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Search Results: 1 - 10 of 438902 matches for " J. P. Franklin "
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Multifocal epithelioid glioblastoma mimicking cerebral metastasis: case report Glioblastoma epiteloide multifocal simulando metástasis cerebrales: Presentación de un caso
J. Gasco,B. Franklin,G.N. Fuller,P. Salinas
Neurocirugía , 2009,
Abstract: Objective. Epithelioid glioblastoma is a rare morphologic subtype of glioblastoma that closely mimics metastatic carcinoma or metastatic melanoma histologically. All previous case reports of this unusual glioblastoma variant have been solitary lesions. We report here the first case to our knowledge of multifocal epithelioid glioblastoma mimicking cerebral metastasis. Clinical presentation. A 67-year-old man with a prior history of mycosis fungoides, a common form of cutaneous T-cell lymphoma, presented with memory loss and impaired peripheral vision. Two discrete brain lesions highly suspicious for metastases were identified by magnetic resonance imaging (MRI). Intervention. The patient underwent two separate craniotomies; both lesions were successfully resected in toto with an excellent post-surgical outcome. Conclusion. Epithelioid glioblastoma is one of the rarest morphologic subtypes of glioblastoma. Here we describe the first case to our knowledge of multifocal epithelioid glioblastoma that convincingly mimicked a secondary metastatic process. Multifocal epithelioid glioblastoma should be included in the differential diagnosis of patients who present with multiple discrete brain lesions. An attempt at gross total resection is recommended when anatomically feasible for definitive histopathological diagnosis and to improve progression free survival of patients who present with similarly ambiguous and potentially misleading multiple lesions. Objetivo. El glioblastoma epiteloide es un subtipo morfológico poco común del glioblastoma que puede imitar al carcinoma o melanoma metastásico histológicamente. Todos los casos reportados de esta variante inusual de glioblastoma han sido lesiones solitarias. Presentamos el primer caso de glioblastoma multifocal epiteloide imitando metástasis cerebral. Presentación clínica. Varón de 67 a os con historia previa de micosis fungoide, una forma común de linfoma cutáneo e células T, cuyos síntomas fueron pérdida de memoria y alteraciones del campo visual periférico. Dos lesiones sospechosas de metástasis fueron identificadas por resonancia magnética. Intervención. Mediante dos craneotomías independientes, ambas lesiones se resecaron in toto con buen resultado post-quirúrgico. Conclusión. El glioblastoma epiteloide es uno de los subtipos morfológicos mas raros de glioblastoma. Los autores describen aquí el primer caso de glioblastoma epiteloide multifocal con apariencia de metástasis secundaria. Este diagnóstico debe ser incluido en el diferencial de pacientes con lesiones multifocales. El intento de resección total se
Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl
Michael J. Franklin,Joel T. Weadge,P. Lynne Howell
Frontiers in Microbiology , 2011, DOI: 10.3389/fmicb.2011.00167
Abstract: Pseudomonas aeruginosa thrives in many aqueous environments and is an opportunistic pathogen that can cause both acute and chronic infections. Environmental conditions and host defenses cause differing stresses on the bacteria, and to survive in vastly different environments, P. aeruginosa must be able to adapt to its surroundings. One strategy for bacterial adaptation is to self-encapsulate with matrix material, primarily composed of secreted extracellular polysaccharides. P. aeruginosa has the genetic capacity to produce at least three secreted polysaccharides; alginate, Psl, and Pel. These polysaccharides differ in chemical structure and in their biosynthetic mechanisms. Since alginate is often associated with chronic pulmonary infections, its biosynthetic pathway is the best characterized. However, alginate is only produced by a subset of P. aeruginosa strains. Most environmental and other clinical isolates secrete either Pel or Psl. Little information is available on the biosynthesis of these polysaccharides. Here, we review the literature on the alginate biosynthetic pathway, with emphasis on recent findings describing the structure of alginate biosynthetic proteins. This information combined with the characterization of the domain architecture of proteins encoded on the Psl and Pel operons allowed us to make predictive models for the biosynthesis of these two polysaccharides. The results indicate that alginate and Pel share certain features, including some biosynthetic proteins with structurally or functionally similar properties. In contrast, Psl biosynthesis resembles the EPS/CPS capsular biosynthesis pathway of Escherichia coli, where the Psl pentameric subunits are assembled in association with an isoprenoid lipid carrier. These models and the environmental cues that cause the cells to produce predominantly one polysaccharide over the others are subjects of current investigation.
