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Search Results: 1 - 10 of 300829 matches for " J. Roger Bider "
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Nesting ecology and hatching success of the Wood Turtle, Glyptemys insculpta in Quebec
Andrew D. Walde,J. Roger Bider,Denis Masse
Herpetological Conservation and Biology , 2007,
Abstract: The nesting ecology of Wood Turtles (Glyptemys insculpta) was studied in Québec, Canada during 1996 and 1997.Females made long-distance migrations to nesting grounds, where they staged for up to nine days before nesting. Fifty-fivepercent of the estimated female population was observed at this staging area. Wood Turtles exhibited strong nest sitefidelity, with 95% of females observed to nest in two consecutive years returning to the same nest site. Nesting occurred forapproximately two weeks during mid-June. Turtles were observed nesting during all daylight hours, with morning andevening peaks in activity. Clutch size was positively correlated to female size with larger females having larger clutches.Mean clutch sizes were significantly different between years. Nest success was 74% in 1996 and 65% in 1997. Nestsconstructed during the first half of the nesting season had significantly greater success, suggesting that northern WoodTurtle populations may be delimited by insufficient degree days for the completion of incubation. Staging, nest-site fidelity,and a short nesting season make them vulnerable to anthropogenic disturbances.
Estudio Farmacocinético de dos formulaciones de Amoxicilina (500 mg T.I.D. en Cápsulas vs. 750 mg B.I.D. en tabletas dispersibles) en voluntarios humanos sanos
M Pérez-González,V Lamanna,J Villalobos,A Bider
Archivos Venezolanos de Farmacología y Terapéutica , 2001,
Abstract: Se evaluó, en voluntarios sanos, el comportamiento de la formulación de 750 mg de Amoxicilina B.I.D., en tabletas dispersibles contra la formulación estándar de 500 mg en cápsulas T.I.D., mediante un estudio de dos vías, entrecruzado con nueve voluntarios sanos. Ambas formulaciones fueron administradas durante un lapso de 6 días consecutivos, con un período de lavado de cuatro semanas antes de cambiar de formulación. Los resultados obtenidos en el día 1 y en el día 6 del régimen muestran que la concentración máxima alcanzada por la formulación de 750 mg b.i.d., fue significativamente mayor (p<0.001). No hubo diferencias significativas entre ambas formulaciones en cuanto al tiempo en que se tardó en alcanzar la concentración plasmática máxima promedio. El estudio del área bajo la curva de la concentración plasmática de amoxicilina en 24 horas (AUC0-24h) demuestró que ambas formulaciones son bioequivalentes. Considerando un valor de MIC = 1 μg/ml (aceptado por el Comité Nacional de Standard para Laboratorios Clínicos (NCSCL) para cepas de patógenos con resistencia intermedia presentes en otitis medias agudas y en infecciones del tracto respiratorio superior) y calculando el tiempo durante el cual las concentraciones plasmáticas se encuentran por debajo de ese MIC, la diferencia entre ambas formulaciones no parece ser clínicamente importante, esto se ha comprobado en la práctica porque ambas formulaciones son igualmente eficaces para el tratamiento de varias patologías infecciosas. This study compared Amoxicilin 750 mg b.i.d., (dispersible tablets) and Amoxicilin 500 mg t.i.d., (capsules) in order to determine their bioequivalence. It was a two way, crossover study performed with nine healthy volunteers. Both formulations were administered for 6 consecutive days with a wash period of four weeks. Results at days 1 and 6 showed a rapid absorption of the drug, with a Cmax higher with 750 mg dosage b.i.d., (p<0.001). There was no signifficant difference in the time to obtain peak concentration with both formulations. Values of AUC0-24h confirmed that both formulations were bioequivalent. lf we consider a MIC value of 1 μg/mL as a NCSCL, accepted value for otitis and upper respiratory mayor patogen strains with intermediate resistance and calculated how long plasma concentrations are below this value in our study, there was no real difference between formulations, that is strongly supported by the clinical observation that both formulations are equally efficient for the treatment of some important infectious pathologies.
