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Search Results: 1 - 10 of 592741 matches for " J.M.; "
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Calcificación vascular: tipos y mecanismos
Nefrología (Madrid) , 2011,
Abstract: vascular calcification has traditionally been considered to be a passive process that was associated with advanced age, atherosclerosis, uncommon genetic diseases and some metabolic alterations such as diabetes mellitus and end-stage kidney failure. however, in the last years, vascular calcification has been proven to be an active and regulated process, similar to bone mineralisation, in which different bone-related proteins are involved. recent results question the classic classification of vascular calcification into intimal and medial calcification, at least in capacitance arteries. pro and anti-calcifying mechanisms play an active role in calcium deposition in vascular cells, making this area an active focus of research. the identification of therapeutic targets which can slow down the progression or even reverse vascular calcification could be an important step forward in the treatment of patients with chronic kidney disease.
El Programa Dental de Atención Infantil (PADI) de Navarra y del País Vasco: logros y nuevas metas
Anales del Sistema Sanitario de Navarra , 2003, DOI: 10.4321/S1137-66272003000500008
Abstract: this paper briefly analyses the results of the infant dental care program (padi) of the basque country (1990) and navarra (1991), aimed at children aged from 6 and 15 years. at the age 12, the lack of caries rose from 31% in 1988 to 57% in 1998 in the basque country, while it was 58% in navarra (1997); the number of caries fell in navarra by some 64% and by some 54% in the basque country, and the index of restoration was 81% in navarra and 73% in the basque country (it was 17% in 1988). emphasis is placed on the importance of a good evaluation of these programs and the opportunities that are opened up by the comparative analysis between spanish autonomous communities for analysing the contribution of factors that are different, and for evaluating the impact of the programs on social inequalities in health. the results of the padi exceed the initial aims of the health plans of navarra (1991) and of the basque country (1990), and endorse the adoption of these programs by the spanish autonomous communities. the development of these programs raises new objectives in dental health policy in navarra and the basque country and, above all, makes it necessary to reflect on the need for spain to include public dental health in its health policy and for the national health system as a whole to include dental services within its services.
Protein folding: a perspective for biology, medicine and biotechnology
Yon, J.M.;
Brazilian Journal of Medical and Biological Research , 2001, DOI: 10.1590/S0100-879X2001000400001
Abstract: at the present time, protein folding is an extremely active field of research including aspects of biology, chemistry, biochemistry, computer science and physics. the fundamental principles have practical applications in the exploitation of the advances in genome research, in the understanding of different pathologies and in the design of novel proteins with special functions. although the detailed mechanisms of folding are not completely known, significant advances have been made in the understanding of this complex process through both experimental and theoretical approaches. in this review, the evolution of concepts from anfinsen's postulate to the "new view" emphasizing the concept of the energy landscape of folding is presented. the main rules of protein folding have been established from in vitro experiments. it has been long accepted that the in vitro refolding process is a good model for understanding the mechanisms by which a nascent polypeptide chain reaches its native conformation in the cellular environment. indeed, many denatured proteins, even those whose disulfide bridges have been disrupted, are able to refold spontaneously. although this assumption was challenged by the discovery of molecular chaperones, from the amount of both structural and functional information now available, it has been clearly established that the main rules of protein folding deduced from in vitro experiments are also valid in the cellular environment. this modern view of protein folding permits a better understanding of the aggregation processes that play a role in several pathologies, including those induced by prions and alzheimer's disease. drug design and de novo protein design with the aim of creating proteins with novel functions by application of protein folding rules are making significant progress and offer perspectives for practical applications in the development of pharmaceuticals and medical diagnostics.