Online measurements of the emissions of intermediate-volatility and semi-volatile organic compounds from aircraft
E. S. Cross,J. F. Hunter,A. J. Carrasquillo,J. P. Franklin
Atmospheric Chemistry and Physics Discussions , 2013, DOI: 10.5194/acpd-13-8065-2013
Abstract: A detailed understanding of the climate and air quality impacts of aviation requires detailed measurements of the emissions of intermediate-volatility and semi-volatile organic compounds (I/SVOCs) from aircraft. Currently both the amount and chemical composition of aircraft I/SVOC emissions remain poorly characterized. Here we characterize I/SVOC emissions from aircraft, using a novel instrument for the online, quantitative measurement of the mass loading and composition of low-volatility organic vapors. Emissions from the NASA DC8 aircraft were sampled on the ground, 143 m downwind of the engines and characterized as a function of engine power from ground idle (~4% maximum rated thrust) through 85% power. Results show that I/SVOC emissions are highest during engine-idle operating conditions, with decreasing but non-zero I/SVOC emissions at higher engine powers. Comparison of I/SVOC emissions with total hydrocarbon (THC) measurements, VOC measurements, and an established emissions profile indicates that I/SVOCs comprise 10–20% of the total organic gas phase emissions at idle, and an increasing fraction of the total gas phase organic emissions at higher powers. Positive matrix factorization of online mass spectra is used to identify three distinct types of I/SVOC emissions: aliphatic, aromatic and oxygenated. The volatility and chemical composition of the emissions suggest that unburned fuel is the dominant source of I/SVOCs at idle, while pyrolysis products make up an increasing fraction of the I/SVOCs at higher powers. Oxygenated I/SVOC emissions were detected at lower engine powers (≤30%) and may be linked to cracked, partially oxidized or unburned fuel components.
Kinetics of the Epoxidation of Geraniol and Model Systems by Dimethyldioxirane
A. L. Baumstark,P. J. Franklin,P. C. Vasquez,B. S. Crow
Molecules , 2004, DOI: 10.3390/90300117
Abstract: The mono-epoxidation of geraniol by dimethyldioxirane was carried out invarious solvents. In all cases, the product ratios for the 2,3 and 6,7 mono-epoxides werein agreement with literature values. Kinetic studies were carried out at 23 oC in thefollowing dried solvent systems: acetone (k2 = 1.49 M-1s-1), carbon tetrachloride/acetone(9/1, k2=2.19 M-1s-1), and methanol/acetone (9/1, k2 = 17 M-1s-1). Individual k2 valueswere calculated for epoxidation of the 2,3 and 6,7 positions in geraniol. The non-conjugated diene system was modeled employing two simple independent alkenes:2-methyl-2-pentene and 3-methyl-2-buten-1-ol by determining the respective k2 valuesfor epoxidation in various solvents. The kinetic results for each independent alkeneshowed that the relative reactivity of the two epoxidation sites in geraniol as a function ofsolvent was not simply a summation of the independent alkene systems.
Hemorrhagic stroke with intraventricular extension in the setting of acute posterior reversible encephalopathy syndrome (PRES): case report
Gasco,J.; Rangel-Castilla,L.; Clark,S.; Franklin,B.; Satchithanandam,L.; Salinas,P.;
Neurocirugía , 2009, DOI: 10.4321/S1130-14732009000100009
Abstract: we report the case of an eighteen year-old pregnant female with preeclampsia and florid signs and symptoms of posterior reversible encephalopathy syndrome (pres) in whom intracerebral hemorrhage was evidenced following delivery. management included blood pressure control, external ventricular drainage and lumboperitoneal shunt. to our knowledge this is the first report of intracranial hemorrhage occurring concurrently with peripartum acute pres. this case was successfully treated with good outcome upon conclusion of management, thus making awareness of this potentially fatal complication and its suggested management for successful outcome necessary for neurosurgeons, neurologists and intensivists alike.
Multifocal epithelioid glioblastoma mimicking cerebral metastasis: case report
Gasco,J.; Franklin,B.; Fuller,G.N.; Salinas,P.; Prabhu,S.;
Neurocirugía , 2009, DOI: 10.4321/S1130-14732009000600004
Abstract: objective. epithelioid glioblastoma is a rare morphologic subtype of glioblastoma that closely mimics metastatic carcinoma or metastatic melanoma histologically. all previous case reports of this unusual glioblastoma variant have been solitary lesions. we report here the first case to our knowledge of multifocal epithelioid glioblastoma mimicking cerebral metastasis. clinical presentation. a 67-year-old man with a prior history of mycosis fungoides, a common form of cutaneous t-cell lymphoma, presented with memory loss and impaired peripheral vision. two discrete brain lesions highly suspicious for metastases were identified by magnetic resonance imaging (mri). intervention. the patient underwent two separate craniotomies; both lesions were successfully resected in toto with an excellent post-surgical outcome. conclusion. epithelioid glioblastoma is one of the rarest morphologic subtypes of glioblastoma. here we describe the first case to our knowledge of multifocal epithelioid glioblastoma that convincingly mimicked a secondary metastatic process. multifocal epithelioid glioblastoma should be included in the differential diagnosis of patients who present with multiple discrete brain lesions. an attempt at gross total resection is recommended when anatomically feasible for definitive histopathological diagnosis and to improve progression free survival of patients who present with similarly ambiguous and potentially misleading multiple lesions.
