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Search Results: 1 - 10 of 527796 matches for " J. P. B. Ximenez "
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BLMH and APOE genes in Alzheimer Disease: A possible relation  [PDF]
J. P. B. Ximenez, L. T. Rasmussen, W. A. Orcini, R. W. Labio, G. V. Arruda, P. H. F. Bertolucci, M. A. Smith, S. L. M. Pay?o
Advances in Alzheimer's Disease (AAD) , 2013, DOI: 10.4236/aad.2013.23015
Abstract: Alzheimer disease (AD) is a progressive and irreversible neurodegenerative disorder that is characterized by cognitive decline, memory loss and confusion. The E4 allele of the apolipoprotein E gene (APOE) is associated with AD and it is the main genetic risk factor for disease. Although the exact physiological function is unknown, bleomycin hydrolase (BLMH) may also be associated with AD development, although previous immunohistochemical findings havebeen inconsistent. Therefore, the purpose ofthis study was to evaluate the genotypic and allele frequencies of theAPOEgene andBLMH1450 G> A polymorphism and assessBLMHexpression using PCR-RFLP and RT-qPCR analyses ofblood samples from patients with Alzheimer disease (AD), healthy elderly adults (EC) andhealthyyoung subjects(YC). BLMHexpression wassignificantly different among groups (p= 0.015) and there was substantial reduction with age and with AD. TheAPOEandBLMHgenotype frequency did not diverge from the Hardy-Weinberg equilibrium. There was a higher frequency of genotype 3/3 inall subjects (61.1%) and the AD group demonstrated a higher frequency of allele 4; however, differences ingenotype and allele distributions were statistically different among groups.

Psychometric and psychological effects of review on computerized fixed and adaptive tests.
Olea J.,Revuelta J.,Ximenez M. C.,Abad F. J.
Psicológica , 2000,
An Interpretation of Structures from the Aeromagnetic Field over a Region in the Nigerian Younger Granite Province  [PDF]
J. Raimi, B. B. M. Dewu, P. Sule
International Journal of Geosciences (IJG) , 2014, DOI: 10.4236/ijg.2014.53031

An interpretation of high resolution aeromagnetic data was carried out to provide new information about the study area. Located between latitude 10°30'N and 11°00'N and longitude 8°30'E and 9°00'E, the interpretation revealed previously unknown folds and magnetic anomaly with a signature that is similar to those associated with ring complexes in the study area but without the surface manifestation that is associated with the complexes. Qualitatively interpreted as unexposed ring complex, the magnetic anomaly is underlain by cross-over of major lineaments; implying presence of weak zone that probably allowed the volcanic eruption that initiated the emplacement of the source of the anomaly. A depth that ranges from outcrop to 1200 m and from outcrop to 1800 m is respectively suggested for the unexposed ring complex and folds by the Euler deconvolution results.

Dynamical Pion Collapse and the Coherence of Conventional Neutrino Beams
B. J. P. Jones
Physics , 2014, DOI: 10.1103/PhysRevD.91.053002
Abstract: In this paper we consider the coherence properties of neutrinos produced by the decays of pions in conventional neutrino beams. Using a multi-particle density matrix formalism we derive the oscillation probability for neutrinos emitted by a decaying pion in an arbitrary quantum state. Then, using methods from decoherence theory we calculate the pion state which evolves through interaction with decay-pipe gases in a typical accelerator neutrino experiment. These two ingredients are used to obtain the distance scales for neutrino beam coherence loss. We find that for the known neutrino mass splittings, no non-standard oscillation effects are expected on terrestrial baselines. Heavy sterile neutrinos may experience terrestrial loss of coherence, and we calculate both the distance over which this occurs and the energy resolution required to observe the effect. By treating the pion-muon-neutrino-environment system quantum mechanically, neutrino beam coherence properties are obtained without assuming arbitrary spatial or temporal scales at the neutrino production vertex.
A Simulation of the Optical Attenuation of TPB Coated Light-guide Detectors
B. J. P. Jones
Physics , 2013, DOI: 10.1088/1748-0221/8/10/C10015
Abstract: This note describes simple simulations which were performed in order to understand the attenuation behaviors of acrylic light-guides operated in air and argon, which were characterized in \cite{Baptista:2012bf}. Whilst these simulations are only at the level of sophistication of a toy model, they illustrate interesting non-exponential light attenuation effects and the differences between operating light-guide based detectors in argon and air environments. We investigate the effects of surface absorption, surface roughness and wavelength dependence, and use a model tuned on the light-guide attenuation curve measured in air to make a prediction of the light-guide attenuation curve in argon. This curve is compared with data from a liquid argon test stand, and an improvement over a simple exponential model is observed.
Broadening Thermal Energy Levels and Density States Quasi One-Dimensional Electron Gas  [PDF]
P. J. Baymatov, A. G. Gulyamov, A. B. Davlatov, B. B. Uzakov
Journal of Applied Mathematics and Physics (JAMP) , 2016, DOI: 10.4236/jamp.2016.44081
Abstract: We have investigated the energy states of a one-dimensional electron gas and analyzed the temperature dependence of the density of states. It is shown that with increasing temperature due to thermal broadening of quantum, levels are blurred.
The Role of Gallium (Ga-67) Scintigraphy in the Diagnosis of Sarcoidosis  [PDF]
A. B. Allard, J. Buscombe, D. P. Kidd
Modern Research in Inflammation (MRI) , 2014, DOI: 10.4236/mri.2014.33012

