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Search Results: 1 - 10 of 592827 matches for " J.M. Roda "
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Hemangioblastoma of the lateral ventricle: case report and review of the literature
Prieto,R.; Roda,J.M.;
Neurocirugía , 2005, DOI: 10.4321/S1130-14732005000100009
Abstract: we report a unique case of hemangioblastoma of the lateral ventricle in a 73 year-old man with cognitive deficits and fluent dysphasia. he harboured an intraventricular tumor, placed at the trigone of the left lateral ventricle. the tumor was successfully excised, by means of a temporal craniotomy. the patient became mute in the immediate postoperative with restoration of speech within a few days. the literature has been reviewed and only three other similar cases have been reported. discovery of lesions in such unusual location should raise a high degree of suspicion for von hippel- lindau disease.
Hemangioblastoma of the lateral ventricle: case report and review of the literature Hemangioblastoma del ventrículo lateral: caso clínico y revisión de la literatura
R. Prieto,J.M. Roda
Neurocirugía , 2005,
Abstract: We report a unique case of hemangioblastoma of the lateral ventricle in a 73 year-old man with cognitive deficits and fluent dysphasia. He harboured an intraventricular tumor, placed at the trigone of the left lateral ventricle. The tumor was successfully excised, by means of a temporal craniotomy. The patient became mute in the immediate postoperative with restoration of speech within a few days. The literature has been reviewed and only three other similar cases have been reported. Discovery of lesions in such unusual location should raise a high degree of suspicion for von Hippel- Lindau disease. En este trabajo describimos el caso de un paciente de 73 a os con déficits cognitivos y disfasia sensitiva y que fue diagnosticado mediante tomografía computarizada y resonancia magnética cerebral de una lesión tumoral situada en la encrucijada ventricular izquierda. La lesión se abordó quirúrgicamente a través de una craneotomía temporal, realizándose una extirpación total. El estudio anatomopatológico confirmó el diagnóstico de un hemangioblastoma. Durante la evolución postquirúrgica el paciente presentó un cuadro de mutismo transitorio. Una revisión exhaustiva de la literatura ha evidenciado la existencia de tan sólo tres casos similares descritos previamente. El diagnóstico de este tipo de lesiones en una localización tan infrecuente debería hacernos sospechar la enfermedad de von Hippel-Lindau.
Modelos experimentales de traumatismo craneoencefálico Experimental models of traumatic brain injury
R. Prieto,R. Gutiérrez-González,J.M. Pascual,J.M. Roda
Neurocirugía , 2009,
Abstract: Objetivo. El objetivo de este trabajo es proporcionar una revisión de los diversos modelos experimentales de traumatismo craneoencefálico (TCE) que se han desarrollado para la investigación del da o cerebral traumático tanto en condiciones in vivo como in vitro, así como detallar los principales conocimientos fisiopatológicos obtenidos a partir de su aplicación. Se expone de forma sintética tanto el tipo de lesión cerebral traumática que cada modelo reproduce como los detalles técnicos necesarios para su utilización por investigadores en el campo del trauma cerebral. Desarrollo. El pronóstico de los pacientes que han sufrido un TCE ha mejorado gracias a las medidas iniciales de estabilización hemodinámica y control de la vía aérea, pero no existe todavía ningún tratamiento específico y eficaz para detener o limitar las lesiones cerebrales causadas por el traumatismo, exceptuando las medidas de control de la presión arterial y la presión intracraneal. Entender la fisiopatología del TCE es el paso básico y fundamental para desarrollar posibles abordajes terapéuticos con aplicación clínica. El da o cerebral traumático en humanos es una patología heterogénea y muy compleja. Por ello, cada modelo experimental se ha desarrollado con el objetivo de reproducir un tipo concreto de las diferentes lesiones cerebrales observadas en pacientes tras un TCE. El uso de estos modelos ha permitido ampliar el conocimiento sobre la fisiopatología del da o cerebral traumático, incluyendo las alteraciones inducidas a nivel celular y molecular. Conclusión. Los modelos experimentales suponen actualmente la mejor herramienta para el estudio de los mecanismos subyacentes a las lesiones cerebrales traumáticas, pero su simplicidad y por lo tanto su incapacidad de reproducir exactamente el da o heterogéneo observado en la práctica clínica puede ser uno de los motivos que explique la discrepancia en la respuesta terapéutica entre los estudios experimentales y clínicos. Aim. To provide a summary of the different experimental models of traumatic brain injury (TBI) designed under both in vivo and in vitro conditions. A comprehensible review of the specific types of brain lesions induced, as well as the technical details to reproduce each model at the laboratory is given. Development. Outcome of patients suffering from a TBI has significantly improved with the rapid application of vital supporting measures in addition to a strict control of blood and intracranial pressure at the intensive care units. However no specific treatment for post-traumatic brain lesions has proven as efficacious
Modelos experimentales de traumatismo craneoencefálico
Prieto,R.; Gutiérrez-González,R.; Pascual,J.M.; Roda,J.M.; Cerdán,S.; Matias-Guiu,J.; Barcia,J.A.;
Neurocirugía , 2009, DOI: 10.4321/S1130-14732009000300001
