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Search Results: 1 - 10 of 286924 matches for " JOSé IGNACIO RODRIGUEZ C. "
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Uso de mascarilla laríngea para fibrobroncoscopía en lactantes durante ventilación mecánica USE OF LARYNGEAL MASK WHILE FLEXIBLE BRONCHOSCOPY IS PERFORMED IN INFANTS UNDER MECHANICAL VENTILATION
CECILIA ALVAREZ G.,JOSé IGNACIO RODRIGUEZ C.,RICARDO RONCO M.,ANDRéS CASTILLA M.
Revista Chilena de Enfermedades Respiratorias , 2002,
Abstract: La mascarilla laríngea (ML) se utiliza para el manejo de la vía aérea en adultos y ni os bajo anestesia general con el objetivo de evitar la intubación traqueal y su uso se ha extendido para fibrobroncoscopía bajo anestesia general. Durante ventilación mecánica (VM) la fibrobroncoscopía (FB) se limita a tubos endotraqueales (TET) > 4,5 mm de diámetro ya que el fibrobroncoscopio con canal de succión más peque o es de 3,5 mm. Nuestro objetivo fue evaluar la utilidad de la ML para FB en ni os sometidos a VM con TET < 4,5 mm de diámetro. Todos los pacientes fueron premedicados con atropina, midazolam, paralización con vecuronio y monitorizados con oxímetro de pulso y monitor cardiorespiratorio. Se introdujo la ML y se verificó su posición por auscultación pulmonar. Se utilizó un fibrobroncoscopio Olympus BF-C30 de 3,5 mm de diámetro. Desde Diciembre de 1997 a Octubre de 1998 se realizaron 11 procedimientos en 6 pacientes con edad promedio de 6,2 meses (0,5-33), peso promedio de 4,9 kg (2,7-10,5) y VM con valores promedios de FiO2: 0,45 (0,4-1), PIM: 28,4 cm de H2O (20-60) y PEEP 5,18 cm de H2O (3-8). En todos se utilizó la ML número 1 que tiene un diámetro interno de 5,25 mm. Las indicaciones de FB fueron atelectasia (6), traqueobroncomalacia (2), hemoptisis (2) y estenosis subglótica (1). La inserción de la ML fue exitosa al primer intento en 9 procedimientos y no hubo complicaciones en su inserción. Durante el procedimiento se mantuvo ventilación a presión positiva sin desplazamientos de la ML que obligaran a su reinserción y SaO2 promedio de 94%. Se reintubó al paciente, conectándose a los parámetros de VM previos al procedimiento. En resumen, creemos que la ML provee una vía aérea efectiva y segura para ventilación a presión positiva durante FB en ni os con VM y TET < 4,5 mm en que junto a visualización se requiere lavado y aspiración de secreciones. (palabras claves: endoscopía, insuficiencia respiratoria, UCI) Laryngeal mask (LM) has been used to manage airways during general anesthesia, in both children and adults, to avoid tracheal intubation. Lately its use has been extended to perform flexible bronchoscopy (FB). In an infant under mechanical ventilation (MV), most of FB require an endotracheal tube # 4.5 because the smallest instrument with a suction channel has a 3.5 mm diameter. Our objective was to evaluate the use of LM while performing FB in patients on MV. Patients were sedated (atropine- midazolam and vecuronium), and monitored with transcutaneous oxygen saturation and cardiorespiratory monitor in an Intensive Care Unit setup. LM was introdu
Uso de mascarilla laríngea para fibrobroncoscopía en lactantes durante ventilación mecánica
ALVAREZ G.,CECILIA; RODRIGUEZ C.,JOSé IGNACIO; RONCO M.,RICARDO; CASTILLA M.,ANDRéS; CAMPOS N.,EUGENIA; SáNCHEZ D.,IGNACIO;
Revista chilena de enfermedades respiratorias , 2002, DOI: 10.4067/S0717-73482002000200005
Abstract: laryngeal mask (lm) has been used to manage airways during general anesthesia, in both children and adults, to avoid tracheal intubation. lately its use has been extended to perform flexible bronchoscopy (fb). in an infant under mechanical ventilation (mv), most of fb require an endotracheal tube # 4.5 because the smallest instrument with a suction channel has a 3.5 mm diameter. our objective was to evaluate the use of lm while performing fb in patients on mv. patients were sedated (atropine- midazolam and vecuronium), and monitored with transcutaneous oxygen saturation and cardiorespiratory monitor in an intensive care unit setup. lm was introduced, and its position was verified by clinical auscultation. fb