Purpose: To identify and interrogate the role of Gallium-67 scintigraphy in the diagnosis of Sarcoidosis. Methods: A retrospective study of 75 patients with suspected Sarcoidosis in a large teaching hospital with a specialist Sarcoidosis Centre. Results: Ga-67 scintigraphy in patients considered on clinical grounds to have Sarcoidosis is a useful and sensitive test, and furthermore, by relaxing the interpretation of gallium scintigraphy sensitivity may be increased (from 20% to 80%) for a relatively small drop in specificity. Conclusions: The sensitivity of diagnostic power may be increased with a change in diagnostic criteria at the expense of only a small drop in specificity. In the context of Neurosarcoidosis, our results support the theory that Ga-67 scintigraphy has value in identifying potential, asymptomatic biopsy sites outside of the CNS that may not be identified by other forms of imaging.

Growth of Pure and Mo Doped Potassium Titanyl Phosphate (KTP) Crystals:Influence of KTP/Flux Ratios on the Growth Morphology  [PDF]
J. Rajeev Gandhi, B. Vijayalakshmi, M. Rathnakumari, P. Sureshkumar
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.108053
Abstract: Pure and Molybdenum (Mo) doped Potassium Titanyl Phosphate (KTP) inorganic crystals were grown by high temperature solution growth (HTSG) from poly phosphate (K6P4O13) flux using different KTP/Flux ratios. The pure and doped KTP crystals of size 20x13x5 mm3 and 7x5x2.5 mm3 respectively were grown successfully by spontaneous nucleation. The grown crystals were characterized by XRD, UV, FTIR and Hardness studies. Micro hardness studies show that the pure crystals are harder than the Mo doped crystals.
Effect of Temperature and Band Nonparabolicity on Density of States of Two Dimensional Electron Gas  [PDF]
G. Gulyamov, P. J. Baymatov, B. T. Abdulazizov
Journal of Applied Mathematics and Physics (JAMP) , 2016, DOI: 10.4236/jamp.2016.42034
Abstract: The analysis of the density of states for electrons in single quantum well, the conduction band nonparabolicity take is account. It is shown that the degree of conduction band nonparabolicity pronounces depending on the energy density of states. With increasing temperature, a step change in the density of states smoothes and at high temperatures is completely blurred. Nonparabolicity dispersion law manifests itself in a wide range of temperatures. Calculations are carried out for the example of the quantum wells in InAs and InSb.
Detection of mixed populations of wild-type and YMDD hepatitis B variants by pyrosequencing in acutely and chronically infected patients
Francisco C A Mello, Bárbara V Lago, Lia L Lewis-Ximenez, Carlos A Fernandes, Selma A Gomes
BMC Microbiology , 2012, DOI: 10.1186/1471-2180-12-96
Abstract: Phylogenic analyses of direct-sequenced isolates showed the expected genotypes (A, D and F) for the Brazilian population in both acute and chronic infections. However, within genotype A isolates, subgenotype A2 was more frequently detected in acute cases than in chronic cases (P?=?0.012). As expected, none of the individuals with acute hepatitis B had LAM-resistant isolates as a dominant virus population, whether detected by direct sequencing or pyrosequencing. However, pyrosequencing analyses showed that 45% of isolates (9/20) had minor subpopulations (4-17%) of LAM-resistant isolates. Among chronic patients undergoing LAM treatment, YMDD mutants were frequently found as a dominant virus population. In cases where wild-type virus was the dominant population, subpopulations of YMDD variants were usually found, demonstrating the complexity of HBV quasispecies.YMDD variants were frequently detected as a minor population in acute HBV infection. The occurrence of pre-existing variants may lead to a high frequency of resistant mutants during antiviral therapy in the chronic phase. In chronic infection, detection of YMDD variants before virological or biochemical breakthrough might contribute to making better therapy choices and thus improving treatment outcome.The genetic variability of hepatitis B virus (HBV) contributes to the development of drug resistance, the major drawback of currently used antiviral treatments for chronic hepatitis B. Nucleoside/nucleotide analogs (NAs) are orally administered drugs designed to inhibit the function of HBV reverse transcriptase (rt). Although these drugs are highly effective in controlling viral replication, their efficacy is often hindered by the selection of drug-resistant viruses [1]. The selection pressure imposed by the presence of the drug gradually favors an increase in the population of viruses with mutations that confer resistance to the drug; this is often followed by an increase in viral load and serum alanine aminotrans
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