Estudio Farmacocinético de dos formulaciones de Amoxicilina (500 mg T.I.D. en Cápsulas vs. 750 mg B.I.D. en tabletas dispersibles) en voluntarios humanos sanos
Pérez-González,M; Lamanna,V; Villalobos,J; Bider,A; Sáenz,H; de Nucci,G;
Archivos Venezolanos de Farmacología y Terapéutica , 2001,
Abstract: this study compared amoxicilin 750 mg b.i.d., (dispersible tablets) and amoxicilin 500 mg t.i.d., (capsules) in order to determine their bioequivalence. it was a two way, crossover study performed with nine healthy volunteers. both formulations were administered for 6 consecutive days with a wash period of four weeks. results at days 1 and 6 showed a rapid absorption of the drug, with a cmax higher with 750 mg dosage b.i.d., (p<0.001). there was no signifficant difference in the time to obtain peak concentration with both formulations. values of auc0-24h confirmed that both formulations were bioequivalent. lf we consider a mic value of 1 μg/ml as a ncscl, accepted value for otitis and upper respiratory mayor patogen strains with intermediate resistance and calculated how long plasma concentrations are below this value in our study, there was no real difference between formulations, that is strongly supported by the clinical observation that both formulations are equally efficient for the treatment of some important infectious pathologies.
HOW TO MOTIVATE FASTER GROWTH IN COLOMBIA: THE LEADING SECTOR STRATEGY REVISITED
SANDILANDS,ROGER J.;
Estudios Gerenciales , 2002,
Abstract: this paper reproduces two public lectures given at an incolda conference in bogota, october 1, 2002 on " la realidad de la economía colombiana ". it reviews the great structural changes in output and employment over recent decades and how macroeconomic policies can strengthen or weaken the natural forces underlying these changes. it distinguishes between potentially inflationary policies designed to increase demand in a monetary sense, and those that focus on institutional changes that enhance competition and mobility. it explains how inflation distorts the allocation of resources, and why it especially harms long-term housing finance and exports. it explains the logic of lauchlin currie′s leading sector theory of growth and shows why and how housing and exports can be given special protection to accelerate development.
Online-Fokusgruppen Online Focus Groups: Electronic Discussions for Research Grupos focales online: Discusiones electrónicas para la investigación
Roger J. Rezabek
Forum : Qualitative Social Research , 2000,
Abstract: Als Teil einer Promotionsarbeit wurden im Rahmen einer Online-Fokusgruppe Fragen und Themenbereiche entwickelt, die in (Tiefen-) Interviews mit Fernkursstudenten Anwendung fanden. Die Untersuchung betraf Motive, Erschwernisse usw., die für eine Entscheidung, an Fernstudieng nge teilzunehmen, bedeutungsvoll waren. Im Rahmen der Fokusgruppe wurden ca. zweieinhalb Monate asynchrone Gespr che geführt. Von dieser Untersuchung ausgehend enth lt der Beitrag auch ein FAQ (Frequently Asked Questions) für Online-Fokusgruppen. URN: urn:nbn:de:0114-fqs0001185 As part of a dissertation research project, an online focus group was created in order to help determine questions and issues to be asked in depth interviews of distance learning students about their motives, barriers and enablers in their decision to enroll in adult distance learning courses. The focus group used asynchronous discussion through a listserve for approximately two and a half months, and identified several key issues that were explored in the depth interviews. An FAQ for Online Focus Groups is included. URN: urn:nbn:de:0114-fqs0001185 URN: urn:nbn:de:0114-fqs0001185
TSUNAMI CATALOG AND VULNERABILITY OF MARTINIQUE (LESSER ANTILLES, FRANCE)
Accary, F.,Roger, J.
Science of Tsunami Hazards , 2010,
Abstract: In addition to meteorological hazards (hurricanes, heavy rainfalls, long-period swells, etc.), the Caribbean Islands are vulnerable to geological hazards such as earthquakes, landslides and volcanic eruptions caused by the complex tectonic activity and interactions in the region. Such events have generated frequently local or regional tsunamis, which often have affected the island of Martinique in the French West Indies. Over the past centuries, the island has been struck by destructive waves associated with local or regional events - such as those associated with the eruption of the Saint-Vincent volcano in 1902 and by tsunamis of distant origin as that generated by the 1755 Lisbon earthquake.The present study includes a classification of tsunamis that have affected Martinique since its discovery in 1502. It is based on international tsunami catalogs, historical accounts, and previous scientific studies and identifies tsunamigenic areas that could potentially generate destructive waves that could impact specific coastal areas of Martinique Island. The potential threat from tsunamis has been greatly increasing because of rapid urban expansion of coastal areas and development of tourism on the island.