olympus bf c-30, with 3.5 mm diameter was used. from december 1997 to october 1998 eleven procedures were done in 6 patients. their mean age was 6.2 months (range: 0.5-33), weight 4.9 kg (2.7-10.5). mv parameters were fio2 0.45 (0.4-1), mip 28.4 cm h2o (20-60) and peep 5,18 cm h2o (3-8). in all patients we used lm # 1.0, with an internal diameter 5.25 mm. indications for fb were: atelectasis (6), tracheobronchomalacia (2), hemoptisis (2) and subglotic stenosis (1). lm was introduced during the first attempt in 9 procedures, without complications. we maintained positive pressure ventilation without displacements of lm. after the fb, the patients were reintubated, with similar parameters compared to prior procedure. to sum up, we found that lm provides a safe artificial airway to ventilate patients who need fb during mechanical ventilation on small endotracheal tubes. this technique allows bronchial visualization, and aspiration and to perform bronchoalveolar lavage to carry out cell counting and cultures
The Symbiosis Interactome: a computational approach reveals novel components, functional interactions and modules in Sinorhizobium meliloti
Ignacio Rodriguez-Llorente, Miguel A Caviedes, Mohammed Dary, Antonio J Palomares, Francisco M Cánovas, José M Peregrín-Alvarez
BMC Systems Biology , 2009, DOI: 10.1186/1752-0509-3-63
Abstract: Here we present an analysis of the 'Symbiosis Interactome' using novel computational methods in order to address the complex dynamic interactions between proteins involved in the symbiosis of the model bacteria Sinorhizobium meliloti with its plant hosts. Our study constitutes the first large-scale analysis attempting to reconstruct this complex biological process, and to identify novel proteins involved in establishing symbiosis. We identified 263 novel proteins potentially associated with the Symbiosis Interactome. The topology of the Symbiosis Interactome was used to guide experimental techniques attempting to validate novel proteins involved in different stages of symbiosis. The contribution of a set of novel proteins was tested analyzing the symbiotic properties of several S. meliloti mutants. We found mutants with altered symbiotic phenotypes suggesting novel proteins that provide key complementary roles for symbiosis.Our 'systems-based model' represents a novel framework for studying host-microbe interactions, provides a theoretical basis for further experimental validations, and can also be applied to the study of other complex processes such as diseases.Plant-microbe interactions play an important role in agriculture and a lot of effort has been dedicated to analyse these interactions in detail. One of these interactions is the Rhizobium-Legume symbiosis, a process that allows the growth of the plant in the absence of externally supplied nitrogen. This is a well studied agronomically important process that is also used as a model to study general genetic aspects of plant-microbe interactions [1,2]. Rhizobial bacteria and legumes have evolved complex signal exchange mechanisms in which a lot of genes are involved [3]. To probe this complexity further we chose to study the model rhizobial symbiont genome Sinorhizobium meliloti [4]. S. meliloti is a model bacterium that can engage in a symbiotic interaction by infecting the roots of members of the genera Medic
DNA Methylation Profiles and Their Relationship with Cytogenetic Status in Adult Acute Myeloid Leukemia
Sara Alvarez,Javier Suela,Ana Valencia,Agustín Fernández,Mark Wunderlich,Xabier Agirre,Felipe Prósper,José Ignacio Martín-Subero,Alba Maiques,Francesco Acquadro,Sandra Rodriguez Perales,María José Calasanz,Jose Roman-Gómez,Reiner Siebert,James C. Mulloy,José Cervera,Miguel Angel Sanz,Manel Esteller,Juan C. Cigudosa
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0012197
Abstract: Aberrant promoter DNA methylation has been shown to play a role in acute myeloid leukemia (AML) pathophysiology. However, further studies to discuss the prognostic value and the relationship of the epigenetic signatures with defined genomic rearrangements in acute myeloid leukemia are required.