Abstract: aim. to provide a summary of the different experimental models of traumatic brain injury (tbi) designed under both in vivo and in vitro conditions. a comprehensible review of the specific types of brain lesions induced, as well as the technical details to reproduce each model at the laboratory is given. development. outcome of patients suffering from a tbi has significantly improved with the rapid application of vital supporting measures in addition to a strict control of blood and intracranial pressure at the intensive care units. however no specific treatment for post-traumatic brain lesions has proven as efficacious in the clinical settings. a deeper knowlegde of the physiopathological events associated with tbi is necessary for the development of new specific therapies. due to the heterogeneity of the human tbi, each experimental model has been designed to reproduce a different type of brain lesion. experimental tbi models allow the study of the dynamic evolution of brain injuries under controlled conditions. usefulness of experimental models is limited by their reliability and reproducibility among different researchers. small rodents have been the preferred animals to reproduce tbi injuries, mainly due to the similar cerebral physiology shared by these animals and the human beings. conclusion. the use of experimental models of tbi is the most appropiate tool to study the mechanisms underlying this type of injury. however their simplicity precludes an exact reproduction of the heterogeneous cerebral damage observed in clinical settings. this could be the main reason for the discrepancies observed in the therapeutic effects of treatments between experimental and clinical studies.
Calcificación vascular: tipos y mecanismos
Valdivielso,J.M.;
Nefrología (Madrid) , 2011,
Abstract: vascular calcification has traditionally been considered to be a passive process that was associated with advanced age, atherosclerosis, uncommon genetic diseases and some metabolic alterations such as diabetes mellitus and end-stage kidney failure. however, in the last years, vascular calcification has been proven to be an active and regulated process, similar to bone mineralisation, in which different bone-related proteins are involved. recent results question the classic classification of vascular calcification into intimal and medial calcification, at least in capacitance arteries. pro and anti-calcifying mechanisms play an active role in calcium deposition in vascular cells, making this area an active focus of research. the identification of therapeutic targets which can slow down the progression or even reverse vascular calcification could be an important step forward in the treatment of patients with chronic kidney disease.
El Programa Dental de Atención Infantil (PADI) de Navarra y del País Vasco: logros y nuevas metas
Freire,J.M.;
Anales del Sistema Sanitario de Navarra , 2003, DOI: 10.4321/S1137-66272003000500008
Abstract: this paper briefly analyses the results of the infant dental care program (padi) of the basque country (1990) and navarra (1991), aimed at children aged from 6 and 15 years. at the age 12, the lack of caries rose from 31% in 1988 to 57% in 1998 in the basque country, while it was 58% in navarra (1997); the number of caries fell in navarra by some 64% and by some 54% in the basque country, and the index of restoration was 81% in navarra and 73% in the basque country (it was 17% in 1988). emphasis is placed on the importance of a good evaluation of these programs and the opportunities that are opened up by the comparative analysis between spanish autonomous communities for analysing the contribution of factors that are different, and for evaluating the impact of the programs on social inequalities in health. the results of the padi exceed the initial aims of the health plans of navarra (1991) and of the basque country (1990), and endorse the adoption of these programs by the spanish autonomous communities. the development of these programs raises new objectives in dental health policy in navarra and the basque country and, above all, makes it necessary to reflect on the need for spain to include public dental health in its health policy and for the national health system as a whole to include dental services within its services.
Protein folding: a perspective for biology, medicine and biotechnology
Yon, J.M.;
Brazilian Journal of Medical and Biological Research , 2001, DOI: 10.1590/S0100-879X2001000400001
Abstract: at the present time, protein folding is an extremely active field of research including aspects of biology, chemistry, biochemistry, computer science and physics. the fundamental principles have practical applications in the exploitation of the advances in genome research, in the understanding of different pathologies and in the design of novel proteins with special functions. although the detailed mechanisms of folding are not completely known, significant advances have been made in the understanding of this complex process through both experimental and theoretical approaches. in this review, the evolution of concepts from anfinsen's postulate to the "new view" emphasizing the concept of the energy landscape of folding is presented. the main rules of protein folding have been established from in vitro experiments. it has been long accepted that the in vitro refolding process is a good model for understanding the mechanisms by which a nascent polypeptide chain reaches its native conformation in the cellular environment. indeed, many denatured proteins, even those whose disulfide bridges have been disrupted, are able to refold spontaneously. although this assumption was challenged by the discovery of molecular chaperones, from the amount of both structural and functional information now available, it has been clearly established that the main rules of protein folding deduced from in vitro experiments are also valid in the cellular environment. this modern view of protein folding permits a better understanding of the aggregation processes that play a role in several pathologies, including those induced by prions and alzheimer's disease. drug design and de novo protein design with the aim of creating proteins with novel functions by application of protein folding rules are making significant progress and offer perspectives for practical applications in the development of pharmaceuticals and medical diagnostics.