Chemoreceptors and cardiovascular control in acute and chronic systemic hypoxia
Marshall, J.M.;
Brazilian Journal of Medical and Biological Research , 1998, DOI: 10.1590/S0100-879X1998000700002
Abstract: this review describes the ways in which the primary bradycardia and peripheral vasoconstriction evoked by selective stimulation of peripheral chemoreceptors can be modified by the secondary effects of a chemoreceptor-induced increase in ventilation. the evidence that strong stimulation of peripheral chemoreceptors can evoke the behavioural and cardiovascular components of the alerting or defence response which is characteristically evoked by novel or noxious stimuli is considered. the functional significance of all these influences in systemic hypoxia is then discussed with emphasis on the fact that these reflex changes can be overcome by the local effects of hypoxia: central neural hypoxia depresses ventilation, hypoxia acting on the heart causes bradycardia and local hypoxia of skeletal muscle and brain induces vasodilatation. further, it is proposed that these local influences can become interdependent, so generating a positive feedback loop that may explain sudden infant death syndrome (sids). it is also argued that a major contributor to these local influences is adenosine. the role of adenosine in determining the distribution of o2 in skeletal muscle microcirculation in hypoxia is discussed, together with its possible cellular mechanisms of action. finally, evidence is presented that in chronic systemic hypoxia, the reflex vasoconstrictor influences of the sympathetic nervous system are reduced and/or the local dilator influences of hypoxia are enhanced. in vitro and in vivo findings suggest this is partly explained by upregulation of nitric oxide (no) synthesis by the vascular endothelium which facilitates vasodilatation induced by adenosine and other no-dependent dilators and attenuates noradrenaline-evoked vasoconstriction.
Chemokines, lymphocytes, and HIV
Farber, J.M.;
Brazilian Journal of Medical and Biological Research , 1998, DOI: 10.1590/S0100-879X1998000100002
Abstract: chemokines are members of a family of more than 30 human cytokines whose best-described activities are as chemotactic factors for leukocytes and that are presumed to be important in leukocyte recruitment and trafficking. while many chemokines can act on lymphocytes, the roles of chemokines and their receptors in lymphocyte biology are poorly understood. the recent discoveries that chemokines can suppress infection by hiv-1 and that chemokine receptors serve, along with cd4, as obligate co-receptors for hiv-1 entry have lent urgency to studies on the relationships between chemokines and lymphocytes. my laboratory has characterized mig and crg-2/ip-10, chemokines that are induced by ifn-g and that specifically target lymphocytes, particularly activated t cells. we have demonstrated that the genes for these chemokines are widely expressed during experimental infections in mice with protozoan and viral pathogens, but that the patterns of mig and crg-2 expression differed, suggesting non-redundant roles in vivo. our related studies to identify new chemokine receptors from activated lymphocytes resulted in the cloning of strl22 and strl33. we and others have shown that strl22 is a receptor for the cc chemokine mip-3a, and strl22 has been re-named ccr6. although strl33 remains an orphan receptor, we have shown that it can function as a co-receptor for hiv-1 envelope glycoproteins, and that it is active with a broader range of hiv-1 envelope glycoproteins than the major co-receptors described to date. the ability of strl33 to function with a wide variety of envelope glycoproteins may become particularly important if therapies are instituted to block other specific co-receptors. we presume that investigations into the roles of chemokines and their receptors in lymphocyte biology will provide information important for understanding the pathogenesis of aids and for manipulating immune and inflammatory responses for clinical benefit
Environmental Impact Assessment of Steam Injection Mining Method of Agbabu Bitumen Deposit
J.M. Akande
Journal of Engineering and Applied Sciences , 2012,
Abstract: An environmental impact of steam injection mining method applicable to Agbabu bitumen deposit was studied. Steam injection tests were carried out on the deposit. The environmental pollutants evolved from the tests were evaluated with respect to their source, impact, monitoring or detection and control. The results of the analysis indicated that steam injection method would control the contaminated water in the mining of Agbabu bitumen deposit.
