oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 290 )

2018 ( 547 )

2017 ( 500 )

2016 ( 721 )

Custom range...

Search Results: 1 - 10 of 386988 matches for " J. O; Igbigbi "
All listed articles are free for downloading (OA Articles)
Page 1 /386988
Display every page Item
Effects of Chronic Administration of Efavirenz on the Chromatophilic Substance of the Intracranial Auditory Relay Centres of Adult Wistar Rats
Adjene,J. O; Igbigbi,P. S;
International Journal of Morphology , 2012, DOI: 10.4067/S0717-95022012000300037
Abstract: the effects of chronic administration of efavirenz commonly used as part of highly active antiretroviral therapy (haart) for the treatment of human immunodeficiency virus (hiv) type-1 therapy on the chromatophilic substance of the intracranial auditory relay centre namely the inferior colliculus and medial geniculate body of adult wistar rats were carefully studied. the rats of both sexes (n=20), with an average weight of 200g were randomly assigned into treatment (n=10) and control (n=10) groups. the rats in the treatment group received 600 mg/70kg body weight of efavirenz dissolved in distilled water daily for 30 days through the orogastric tube. the control group received equal volume of distilled water daily for 30 days through the same route. the rats were fed with grower's mash obtained from edo feeds and flour mill limited, ewu, edo state, nigeria and given water liberally. the rats were sacrificed by cervical dislocation method on the thirty-first day of the experiment. the inferior colliculus and medial geniculate body were carefully dissected out and quickly fixed in 10% formal saline for histological study. the histological findings indicated that the treated sections of the inferior colliculus and medial geniculate body showed that the chromatophilics substances were less intensely stained as compared to the control. the parenchyme was vacuolated and with evidence of hypertrophy and more spaces between the axonal mesh around the sparsely distributed neurons as compared to the control group. the treated section of the inferior colliculus showed neurons with faintly stained chromatophilics substances in large, medium and small sized neurons while that of the medial geniculate body showed less intense and enlarge chromatophilics substances with some vacuolations. chronic administration of efavirenz may therefore have an adverse effect on the chromatophilics substances of the inferior colliculus and medial geniculate body of adult wistar rats. it is recommen
Effects of Chronic Administration of Efavirenz on the Chromatophilic Substance of the Intracranial Auditory Relay Centres of Adult Wistar Rats Efectos de la Administración Crónica de Efavirenz sobre la Sustancia Cromatofílica de los Centros de Relevo Auditivos Intracraneales de Ratas Wistar Adultas
J. O Adjene,P. S Igbigbi
International Journal of Morphology , 2012,
Abstract: The effects of chronic administration of efavirenz commonly used as part of highly active antiretroviral therapy (HAART) for the treatment of Human Immunodeficiency Virus (HIV) type-1 therapy on the chromatophilic substance of the intracranial auditory relay centre namely the inferior colliculus and medial geniculate body of adult wistar rats were carefully studied. The rats of both sexes (n=20), with an average weight of 200g were randomly assigned into treatment (n=10) and control (n=10) groups. The rats in the treatment group received 600 mg/70kg body weight of efavirenz dissolved in distilled water daily for 30 days through the orogastric tube. The control group received equal volume of distilled water daily for 30 days through the same route. The rats were fed with grower's mash obtained from Edo Feeds and Flour Mill Limited, Ewu, Edo state, Nigeria and given water liberally. The rats were sacrificed by cervical dislocation method on the thirty-first day of the experiment. The inferior colliculus and medial geniculate body were carefully dissected out and quickly fixed in 10% formal saline for histological study. The histological findings indicated that the treated sections of the inferior colliculus and medial geniculate body showed that the chromatophilics substances were less intensely stained as compared to the control. The parenchyme was vacuolated and with evidence of hypertrophy and more spaces between the axonal mesh around the sparsely distributed neurons as compared to the control group. The treated section of the inferior colliculus showed neurons with faintly stained chromatophilics substances in large, medium and small sized neurons while that of the medial geniculate body showed less intense and enlarge chromatophilics substances with some vacuolations. Chronic administration of efavirenz may therefore have an adverse effect on the chromatophilics substances of the inferior colliculus and medial geniculate body of adult wistar rats. It is recommended that further studies aimed at corroborating these observations be carried out. Fueron estudiados los efectos de la administración crónica del efavirenz, comúnmente utilizado como parte del tratamiento antirretroviral de gran actividad para el VIH tipo 1, sobre la sustancia cromatofílica del centro de relevo auditivo intracraneal, el colículo inferior y cuerpo geniculado medial, en ratas Wistar adultas. Ratas de ambos sexos (n = 20), con un peso promedio de 200g fueron asignadas aleatoriamente a tratamiento (n = 10) y control (n = 10). Las ratas del grupo tratado recibieron 600mg/70kg peso
