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Search Results: 1 - 10 of 593620 matches for " J.-M. Triscone "
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Unrelated Hematopoietic Stem Cell Donor Matching Probability and Search Algorithm
J.-M. Tiercy
Bone Marrow Research , 2012, DOI: 10.1155/2012/695018
Abstract: In transplantation of hematopoietic stem cells (HSCs) from unrelated donors a high HLA compatibility level decreases the risk of acute graft-versus-host disease and mortality. The diversity of the HLA system at the allelic and haplotypic level and the heterogeneity of HLA typing data of the registered donors render the search process a complex task. This paper summarizes our experience with a search algorithm that includes at the start of the search a probability estimate (high/intermediate/low) to identify a HLA-A, B, C, DRB1, DQB1-compatible donor (a 10/10 match). Based on 2002–2011 searches about 30% of patients have a high, 30% an intermediate, and 40% a low probability search. Search success rate and duration are presented and discussed in light of the experience of other centers. Overall a 9-10/10 matched HSC donor can now be identified for 60–80% of patients of European descent. For high probability searches donors can be selected on the basis of DPB1-matching with an estimated success rate of >40%. For low probability searches there is no consensus on which HLA incompatibilities are more permissive, although HLA-DQB1 mismatches are generally considered as acceptable. Models for the discrimination of more detrimental mismatches based on specific amino acid residues rather than specific HLA alleles are presented. 1. Introduction An increasing number of transplantations are now performed with hematopoietic stem cells (HSC) from unrelated volunteer donors. This trend has been largely facilitated by the impressive growth of volunteer donor registries in the last decade: 8 million donors in 2002 and more than 20 million in 2012. The implementation of recipient and donor HLA high resolution genotyping in the clinical practice has clearly contributed to improve the success of transplantation through a better matching [1, 2]. On the other hand the polymorphism of HLA genes turns out to be much higher than anticipated, resulting in larger difficulties in identifying a perfectly matched donor. Because most donors in the Bone Marrow Donor Worldwide (BMDW) registry are of European descent, searches for patients of other ethnic backgrounds have a lower success rate, particularly for those patients with a mixed origin. HLA matching is commonly based on exons 2 and 3 polymorphism for class I loci and on exon 2 polymorphism for class II loci. The nature of HLA polymorphism with reshuffling of gene segments coding for just a few amino acids has rendered HLA typing a challenging task. The HLA typing techniques currently used in the clinical laboratories often lead
Experimental Data for Assesments
Joubert J.-M.
EPJ Web of Conferences , 2011, DOI: 10.1051/epjconf/20111403002
Elusive multiquark spectroscopy
Richard J.-M.
EPJ Web of Conferences , 2010, DOI: 10.1051/epjconf/20100301015
Abstract: A review is presented of past and recent attempts to build multiquark states within current models already describing ordinary mesons and baryons. This includes: coherence in the chromomagnetic interaction, tetraquarks with two heavy quarks, Steiner-tree models of con nement, and hadronic molecules, in particular in the hidden-charm sector. Some emphasis is put on the di culties encountered when extrapolating toward higher con gurations the dynamics of con ning forces, starting from the simple case of a quark and an antiquark, or three quarks in a colour singlet.
Structure of free surface crystallization of Hg: a first attempt
Bomont J.-M.
EPJ Web of Conferences , 2011, DOI: 10.1051/epjconf/20111501026
Abstract: Oscillatory density profiles (DP) are a well-known feature occurring at the free surfaces of liquid metals. We analyse first the layered structure of Hg at or below the melting temperature with a simple interaction model [J.-M. Bomont and J.-L. Bretonnet, J. Chem. Phys. 124, 054504 (2006)], by molecular dynamics simulation in slab geometry. Then, by investigating the in-plane structure, some state transitions are observed. In particular, crystalline planes, whose axes are tilted by several degrees from the surface normal, appear and seem to be signalized by flat DP.