Analysis of Steam Injection and in situ Combustion Methods of Mining Agbabu Bitumen Deposit in Ondo State, Nigeria
J.M. Akande
Journal of Engineering and Applied Sciences , 2012,
Abstract: Steam injection and in situ combustion methods of mining Agbabu bitumen deposit were studied. Cyclic steam injection test and in situ combustion laboratory experiment were carried out on the bitumen deposit. The steam injection analysis was used to deduce values for key performance indicators such as: water-oil ratio; oil steam ratio; thermal ratio; heat loss to formation and energy requirements while the in situ combustion laboratory analysis was used to obtain information on combustion characteristics of the formation: Air requirements and fuel consumption, etc. The results of the investigation indicate high susceptibility of Agbabu bitumen formation to the two mining methods. In addition, the comparative results of the two mining methods showed that the in situ combustion method was more efficient and economical than the steam injection method in the mining of the Agbabu bitumen deposit.
Local anaesthetic toxicity
J.M Dippenaar
Southern African Journal of Anaesthesia and Analgesia , 2007,
Abstract: Local anaesthetic toxicity has been known since the introduction of local anaesthetic drugs into anaesthetic practice more than a hundred years ago. The aim of this review is to follow the history of the search for less toxic local anaesthetic drugs, to highlight molecular mechanisms thought to contribute to the clinical phenomenon of toxicity, and to finally discuss novel treatment strategies.
Papillary adenocarcinoma of thyroid in a patient with right submandibular mass - a rare case of 'lateralaberrant thyroid’
J.M Adotey
Nigerian Journal of Clinical Practice , 2009,
Abstract: Ectopic thyroid is a rare entity in the study of thyroid disease. The occurrence of ectopic thyroid tissue as amass in the submandibular region is even rarer. To report a case of papillary adenocarcinoma of thyroid within a right submandibularmass in a 67 year-old man.Additionally this is to alert doctors on the possibility of the condition and re-emphasize the need for proper and thorough histologic investigation. The case notes of the patient, who had presented a year earlier with right submandibular mass, were retrieved and studied. At the initial presentation chest radiograph and assessment of the oropharynx by an otorhinolaryngologist were carried out. Full blood count, erythrocyte sedimentation rate (ESR) and fine needle aspiration biopsy (FNAB)were done at the second presentation. An ultrasound scan of the neck and repeat chest radiograp hwere also performed. The right submandibular mass had increased in size about 10-fold by the time the patient was seen 13 months later. The chest radiograph and oropharyngeal examination were normal. The neck ultrasound scan demonstrated the presence of a solid right submandibularmass.The FNAB showed papillary adenocarcinoma of the thyroid.He declined a near-total thyroidectomy and demanded nonsurgical treatment. Low dose L-thyroxine (0.1mg) daily was started and referred to another centre for possible radioactive iodine treatment. This latter treatment could not be given because of lack of facilities. Follow-up review in 3 months showed that the patient was only on L-thyroxine therapy and his clinical condition had deteriorated.Hewas subsequently lost to followup. This patient illustrates the even rarer case of a 'lateral aberrant thyroid' presenting as a malignant submandibular mass. It is probably the latest addition to the rather rare number of such cases in the literature. Doctors should be aware of the possibility of the condition and the need for proper an d thorough histologic investigation is re-emphasized.
系统工程理论与实践 , 1982,
Abstract: 大家知道,科学问题如能获得正确表示,就可在很大程度上确保问题的顺利解决,特别对范围广泛的全球问题尤为如此。这就是这里通篇讨论的范围甚广的全球问题要求确立方法论概念的原由。没有正确的方法,科学问题就不可能准确表述。 必须指出,只有在某问题出现严重危机时才常带全球性质。这种危机往往给人以“利剑悬顶”之感,至少也会带来“一种不可逆转的消极后果”。在危机关头下得出的科学解法,常在不同程度上受到群众觉悟和狭隘功利主义态度的影响。无须争辩,这样的解法基本上不宜用作合理的全球模型的构模方法。
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