increased, inducing the pharmaceutical and food industries to focus its efforts in researches related to their use. one of the most demanding raw materials both in foreign and national markets is aloe vera, a vegetable which can be obtained for cosmetics, pharmaceutical and food purposes. from the point of view of human nutrition, scientists have identified more than 75 components in aloe vera, mainly vitamins, minerals, enzymes and amino acids, besides other substances of interest to our organism with emollient, healing, clotting, moisturizing, antiallergenic, antiseptic, antinflammatory, astringent, choleretic and laxative action. thus this plant can provide nutritional components as raw material to elaborate functional foods, considered as ?future food? nowadays. aloe vera can become an excellent source of chemical nutritional products for the development of new products for the chilean food industry
EL ALOE VERA (ALOE BARBADENSIS MILLER) COMO COMPONENTE DE ALIMENTOS FUNCIONALES ALOE VERA (ALOE BARBADENSIS MILLER) AS A COMPONENT OF FUNCTIONAL FOODS
Antonio Vega G,Nevenka Ampuero C,Luis Díaz N,Roberto Lemus M
Revista Chilena de Nutricíon , 2005,
Abstract: Debido a la preocupación e interés actual de la población por las condiciones de salud y calidad de vida, es que ha aumentado la demanda de productos naturales, lo cual hace que las industrias farmacéuticas y de los alimentos centren sus esfuerzos en investigaciones relacionadas con su utilización. Una de las materias primas de gran demanda, tanto en el mercado externo como en el nacional, es el Aloe vera, vegetal del cual se pueden obtener productos con fines cosmetológicos, farmacéuticos y alimenticios. Desde el punto de vista de la nutrición humana, los científicos han identificado más de 75 compuestos en el Aloe vera; principalmente vitaminas, minerales, enzimas y aminoácidos, además de otras sustancias de interés para nuestro organismo con acción emoliente, cicatrizante, coagulante, hidratante, antialérgica, desinfectante, antiinflamatoria, astringente, colerética y laxante. Por lo tanto, esta planta puede aportar componentes nutricionales como materia prima para la elaboración de alimentos funcionales, considerados en la actualidad como los alimentos del futuro. Así, el Aloe vera puede convertirse en una excelente fuente de productos químicos nutricionales para el desarrollo y comercialización de nuevos productos para la industria de alimentos chilena Because of the current population concern and interest about health conditions and life quality, the demand for natural products has increased, inducing the pharmaceutical and food industries to focus its efforts in researches related to their use. One of the most demanding raw materials both in foreign and national markets is Aloe Vera, a vegetable which can be obtained for cosmetics, pharmaceutical and food purposes. From the point of view of human nutrition, scientists have identified more than 75 components in Aloe Vera, mainly vitamins, minerals, enzymes and amino acids, besides other substances of interest to our organism with emollient, healing, clotting, moisturizing, antiallergenic, antiseptic, antinflammatory, astringent, choleretic and laxative action. Thus this plant can provide nutritional components as raw material to elaborate functional foods, considered as future food nowadays. Aloe vera can become an excellent source of chemical nutritional products for the development of new products for the Chilean food industry
LA INICIATIVA PROBATORIA DEL JUEZ Y LA IGUALDAD DE ARMAS EN EL PROYECTO DE CóDIGO PROCESAL CIVIL
Hunter Ampuero,Iván;
Ius et Praxis , 2011, DOI: 10.4067/S0718-00122011000200004
Abstract: the present work meets two purposes: first of all, to explain what is the relation between procedural equality and judge's probative activity. thus, to define if the ex officio jurisdictional initiative related to proofs can lead to achieve procedural balances when individuals are surrounded by substantive inequality. secondly, to define the role to be assumed by the judge according to the equality requirements which involve a trial. these requirements are entrusted to the judge in the civil procedural code project.
EL PODER DEL JUEZ PARA RECHAZAR IN LIMINE LA DEMANDA POR MANIFIESTA FALTA DE FUNDAMENTO
Hunter Ampuero,Iván;
Ius et Praxis , 2009, DOI: 10.4067/S0718-00122009000200005
Abstract: this paper aims to investigate the content and scope of the legal authority contained in article 18 number 1 of the civil procedural code project. this paper deals with the possibility that judges may refuse a complaint in limine when it is unfounded. the author addresses two issues: on the one hand, it defines the necessary elements that allow the use or invocation of this power, that is, to define what is necessary for a complaint to be considered unfounded; on the other hand, it addresses questions pertaining to the constitutional legitimacy of the power, specifically, its compatibility (or lack of) with respect to the effective protection of the law and due process.
IURA NOVIT CURIA EN LA JURISPRUDENCIA CIVIL CHILENA
Hunter Ampuero,Iván;
Revista de derecho (Valdivia) , 2010, DOI: 10.4067/S0718-09502010000200010
Abstract: the present paper carries out a critical analysis of the most relevant chilean judicial decisions regarding the legal authority of the courts to decide about the legal rules that are applicable to a particular case. in its first part, it is explained how the distribution of procedural roles has responded to a series of hardly questionable dogma, and how its influence on judicial decisions is clear. also, it deals with the most important consequences of the distinction between matters of law -which determination is assigned to the courts- and factual subject -which determination is assigned to the parties. lastly, based upon diverse rulings, the paper explains the need to leave that rigid separation, in the light of procedural rights as the right of defense.
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