R. Opsommer, 'Omme dat leengoed es thoochste dinc van der weerelt'. Het leenrecht in Vlaanderen in de 14de en 15de eeuw
J.-M. Cauchies
BMGN : Low Countries Historical Review , 1999,
Epitaxial Piezoelectric Pb( ) Thin Films on Silicon for Energy Harvesting Devices
A. Sambri,D. Isarakorn,A. Torres-Pardo,S. Gariglio,Pattanaphong Janphuang,D. Briand,O. Stéphan,J. W. Reiner,J.-M. Triscone,Nico F. de Rooij,C. H. Ahn
Smart Materials Research , 2012, DOI: 10.1155/2012/426048
Abstract: We report on the properties of ferroelectric Pb(Zr0.2Ti0.8)O3 (PZT) thin films grown epitaxially on (001) silicon and on the performance of such heterostructures for microfabricated piezoelectric energy harvesters. In the first part of the paper, we investigate the epitaxial stacks through transmission electron microscopy and piezoelectric force microscopy studies to characterize in detail their crystalline structure. In the second part of the paper, we present the electrical characteristics of piezoelectric cantilevers based on these epitaxial PZT films. The performance of such cantilevers as vibration energy transducers is compared with other piezoelectric harvesters and indicates the potential of the epitaxial approach in the field of energy harvesting devices. 1. Introduction In the last decade, studies on epitaxial ferroelectric thin films have led to many interesting results and exciting discoveries [1]. The possibility of tailoring or even enhancing some physical parameters via epitaxial strain engineering [2–4] has suggested the idea of the exploitation of such thin films for several technological applications [5]. Nevertheless, the benefits of the epitaxial approach on the performances of ferroelectric thin film-based devices have to compensate the hurdles related to the epitaxial growth on industrial substrates such as silicon, the modern technological platform. It is in fact well known that the basic requirements for the epitaxy, that is, a good lattice match between substrate and film and a reciprocal chemical stability, are not easily fulfilled in the case of oxide growth on silicon. Beside the difference in lattice parameters and thermal expansion coefficients, the main problem is the surface reactivity of silicon to oxygen, with the formation of an amorphous layer of silicon dioxide that hints any further epitaxy. Moreover, the cations of most ferroelectric compounds interdiffuse into the silicon substrate, forming spurious extra phases at the interface [6]. In order to overcome such difficulties, a suitable buffer layer is needed that acts as a barrier for cations migration and as a structural template for the growth of the ferroelectric epitaxial film [7–9]. PZT is one of the most investigated ferroelectric materials, due to its high values of remnant polarization and piezoelectric coefficients. In the bulk form, it displays a complex phase diagram versus the Ti/Zr content: for the stoichiometry of our choice, that is, Pb( )O3 (PZT 20/80), it is ferroelectric with a tetragonal structure up to a transition temperature of 460°C [10]. It
Le charbon, voies nouvelles d'utilisation les procédés de gazéification et de liquéfaction Coal New Way to Use It. Gasification and Liquefaction Processes
Aune J. P.,Dou J.-M.
Oil & Gas Science and Technology , 2006, DOI: 10.2516/ogst:1979021
Abstract: Les principaux procédés de gazéification et de liquéfaction du charbon sont présentés. Leur évolution probable, et les perspectives d'application sont précisées. Les problèmes liés aux différents mécanismes de séparation (identification des produits obtenus) sont exposés. Enfin, les principales techniques d'épuration sont citées en mettant en valeur les points importants restant à approfondir. The leading gasification and liquéfaction processes are described. Their probable évolution and thé outlook for their application are discussed. The problems linked ta différent séparation mechanisms (identification of the produits obtained) are described. The leading purification techniques are mentioned, with emphasis on the important points remaining ta be worked out.
Design of Processor Array Based on an Optimized Multiprojection Approach
Advances in Electrical and Computer Engineering , 2012, DOI: 10.4316/aece.2012.04014
Abstract: Parallelization methodologies allow to automate the process of designing optimal processor arrays based on mathematical representations of the algorithm to be implemented. In this work, an optimized multiprojection approach based on the Polytope model is proposed as well as an automated way for getting the scheduler and the allocator vectors. Using a recurrence equations representation, three key criteria for choosing the characteristics of the final implementation are also proposed. As a case of study, the methodology is applied on a matrix-vector multiplication example. Results and relevance of the proposed methodology are finally discussed.
On the computation of the barotropic mode of a free-surface world ocean model
E. Deleersnijder,J.-M. Campin
Annales Geophysicae (ANGEO) , 2003,
Abstract: The free-surface formulation of the equations of our world ocean model is briefly described. The barotropic mode equations are solved according to the split-explicit method, using different time steps for the external and internal modes. Because the numerical algorithm is implemented on the B-grid, a spurious, free-surface, two-grid interval mode may develop. This mode must be filtered out. The properties of two filters are theoretically investigated and their actual performance is tested in a series of numerical experiments. It is seen that one of these filters may severely perturb the local mass conservation, rendering it impossible to enforce the impermeability of the surface or the bottom of the ocean. The dynamics of the external mode is also examined, by studying the depth-integrated momentum equations. The depth-integral of the pressure force due to the slope of the ocean surface is approximately balanced by the depth-integral of the force ensuing from the horizontal variations of the density. The depth-integral of the Coriolis force is an order of magnitude smaller, except in the Southern Ocean. Two variational principles are resorted to for computing the fictitious ocean surface elevation corresponding to the approximate equilibrium between the dominant forces of the barotropic momentum equations.
Statistical field theory for liquid vapor interface
V. Russier,J.-M. Caillol
Condensed Matter Physics , 2010,
Abstract: A statistical field theory for an inhomogeneous liquid, a planar liquid/vapor interface, is devised from first principles. The grand canonical partition function is represented via a Hubbard-Stratonovitch transformation leading, close to the critical point, to the usual φ4 scalar field theory which is then rigorously considered at the one-loop level. When further simplified it yields the well-known capillary wave theory without any ad hoc phenomenological parameter. Internal coherence of the one-loop approximation is discussed and good overall qualitative agreement with recent numerical simulations is stressed.
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