Incidência e severidade de cancro cítrico em laranja 'Pêra Rio' sob condi??es de controle químico e prote??o com quebra-vento
Behlau, Franklin;Belasque Júnior, José;Bergamin Filho, Armando;Leite Junior, Rui P.;
Fitopatologia Brasileira , 2007, DOI: 10.1590/S0100-41582007000400005
Abstract: the objective of this work was to study citrus canker incidence and severity under natural conditions in an orchard of 'pera rio' sweet orange planted in ourizona county, northwest of parana state, brazil. chemical control, by using copper sprays, and windbreak protection were evaluated to reduce citrus canker incidence and severity on leaves. levels of disease incidence were determined monthly by rating diseased leaves. severity was evaluated monthly by using specific diagrammatic scales. levels of severity were calculated considering just the diseased leaves assessed. data were plotted on temporal progress curves and analyzed regarding the standardized area under disease progress curve (audpc*). the coefficient of determination (r2) between incidence and severity levels was also determined. whereas copper sprays significantly reduced citrus canker on leaves, windbreak did not contribute significantly to disease control. after 29 assessments, plants submitted to frequent copper sprays showed audpc* values for citrus canker incidence 43.5% lower than those observed on plants not protected with chemical sprays. the same result was observed for citrus canker severity. after 18 assessments, plants sprayed with copper showed audpc* values for severity 37.1% lower than for check plants. in both years, the values of r2 between incidence and severity levels were higher than 0.80 (p<0.01).
Efficient modeling of sun/shade canopy radiation dynamics explicitly accounting for scattering
P. Bodin,O. Franklin
Geoscientific Model Development (GMD) & Discussions (GMDD) , 2012, DOI: 10.5194/gmd-5-535-2012
Abstract: The separation of global radiation (Rg) into its direct (Rb) and diffuse constituents (Rg) is important when modeling plant photosynthesis because a high Rd:Rg ratio has been shown to enhance Gross Primary Production (GPP). To include this effect in vegetation models, the plant canopy must be separated into sunlit and shaded leaves. However, because such models are often too intractable and computationally expensive for theoretical or large scale studies, simpler sun-shade approaches are often preferred. A widely used and computationally efficient sun-shade model was developed by Goudriaan (1977) (GOU). However, compared to more complex models, this model's realism is limited by its lack of explicit treatment of radiation scattering. Here we present a new model based on the GOU model, but which in contrast explicitly simulates radiation scattering by sunlit leaves and the absorption of this radiation by the canopy layers above and below (2-stream approach). Compared to the GOU model our model predicts significantly different profiles of scattered radiation that are in better agreement with measured profiles of downwelling diffuse radiation. With respect to these data our model's performance is equal to a more complex and much slower iterative radiation model while maintaining the simplicity and computational efficiency of the GOU model.
Efficient modeling of sun/shade canopy radiation dynamics explicitly accounting for scattering
P. Bodin,O. Franklin
Geoscientific Model Development Discussions , 2011, DOI: 10.5194/gmdd-4-1793-2011
Abstract: The separation of global radiation (Rg) into its direct (Rb) and diffuse constituents (Rd) is important when modeling plant photosynthesis because a high Rd:Rg ratio has been shown to enhance Gross Primary Production (GPP). To include this effect in vegetation models, the plant canopy must be separated into sunlit and shaded leaves, for example using an explicit 3-dimensional ray tracing model. However, because such models are often too intractable and computationally expensive for theoretical or large scale studies simpler sun-shade approaches are often preferred. A widely used and computationally efficient sun-shade model is a model originally developed by Goudriaan (1977) (GOU), which however does not explicitly account for radiation scattering. Here we present a new model based on the GOU model, but which in contrast explicitly simulates radiation scattering by sunlit leaves and the absorption of this radiation by the canopy layers above and below (2-stream approach). Compared to the GOU model our model predicts significantly different profiles of scattered radiation that are in better agreement with measured profiles of downwelling diffuse radiation. With respect to these data our model's performance is equal to a more complex and much slower iterative radiation model while maintaining the simplicity and computational efficiency of the GOU model.
Will the South Rise Again? Monochromatic Politics and Political Clout in the Modern South
Daniel P. Franklin
American Studies Journal , 2012,
Abstract: In this paper I make the argument that the South runs the very real risk of becoming irrelevant to American national politics, the consequences of which can be devastating to what is one of the poorest regions in the country. Some of our most vulnerable citizens live in the South, in what are low tax, low service states. Without the intervention of the Federal government, the South runs the risk of becoming a country within a country, a third world state with dramatic disparities in the standard of living for the rich and the poor, nonexistent consumer protection, a crumbling infrastructure, and inadequate public schools and health care.
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