On the Power and the Systematic Biases of the Detection of Chromosomal Inversions by Paired-End Genome Sequencing
José Ignacio Lucas Lledó, Mario Cáceres
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061292
Abstract: One of the most used techniques to study structural variation at a genome level is paired-end mapping (PEM). PEM has the advantage of being able to detect balanced events, such as inversions and translocations. However, inversions are still quite difficult to predict reliably, especially from high-throughput sequencing data. We simulated realistic PEM experiments with different combinations of read and library fragment lengths, including sequencing errors and meaningful base-qualities, to quantify and track down the origin of false positives and negatives along sequencing, mapping, and downstream analysis. We show that PEM is very appropriate to detect a wide range of inversions, even with low coverage data. However, % of inversions located between segmental duplications are expected to go undetected by the most common sequencing strategies. In general, longer DNA libraries improve the detectability of inversions far better than increments of the coverage depth or the read length. Finally, we review the performance of three algorithms to detect inversions —SVDetect, GRIAL, and VariationHunter—, identify common pitfalls, and reveal important differences in their breakpoint precisions. These results stress the importance of the sequencing strategy for the detection of structural variants, especially inversions, and offer guidelines for the design of future genome sequencing projects.
Pronóstico de la Concentración de Ozono en Guadalajara-México usando Redes Neuronales Artificiales
García,Ignacio; Marbán,Alonso; Tenorio,Yenisse M; Rodriguez,José G;
Información tecnológica , 2008, DOI: 10.4067/S0718-07642008000300013
Abstract: a forecasting model to predict the maximum ozone concentration in a specific day in the metropolitan area of guadalajara-mexico was developed. an artificial neuronal network fed with six meteorological variables and three chemicals was used. nodes in the hidden layer were varying in a number among 12 and 15. the transfer functions were log-sigmoid for the hidden layer and linear for the output layer. for the network training the levenberg-marquardt algorithm with historical dates from 1999 to 2004. data for 2005 were used to evaluate the predictive capabilities of the trained network, evaluating the quality of the air at three levels: good, moderate, and unhealthy. the model presented global efficiencies of around 50%, reaching and 65% for high ozone concentrations.
Pronóstico de la Concentración de Ozono en Guadalajara-México usando Redes Neuronales Artificiales Ozone Concentration Forecast in Guadalajara-Mexico using Artificial Neuronal Networks
Ignacio García,Alonso Marbán,Yenisse M Tenorio,José G Rodriguez
Información Tecnológica , 2008,
Abstract: Se desarrolló un modelo de pronóstico de la concentración de ozono máxima para el día de interés para la Zona Metropolitana de Guadalajara-México. Se uso una Red Neuronal Artificial alimentada con seis variables meteorológicas y tres químicas. Los nodos de la capa oculta se variaron entre doce y quince, las funciones de transferencia de la capa interna fueron log-sigmoidal, y de la de salida fue lineal. Para entrenar la red se empleó un algoritmo de Levenberg-Marquardt con datos históricos de 1999 a 2004. Datos del a o 2005 fueron usados para verificar la capacidad predictiva de la red ya entrenada, y evaluar la calidad del aire en tres niveles: buena, moderada y mala. El modelo tuvo eficiencias globales de alrededor del 50%, llegando a 65% para concentraciones elevadas de ozono. A forecasting model to predict the maximum ozone concentration in a specific day in the Metropolitan Area of Guadalajara-Mexico was developed. An Artificial Neuronal Network fed with six meteorological variables and three chemicals was used. Nodes in the hidden layer were varying in a number among 12 and 15. The transfer functions were log-sigmoid for the hidden layer and linear for the output layer. For the network training the Levenberg-Marquardt algorithm with historical dates from 1999 to 2004. Data for 2005 were used to evaluate the predictive capabilities of the trained network, evaluating the quality of the air at three levels: good, moderate, and unhealthy. The model presented global efficiencies of around 50%, reaching and 65% for high ozone concentrations.