Chemoreceptors and cardiovascular control in acute and chronic systemic hypoxia
Marshall, J.M.;
Brazilian Journal of Medical and Biological Research , 1998, DOI: 10.1590/S0100-879X1998000700002
Abstract: this review describes the ways in which the primary bradycardia and peripheral vasoconstriction evoked by selective stimulation of peripheral chemoreceptors can be modified by the secondary effects of a chemoreceptor-induced increase in ventilation. the evidence that strong stimulation of peripheral chemoreceptors can evoke the behavioural and cardiovascular components of the alerting or defence response which is characteristically evoked by novel or noxious stimuli is considered. the functional significance of all these influences in systemic hypoxia is then discussed with emphasis on the fact that these reflex changes can be overcome by the local effects of hypoxia: central neural hypoxia depresses ventilation, hypoxia acting on the heart causes bradycardia and local hypoxia of skeletal muscle and brain induces vasodilatation. further, it is proposed that these local influences can become interdependent, so generating a positive feedback loop that may explain sudden infant death syndrome (sids). it is also argued that a major contributor to these local influences is adenosine. the role of adenosine in determining the distribution of o2 in skeletal muscle microcirculation in hypoxia is discussed, together with its possible cellular mechanisms of action. finally, evidence is presented that in chronic systemic hypoxia, the reflex vasoconstrictor influences of the sympathetic nervous system are reduced and/or the local dilator influences of hypoxia are enhanced. in vitro and in vivo findings suggest this is partly explained by upregulation of nitric oxide (no) synthesis by the vascular endothelium which facilitates vasodilatation induced by adenosine and other no-dependent dilators and attenuates noradrenaline-evoked vasoconstriction.
Chemokines, lymphocytes, and HIV
Farber, J.M.;
Brazilian Journal of Medical and Biological Research , 1998, DOI: 10.1590/S0100-879X1998000100002
Abstract: chemokines are members of a family of more than 30 human cytokines whose best-described activities are as chemotactic factors for leukocytes and that are presumed to be important in leukocyte recruitment and trafficking. while many chemokines can act on lymphocytes, the roles of chemokines and their receptors in lymphocyte biology are poorly understood. the recent discoveries that chemokines can suppress infection by hiv-1 and that chemokine receptors serve, along with cd4, as obligate co-receptors for hiv-1 entry have lent urgency to studies on the relationships between chemokines and lymphocytes. my laboratory has characterized mig and crg-2/ip-10, chemokines that are induced by ifn-g and that specifically target lymphocytes, particularly activated t cells. we have demonstrated that the genes for these chemokines are widely expressed during experimental infections in mice with protozoan and viral pathogens, but that the patterns of mig and crg-2 expression differed, suggesting non-redundant roles in vivo. our related studies to identify new chemokine receptors from activated lymphocytes resulted in the cloning of strl22 and strl33. we and others have shown that strl22 is a receptor for the cc chemokine mip-3a, and strl22 has been re-named ccr6. although strl33 remains an orphan receptor, we have shown that it can function as a co-receptor for hiv-1 envelope glycoproteins, and that it is active with a broader range of hiv-1 envelope glycoproteins than the major co-receptors described to date. the ability of strl33 to function with a wide variety of envelope glycoproteins may become particularly important if therapies are instituted to block other specific co-receptors. we presume that investigations into the roles of chemokines and their receptors in lymphocyte biology will provide information important for understanding the pathogenesis of aids and for manipulating immune and inflammatory responses for clinical benefit
Environmental Impact Assessment of Steam Injection Mining Method of Agbabu Bitumen Deposit
J.M. Akande
Journal of Engineering and Applied Sciences , 2012,
Abstract: An environmental impact of steam injection mining method applicable to Agbabu bitumen deposit was studied. Steam injection tests were carried out on the deposit. The environmental pollutants evolved from the tests were evaluated with respect to their source, impact, monitoring or detection and control. The results of the analysis indicated that steam injection method would control the contaminated water in the mining of Agbabu bitumen deposit.
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