Effects of chronic administration of efavirenz on the deoxyribonucleic acid (DNA) of the intracranial auditory relay centres of adult wistar rats.
J.O. Adjene,P.S. Igbigbi
Bioscience Research , 2011,
Abstract: The effects of chronic administration of efavirenz commonly used as part of highly active antiretroviral therapy (HAART) for the treatment of Human Immunodeficiency Virus (HIV) type-1 therapy on the DNA of the intracranial auditory relay centre namely the inferior colliculus and medial geniculate body of adult wistar rats were carefully studied. The rats of both sexes (n=20), with an average weight of 200g were randomly assigned into treatment (n=10) and control (n=10) groups. The rats in the treatment group received 600mg/70kg body weight of efavirenz dissolved in distilled water daily for 30 days through the orogastric tube. The control group received equal volume of distilled water daily for 30 days through the same route. The rats were fed with grower’s mash obtained from Edo Feeds and Flour Mill Limited, Ewu, Edo state, Nigeria and given water liberally. The rats were sacrificed by cervical dislocation method on the thirty-first day of the experiment. The inferior colliculus and medial geniculate body were carefully dissected out and quickly fixed in 10% formal saline for histochemical study. The histochemical findings indicated that the treated sections of the inferior colliculus and medial geniculate body showed less intense staining and appearing pachychromatic. The stained neurons and glia cells were few as compared to the control sections. There were observations of neuronal enlargement in the inferior colliculus and medial geniculate body of the treated sections. The inferior colliculus of the treated group showed evidence of hypertrophy and microcytic changes in the darkly stained DNA positive granules, while the treated section of the medial geniculate body showed positively stained DNA granules of various sizes and shapes, with an indication of hypertrophy and microcytic changes as compared to the control group. Chronic administration of efavirenz may therefore have an adverse effect on the DNA of the inferior colliculus and medial geniculate body of adult wistar rats. It is recommended that further studies aimed at corroborating these observations be carried out.
HISTOLOGICAL EFFECTS OF CHRONIC CONSUMPTION OF NUTMEG ON THE LATERAL GENICULATE BODY OF ADULT WISTAR RATS.
J.O. Adjene,P.S. Igbigbi
Electronic Journal of Biomedicine , 2010,
Abstract: The effects of chronic consumption of nutmeg commonly used as a spice in various dishes, as components of teas and soft drinks or mixed in milk and alcohol on the lateral geniculate body of adult wistar rats was studied.The rats of both sexes, with average weight of 200g were randomly assigned into treatment and control groups. The rats in the treatment group (n=8) received 2g of nutmeg thoroughly mixed with the feeds on a daily basis for thirty-two days. The control group (n=8) received equal amount of feeds daily without nutmeg added for thirty-two days. The growers mash feeds was obtained from Edo Feeds and Flour Mill Limited, Ewu, Edo State, Nigeria and the rats were given water liberally. The rats were sacrificed on the thirty-three day of the experiment. The lateral geniculate body was carefully dissected out and quickly fixed in 10% formal saline for histological study.The findings indicate that rats in the treated group showed some cellular degenerative changes like sparse cellular population, pyknotic nuclei with some microcystic changes, edema and vacuolations in the stroma of the treated lateral geniculate body as compared to that of the control group.Chronic consumption of nutmeg may therefore have an adverse effect on the visual sensibilities by affecting the microanatomy of the lateral geniculate body of adult wistar rats. It is recommended for further studies aimed at corroborating these observations.
A Look at the Effect of Hand Dominance on Learning
E. Emore,O.A. Ebeye,H.K. Odion-Obomhense,P.S. Igbigbi
Journal of Applied Sciences , 2008,
Abstract: Hand dominance or handedness has been associated with a lot of other conditions; in the case of left handedness, most of them deleterious. Left handedness was also thought to adversely affect learning. In this study, self-assessment questionnaires were filled by 606 primary school pupils. Their ages ranged between 6 and 16 years, with a mean age of 11.1 and a mode of 12 years. The questionnaires were analysed using Chi-square test on SPSS. The handedness of the respondents was associated with learning, using their graded performance in class. There were 537 (94.9%) right-handers, thirty (5.1%) non-right handed children. A significant proportion of the non-right handed respondents performed above their class average. Handedness was thus found to significantly affect learning (p< 0.05).
Histopathological Effect of Piper guineese Extract on Wistar Rats
O.A. Ebeye,E. Emore,B.U. Enaibe,P.S. Igbigbi
Journal of Biological Sciences , 2007,