How to motivate faster growth in Colombia: the leading sector strategy revisited
Roger J. Sandilands
Estudios Gerenciales , 2002,
Abstract: This paper reproduces two public lectures given at an Incolda conference in Bogota, October 1, 2002 on La Realidad de la Economía Colombiana . It reviews the great structural changes in output and employment over recent decades and how macroeconomic policies can strengthen or weaken the natural forces underlying these changes. It distinguishes between potentially inflationary policies designed to increase demand in a monetary sense, and those that focus on institutional changes that enhance competition and mobility. It explains how inflation distorts the allocation of resources, and why it especially harms long-term housing finance and exports. It explains the logic of Lauchlin Currie s leading sector theory of growth and shows why and how housing and exports can be given special protection to accelerate development.
Financing Developing Country Debt: A Sovereign Borrowing Entity Proposal  [PDF]
David J. Moore, Roger W. Clark, George C. Philippatos
Journal of Financial Risk Management (JFRM) , 2014, DOI: 10.4236/jfrm.2014.33008
Abstract:

This paper proposes the creation of a Sovereign Borrowing Entity (SBE) under the auspices of the International Monetary Fund (IMF) and other International Financial Institutions (IFIs). The SBE guarantees bond issuances by developing nations, packages them in relatively small denominations, and auctions them to the public. Should a developing debtor country fail to pay its debt, the SBE would raise funds through a punitive tariff on all exports administered by the IMF member nations. We develop a theoretical model of the proposed Sovereign Borrowing Entity (SBE) and provide viability evidence using export and debt data from the World Bank. It is our hope that this paper will encourage further dialogue and research on financing developing country debt in a more effective manner.

The “Ets” Factor: Vessel Formation in Zebrafish—The Missing Link?
Lucy J. Patterson,Roger Patient
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0040024
Abstract:
Tyrosine kinase signalling in breast cancer: Modulation of tyrosine kinase signalling in human breast cancer through altered expression of signalling intermediates
Rania Kairouz, Roger J Daly
Breast Cancer Research , 2000, DOI: 10.1186/bcr54
Abstract: Ligand binding to RTKs induced receptor dimerization, leading to activation of the intracellular kinase domain and autophosphorylation of specific tyrosine residues. This creates binding sites for phosphotyrosine binding modules on signalling proteins, such as SH2 and phosphotyrosine-binding domains [1]. SH2 domains are modules of approximately 100 amino acids that recognize phosphotyrosines within specific sequence contexts. This is achieved through a bipartite binding site that consists of a phosphotyrosine binding pocket and a pocket or groove for specific residues that are carboxyl-terminal to the phosphotyrosine. Phosphotyrosine-binding domains are conserved sequences of 100-150 amino acids, a subset of which recognize the consensus sequence NPXpY [1].In addition to SH2 domains, many signalling proteins also contain SH3 and/or pleckstrin homology domains. SH3 domains consist of 50-75 residues and bind proline-rich motifs with the core sequence PXXP. Pleckstrin homology domains bind to specific polyphosphoinositides and inositol polyphosphates, and thus regulate membrane association and/or responses to the generation of specific second messengers [1].SH2 domain-containing proteins are divided into two classes (Fig. 1a) [2]: class I proteins possess enzymatic activity and include c-Src and phospholipase C (PLC)-γ1; and class II SH2 proteins, such as Grb2, do not have a known catalytic activity and function as adaptor proteins, linking receptors or cytoplasmic tyrosine kinases to downstream effectors.Overexpression of class I SH2 proteins may lead to signal amplification through enhanced recruitment of the enzyme to activated receptors. Class II SH2 proteins, however, must bind to effector proteins with enzymatic activity in order to generate a signalling cascade. In this case, the effect of overexpression will depend on the ratio of catalytic subunits to adaptors. If the adaptor is limiting, then overexpression will result in increased complex formation between a
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