Long-term effect of autologous progenitor cell therapy to induce neo angiogenesis in patients with critical limb ischemia transplantated via intramuscular vs combined intramuscular and distal retrograde intra venous  [PDF]
Luis Padilla, Juan Rodriguez-Trejo, Ignacio Escotto, Manuel López-Hernandez, Mauricio González, José De Diego, Neftaly Rodrgiuez, Jesús Tapia, Takeshi Landero, Carranza Pilar Hazel, Olguin Juarez Horacio, Mauricio Di Silvio, Paul Mondragon-Teran
Stem Cell Discovery (SCD) , 2012, DOI: 10.4236/scd.2012.24020
Abstract: Critical limb ischemia is a medical condition that decreases blood flow and limb oxygen supply; this disease in its late stages of progression leads to only two possible options: either surgical bypass revascularization or limb amputation. We investigated a novel method using autologous transplantation of progenitor cells derived from mobilized peripheral blood bone marrow mononuclear cells to evaluate its long-term effect as a cell therapy to induce neo-angiogenesis and restore blood flow in the affected ischemic limbs. A total of 20 ischemic limbs from critical limb ischemia diagnosed patients, non candidates to surgical revascularization were transplanted with autologous progenitor cells by either intramuscular combined with intravenous (group A) or intramuscular (group B) procedure. Patients were monitored during 31 months. Treatment efficacy was evaluated according to the following parameters: ankle brachial index which increased at a range of 0.29-1.0 in group A and 0.40-0.90 in group B; pain-free walking distance which increased at a range of 50-600 m in group A and 50-300 m in group B; and blood perfusion (measured by Laser Doppler) which increased at a range of 48-299 in group A and 135-225 in group B. We achieved 90% treated ischemic limbs free of amputation in both transplanted groups. Results here described provide a safe, efficient and minimally invasive therapy with progenitor cells to induce angiogenesis and preserve limbs from amputation in CLI diagnosed patients.
Análisis comparativo sobre el empleo de plantas medicinales en la medicina tradicional de Cuba e Islas Canarias
Torres Jiménez,Israel Bernardo; Quintana Cárdenes,Ignacio José;
Revista Cubana de Plantas Medicinales , 2004,
Abstract: the use of the different plant species in cuba and in the canary islands was comparatively analyzed based on the most important works on medicinal plants from these countries. 179 species grouped into 147 genera of 62 families that are used in traditional medicine in cuba and the canary islands are dealt with. their properties as well as the affections for which they are used in both regions are stressed.
Use of the information gathered during I/M programs to estimate emissions from gasoline vehicles
Huertas,José Ignacio; Mendoza,Efrén; Córdoba,Jorge;
Revista Facultad de Ingeniería Universidad de Antioquia , 2010,
Abstract: currently, most of the vehicular emissions inventories developed for large cities are based on the emissions factors developed by the us epa. trying to use the us epa mobile tool, the local environmental authorities concentrate their efforts in modifying those emissions factors to take care of the particular characteristics of each city. however, there is still a need for a methodology based on experimental tests to improve the accuracy of the emission inventories developed for large cities. to address this need, the present work proposes a methodology to improve the accuracy of the vehicular emissions inventory using the information gathered during the inspection and maintenance (i/m) programs where the emissions of 100% of the vehicular fleet is evaluated using the asm 5015, asm 2525 or similar type of tests. experimental work on road and on a chassis dynamometer was developed to explore the feasibility of implementing such methodology for the case of the constant speed mode of operation in a particular type of car. preliminary results show that the proposed methodology has the potential to be implemented for the case of constant speed mode of operation.
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