Abstract: The toxicity of Piper guineese extract, known as a spice and seasoning and also used in treatment of different ailment such as malaria was investigated in rats. Twenty four wistar rats were obtained, weighed and divided into four groups of six per group. They were allowed access to rat feed and tap water ad- libitum for two weeks period of acclimatization. Different concentrations of Piper guineese extract were administered to three of the experimental groups. 25, 50 and 75 mg/100 g, while the fourth group received 100% tap water and served as control. The study lasted 21 days. The results obtained showed slightly reduced agility, loss of appetite in animals treated with higher concentration of extract. Sections through the kidneys and livers of the sacrificed animals showed alteration of their normal cyto-architecture, some of which were pathological. The result of the present study suggests that Piper guineese could be toxic at certain dosage and over prolonged periods.
Palmar and digital dermatoglyphic traits of Kenyan and Tanzanian subjects
PS Igbigbi, BC Msamati
West African Journal of Medicine , 2005,
Abstract: Dermatoglyphic traits, along with other morphological, molecular and biochemical markers have traditionally been used in biological anthropology to explore affinities and differences among human groups. Methodology: We carried out a cross-sectional study of healthy able-bodied volunteers of indigenous Kenyan and Tanzanian subjects to establish their palmar and digital dermatoglyphic traits, by counting and classifying their ridge pattern configurations of arches, loops, whorls and ridges based on standard techniques. Results: Ulnar loops were the most prevalent digital ridge patterns and arches were the least in our samples with significant sex differences exhibited in arches, ulnar loops and whorls (P < 0.05). Similarly, men had significantly higher TFRC than women in Kenyans (P < 0.001), while Tanzanians showed no sex difference (P < 0.5). Women, however, had higher PII than men in Kenyans but the reverse was true in Tanzanians. In both groups, men showed significantly higher mean a-b ridge counts than women (P < 0.001, Kenyans; < 0.01, Tanzanians), and women showed greater mean atd angles than men (P > 0.5). The TFRC, atd angle and a-b ridge count were significantly different between Kenyans and Tanzanians (P < 0.001). Conclusion: This study documents probably for the first time the normal and comparative dermatoglyphic traits of two East African populations, indicating that Tanzanians are dermatoglyphically closer to Malawians than Kenyans.
The position and dimensions of the mental foramen in adult Malawian mandibles
PS Igbigbi, S Lebona
West African Journal of Medicine , 2005,
Abstract:
Dermatoglyphics of mothers of Malawian children with spina bifida cystica: A comparative study with female controls
PS Igbigbi, A Adeloye
West African Journal of Medicine , 2005,
Abstract: Dermatoglyphic traits are formed under genetic control early in development and do not change thereafter, thus maintaining stability not affected by age. Methodology: We determined the dermatoglyphic traits of mothers of children with spina bifida cystica and compared then with controls matched for number, age and parity, by counting and classifying palmar, plantar and digital ridge pattern configurations of arches, loops, whorls and ridges based on standard techniques. Results: Palmar pattern types, showed absence of arches, significantly higher frequency of whorls (P > 0.05), lower total finger ridge count (TFRC) and higher Pattern Intensity Index (PII) in these mothers than in the controls (P > 0.001). However, no significant differences were observed between both groups in atd angle and a-b ridge count (P = 1.30, 0.70 respectively). Plantar pattern types showed loops restricted to the first two digits and absence of arches in the first digit in these mothers compared to controls in whom there were loops in the first four digits and a 100% frequency of arches. Similarly, PII was higher and Dankmeijer's Index (DI) lower in these mothers than in controls. Conclusion: Our findings demonstrate dermatoglyphic differences between both groups that suggest that mothers presenting with these traits are more predisposed to giving birth to children with spina bifida cystica.
Age estimation of Malawian adults from dental radiographs
PS Igbigbi, Saulos K Nyirenda
West African Journal of Medicine , 2005,
Abstract: Background: Previous studies have shown that with advancing age the size of the dental pulp cavity is reduced as a result of secondary dentine deposit, so that measurements of this reduction can be used as an indicator of age. Age estimation is one of the indicators used in forensic identification and teeth are biological markers for human age estimation. Methodology: We measured the height (mm) of the crown (CH = Coronal Height) and the height (mm) of the coronal pulp cavity (CPCH = Coronal pulp cavity height) of premolars and molars of 134 adult Malawians (77 males, 57 females) aged 20 80 years from dental radiographs. The Tooth-Coronal Index (TCI) was computed for each tooth and regressed on real age. Result: The correlation coefficients ranged from r 0.650 to 0.799 and were significant in both gender, in premolars and molars (P<0.01). The equations obtained allowed estimation of age with an error of ±5 years in our studied population, the molar equation estimated age better for males while the premolar equation was for female and combined samples. The percentage accuracy levels of our sample population were higher than Caucasians previously reported using similar methods. Conclusion: Our study demonstrates the potential value of this method of age estimation which is precise, simple, non invasive and applicable to both living individuals and skeletal materials of unknown age.
Page 1 /386988
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.